Cdh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdh2
Entrez Gene ID	83501
Full Name	cadherin 2
Synonyms	N-cadherin
General protein information	Preferred Names cadherin 2 Names cadherin-2 cadherin 2, type 1, N-cadherin (neuronal) neural cadherin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p13
Summary	cell-cell adhesion molecule; may play a role in smooth muscle cell migration and adhesion in response to injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031333.1	NP_112623.1	cadherin-2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CDH2	NP_001159964.1
Mus musculus (house mouse)	Cdh2	NP_031690.3
Homo sapiens (human)	CDH2	NP_001783.2
	LOC711526	XP_002808206.1
Rattus norvegicus (Norway rat)	Cdh2	NP_112623.1
Danio rerio (zebrafish)	cdh2	NP_571156.2
Pan troglodytes (chimpanzee)	CDH2	XP_523898.3
Canis lupus familiaris (dog)	CDH2	XP_537293.3
Gallus gallus (chicken)	CDH2	NP_001001615.1
Xenopus tropicalis (tropical clawed frog)	cdh2	NP_001120890.1

Gene Ontology
Bibliography

Related articles in PubMed

N?cadherin attenuates nucleus pulposus cell senescence under high?magnitude compression.
Niu M, Ma F, Qian J, Li J, Wang T, Gao Y, Jin J
Molecular medicine reports17(2)2879-2884(2018 Feb)

PKD1 Promotes Functional Synapse Formation Coordinated with N-Cadherin in Hippocampus.
Cen C, Luo LD, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou Y, Wang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience38(1)183-199(2018 Jan)

Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform.
Silva DI, Santos BPD, Leng J, Oliveira H, Am?d?e J
Cell death & disease8(12)3209(2017 Dec)

N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3? Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression.
Li P, Liang Z, Hou G, Song L, Zhang R, Gan Y, Zhang C, Xu Y, Zhou Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(1)229-239(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Silk fibroin peptide (SF16) hydrogel promotes PC12 growth/adhesion via mTOR/cadherin signaling pathway.
Title: Promotion of cell growth and adhesion of a peptide hydrogel scaffold via mTOR/cadherin signaling.

Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex.
Title: A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.

These observations provide compelling evidence that N-cadherin adherens junctions (AJs) are sensitive to pressure and vasomotor agonists in vascular smooth muscle cells and support a functional role of N-cadherin AJs in vasomotor regulation
Title: N-Cadherin, a novel and rapidly remodelling site involved in vasoregulation of small cerebral arteries.

Supplementation with vitamin E, with or without caloric restriction, upregulated the mRNA expression of Cx26, N-cad, E-cad and genes involved in cholesterol metabolism, suggesting the maintenance of hepatic homeostasis.
Title: Vitamin E and caloric restriction promote hepatic homeostasis through expression of connexin 26, N-cad, E-cad and cholesterol metabolism genes.

N-cadherin coordinates the vascular protective actions of AMPK through a functional link with the kinase
Title: N-cadherin coordinates AMP kinase-mediated lung vascular repair.

The following Cdh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07849	NM_031333.1 Latest version!	Rattus norvegicus cadherin 2 (Cdh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdh2 ( NM_031333.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112623.1 Rattus norvegicus cadherin 2 (Cdh2), mRNA.

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CloneID	ORa07849
Clone ID Related Accession (Same CDS sequence)	NM_031333.1
Accession Version	NM_031333.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2721bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cadherin-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB017695.1. On Jan 12, 2005 this sequence version replaced XM_346508.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB017695.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906349 [ECO:0000350] ##Evidence-Data-END##

ATGTGCCGGA TAGCGGGAGC GCCGCGGACC CTGCTGCCGC TTCTGGCGGC CTTGCTTCAG 
GCATCTCTGG AGGCTTCTGG TGAACTTGCA TTATGCAAGA CTGGATTTCC TGAAGATGTT 
TACAGCGCGG TCTTACCGAA GGACGTGCAC GAAGGCCAGC CTCTTCTCAA TGTGAAATTC 
AGCAACTGCA ATAGAAAAAG GAAAGTTCAG TATGAAAGCA GTGAACCAGC AGATTTCAAG 
GTGGATGAGG ACGGCACAGT GTACGCTGTG AGAAGCTTCC CTCTCTCTGC AGAGCAGGCA 
AAGTTCCTGA TATATGCCCA AGACAAAGAA ACCCAGGAAA AGTGGCAGGT AGCTGTTAAC 
CTGAGCCTGG AGCCCAGCCT GACTGAGGAG CCGATGAAGG AACCACATGA AATTGAAGAA 
ATAGTATTCC CTAGACAACT CGCCAAGCAC AGCGGACGTC TACAAAGGCA GAAGAGAGAC 
TGGGTCATCC CTCCGATCAA CTTGCCAGAA AACTCCAGAG GACCCTTTCC GCAAGAGCTT 
GTCAGAATCA GGTCTGATAG AGATAAGAAC CTATCTCTGA GATACAGTGT CACTGGGCCA 
GGAGCTGACC AGCCTCCAAC GGGCATCTTC ATCATCAACC CCATCTCTGG ACAACTGTCA 
GTCACAAAGC CTCTGGACAG AGAACTGATA GCCCGGTTTC ACCTGAGGGC ACATGCAGTT 
GACATCAATG GCAATCAAGT GGAGAACCCC ATTGACATCG TCATCAATGT CATCGACATG 
AATGATAACA GACCTGAGTT TCTGCACCAG GTTTGGAATG GGTCTGTTCC AGAGGGATCA 
AAGCCTGGGA CGTATGTGAT GACTGTCACT GCCATTGATG CAGATGACCC AAATGCCCTG 
AATGGGATGC TGAGGTACAG GATCCTCTCC CAGGCACCCA GCACCCCTTC TCCCAACATG 
TTTACAATCA ACAACGAGAC CGGGGACATC ATCACTGTGG CAGCTGGTCT GGACCGAGAG 
AAAGTGCAAC AGTATACGTT AATAATTCAA GCCACTGACA TGGAAGGCAA TCCCACTTAC 
GGCCTTTCAA ACACAGCCAC AGCCGTCATC ACAGTGACAG ATGTCAATGA CAATCCTCCA 
GAGTTTACTG CCATGACCTT CTACGGAGAA GTCCCTGAGA ACAGAGTGGA TGTCATTGTA 
GCCAACCTGA CTGTCACCGA CAAGGACCAG CCCCACACAC CAGCCTGGAA TGCGGCATAC 
AGAATCAGTG GTGGAGACCC CACGGGAAGG TTTGCCATCC TGACAGACCC CAACAGCAAT 
GATGGGCTAG TCACAGTGGT AAAACCAATT GACTTTGAAA CGAATAGGAT GTTTGTCCTC 
ACTGTTGCTG CAGAAAACCA AGTGCCATTA GCTAAGGGGA TCCAGCACCC ACCTCAGTCG 
ACAGCCACGG TGTCTGTGAC AGTTATTGAT GTCAATGAAA ATCCTTATTT TGCCCCAAAT 
CCTAAAATCA TTCGCCAAGA GGAAGGCCTC CACGCAGGTA CCATGCTGAC CACTCTCACT 
GCTCAGGACC CCGATCGATA TATGCAACAG AATATCAGAT ACACAAAGTT ATCTGACCCT 
GCCAACTGGC TGAAAATAGA CCCTGTGAAC GGGCAGATCA CCACTATCGC TGTTCTGGAC 
AGAGAGTCGC CAAATGTCAA AAACAACATC TATAATGCTA CCTTCCTTGC TTCTGACAAT 
GGAATCCCTC CTATGAGTGG AACAGGAACG CTGCAAATCT ATTTACTTGA TATCAATGAC 
AACGCCCCTC AGGTGTTACC TCAAGAGGCC GAGACTTGTG AAACTCCAGA ACCCAATTCA 
ATTAACATCA CAGCGCTTGA TTATGACATA GACCCCAATG CAGGGCCCTT TGCATTTGAC 
CTTCCCTTAT CCCCAGTGAC CATTAAAAGA AACTGGACCA TCACCCGGCT TAAGGGTGAT 
TTTGCTCAGC TCAATTTAAA GATCAAGTTT TTGGAAGCTG GCATCTATGA AGTTCCCATC 
GTTATCACAG ATTCAGGGAA TCCCCCCAAG TCCAATATTT CGATCCTGCG TGTGAAAGTT 
TGCCAATGTG ACTCCAATGG AGACTGCACC GACGTAGACA GGATCGTGGG TGCAGGGCTT 
GGCACGGGCG CCATCATCGC GATACTTCTG TGTATCATCA TCCTGCTGAT CCTTGTCCTC 
ATGTTCGTGG TATGGATGAA ACGCCGGGAT AAAGAGCGCC AGGCCAAGCA GCTTTTAATA 
GACCCAGAAG ATGATGTAAG AGATAACATA TTGAAATATG ATGAAGAAGG TGGAGGAGAG 
GAAGACCAGG ACTATGACTT GAGCCAGCTC CAGCAACCAG ATACCGTGGA GCCTGATGCC 
ATCAAACCTG TGGGAATCAG ACGGCTAGAC GAGAGGCCTA TCCACGCTGA GCCACAATAT 
CCAGTCCGAT CCGCAGCCCC ACACCCTGGG GATATTGGGG ACTTCATTAA TGAGGGCCTT 
AAAGCTGCTG ACAATGACCC CACGGCGCCA CCATATGACT CCCTTTTAGT CTTCGACTAT 
GAGGGCAGCG GCTCCACGGC TGGCTCCTTG AGCTCTCTCA ACTCCTCCAG CAGCGGCGGG 
GACCAGGACT ATGACTACCT GAATGACTGG GGACCCCGCT TCAAGAAGCT GGCCGACATG 
TATGGTGGTG GTGATGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112623.1
CDS	337..3057
Translation	MCRIAGAPRTLLPLLAALLQASLEASGELALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLSAEQAKFLIYAQDKETQEKWQVAVNLSLEPSLTEEPMKEPHEIEEIVFPRQLAKHSGRLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLKGDFAQLNLKIKFLEAGIYEVPIVITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD

Target ORF information:

RefSeq Version	NM_031333.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cadherin 2 (Cdh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031333.1

ORF Insert Sequence:

ATGTGCCGGA TAGCGGGAGC GCCGCGGACC CTGCTGCCGC TTCTGGCGGC CTTGCTTCAG 
GCATCTCTGG AGGCTTCTGG TGAACTTGCA TTATGCAAGA CTGGATTTCC TGAAGATGTT 
TACAGCGCGG TCTTACCGAA GGACGTGCAC GAAGGCCAGC CTCTTCTCAA TGTGAAATTC 
AGCAACTGCA ATAGAAAAAG GAAAGTTCAG TATGAAAGCA GTGAACCAGC AGATTTCAAG 
GTGGATGAGG ACGGCACAGT GTACGCTGTG AGAAGCTTCC CTCTCTCTGC AGAGCAGGCA 
AAGTTCCTGA TATATGCCCA AGACAAAGAA ACCCAGGAAA AGTGGCAGGT AGCTGTTAAC 
CTGAGCCTGG AGCCCAGCCT GACTGAGGAG CCGATGAAGG AACCACATGA AATTGAAGAA 
ATAGTATTCC CTAGACAACT CGCCAAGCAC AGCGGACGTC TACAAAGGCA GAAGAGAGAC 
TGGGTCATCC CTCCGATCAA CTTGCCAGAA AACTCCAGAG GACCCTTTCC GCAAGAGCTT 
GTCAGAATCA GGTCTGATAG AGATAAGAAC CTATCTCTGA GATACAGTGT CACTGGGCCA 
GGAGCTGACC AGCCTCCAAC GGGCATCTTC ATCATCAACC CCATCTCTGG ACAACTGTCA 
GTCACAAAGC CTCTGGACAG AGAACTGATA GCCCGGTTTC ACCTGAGGGC ACATGCAGTT 
GACATCAATG GCAATCAAGT GGAGAACCCC ATTGACATCG TCATCAATGT CATCGACATG 
AATGATAACA GACCTGAGTT TCTGCACCAG GTTTGGAATG GGTCTGTTCC AGAGGGATCA 
AAGCCTGGGA CGTATGTGAT GACTGTCACT GCCATTGATG CAGATGACCC AAATGCCCTG 
AATGGGATGC TGAGGTACAG GATCCTCTCC CAGGCACCCA GCACCCCTTC TCCCAACATG 
TTTACAATCA ACAACGAGAC CGGGGACATC ATCACTGTGG CAGCTGGTCT GGACCGAGAG 
AAAGTGCAAC AGTATACGTT AATAATTCAA GCCACTGACA TGGAAGGCAA TCCCACTTAC 
GGCCTTTCAA ACACAGCCAC AGCCGTCATC ACAGTGACAG ATGTCAATGA CAATCCTCCA 
GAGTTTACTG CCATGACCTT CTACGGAGAA GTCCCTGAGA ACAGAGTGGA TGTCATTGTA 
GCCAACCTGA CTGTCACCGA CAAGGACCAG CCCCACACAC CAGCCTGGAA TGCGGCATAC 
AGAATCAGTG GTGGAGACCC CACGGGAAGG TTTGCCATCC TGACAGACCC CAACAGCAAT 
GATGGGCTAG TCACAGTGGT AAAACCAATT GACTTTGAAA CGAATAGGAT GTTTGTCCTC 
ACTGTTGCTG CAGAAAACCA AGTGCCATTA GCTAAGGGGA TCCAGCACCC ACCTCAGTCG 
ACAGCCACGG TGTCTGTGAC AGTTATTGAT GTCAATGAAA ATCCTTATTT TGCCCCAAAT 
CCTAAAATCA TTCGCCAAGA GGAAGGCCTC CACGCAGGTA CCATGCTGAC CACTCTCACT 
GCTCAGGACC CCGATCGATA TATGCAACAG AATATCAGAT ACACAAAGTT ATCTGACCCT 
GCCAACTGGC TGAAAATAGA CCCTGTGAAC GGGCAGATCA CCACTATCGC TGTTCTGGAC 
AGAGAGTCGC CAAATGTCAA AAACAACATC TATAATGCTA CCTTCCTTGC TTCTGACAAT 
GGAATCCCTC CTATGAGTGG AACAGGAACG CTGCAAATCT ATTTACTTGA TATCAATGAC 
AACGCCCCTC AGGTGTTACC TCAAGAGGCC GAGACTTGTG AAACTCCAGA ACCCAATTCA 
ATTAACATCA CAGCGCTTGA TTATGACATA GACCCCAATG CAGGGCCCTT TGCATTTGAC 
CTTCCCTTAT CCCCAGTGAC CATTAAAAGA AACTGGACCA TCACCCGGCT TAAGGGTGAT 
TTTGCTCAGC TCAATTTAAA GATCAAGTTT TTGGAAGCTG GCATCTATGA AGTTCCCATC 
GTTATCACAG ATTCAGGGAA TCCCCCCAAG TCCAATATTT CGATCCTGCG TGTGAAAGTT 
TGCCAATGTG ACTCCAATGG AGACTGCACC GACGTAGACA GGATCGTGGG TGCAGGGCTT 
GGCACGGGCG CCATCATCGC GATACTTCTG TGTATCATCA TCCTGCTGAT CCTTGTCCTC 
ATGTTCGTGG TATGGATGAA ACGCCGGGAT AAAGAGCGCC AGGCCAAGCA GCTTTTAATA 
GACCCAGAAG ATGATGTAAG AGATAACATA TTGAAATATG ATGAAGAAGG TGGAGGAGAG 
GAAGACCAGG ACTATGACTT GAGCCAGCTC CAGCAACCAG ATACCGTGGA GCCTGATGCC 
ATCAAACCTG TGGGAATCAG ACGGCTAGAC GAGAGGCCTA TCCACGCTGA GCCACAATAT 
CCAGTCCGAT CCGCAGCCCC ACACCCTGGG GATATTGGGG ACTTCATTAA TGAGGGCCTT 
AAAGCTGCTG ACAATGACCC CACGGCGCCA CCATATGACT CCCTTTTAGT CTTCGACTAT 
GAGGGCAGCG GCTCCACGGC TGGCTCCTTG AGCTCTCTCA ACTCCTCCAG CAGCGGCGGG 
GACCAGGACT ATGACTACCT GAATGACTGG GGACCCCGCT TCAAGAAGCT GGCCGACATG 
TATGGTGGTG GTGATGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

N?cadherin attenuates nucleus pulposus cell senescence under high?magnitude compression.
Molecular medicine reports17(2)2879-2884(2018 Feb)
Niu M,Ma F,Qian J,Li J,Wang T,Gao Y,Jin J

PKD1 Promotes Functional Synapse Formation Coordinated with N-Cadherin in Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience38(1)183-199(2018 Jan)
Cen C,Luo LD,Li WQ,Li G,Tian NX,Zheng G,Yin DM,Zou Y,Wang Y

Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform.
Cell death & disease8(12)3209(2017 Dec)
Silva DI,Santos BPD,Leng J,Oliveira H,Am?d?e J

N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3? Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(1)229-239(2017)
Li P,Liang Z,Hou G,Song L,Zhang R,Gan Y,Zhang C,Xu Y,Zhou Q

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Cdh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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