Cdh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdh1
Entrez Gene ID	83502
Full Name	cadherin 1
General protein information	Preferred Names cadherin 1 Names cadherin-1 E-cadherin epithelial cadherin uvomorulin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12
Summary	cell-cell adhesion molecule; may play a role in axonal growth and synase formation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031334.1	NP_112624.1	cadherin-1 precursor

Pathways from BioSystems

Homologies

	CDH1	XP_002802562.1
Rattus norvegicus (Norway rat)	Cdh1	NP_112624.1
Danio rerio (zebrafish)	cdh1	NP_571895.1
Homo sapiens (human)	CDH1	NP_004351.1
Danio rerio (zebrafish)	LOC568392	XP_696808.4
Canis lupus familiaris (dog)	CDH1	XP_536807.3
Xenopus tropicalis (tropical clawed frog)	LOC100485633	XP_002936044.1
Bos taurus (cattle)	CDH1	NP_001002763.1
Gallus gallus (chicken)	CDH1	NP_001034347.2
Danio rerio (zebrafish)	si:dkey-173l11.3	XP_005166659.1
Pan troglodytes (chimpanzee)	CDH1	XP_001168150.1
Mus musculus (house mouse)	Cdh1	NP_033994.1
Danio rerio (zebrafish)	si:ch211-206i14.2	XP_695998.5
Danio rerio (zebrafish)	si:busm1-71b9.3	XP_005166660.1

Gene Ontology
Bibliography

Related articles in PubMed

Upregulation of Cdh1 signaling in the hippocampus attenuates brain damage after transient global cerebral ischemia in rats.
Zhang B, Wei K, Li X, Hu R, Qiu J, Zhang Y, Yao W, Zhang C, Zhu C
Neurochemistry international112166-178(2018 Jan)

Blepharocheilodontic syndrome is a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1.
Ghoumid J, Stichelbout M, Jourdain AS, Frenois F, Lejeune-Dumoulin S, Alex-Cordier MP, Lebrun M, Guerreschi P, Duquennoy-Martinot V, Vinchon M, Ferri J, Jung M, Vicaire S, Vanlerberghe C, Escande F, Petit F, Manouvrier-Hanu S
Genetics in medicine : official journal of the American College of Medical Genetics19(9)1013-1021(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Silk fibroin peptide (SF16) hydrogel promotes PC12 growth/adhesion via mTOR/cadherin signaling pathway.
Title: Promotion of cell growth and adhesion of a peptide hydrogel scaffold via mTOR/cadherin signaling.

The present results suggest that E-cadherin-mediated cell attachment is necessary for the activation of Notch signaling in the anterior pituitary gland but not for the expression of the Notch2 molecule.
Title: Notch signaling-mediated cell-to-cell interaction is dependent on E-cadherin adhesion in adult rat anterior pituitary.

Supplementation with vitamin E, with or without caloric restriction, upregulated the mRNA expression of Cx26, N-cad, E-cad and genes involved in cholesterol metabolism, suggesting the maintenance of hepatic homeostasis.
Title: Vitamin E and caloric restriction promote hepatic homeostasis through expression of connexin 26, N-cad, E-cad and cholesterol metabolism genes.

Rab7 regulates CDH1 endocytosis, circular dorsal ruffles genesis, and thyroglobulin pinocytosis in a thyroid cell line.
Title: Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line.

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons
Title: Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.

The following Cdh1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdh1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07850	NM_031334.1 Latest version!	Rattus norvegicus cadherin 1 (Cdh1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$524.30 $749.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdh1 ( NM_031334.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112624.1 Rattus norvegicus cadherin 1 (Cdh1), mRNA.

Price & Availability↑

CloneID	ORa07850
Clone ID Related Accession (Same CDS sequence)	NM_031334.1
Accession Version	NM_031334.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2661bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Rattus norvegicus(Norway rat)
Product	cadherin-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB017696.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB017696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END##

ATGGGAGCCC GGTGCCGCAG CTTCTCCGCG CTCCTGCTCC TGCTGCAGGT CTCCTCGTGG 
CTTTGTCAGC AGCCGGAGTC GGAGTCTGAC TCCTGCCGTC CCGGCTTCAG TTCCGAGGTC 
TACACCTTCC TGGTGCCGGA GAGGCACCTG GAGAGAGGCC ACATCCTGGG CAGAGTGAAA 
TTTGAAGGAT GCACCGGCCG TCCAAGGACA GCCTTCTTTT CTGAAGACTC CCGATTCAAA 
GTGTCTACAG ATGGCGTCAT CACAGTCAAA CGGCATCTAA AGCTTCACAA GCTGGAGACC 
AGTTTTCTCG TCCATGCCTG GGACTCCAGT TACAGGAAGC TTTCTACCAA AGTGACACTG 
AAGTCCCTGG GCCACCACCA CCACCGGCAT CACCACAGAG ACCCTGTCTC TGAATCCAAC 
CCAGAGCTGC TCACGTTTCC CAGCTTTCAC CAGGGTCTGA GAAGACAGAA ACGAGACTGG 
GTCATCCCTC CCATCAACTG CCCGGAAAAT CAAAAGGGCG AATTCCCCCA GCGACTGGTT 
CAGATCAAAT CCAACAGGGA CAAAGAGACA ACGGTTTTCT ACAGCATCAC CGGCCCAGGA 
GCTGACAAAC CCCCTGTTGG CGTTTTCATC ATTGAGAGGG AGACAGGCTG GCTGAAAGTG 
ACGCAGCCTC TGGACAGAGA AGCCATTGAC AAGTACCTTC TCTACTCTCA TGCTGTGTCA 
TCAAATGGGG AAGCCGTGGA GGATCCCATG GAGATAGTGG TCACAGTCAC AGATCAGAAT 
GACAACAGGC CAGAGTTTAT CCAGGAGGTC TTTGAGGGAT CTGTTGCAGA AGGCGCTCTT 
CCAGGAACCT CCGTGATGCA GGTCTCAGCC ACTGATGCAG ACGATGACAT AAACACCTAC 
AATGCTGCCA TCGCCTACAC CATCCTCAGC CAAGATCCTG AGCTGCCTCA CAAAAACATG 
TTCACTGTCA ACCGGGACAC TGGGGTCATC AGTGTGGTCA CCTCCGGACT GGACCGAGAG 
AGTTACCCTA CATATACTCT GGTGGTTCAG GCTGCCGACC TTCAAGGCGA AGGCCTAAGC 
ACAACAGCAA AAGCTGTGAT CACTGTCAAG GATATTAATG ACAACGCTCC CATCTTCAAC 
CCAAGCACGT ACCAGGGTCA AGTGCTTGAG AATGAGGTCG GTGCCCGTAT TGCCACACTC 
AAGGTGACTG ATGATGATGC CCCCAACACT CCAGCGTGGA ATGCTGTGTA CACCGTAGTC 
AATGATCCTG ATCATCAGTT CACTGTCATC ACAGACCCCA AGACCAACGA GGGCATTCTG 
AAAACAGCCA AGGGCTTGGA TTTTGAGGCC AAGCAGCAGT ACATTCTGCA CGTGACAGTG 
GAAAATGAGG AGCCCTTTGA GGGGTCTCTT GTCCCTTCCA CAGCCACTGT CACCGTGGAT 
GTGGTAGACG TGAATGAAGC CCCCATTTTT GTGCCTGCGG AGAAGAGAGT CGAGGTGCCT 
GAGGACTTTG GTGTGGGTCT GGAGATCGCA TCTTACACTG CGCGAGAGCC AGACACATTC 
ATGGAACAGA AGATCACGTA TCGGATTTGG AGGGACACTG CCAATTGGCT GGAGATTAAC 
CCAGAGACTG GGGTCATTTC CACTCGGGCT GAGATGGACA GAGAAGATTC GGAGCATGTG 
AAGAACAGCA CGTATACAGC TCTCATCATT GCCACAGATG ATGGTTCACC CATTGCCACT 
GGCACAGGGA CTCTTCTCCT GGTCCTGTCA GACGTCAACG ACAATGCTCC CATCCCAGAA 
CCTCGAAATA TGCAGTTCTG CCAGAGAAAC CCGAAGCCCC ATGTCATCAC CATCTTGGAT 
CCAGACCTTC CCCCAAACAC ATCCCCCTTC ACTGCAGAGC TCACCCATGG GGCCAGCGTC 
AACTGGACCA TTGAGTACAA TGACGCAGAA CAAGAATCTC TCATTTTGCA ACCAAGAAAG 
GACTTAGAGA TTGGCGAATA CAAAATCAAT CTCAAGCTCT CGGATAACCA GAATAAAGAC 
CAGGTGACCA CGTTGGAGGT CCACGTGTGT GACTGTGAAG GGACCGTCAA CAACTGCATG 
AAGGCGATCT CCCTGGAAGC AGGATTACAA GTTCCCGCCA TCCTTGGAAT CCTGGGAGGG 
ATCCTGGCCC TCCTGATTCT GATCCTCCTG CTCCTACTGT TTCTACGGAG GAGAACGGTG 
GTCAAAGAGC CCTTGCTGCC ACCAGATGAC GATACCCGGG ACAATGTGTA TTACTATGAT 
GAAGAGGGAG GTGGAGAAGA AGACCAGGAC TTTGATTTGA GCCAGCTGCA CAGGGGCCTT 
GATGCCAGAC CGGAAGTGAT TCGAAATGAT GTGGCTCCCA CCCTCATGAG CATGCCCCAG 
TATCGTCCCC GTCCAGCCAA TCCTGATGAA ATCGGGAACT TCATCGATGA AAACCTGAAG 
GCAGCGGACA GTGACCCCAC AGCGCCCCCT TACGACTCTC TGTTGGTGTT TGACTATGAG 
GGGAGTGGTT CTGAAGCTGC CTCCCTGAGC TCGCTGAACT CCTCTGAGTC AGATCAGGAC 
CAGGACTACG ATTATCTGAA CGAATGGGGC AACCGGTTCA AGAAGCTGGC CGATATGTAT 
GGTGGCGGCG AAGAAGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112624.1
CDS	127..2787
Translation	MGARCRSFSALLLLLQVSSWLCQQPESESDSCRPGFSSEVYTFLVPERHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSYRKLSTKVTLKSLGHHHHRHHHRDPVSESNPELLTFPSFHQGLRRQKRDWVIPPINCPENQKGEFPQRLVQIKSNRDKETTVFYSITGPGADKPPVGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRPEFIQEVFEGSVAEGALPGTSVMQVSATDADDDINTYNAAIAYTILSQDPELPHKNMFTVNRDTGVISVVTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVLENEVGARIATLKVTDDDAPNTPAWNAVYTVVNDPDHQFTVITDPKTNEGILKTAKGLDFEAKQQYILHVTVENEEPFEGSLVPSTATVTVDVVDVNEAPIFVPAEKRVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTANWLEINPETGVISTRAEMDREDSEHVKNSTYTALIIATDDGSPIATGTGTLLLVLSDVNDNAPIPEPRNMQFCQRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEQESLILQPRKDLEIGEYKINLKLSDNQNKDQVTTLEVHVCDCEGTVNNCMKAISLEAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVIRNDVAPTLMSMPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEED

Target ORF information:

RefSeq Version	NM_031334.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cadherin 1 (Cdh1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031334.1

ORF Insert Sequence:

ATGGGAGCCC GGTGCCGCAG CTTCTCCGCG CTCCTGCTCC TGCTGCAGGT CTCCTCGTGG 
CTTTGTCAGC AGCCGGAGTC GGAGTCTGAC TCCTGCCGTC CCGGCTTCAG TTCCGAGGTC 
TACACCTTCC TGGTGCCGGA GAGGCACCTG GAGAGAGGCC ACATCCTGGG CAGAGTGAAA 
TTTGAAGGAT GCACCGGCCG TCCAAGGACA GCCTTCTTTT CTGAAGACTC CCGATTCAAA 
GTGTCTACAG ATGGCGTCAT CACAGTCAAA CGGCATCTAA AGCTTCACAA GCTGGAGACC 
AGTTTTCTCG TCCATGCCTG GGACTCCAGT TACAGGAAGC TTTCTACCAA AGTGACACTG 
AAGTCCCTGG GCCACCACCA CCACCGGCAT CACCACAGAG ACCCTGTCTC TGAATCCAAC 
CCAGAGCTGC TCACGTTTCC CAGCTTTCAC CAGGGTCTGA GAAGACAGAA ACGAGACTGG 
GTCATCCCTC CCATCAACTG CCCGGAAAAT CAAAAGGGCG AATTCCCCCA GCGACTGGTT 
CAGATCAAAT CCAACAGGGA CAAAGAGACA ACGGTTTTCT ACAGCATCAC CGGCCCAGGA 
GCTGACAAAC CCCCTGTTGG CGTTTTCATC ATTGAGAGGG AGACAGGCTG GCTGAAAGTG 
ACGCAGCCTC TGGACAGAGA AGCCATTGAC AAGTACCTTC TCTACTCTCA TGCTGTGTCA 
TCAAATGGGG AAGCCGTGGA GGATCCCATG GAGATAGTGG TCACAGTCAC AGATCAGAAT 
GACAACAGGC CAGAGTTTAT CCAGGAGGTC TTTGAGGGAT CTGTTGCAGA AGGCGCTCTT 
CCAGGAACCT CCGTGATGCA GGTCTCAGCC ACTGATGCAG ACGATGACAT AAACACCTAC 
AATGCTGCCA TCGCCTACAC CATCCTCAGC CAAGATCCTG AGCTGCCTCA CAAAAACATG 
TTCACTGTCA ACCGGGACAC TGGGGTCATC AGTGTGGTCA CCTCCGGACT GGACCGAGAG 
AGTTACCCTA CATATACTCT GGTGGTTCAG GCTGCCGACC TTCAAGGCGA AGGCCTAAGC 
ACAACAGCAA AAGCTGTGAT CACTGTCAAG GATATTAATG ACAACGCTCC CATCTTCAAC 
CCAAGCACGT ACCAGGGTCA AGTGCTTGAG AATGAGGTCG GTGCCCGTAT TGCCACACTC 
AAGGTGACTG ATGATGATGC CCCCAACACT CCAGCGTGGA ATGCTGTGTA CACCGTAGTC 
AATGATCCTG ATCATCAGTT CACTGTCATC ACAGACCCCA AGACCAACGA GGGCATTCTG 
AAAACAGCCA AGGGCTTGGA TTTTGAGGCC AAGCAGCAGT ACATTCTGCA CGTGACAGTG 
GAAAATGAGG AGCCCTTTGA GGGGTCTCTT GTCCCTTCCA CAGCCACTGT CACCGTGGAT 
GTGGTAGACG TGAATGAAGC CCCCATTTTT GTGCCTGCGG AGAAGAGAGT CGAGGTGCCT 
GAGGACTTTG GTGTGGGTCT GGAGATCGCA TCTTACACTG CGCGAGAGCC AGACACATTC 
ATGGAACAGA AGATCACGTA TCGGATTTGG AGGGACACTG CCAATTGGCT GGAGATTAAC 
CCAGAGACTG GGGTCATTTC CACTCGGGCT GAGATGGACA GAGAAGATTC GGAGCATGTG 
AAGAACAGCA CGTATACAGC TCTCATCATT GCCACAGATG ATGGTTCACC CATTGCCACT 
GGCACAGGGA CTCTTCTCCT GGTCCTGTCA GACGTCAACG ACAATGCTCC CATCCCAGAA 
CCTCGAAATA TGCAGTTCTG CCAGAGAAAC CCGAAGCCCC ATGTCATCAC CATCTTGGAT 
CCAGACCTTC CCCCAAACAC ATCCCCCTTC ACTGCAGAGC TCACCCATGG GGCCAGCGTC 
AACTGGACCA TTGAGTACAA TGACGCAGAA CAAGAATCTC TCATTTTGCA ACCAAGAAAG 
GACTTAGAGA TTGGCGAATA CAAAATCAAT CTCAAGCTCT CGGATAACCA GAATAAAGAC 
CAGGTGACCA CGTTGGAGGT CCACGTGTGT GACTGTGAAG GGACCGTCAA CAACTGCATG 
AAGGCGATCT CCCTGGAAGC AGGATTACAA GTTCCCGCCA TCCTTGGAAT CCTGGGAGGG 
ATCCTGGCCC TCCTGATTCT GATCCTCCTG CTCCTACTGT TTCTACGGAG GAGAACGGTG 
GTCAAAGAGC CCTTGCTGCC ACCAGATGAC GATACCCGGG ACAATGTGTA TTACTATGAT 
GAAGAGGGAG GTGGAGAAGA AGACCAGGAC TTTGATTTGA GCCAGCTGCA CAGGGGCCTT 
GATGCCAGAC CGGAAGTGAT TCGAAATGAT GTGGCTCCCA CCCTCATGAG CATGCCCCAG 
TATCGTCCCC GTCCAGCCAA TCCTGATGAA ATCGGGAACT TCATCGATGA AAACCTGAAG 
GCAGCGGACA GTGACCCCAC AGCGCCCCCT TACGACTCTC TGTTGGTGTT TGACTATGAG 
GGGAGTGGTT CTGAAGCTGC CTCCCTGAGC TCGCTGAACT CCTCTGAGTC AGATCAGGAC 
CAGGACTACG ATTATCTGAA CGAATGGGGC AACCGGTTCA AGAAGCTGGC CGATATGTAT 
GGTGGCGGCG AAGAAGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulation of Cdh1 signaling in the hippocampus attenuates brain damage after transient global cerebral ischemia in rats.
Neurochemistry international112166-178(2018 Jan)
Zhang B,Wei K,Li X,Hu R,Qiu J,Zhang Y,Yao W,Zhang C,Zhu C

Blepharocheilodontic syndrome is a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1.
Genetics in medicine : official journal of the American College of Medical Genetics19(9)1013-1021(2017 Sep)
Ghoumid J,Stichelbout M,Jourdain AS,Frenois F,Lejeune-Dumoulin S,Alex-Cordier MP,Lebrun M,Guerreschi P,Duquennoy-Martinot V,Vinchon M,Ferri J,Jung M,Vicaire S,Vanlerberghe C,Escande F,Petit F,Manouvrier-Hanu S

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Cdh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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