Kl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kl
Entrez Gene ID	83504
Full Name	Klotho
General protein information	Preferred Names Klotho Names klotho
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p12
Summary	may be involved in suprresion of aging phenotypes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031336.1	NP_112626.1	klotho precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KL	XP_522655.2
	LOC714042	XP_001101127.1
Homo sapiens (human)	KL	NP_004786.2
Canis lupus familiaris (dog)	KL	XP_003433357.1
Bos taurus (cattle)	KL	NP_001178124.1
Mus musculus (house mouse)	Kl	NP_038851.2
Danio rerio (zebrafish)	kl	XP_690797.4
Rattus norvegicus (Norway rat)	Kl	NP_112626.1
Gallus gallus (chicken)	KL	XP_004938814.1
Xenopus tropicalis (tropical clawed frog)	kl	XP_002934067.1

Gene Ontology
Bibliography

Related articles in PubMed

Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury.
Gazdhar A, Ravikumar P, Pastor J, Heller M, Ye J, Zhang J, Moe OW, Geiser T, Hsia CCW
Stem cells (Dayton, Ohio)(2017 Dec)

Klotho & Activin A in kidney injury Plasma Klotho is maintained in unilateral obstruction despite no upregulation of Klotho biosynthesis in contralateral kidney.
Nordholm A, Mace ML, Gravesen E, Hofman-Bang J, Morevati M, Olgaard K, Lewin E
American journal of physiology. Renal physiologyajprenal005282017(2017 Nov)

Differential regulation of renal Klotho and FGFR1 in normal and uremic rats.
Mu?oz-Casta?eda JR, Herencia C, Pend?n-Ruiz de Mier MV, Rodriguez-Ortiz ME, Diaz-Tocados JM, Vergara N, Mart?nez-Moreno JM, Salmer?n MD, Richards WG, Felsenfeld A, Kuro-O M, Almad?n Y, Rodr?guez M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(9)3858-3867(2017 Sep)

Klotho inhibits angiotensin II-induced cardiomyocyte hypertrophy through suppression of the AT1R/beta catenin pathway.
Yu L, Meng W, Ding J, Cheng M
Biochemical and biophysical research communications473(2)455-61(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In summary, high FGF23 levels increase FGFR1, whereas phosphaturia decreases Klotho expression through the activation of Wnt/beta-catenin pathway.
Title: Differential regulation of renal Klotho and FGFR1 in normal and uremic rats.

The antiaging protein klotho inhibits angiotensin II -induced cardiomyocyte hypertrophy.
Title: Klotho inhibits angiotensin II-induced cardiomyocyte hypertrophy through suppression of the AT1R/beta catenin pathway.

Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho via the calcitonin receptor/modifying protein complex and protein kinase A signaling.
Title: Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of ?-Klotho.

The results suggested that the cardioprotective effects of klotho were related to the attenuation of oxidative stress, and oxidative stress suppressed the transcription of klotho
Title: Klotho ameliorated isoproterenol-induced pathological changes in cardiomyocytes via the regulation of oxidative stress.

These results indicated that klotho gene delivery ameliorated renal hypertrophy and fibrosis in diabetic rats, possibly by suppressing the ROCK signaling pathway
Title: Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway.

The following Kl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12901	NM_031336.1 Latest version!	Rattus norvegicus Klotho (Kl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$748.30 $1069.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kl ( NM_031336.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112626.1 Rattus norvegicus Klotho (Kl), mRNA.

Price & Availability↑

CloneID	ORa12901
Clone ID Related Accession (Same CDS sequence)	NM_031336.1
Accession Version	NM_031336.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3045bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	klotho precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB017820.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB017820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCAGCCC GCGCCCCTCC TCGCCGCCTG CCGCGGCTCT TGCTGCTCCG TTTGCTGTCG 
CTGCATCTGC TGTTGCTCAC CCTGCGCGCC CGCTGCCTAA GCGCTGAGCC GGGTCAGGGC 
GCGCAGACCT GGGCTCGCTT TGCGCGCCCT CCTGTCCCAG AGGCCTCTGG CCTCCTCCAT 
GACACCTTCC CCGATGGTTT CCTCTGGGCG GTAGGCAGCG CCGCCTACCA GACGGAGGGC 
GGCTGGCGAC AGCACGGCAA AGGCGCGTCC ATCTGGGACA CTTTCACCCA TCACCCTCGG 
GCCATCCCGG AGGACTCCCC GATCGTCATG GCGCCGTCGG GTGCCCCGTT GCCTCCCCTG 
CCCTCCACTG GAGATGTGGC CAGCGACAGT TACAACAACG TCTACCGCGA CACAGAGGGG 
CTACGCGAAC TGGGGGTCAC CCACTACCGC TTCTCCATAT CGTGGGCGCG GGTGCTCCCC 
AATGGCACCG CGGGCACCCC CAACCGCGAG GGGCTGCGCT ACTACCGGCG GCTGCTGGAG 
CGGCTGAGGG AGCTGGGCGT GCAGCCGGTG GTCACTCTGT ACCATTGGGA CCTGCCGCAG 
CGCCTGCAGG ACACCTATGG CGGCTGGGCC AATCGCGCCC TGGCCGACCA TTTCAGGGAT 
TACGCCGAGC TCTGCTTCCG CCACTTCGGT GGTCAGGTCA AGTACTGGAT CACCATTGAC 
AACCCCTACG TGGTGGCCTG GCACGGGTAC GCCACCGGCC GCCTGGCCCC GGGCGTGCGG 
GGCAGCTCCA GGCTCGGGTA CCTGGTTGCC CACAACCTAC TTTTGGCTCA CGCCAAAGTC 
TGGCGTCTCT ACAACACCTC CTTCCGCCCC ACTCAGGGGG GCCGGGTGTC CATCGCCTTA 
GGTTCCCATT GGATCACCCC TCGAAGGATG ACCGACTATC ACATCAGAGA GTGTCAGAAG 
TCTCTTGACT TCGTGCTAGG CTGGTTTGCC AAGCCCATAT TTATCGATGG CGACTACCCA 
AAGAGTATGA AGAACAACCT CTCATCCCTG CTGCCCGATT TTACTGAATC CGAGAAGAGA 
TTCATCAGGG GAACAGCTGA CTTCTTTGCT CTCTCCTTCG GACCAACCTT GAGCTTTCAA 
CTACTGGACC CCAGCATGAA GTTCCGCCAG CTGGAGTCTC CCAGCCTGAG GCAGCTTCTG 
TCTTGGATAG ATCTGGAGTA TAACCACCCT CAGATATTTA TTGTAGAAAA TGGCTGGTTT 
GTCTCGGGGA CCACCAGAAG AGATGATGCC AAATACATGT ATTATCTCAA GAAGTTCATA 
ATGGAAAGCT TAAAAGCCAT CAGGCTGGAT GGGGTCGACG TCATTGGGTA CACCGCATGG 
TCCCTCATGG ATGGTTTCGA GTGGCACAGG GGCTACAGCA TCCGACGAGG ACTCTTCTAT 
GTCGACTTTC TGAGTCAGGA CAAGGAGTTG TTGCCCAAGT CTTCGGCCTT GTTCTACCAA 
AAGCTGATAG AGAACAATGG CTTCCCTCCT TTACCTGAGA ACCAGCCCCT TGAAGGGACG 
TTTCCCTGTG ACTTTGCTTG GGGAGTGGTT GACAACTACA TTCAAGTGGA CCCCACTCTC 
TCTCAGTTTA CTGACCCGAA TGTCTATCTG TGGGATGTGC ATCACAGTAA GAGGCTTATT 
AAAGTAGACG GGGTTGTAGC CAAGAAGAGA AAACCTTACT GTGTTGATTT CTCTGCCATC 
CGGCCTCAGA TAACCTTACT TCGAGAAATG CGGGTCACCC ACTTTCGGTT CTCCCTAGAC 
TGGGCCCTGA TCTTGCCTCT GGGTAACCAG ACTCAAGTGA ACCGCACGGT TCTGCACTTC 
TACCGCTGTA TGGTCAGCGA GCTGGTGCAC GCCAACATCA CTCCAGTGGT GGCCCTGTGG 
CAACCAGCAA CCCCACACCA AGGCCTGCCA CATGCCCTTG CAAAACATGG GGCCTGGGAG 
AACCCGCACA CTGCCCTGGC ATTTGCAGAC TACGCAAACC TGTGCTTTGA AGAGCTAGGC 
CACTGGGTCA AGTTCTGGAT CACCATAAAT GAGCCAAACT CACGGAACAT GACATACCGT 
GCGGGGCACC ACCTGCTTAA GGCTCATGCC TTGGCATGGC ACCTGTACGA TGACAAATTT 
AGGGCGGCTC AGAAAGGCAA AATATCCATC GCCTTGCAGG TTGACTGGAT AGAACCGGCC 
TGCCCATTCT CTCAGAAGGA CAAAGAAGTG GCGGAGAGAG TTTTGGAATT TGATGTAGGC 
TGGCTGGCAG AGCCCATTTT CGGCTCCGGA GATTATCCGC ATGTGATGAG GGAATGGCTG 
AACCAAAAAA ACAACTTTCT TCTGCCCTAT TTCACGGAAG ATGAGAAAAA GCTAATCCGG 
GGTTCCTTTG ACTTCCTGGC GTTGAGCCAT TACACCACCA TCCTTGTAGA CTGGGAAAAG 
GAGGATCCGA TAAAATACAA CGATTACCTG GAGGTGCAGG AGATGACTGA CATCACGTGG 
CTCAACTCCC CCAATCAGGT GGCGGTGGTG CCTTGGGGGC TGCGCAAAGC GCTCAACTGG 
CTAAGGTTCA AGTATGGAGA CCTCCCGATG TTCGTGACAG CCAATGGCAT TGATGACGAT 
CCCCATGCCG AGCAAGACTC ACTGAGGATG TATTATATTA AGAATTACGT GAATGAGGCT 
CTGAAAGCCT ACGTGTTGGA CGGCATCAAC CTTTGTGGCT ACTTTGCGTA TTCGCTTAGT 
GACCGCTCAG TTCCCAAGTC CGGCTTTTAT CGATACGCTG CGAATCAGTT CGAGCCCAAA 
CCGTCTATTA AACATTACAG GAAAATTATT GACAACAACG GCTTCCTGGG TTCTGGAACG 
CTGGGAAGGT TTTGTCCGGA AGAGTACACC GTGTGCACCG GATGCGGCTT TTTTCAAACC 
CGGAAGTCCC TGCTGGCCTT CATCTCGTTT CTAGTTTTTG CTTTCGTTAC TTCTCTCGCT 
CTTATTTATT ACTACTCCAA GAAAGGCCGG AGACGTTATA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112626.1
CDS	19..3063
Translation	MPARAPPRRLPRLLLLRLLSLHLLLLTLRARCLSAEPGQGAQTWARFARPPVPEASGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHPRAIPEDSPIVMAPSGAPLPPLPSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWRLYNTSFRPTQGGRVSIALGSHWITPRRMTDYHIRECQKSLDFVLGWFAKPIFIDGDYPKSMKNNLSSLLPDFTESEKRFIRGTADFFALSFGPTLSFQLLDPSMKFRQLESPSLRQLLSWIDLEYNHPQIFIVENGWFVSGTTRRDDAKYMYYLKKFIMESLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIENNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDPTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNRTVLHFYRCMVSELVHANITPVVALWQPATPHQGLPHALAKHGAWENPHTALAFADYANLCFEELGHWVKFWITINEPNSRNMTYRAGHHLLKAHALAWHLYDDKFRAAQKGKISIALQVDWIEPACPFSQKDKEVAERVLEFDVGWLAEPIFGSGDYPHVMREWLNQKNNFLLPYFTEDEKKLIRGSFDFLALSHYTTILVDWEKEDPIKYNDYLEVQEMTDITWLNSPNQVAVVPWGLRKALNWLRFKYGDLPMFVTANGIDDDPHAEQDSLRMYYIKNYVNEALKAYVLDGINLCGYFAYSLSDRSVPKSGFYRYAANQFEPKPSIKHYRKIIDNNGFLGSGTLGRFCPEEYTVCTGCGFFQTRKSLLAFISFLVFAFVTSLALIYYYSKKGRRRYK

Target ORF information:

RefSeq Version	NM_031336.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Klotho (Kl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031336.1

ORF Insert Sequence:

ATGCCAGCCC GCGCCCCTCC TCGCCGCCTG CCGCGGCTCT TGCTGCTCCG TTTGCTGTCG 
CTGCATCTGC TGTTGCTCAC CCTGCGCGCC CGCTGCCTAA GCGCTGAGCC GGGTCAGGGC 
GCGCAGACCT GGGCTCGCTT TGCGCGCCCT CCTGTCCCAG AGGCCTCTGG CCTCCTCCAT 
GACACCTTCC CCGATGGTTT CCTCTGGGCG GTAGGCAGCG CCGCCTACCA GACGGAGGGC 
GGCTGGCGAC AGCACGGCAA AGGCGCGTCC ATCTGGGACA CTTTCACCCA TCACCCTCGG 
GCCATCCCGG AGGACTCCCC GATCGTCATG GCGCCGTCGG GTGCCCCGTT GCCTCCCCTG 
CCCTCCACTG GAGATGTGGC CAGCGACAGT TACAACAACG TCTACCGCGA CACAGAGGGG 
CTACGCGAAC TGGGGGTCAC CCACTACCGC TTCTCCATAT CGTGGGCGCG GGTGCTCCCC 
AATGGCACCG CGGGCACCCC CAACCGCGAG GGGCTGCGCT ACTACCGGCG GCTGCTGGAG 
CGGCTGAGGG AGCTGGGCGT GCAGCCGGTG GTCACTCTGT ACCATTGGGA CCTGCCGCAG 
CGCCTGCAGG ACACCTATGG CGGCTGGGCC AATCGCGCCC TGGCCGACCA TTTCAGGGAT 
TACGCCGAGC TCTGCTTCCG CCACTTCGGT GGTCAGGTCA AGTACTGGAT CACCATTGAC 
AACCCCTACG TGGTGGCCTG GCACGGGTAC GCCACCGGCC GCCTGGCCCC GGGCGTGCGG 
GGCAGCTCCA GGCTCGGGTA CCTGGTTGCC CACAACCTAC TTTTGGCTCA CGCCAAAGTC 
TGGCGTCTCT ACAACACCTC CTTCCGCCCC ACTCAGGGGG GCCGGGTGTC CATCGCCTTA 
GGTTCCCATT GGATCACCCC TCGAAGGATG ACCGACTATC ACATCAGAGA GTGTCAGAAG 
TCTCTTGACT TCGTGCTAGG CTGGTTTGCC AAGCCCATAT TTATCGATGG CGACTACCCA 
AAGAGTATGA AGAACAACCT CTCATCCCTG CTGCCCGATT TTACTGAATC CGAGAAGAGA 
TTCATCAGGG GAACAGCTGA CTTCTTTGCT CTCTCCTTCG GACCAACCTT GAGCTTTCAA 
CTACTGGACC CCAGCATGAA GTTCCGCCAG CTGGAGTCTC CCAGCCTGAG GCAGCTTCTG 
TCTTGGATAG ATCTGGAGTA TAACCACCCT CAGATATTTA TTGTAGAAAA TGGCTGGTTT 
GTCTCGGGGA CCACCAGAAG AGATGATGCC AAATACATGT ATTATCTCAA GAAGTTCATA 
ATGGAAAGCT TAAAAGCCAT CAGGCTGGAT GGGGTCGACG TCATTGGGTA CACCGCATGG 
TCCCTCATGG ATGGTTTCGA GTGGCACAGG GGCTACAGCA TCCGACGAGG ACTCTTCTAT 
GTCGACTTTC TGAGTCAGGA CAAGGAGTTG TTGCCCAAGT CTTCGGCCTT GTTCTACCAA 
AAGCTGATAG AGAACAATGG CTTCCCTCCT TTACCTGAGA ACCAGCCCCT TGAAGGGACG 
TTTCCCTGTG ACTTTGCTTG GGGAGTGGTT GACAACTACA TTCAAGTGGA CCCCACTCTC 
TCTCAGTTTA CTGACCCGAA TGTCTATCTG TGGGATGTGC ATCACAGTAA GAGGCTTATT 
AAAGTAGACG GGGTTGTAGC CAAGAAGAGA AAACCTTACT GTGTTGATTT CTCTGCCATC 
CGGCCTCAGA TAACCTTACT TCGAGAAATG CGGGTCACCC ACTTTCGGTT CTCCCTAGAC 
TGGGCCCTGA TCTTGCCTCT GGGTAACCAG ACTCAAGTGA ACCGCACGGT TCTGCACTTC 
TACCGCTGTA TGGTCAGCGA GCTGGTGCAC GCCAACATCA CTCCAGTGGT GGCCCTGTGG 
CAACCAGCAA CCCCACACCA AGGCCTGCCA CATGCCCTTG CAAAACATGG GGCCTGGGAG 
AACCCGCACA CTGCCCTGGC ATTTGCAGAC TACGCAAACC TGTGCTTTGA AGAGCTAGGC 
CACTGGGTCA AGTTCTGGAT CACCATAAAT GAGCCAAACT CACGGAACAT GACATACCGT 
GCGGGGCACC ACCTGCTTAA GGCTCATGCC TTGGCATGGC ACCTGTACGA TGACAAATTT 
AGGGCGGCTC AGAAAGGCAA AATATCCATC GCCTTGCAGG TTGACTGGAT AGAACCGGCC 
TGCCCATTCT CTCAGAAGGA CAAAGAAGTG GCGGAGAGAG TTTTGGAATT TGATGTAGGC 
TGGCTGGCAG AGCCCATTTT CGGCTCCGGA GATTATCCGC ATGTGATGAG GGAATGGCTG 
AACCAAAAAA ACAACTTTCT TCTGCCCTAT TTCACGGAAG ATGAGAAAAA GCTAATCCGG 
GGTTCCTTTG ACTTCCTGGC GTTGAGCCAT TACACCACCA TCCTTGTAGA CTGGGAAAAG 
GAGGATCCGA TAAAATACAA CGATTACCTG GAGGTGCAGG AGATGACTGA CATCACGTGG 
CTCAACTCCC CCAATCAGGT GGCGGTGGTG CCTTGGGGGC TGCGCAAAGC GCTCAACTGG 
CTAAGGTTCA AGTATGGAGA CCTCCCGATG TTCGTGACAG CCAATGGCAT TGATGACGAT 
CCCCATGCCG AGCAAGACTC ACTGAGGATG TATTATATTA AGAATTACGT GAATGAGGCT 
CTGAAAGCCT ACGTGTTGGA CGGCATCAAC CTTTGTGGCT ACTTTGCGTA TTCGCTTAGT 
GACCGCTCAG TTCCCAAGTC CGGCTTTTAT CGATACGCTG CGAATCAGTT CGAGCCCAAA 
CCGTCTATTA AACATTACAG GAAAATTATT GACAACAACG GCTTCCTGGG TTCTGGAACG 
CTGGGAAGGT TTTGTCCGGA AGAGTACACC GTGTGCACCG GATGCGGCTT TTTTCAAACC 
CGGAAGTCCC TGCTGGCCTT CATCTCGTTT CTAGTTTTTG CTTTCGTTAC TTCTCTCGCT 
CTTATTTATT ACTACTCCAA GAAAGGCCGG AGACGTTATA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury.
Stem cells (Dayton, Ohio)(2017 Dec)
Gazdhar A,Ravikumar P,Pastor J,Heller M,Ye J,Zhang J,Moe OW,Geiser T,Hsia CCW

Klotho & Activin A in kidney injury Plasma Klotho is maintained in unilateral obstruction despite no upregulation of Klotho biosynthesis in contralateral kidney.
American journal of physiology. Renal physiologyajprenal005282017(2017 Nov)
Nordholm A,Mace ML,Gravesen E,Hofman-Bang J,Morevati M,Olgaard K,Lewin E

Differential regulation of renal Klotho and FGFR1 in normal and uremic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(9)3858-3867(2017 Sep)
Mu?oz-Casta?eda JR,Herencia C,Pend?n-Ruiz de Mier MV,Rodriguez-Ortiz ME,Diaz-Tocados JM,Vergara N,Mart?nez-Moreno JM,Salmer?n MD,Richards WG,Felsenfeld A,Kuro-O M,Almad?n Y,Rodr?guez M

Klotho inhibits angiotensin II-induced cardiomyocyte hypertrophy through suppression of the AT1R/beta catenin pathway.
Biochemical and biophysical research communications473(2)455-61(2016 Apr)
Yu L,Meng W,Ding J,Cheng M

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Kl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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