Rab1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab1a
Entrez Gene ID	81754
Full Name	RAB1A, member RAS oncogene family
Synonyms	Ac2-048,Rab1,Rab1r
General protein information	Preferred Names RAB1A, member RAS oncogene family Names ras-related protein Rab-1A RAB1, member RAS oncogene family
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q22
Summary	may have GTPase activity; may regulate intracellular protein transport from the endoplasmic reticulum to the Golgi apparatus [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031090.2	NP_112352.2	ras-related protein Rab-1A

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RAB1A	XP_530454.3
Danio rerio (zebrafish)	rab1a	NP_001007162.1
Saccharomyces cerevisiae (baker's yeast)	YPT1	NP_116615.1
Kluyveromyces lactis	KLLA0D05313g	XP_453297.1
Neurospora crassa	NCU08477	XP_963146.2
Xenopus tropicalis (tropical clawed frog)	rab1a	NP_001004787.1
Caenorhabditis elegans (roundworm)	rab-1	NP_503397.1
Eremothecium gossypii	AGOS_ABR220W	NP_983169.1
Arabidopsis thaliana (thale cress)	RA-5	NP_171715.1
Oryza sativa (rice)	Os01g0558600	NP_001043336.1
Homo sapiens (human)	RAB1A	NP_004152.1
Gallus gallus (chicken)	RAB1A	NP_001257591.1
Drosophila melanogaster (fruit fly)	Rab1	NP_732610.1
Schizosaccharomyces pombe (fission yeast)	ypt1	NP_596205.1
	RAB1A	XP_001090072.1
Canis lupus familiaris (dog)	RAB1A	NP_001003153.1
Magnaporthe oryzae (rice blast fungus)	MGG_06962	XP_003709708.1
Mus musculus (house mouse)	Rab1	NP_033022.1
Rattus norvegicus (Norway rat)	Rab1a	NP_112352.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004146	XP_313029.4

Gene Ontology
Bibliography

Related articles in PubMed

Rab1A mediates proinsulin to insulin conversion in ?-cells by maintaining Golgi stability through interactions with golgin-84.
Liu X, Wang Z, Yang Y, Li Q, Zeng R, Kang J, Wu J
Protein & cell7(9)692-6(2016 09)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
Molecular biology of the cell24(18)2849-60(2013 Sep)

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Boyken J, Gr?nborg M, Riedel D, Urlaub H, Jahn R, Chua JJ
Neuron78(2)285-97(2013 Apr)

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.
Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F
Cell150(5)1029-41(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rab1A mediates proinsulin to insulin conversion in beta-cells by maintaining Golgi stability through interactions with golgin-84.
Title: Rab1A mediates proinsulin to insulin conversion in ?-cells by maintaining Golgi stability through interactions with golgin-84.

Results imply that Rab1a regulates minus-end-directed motility largely by recruiting Kifc1 to early endocytic vesicles.
Title: Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles.

These data strongly indicate that Rab1 modulates pulmonary artery smooth muscle cell function by manipulating AT1R traffic from the endoplasmic reticulum to the Golgi.
Title: Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia.

The role of Rab1, a Ras-like GTPase that coordinates protein transport from the endoplasmic reticulum (ER) to the Golgi body and regulates the cell-surface targeting and function of endogenous beta-ARs, was investigated.
Title: Rab1 GTPase promotes expression of beta-adrenergic receptors in rat pulmonary microvascular endothelial cells.

Rab1 and Rab6 GTPases may play a role in modulating the function of retina by mediating the transport of nascent proteins along the early secretary pathway, particularly in the process of the light adaptation.
Title: Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas.

The following Rab1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07564	NM_031090.2 Latest version!	Rattus norvegicus RAB1A, member RAS oncogene family (Rab1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab1a ( NM_031090.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112352.2 Rattus norvegicus RAB1A, member RAS oncogene family (Rab1a), mRNA.

Price & Availability↑

CloneID	ORa07564
Clone ID Related Accession (Same CDS sequence)	NM_031090.2
Accession Version	NM_031090.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	ras-related protein Rab-1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066662.1. On Mar 14, 2004 this sequence version replaced NM_031090.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066662.1, FQ209441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCCAGCA TGAATCCCGA ATATGATTAT TTATTCAAGT TACTCCTGAT TGGCGACTCT 
GGGGTTGGAA AGTCTTGCCT TCTCCTTAGG TTTGCGGATG ACACGTATAC GGAAAGCTAC 
ATCAGCACGA TTGGTGTGGA TTTCAAGATA CGGACTATAG AGCTAGACGG GAAAACAATC 
AAGCTTCAGA TATGGGACAC AGCAGGCCAG GAAAGATTTC GAACAATCAC CTCCAGTTAT 
TACAGAGGAG CCCATGGCAT CATAGTTGTG TATGATGTGA CAGACCAGGA GTCCTTCAAT 
AACGTGAAAC AGTGGCTGCA GGAGATCGAT CGCTACGCCA GCGAAAATGT CAACAAGTTG 
TTGGTAGGGA ACAAATGTGA CCTGACCACA AAGAAAGTAG TAGACTACAC AACAGCCAAG 
GAATTTGCAG ATTCCCTTGG AATTCCATTT TTGGAAACCA GTGCTAAGAA CGCAACGAAT 
GTAGAACAGT CTTTCATGAC CATGGCAGCG GAGATTAAAA AGCGGATGGG TCCTGGAGCA 
ACAGCTGGAG GTGCGGAGAA GTCCAATGTT AAAATCCAGA GCACTCCAGT CAAGCAGTCA 
GGTGGAGGCT GCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112352.2
CDS	178..795
Translation	MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC

Target ORF information:

RefSeq Version	NM_031090.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RAB1A, member RAS oncogene family (Rab1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031090.2

ORF Insert Sequence:

ATGTCCAGCA TGAATCCCGA ATATGATTAT TTATTCAAGT TACTCCTGAT TGGCGACTCT 
GGGGTTGGAA AGTCTTGCCT TCTCCTTAGG TTTGCGGATG ACACGTATAC GGAAAGCTAC 
ATCAGCACGA TTGGTGTGGA TTTCAAGATA CGGACTATAG AGCTAGACGG GAAAACAATC 
AAGCTTCAGA TATGGGACAC AGCAGGCCAG GAAAGATTTC GAACAATCAC CTCCAGTTAT 
TACAGAGGAG CCCATGGCAT CATAGTTGTG TATGATGTGA CAGACCAGGA GTCCTTCAAT 
AACGTGAAAC AGTGGCTGCA GGAGATCGAT CGCTACGCCA GCGAAAATGT CAACAAGTTG 
TTGGTAGGGA ACAAATGTGA CCTGACCACA AAGAAAGTAG TAGACTACAC AACAGCCAAG 
GAATTTGCAG ATTCCCTTGG AATTCCATTT TTGGAAACCA GTGCTAAGAA CGCAACGAAT 
GTAGAACAGT CTTTCATGAC CATGGCAGCG GAGATTAAAA AGCGGATGGG TCCTGGAGCA 
ACAGCTGGAG GTGCGGAGAA GTCCAATGTT AAAATCCAGA GCACTCCAGT CAAGCAGTCA 
GGTGGAGGCT GCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab1A mediates proinsulin to insulin conversion in ?-cells by maintaining Golgi stability through interactions with golgin-84.
Protein & cell7(9)692-6(2016 09)
Liu X,Wang Z,Yang Y,Li Q,Zeng R,Kang J,Wu J

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Molecular biology of the cell24(18)2849-60(2013 Sep)
Monteiro AC,Sumagin R,Rankin CR,Leoni G,Mina MJ,Reiter DM,Stehle T,Dermody TS,Schaefer SA,Hall RA,Nusrat A,Parkos CA

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Neuron78(2)285-97(2013 Apr)
Boyken J,Gr?nborg M,Riedel D,Urlaub H,Jahn R,Chua JJ

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.
Cell150(5)1029-41(2012 Aug)
Dong N,Zhu Y,Lu Q,Hu L,Zheng Y,Shao F

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Rab1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報