Actr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Actr3
Entrez Gene ID	81732
Full Name	ARP3 actin related protein 3 homolog
Synonyms	Arp3
General protein information	Preferred Names ARP3 actin related protein 3 homolog Names actin-related protein 3 actin-like protein 3 actin-related protein 3 homolog (yest)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q12
Summary	actin related protein that may participate in the organization of filament/membrane adhesions [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031068.1	NP_112330.1	actin-related protein 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Actr3	NP_001192314.1
Saccharomyces cerevisiae (baker's yeast)	ARP3	NP_012599.3
Kluyveromyces lactis	KLLA0B13904g	XP_452150.1
Eremothecium gossypii	AGOS_AFR419C	NP_985966.1
Schizosaccharomyces pombe (fission yeast)	arp3	NP_592898.1
Bos taurus (cattle)	ACTR3	NP_776651.1
Canis lupus familiaris (dog)	ACTR3B	XP_853309.2
Rattus norvegicus (Norway rat)	Actr3	NP_112330.1
Homo sapiens (human)	ACTR3	NP_005712.1
Pan troglodytes (chimpanzee)	ACTR3	XP_001154210.1
Danio rerio (zebrafish)	actr3	NP_001003944.1
Drosophila melanogaster (fruit fly)	Arp3	NP_523968.1
Caenorhabditis elegans (roundworm)	arx-1	NP_491066.1
Neurospora crassa	NCU01756	XP_957179.2
Gallus gallus (chicken)	ACTR3	NP_989638.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005110	XP_313987.1
Magnaporthe oryzae (rice blast fungus)	MGG_03879	XP_003720000.1
Xenopus tropicalis (tropical clawed frog)	actr3	NP_989368.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics.
Detsika MG, Lygirou V, Frantzis V, Zoidakis J, Atsaves V, Poulaki E, Gakiopoulou H, Vlahou A, Lianos EA
American journal of nephrology43(6)441-50(2016)

Plasma IgG autoantibody against actin-related protein 3 in liver fluke Opisthorchis viverrini infection.
Rucksaken R, Haonon O, Pinlaor P, Pairojkul C, Roytrakul S, Yongvanit P, Selmi C, Pinlaor S
Parasite immunology37(7)340-8(2015 Jul)

RasGRP3 regulates the migration of glioma cells via interaction with Arp3.
Lee HK, Finniss S, Cazacu S, Xiang C, Poisson LM, Blumberg PM, Brodie C
Oncotarget6(3)1850-64(2015 Jan)

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces.
Yu CH, Rafiq NB, Krishnasamy A, Hartman KL, Jones GE, Bershadsky AD, Sheetz MP
Cell reports5(5)1456-68(2013 Dec)

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
Ottis P, Topic B, Loos M, Li KW, de Souza A, Schulz D, Smit AB, Huston JP, Korth C
PloS one8(9)e75112(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
Title: Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.

Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
Title: Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.

Arp3 expression in the testis has a role in blood-testis barrier disruption during junction restructuring at spermatogenesis
Title: Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis.

PICK1 is a negative regulator of Arp2/3-mediated actin polymerization that is critical for a specific form of vesicle trafficking, and also for the development of neuronal architecture
Title: Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis.

These data suggest that Arp3 is a candidate for the Pur1 gene.
Title: Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats.

The following Actr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Actr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07505	NM_031068.1 Latest version!	Rattus norvegicus actin related protein 3 (Actr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Actr3 ( NM_031068.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112330.1 Rattus norvegicus actin related protein 3 (Actr3), mRNA.

Price & Availability↑

CloneID	ORa07505
Clone ID Related Accession (Same CDS sequence)	NM_031068.1
Accession Version	NM_031068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	actin-related protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098014.1. On Jul 18, 2005 this sequence version replaced XM_341112.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098014.1, FQ212256.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGGAC GGCTGCCGGC CTGTGTGGTG GACTGTGGCA CGGGATATAC AAAACTAGGA 
TATGCTGGAA ATACAGAACC ACAGTTTATC ATCCCATCAT GTATTGCCAT TAAAGAGTCT 
GCAAAAGTGG GTGATCAAGC CCAGAGGAGG GTGATGAAAG GCGTGGATGA CCTAGACTTC 
TTCATTGGTG ATGAAGCAAT AGAAAAGCCC ACATATGCAA CAAAGTGGCC AATCCGCCAT 
GGTATAGTTG AAGACTGGGA CTTAATGGAA AGGTTTATGG AGCAAGTGAT TTTTAAATAT 
TTAAGGGCAG AACCTGAAGA TCATTACTTT CTTTTGACTG AACCTCCACT GAATACTCCA 
GAAAACAGGG AATATACTGC TGAGATAATG TTTGAGTCCT TCAATGTTCC AGGCCTGTAC 
ATTGCTGTGC AGGCTGTTCT TGCCTTAGCT GCATCCTGGA CCTCAAGACA AGTAGGAGAG 
CGGACACTGA CGGGTACAGT AATAGACAGT GGAGACGGAG TCACTCATGT CATTCCTGTG 
GCTGAAGGAT ATGTTATCGG CAGCTGTATT AAACACATTC CAATCGCTGG AAGAGATATA 
ACATATTTTA TTCAGCAACT GCTGAGAGAC CGAGAAGTAG GAATCCCTCC TGAACAGTCC 
TTGGAAACTG CAAAAGCAGT GAAGGAGCGC TACAGTTATG TCTGCCCAGA TTTAGTAAAA 
GAATTTAACA AGTATGACAC TGATGGGTCA AAGTGGATCA AACAGTACAC CGGAGTCAAC 
GCCATCTCAA AGAAGGAATT CTCCATTGAT GTTGGCTACG AGCGATTTCT GGGACCGGAG 
ATCTTTTTCC ATCCAGAGTT TGCTAATCCA GATTTTACAC AACCTATCTC AGAAGTTGTA 
GATGAAGTCA TTCAGAATTG CCCCATTGAT GTCCGGCGTC CTCTCTACAA GAACATTGTC 
CTCTCTGGTG GTTCAACCAT GTTCAGGGAC TTTGGACGTC GTTTGCAAAG AGATCTGAAG 
AGAACTGTAG ATGCCAGGCT GAAGTTGAGT GAGGAGCTGA GCGGTGGCAG ATTGAAGCCC 
AAGCCTATTG ATGTACAAGT TATTACACAC CACATGCAGC GGTATGCAGT CTGGTTTGGA 
GGATCAATGC TGGCTTCCAC GCCTGAGTTC TACCAAGTAT GCCACACCAA AAAGGATTAT 
GAAGAAATCG GACCTAGCAT TTGTCGTCAC AATCCAGTGT TTGGAGTCAT GTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112330.1
CDS	86..1342
Translation	MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS

Target ORF information:

RefSeq Version	NM_031068.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus actin related protein 3 (Actr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031068.1

ORF Insert Sequence:

ATGGCGGGAC GGCTGCCGGC CTGTGTGGTG GACTGTGGCA CGGGATATAC AAAACTAGGA 
TATGCTGGAA ATACAGAACC ACAGTTTATC ATCCCATCAT GTATTGCCAT TAAAGAGTCT 
GCAAAAGTGG GTGATCAAGC CCAGAGGAGG GTGATGAAAG GCGTGGATGA CCTAGACTTC 
TTCATTGGTG ATGAAGCAAT AGAAAAGCCC ACATATGCAA CAAAGTGGCC AATCCGCCAT 
GGTATAGTTG AAGACTGGGA CTTAATGGAA AGGTTTATGG AGCAAGTGAT TTTTAAATAT 
TTAAGGGCAG AACCTGAAGA TCATTACTTT CTTTTGACTG AACCTCCACT GAATACTCCA 
GAAAACAGGG AATATACTGC TGAGATAATG TTTGAGTCCT TCAATGTTCC AGGCCTGTAC 
ATTGCTGTGC AGGCTGTTCT TGCCTTAGCT GCATCCTGGA CCTCAAGACA AGTAGGAGAG 
CGGACACTGA CGGGTACAGT AATAGACAGT GGAGACGGAG TCACTCATGT CATTCCTGTG 
GCTGAAGGAT ATGTTATCGG CAGCTGTATT AAACACATTC CAATCGCTGG AAGAGATATA 
ACATATTTTA TTCAGCAACT GCTGAGAGAC CGAGAAGTAG GAATCCCTCC TGAACAGTCC 
TTGGAAACTG CAAAAGCAGT GAAGGAGCGC TACAGTTATG TCTGCCCAGA TTTAGTAAAA 
GAATTTAACA AGTATGACAC TGATGGGTCA AAGTGGATCA AACAGTACAC CGGAGTCAAC 
GCCATCTCAA AGAAGGAATT CTCCATTGAT GTTGGCTACG AGCGATTTCT GGGACCGGAG 
ATCTTTTTCC ATCCAGAGTT TGCTAATCCA GATTTTACAC AACCTATCTC AGAAGTTGTA 
GATGAAGTCA TTCAGAATTG CCCCATTGAT GTCCGGCGTC CTCTCTACAA GAACATTGTC 
CTCTCTGGTG GTTCAACCAT GTTCAGGGAC TTTGGACGTC GTTTGCAAAG AGATCTGAAG 
AGAACTGTAG ATGCCAGGCT GAAGTTGAGT GAGGAGCTGA GCGGTGGCAG ATTGAAGCCC 
AAGCCTATTG ATGTACAAGT TATTACACAC CACATGCAGC GGTATGCAGT CTGGTTTGGA 
GGATCAATGC TGGCTTCCAC GCCTGAGTTC TACCAAGTAT GCCACACCAA AAAGGATTAT 
GAAGAAATCG GACCTAGCAT TTGTCGTCAC AATCCAGTGT TTGGAGTCAT GTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics.
American journal of nephrology43(6)441-50(2016)
Detsika MG,Lygirou V,Frantzis V,Zoidakis J,Atsaves V,Poulaki E,Gakiopoulou H,Vlahou A,Lianos EA

Plasma IgG autoantibody against actin-related protein 3 in liver fluke Opisthorchis viverrini infection.
Parasite immunology37(7)340-8(2015 Jul)
Rucksaken R,Haonon O,Pinlaor P,Pairojkul C,Roytrakul S,Yongvanit P,Selmi C,Pinlaor S

RasGRP3 regulates the migration of glioma cells via interaction with Arp3.
Oncotarget6(3)1850-64(2015 Jan)
Lee HK,Finniss S,Cazacu S,Xiang C,Poisson LM,Blumberg PM,Brodie C

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces.
Cell reports5(5)1456-68(2013 Dec)
Yu CH,Rafiq NB,Krishnasamy A,Hartman KL,Jones GE,Bershadsky AD,Sheetz MP

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
PloS one8(9)e75112(2013)
Ottis P,Topic B,Loos M,Li KW,de Souza A,Schulz D,Smit AB,Huston JP,Korth C

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Actr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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