Stxbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stxbp2
Entrez Gene ID	81804
Full Name	syntaxin binding protein 2
Synonyms	Munc18b
General protein information	Preferred Names syntaxin binding protein 2 Names syntaxin-binding protein 2 munc18-2 protein unc-18 homolog 2 protein unc-18 homolog B syntaxin binding protein Munc18-2 unc-18 homolog 2 unc-18 homolog B unc-18B unc18-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p12
Summary	syntaxin binding protein; important for synaptic vesicle exoctyosis; may be a component of the SNARE complex; may be involved with pancreatic beta-cell exocytosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006248783.3	XP_006248845.1	syntaxin-binding protein 2 isoform X1
NM_031126.1	NP_112388.1	syntaxin-binding protein 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	stxbp2	NP_998454.1
Magnaporthe oryzae (rice blast fungus)	MGG_12345	XP_003715299.1
Neurospora crassa	NCU08312	XP_962525.1
Pan troglodytes (chimpanzee)	STXBP2	XP_001153467.2
Rattus norvegicus (Norway rat)	Stxbp2	NP_112388.1
Eremothecium gossypii	AGOS_AGL162C	NP_986505.1
Homo sapiens (human)	STXBP2	NP_001258963.1
Kluyveromyces lactis	KLLA0D17028g	XP_453813.1
Schizosaccharomyces pombe (fission yeast)	sec1	NP_588226.1
Xenopus tropicalis (tropical clawed frog)	stxbp2	NP_001005703.1
Canis lupus familiaris (dog)	STXBP2	NP_001003216.1
Bos taurus (cattle)	STXBP2	NP_001039673.1
Mus musculus (house mouse)	Stxbp2	NP_035633.1
Saccharomyces cerevisiae (baker's yeast)	SEC1	NP_010448.1

Gene Ontology
Bibliography

Related articles in PubMed

Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.
Qin T, Liang T, Zhu D, Kang Y, Xie L, Dolai S, Sugita S, Takahashi N, Ostenson CG, Banks K, Gaisano HY
EBioMedicine16262-274(2017 Feb)

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.
Gandasi NR, Barg S
Nature communications53914(2014 May)

Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.
Brochetta C, Suzuki R, Vita F, Soranzo MR, Claver J, Madjene LC, Attout T, Vitte J, Varin-Blank N, Zabucchi G, Rivera J, Blank U
Journal of immunology (Baltimore, Md. : 1950)192(1)41-51(2014 Jan)

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.
Bin NR, Jung CH, Piggott C, Sugita S
Proceedings of the National Academy of Sciences of the United States of America110(12)4610-5(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that Munc18b overexpression increased fusion of not only newcomer secretory granule (SG), but also predocked SGs in type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets.
Title: Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.

Secretory vesicles dock by inducing syntaxin1/munc18 clustering in the target membrane.
Title: Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.

Munc18-2 and STX3 perform distinct, but complementary, functions to support, respectively, SG translocation and membrane fusion in mast cells.
Title: Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.

Munc18b-mediated exocytosis may be deployed to increase secretory efficiency of secretory granules in deeper cytosolic layers of beta-cells as well as additional primary exocytosis
Title: Munc18b is a major mediator of insulin exocytosis in rat pancreatic ?-cells.

Double knockdown of Munc18-1 and Munc18-2 in mast cells eliminates both IgE-dependent and ionomycin-induced degranulation and causes a significant reduction in syntaxin-11 without altering expressions of the other syntaxin isoforms examined.
Title: Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

The following Stxbp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stxbp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12114	NM_031126.1 Latest version!	Rattus norvegicus syntaxin binding protein 2 (Stxbp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa34553	XM_006248783.3 Latest version!	Rattus norvegicus syntaxin binding protein 2 (Stxbp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stxbp2 ( NM_031126.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112388.1 Rattus norvegicus syntaxin binding protein 2 (Stxbp2), mRNA.

Price & Availability↑

CloneID	ORa12114
Clone ID Related Accession (Same CDS sequence)	NM_031126.1
Accession Version	NM_031126.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-07
Organism	Rattus norvegicus(Norway rat)
Product	syntaxin-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U20283.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U20283.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCCCT TGGGGCTGAA GGCGGTGGTG GTGGAAAAAA TTCTAAGTGG AGTCATCCGG 
AGCGTTAAGA AGGATGGCGA GTGGAAGGTA CTCATCATGG ATCATCCGAG CATGCGAATC 
TTGTCATCCT GTTGTAAAAT GTCAGATATC TTGGCGGAGG GCATCACCAT TGTGGAAGAC 
ATCAACAAAC GGAGAGAACC CATTCCCAGC TTGGAGGCAA TTTATTTGCT GAGTCCCACA 
GAGAAGTCGG TTCAGGCTCT GATTGCGGAC TTCCAGGGGA CACCAACCTT CACCTACAAA 
GCAGCCCATA TCTTCTTCAC GGACACGTGC CCCGAGCCCT TGTTCAGTGA ACTGGGCCGC 
TCTCGCCTGG CGAAGGTGGT GAAGACACTG AAAGAGATCC ACCTCGCCTT CCTCCCCTAT 
GAGGCCCAGG TGTTCTCTCT GGATGCCCCG CACAGCACCT ACAACCTTTA TTGCCCATTT 
CGGGCAGGGG AGCGGGGGCG GCAGCTCGAT GTGCTGGCCC AGCAGATAGC CACACTGTGT 
GCCACTCTTC AGGAATACCC ATCCATTCGC TACCGCAAGG GCCCAGAAGA CACAGCCCAG 
CTGGCCCATG CTGTCCTGGC CAAGCTGAAC GCCTTCAAGG CAGACACTCC CAGTCTGGGC 
GAGGGCCCAG AGAAAACACG CTCACAGTTG CTCATAATGG ACCGGGCAGC AGACCCCGTG 
TCCCCGCTAT TACATGAACT CACATTCCAA GCCATGGCCT ATGATCTTCT GCACATCGAG 
CAGGACACAT ACAGGTATGA GACCACAGGA CTGAGCGAGT CCCGGGAGAA GGCTGTGCTC 
CTGGATGAAG ACGATGACCT GTGGGTGGAA CTCCGGCACA TGCACATAGC GGATGTGTCC 
AAGAAGGTCA CGGAGCTCCT GAAGACATTC TGTGAGAGCA AGCGGCTGAC CACAGACAAG 
GCCAACATCA AAGACCTGTC CCACATCCTG AAAAAGATGC CACAGTATCA GAAGGAGTTG 
AACAAGTACT CCACGCACCT GCACTTGGCA GATGACTGCA TGAAGCACTT CAAGGGCTCG 
GTGGAGAAGC TGTGCGGTGT GGAGCAGGAC CTGGCCATGG GCTCTGATGC AGAGGGTGAG 
AAGATCAAGG ACACCATGAA ACTGATTGTC CCGGTGCTGT TGGATGCCTC CGTGCCACCC 
TATGACAAGA TCCGGGTTCT GCTGCTCTAC ATCCTTCTGC GGAACGGTGT GAGTGAGGAA 
AATCTGGCCA AGCTGATCCA GCATGCTAAT GTGCAGTCCT ACAGCAACCT CATCCGGAAC 
CTGGAGCAGC TGGGGGGCAC TGTCACCAAC TCTGCGGGCT CAGGGACCTC TAGCCGGCTG 
GAGCGGAGAG AACGCATGGA GCCCACCTAC CAGCTGTCTC GCTGGTCCCC AGTCATCAAG 
GACGTGATGG AGGATGTGGT GGAGGACCGG CTAGACCGAA AGCTGTGGCC CTTCGTGTCT 
GACCCTGCCC CTGTGTCTAG CTCCCAAGCA GCTGTCAGCA GTGCTCGCTT TGGCCACTGG 
CATAAAAACA AAGCTGGTAT AGAGGCTCGG GCTGGACCCA GGCTCATCGT GTACATTGTG 
GGTGGTGTCG CCATGTCTGA AATGAGGGCT GCTTATGAGG TGACCAGAGC CACTGAAGGC 
AAGTGGGAGG TACTTATAGG CTCTTCCCAC ATCCTCACTC CAACCCGCTT CCTCGATGAC 
CTCAGGACCC TGGATCAGAA GCTGGAGGAC ATAGCCCTGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112388.1
CDS	7..1791
Translation	MAPLGLKAVVVEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAGERGRQLDVLAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLHIEQDTYRYETTGLSESREKAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCGVEQDLAMGSDAEGEKIKDTMKLIVPVLLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSNLIRNLEQLGGTVTNSAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVSSSQAAVSSARFGHWHKNKAGIEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLRTLDQKLEDIALP

Target ORF information:

RefSeq Version	NM_031126.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus syntaxin binding protein 2 (Stxbp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031126.1

ORF Insert Sequence:

ATGGCGCCCT TGGGGCTGAA GGCGGTGGTG GTGGAAAAAA TTCTAAGTGG AGTCATCCGG 
AGCGTTAAGA AGGATGGCGA GTGGAAGGTA CTCATCATGG ATCATCCGAG CATGCGAATC 
TTGTCATCCT GTTGTAAAAT GTCAGATATC TTGGCGGAGG GCATCACCAT TGTGGAAGAC 
ATCAACAAAC GGAGAGAACC CATTCCCAGC TTGGAGGCAA TTTATTTGCT GAGTCCCACA 
GAGAAGTCGG TTCAGGCTCT GATTGCGGAC TTCCAGGGGA CACCAACCTT CACCTACAAA 
GCAGCCCATA TCTTCTTCAC GGACACGTGC CCCGAGCCCT TGTTCAGTGA ACTGGGCCGC 
TCTCGCCTGG CGAAGGTGGT GAAGACACTG AAAGAGATCC ACCTCGCCTT CCTCCCCTAT 
GAGGCCCAGG TGTTCTCTCT GGATGCCCCG CACAGCACCT ACAACCTTTA TTGCCCATTT 
CGGGCAGGGG AGCGGGGGCG GCAGCTCGAT GTGCTGGCCC AGCAGATAGC CACACTGTGT 
GCCACTCTTC AGGAATACCC ATCCATTCGC TACCGCAAGG GCCCAGAAGA CACAGCCCAG 
CTGGCCCATG CTGTCCTGGC CAAGCTGAAC GCCTTCAAGG CAGACACTCC CAGTCTGGGC 
GAGGGCCCAG AGAAAACACG CTCACAGTTG CTCATAATGG ACCGGGCAGC AGACCCCGTG 
TCCCCGCTAT TACATGAACT CACATTCCAA GCCATGGCCT ATGATCTTCT GCACATCGAG 
CAGGACACAT ACAGGTATGA GACCACAGGA CTGAGCGAGT CCCGGGAGAA GGCTGTGCTC 
CTGGATGAAG ACGATGACCT GTGGGTGGAA CTCCGGCACA TGCACATAGC GGATGTGTCC 
AAGAAGGTCA CGGAGCTCCT GAAGACATTC TGTGAGAGCA AGCGGCTGAC CACAGACAAG 
GCCAACATCA AAGACCTGTC CCACATCCTG AAAAAGATGC CACAGTATCA GAAGGAGTTG 
AACAAGTACT CCACGCACCT GCACTTGGCA GATGACTGCA TGAAGCACTT CAAGGGCTCG 
GTGGAGAAGC TGTGCGGTGT GGAGCAGGAC CTGGCCATGG GCTCTGATGC AGAGGGTGAG 
AAGATCAAGG ACACCATGAA ACTGATTGTC CCGGTGCTGT TGGATGCCTC CGTGCCACCC 
TATGACAAGA TCCGGGTTCT GCTGCTCTAC ATCCTTCTGC GGAACGGTGT GAGTGAGGAA 
AATCTGGCCA AGCTGATCCA GCATGCTAAT GTGCAGTCCT ACAGCAACCT CATCCGGAAC 
CTGGAGCAGC TGGGGGGCAC TGTCACCAAC TCTGCGGGCT CAGGGACCTC TAGCCGGCTG 
GAGCGGAGAG AACGCATGGA GCCCACCTAC CAGCTGTCTC GCTGGTCCCC AGTCATCAAG 
GACGTGATGG AGGATGTGGT GGAGGACCGG CTAGACCGAA AGCTGTGGCC CTTCGTGTCT 
GACCCTGCCC CTGTGTCTAG CTCCCAAGCA GCTGTCAGCA GTGCTCGCTT TGGCCACTGG 
CATAAAAACA AAGCTGGTAT AGAGGCTCGG GCTGGACCCA GGCTCATCGT GTACATTGTG 
GGTGGTGTCG CCATGTCTGA AATGAGGGCT GCTTATGAGG TGACCAGAGC CACTGAAGGC 
AAGTGGGAGG TACTTATAGG CTCTTCCCAC ATCCTCACTC CAACCCGCTT CCTCGATGAC 
CTCAGGACCC TGGATCAGAA GCTGGAGGAC ATAGCCCTGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stxbp2 ( XM_006248783.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248845.1 Rattus norvegicus syntaxin binding protein 2 (Stxbp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34553
Clone ID Related Accession (Same CDS sequence)	XM_006248783.3
Accession Version	XM_006248783.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	syntaxin-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248783.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCCCT TGGGGCTGAA GGCGGTGGTG GGGGAAAAAA TTCTAAGTGG AGTCATCCGG 
AGCGTTAAGA AGGATGGCGA GTGGAAGGTA CTCATCATGG ATCATCCGAG CATGCGAATC 
TTGTCATCCT GTTGTAAAAT GTCAGATATC TTGGCGGAGG GCATCACCAT TGTGGAAGAC 
ATCAACAAAC GGAGAGAACC CATTCCCAGC TTGGAGGCAA TTTATTTGCT GAGTCCCACA 
GAGAAGTCGG TTCAGGCTCT GATTGCGGAC TTCCAGGGGA CACCAACCTT CACCTACAAA 
GCAGCCCATA TCTTCTTCAC GGACACGTGC CCCGAGCCCT TGTTCAGTGA ACTGGGCCGC 
TCTCGCCTGG CGAAGGTGGT GAAGACACTG AAAGAGATCC ACCTCGCCTT CCTCCCCTAT 
GAGGCCCAGG TGTTCTCTCT GGATGCCCCG CACAGCACCT ATAACCTTTA TTGCCCATTT 
CGGGCAGGGG AGCGGGGGCG GCAGCTCGAT GTGCTGGCCC AGCAGATAGC CACACTGTGT 
GCCACTCTTC AGGAATACCC ATCCATTCGC TACCGCAAGG GCCCAGAAGA CACAGCCCAG 
CTGGCCCATG CTGTCCTGGC CAAGCTGAAC GCCTTCAAGG CAGACACTCC CAGTCTGGGC 
GAGGGCCCAG AGAAAACACG CTCACAGTTG CTCATAATGG ACCGGGCAGC AGACCCCGTG 
TCCCCGCTAT TACATGAACT CACATTCCAA GCCATGGCCT ATGATCTTCT GCACATCGAG 
CAGGACACAT ACAGGTATGA GACCACAGGA CTGAGCGAGT CCCGGGAGAA GGCTGTGCTC 
CTGGATGAAG ACGATGACCT GTGGGTGGAA CTCCGGCACA TGCACATAGC GGATGTGTCC 
AAGAAGGTCA CGGAGCTCCT GAAGACATTC TGTGAGAGCA AGCGGCTGAC CACAGACAAG 
GCCAACATCA AAGACCTGTC CCACATCCTG AAAAAGATGC CACAGTATCA GAAGGAGTTG 
AACAAGTACT CCACGCACCT GCACTTGGCA GATGACTGCA TGAAGCACTT CAAGGGCTCG 
GTGGAGAAGC TGTGCGGTGT GGAGCAGGAC CTGGCCATGG GCTCTGATGC AGAGGGTGAG 
AAGATCAAGG ACACCATGAA ACTGATTGTC CCGGTGCTGT TGGATGCCTC CGTGCCACCC 
TATGACAAGA TCCGGGTTCT GCTGCTCTAC ATCCTTCTGC GGAACGGTGT GAGTGAGGAA 
AATCTGGCCA AGCTGATCCA GCATGCTAAT GTGCAGTCCT ACAGCAACCT CATCCGGAAC 
CTGGAGCAGC TGGGGGGCAC TGTCACCAAC TCTGCGGGCT CAGGGACCTC TAGCCGGCTG 
GAGCGGAGAG AACGCATGGA GCCCACCTAC CAGCTGTCTC GCTGGTCCCC AGTCATCAAG 
GACGTGATGG AGGATGTGGT GGAGGACCGG CTAGACCGAA AGCTGTGGCC CTTCGTGTCT 
GACCCTGCCC CTGTGTCTAG CTCCCAAGCA GCTGTCAGTG CTCGCTTTGG CCACTGGCAT 
AAAAACAAAG CTGGTATAGA GGCTCGGGCT GGACCCAGGC TCATCGTGTA CATTGTGGGT 
GGTGTCGCCA TGTCTGAAAT GAGGGCTGCT TATGAGGTGA CCAGGGCCAC TGAAGGCAAG 
TGGGAGGTAC TTATAGGCTC TTCCCACATC CTCACTCCAA CCCGCTTCCT CGATGACCTC 
AGGACCCTGG ATCAGAAGCT GGAGGACATA GCCCTGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248845.1
CDS	56..1837
Translation	MAPLGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAGERGRQLDVLAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLHIEQDTYRYETTGLSESREKAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCGVEQDLAMGSDAEGEKIKDTMKLIVPVLLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSNLIRNLEQLGGTVTNSAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVSSSQAAVSARFGHWHKNKAGIEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLRTLDQKLEDIALP

Target ORF information:

RefSeq Version	XM_006248783.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus syntaxin binding protein 2 (Stxbp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248783.3

ORF Insert Sequence:

ATGGCGCCCT TGGGGCTGAA GGCGGTGGTG GGGGAAAAAA TTCTAAGTGG AGTCATCCGG 
AGCGTTAAGA AGGATGGCGA GTGGAAGGTA CTCATCATGG ATCATCCGAG CATGCGAATC 
TTGTCATCCT GTTGTAAAAT GTCAGATATC TTGGCGGAGG GCATCACCAT TGTGGAAGAC 
ATCAACAAAC GGAGAGAACC CATTCCCAGC TTGGAGGCAA TTTATTTGCT GAGTCCCACA 
GAGAAGTCGG TTCAGGCTCT GATTGCGGAC TTCCAGGGGA CACCAACCTT CACCTACAAA 
GCAGCCCATA TCTTCTTCAC GGACACGTGC CCCGAGCCCT TGTTCAGTGA ACTGGGCCGC 
TCTCGCCTGG CGAAGGTGGT GAAGACACTG AAAGAGATCC ACCTCGCCTT CCTCCCCTAT 
GAGGCCCAGG TGTTCTCTCT GGATGCCCCG CACAGCACCT ATAACCTTTA TTGCCCATTT 
CGGGCAGGGG AGCGGGGGCG GCAGCTCGAT GTGCTGGCCC AGCAGATAGC CACACTGTGT 
GCCACTCTTC AGGAATACCC ATCCATTCGC TACCGCAAGG GCCCAGAAGA CACAGCCCAG 
CTGGCCCATG CTGTCCTGGC CAAGCTGAAC GCCTTCAAGG CAGACACTCC CAGTCTGGGC 
GAGGGCCCAG AGAAAACACG CTCACAGTTG CTCATAATGG ACCGGGCAGC AGACCCCGTG 
TCCCCGCTAT TACATGAACT CACATTCCAA GCCATGGCCT ATGATCTTCT GCACATCGAG 
CAGGACACAT ACAGGTATGA GACCACAGGA CTGAGCGAGT CCCGGGAGAA GGCTGTGCTC 
CTGGATGAAG ACGATGACCT GTGGGTGGAA CTCCGGCACA TGCACATAGC GGATGTGTCC 
AAGAAGGTCA CGGAGCTCCT GAAGACATTC TGTGAGAGCA AGCGGCTGAC CACAGACAAG 
GCCAACATCA AAGACCTGTC CCACATCCTG AAAAAGATGC CACAGTATCA GAAGGAGTTG 
AACAAGTACT CCACGCACCT GCACTTGGCA GATGACTGCA TGAAGCACTT CAAGGGCTCG 
GTGGAGAAGC TGTGCGGTGT GGAGCAGGAC CTGGCCATGG GCTCTGATGC AGAGGGTGAG 
AAGATCAAGG ACACCATGAA ACTGATTGTC CCGGTGCTGT TGGATGCCTC CGTGCCACCC 
TATGACAAGA TCCGGGTTCT GCTGCTCTAC ATCCTTCTGC GGAACGGTGT GAGTGAGGAA 
AATCTGGCCA AGCTGATCCA GCATGCTAAT GTGCAGTCCT ACAGCAACCT CATCCGGAAC 
CTGGAGCAGC TGGGGGGCAC TGTCACCAAC TCTGCGGGCT CAGGGACCTC TAGCCGGCTG 
GAGCGGAGAG AACGCATGGA GCCCACCTAC CAGCTGTCTC GCTGGTCCCC AGTCATCAAG 
GACGTGATGG AGGATGTGGT GGAGGACCGG CTAGACCGAA AGCTGTGGCC CTTCGTGTCT 
GACCCTGCCC CTGTGTCTAG CTCCCAAGCA GCTGTCAGTG CTCGCTTTGG CCACTGGCAT 
AAAAACAAAG CTGGTATAGA GGCTCGGGCT GGACCCAGGC TCATCGTGTA CATTGTGGGT 
GGTGTCGCCA TGTCTGAAAT GAGGGCTGCT TATGAGGTGA CCAGGGCCAC TGAAGGCAAG 
TGGGAGGTAC TTATAGGCTC TTCCCACATC CTCACTCCAA CCCGCTTCCT CGATGACCTC 
AGGACCCTGG ATCAGAAGCT GGAGGACATA GCCCTGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.
EBioMedicine16262-274(2017 Feb)
Qin T,Liang T,Zhu D,Kang Y,Xie L,Dolai S,Sugita S,Takahashi N,Ostenson CG,Banks K,Gaisano HY

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.
Nature communications53914(2014 May)
Gandasi NR,Barg S

Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.
Journal of immunology (Baltimore, Md. : 1950)192(1)41-51(2014 Jan)
Brochetta C,Suzuki R,Vita F,Soranzo MR,Claver J,Madjene LC,Attout T,Vitte J,Varin-Blank N,Zabucchi G,Rivera J,Blank U

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.
Proceedings of the National Academy of Sciences of the United States of America110(12)4610-5(2013 Mar)
Bin NR,Jung CH,Piggott C,Sugita S

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Stxbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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