Msh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Msh2
Entrez Gene ID	81709
Full Name	mutS homolog 2
General protein information	Preferred Names mutS homolog 2 Names DNA mismatch repair protein Msh2 mismatch repair protein mutS protein homolog 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q12
Summary	mismatch repair protein; may have an important role in spermatogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031058.1	NP_112320.1	DNA mismatch repair protein Msh2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Msh2	NP_112320.1
Gallus gallus (chicken)	MSH2	XP_426110.4
Saccharomyces cerevisiae (baker's yeast)	MSH2	NP_014551.1
Kluyveromyces lactis	KLLA0F02706g	XP_455202.1
Eremothecium gossypii	AGOS_AFR603C	NP_986150.1
Schizosaccharomyces pombe (fission yeast)	msh2	XP_001713136.1
Magnaporthe oryzae (rice blast fungus)	MGG_00879	XP_003718090.1
Danio rerio (zebrafish)	msh2	NP_998689.1
Arabidopsis thaliana (thale cress)	MSH2	NP_566804.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010282	XP_319476.4
Homo sapiens (human)	MSH2	NP_000242.1
Canis lupus familiaris (dog)	MSH2	XP_538482.2
Bos taurus (cattle)	MSH2	NP_001029756.1
Mus musculus (house mouse)	Msh2	NP_032654.1
Drosophila melanogaster (fruit fly)	spel1	NP_001246031.1
Neurospora crassa	NCU02230	XP_959643.1
Xenopus tropicalis (tropical clawed frog)	msh2	XP_002935427.2

Gene Ontology
Bibliography

Related articles in PubMed

MCM9 Is Required for Mammalian DNA Mismatch Repair.
Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, M?chali M
Molecular cell59(5)831-9(2015 Sep)

Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.
Mishra M, Kowluru RA
Investigative ophthalmology & visual science55(10)6960-7(2014 Sep)

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.
Ghodgaonkar MM, Lazzaro F, Olivera-Pimentel M, Artola-Bor?n M, Cejka P, Reijns MA, Jackson AP, Plevani P, Muzi-Falconi M, Jiricny J
Molecular cell50(3)323-32(2013 May)

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS?.
Li F, Mao G, Tong D, Huang J, Gu L, Yang W, Li GM
Cell153(3)590-600(2013 Apr)

Apurinic/apyrimidinic endonuclease 1, the sensitive marker for DNA deterioration in dextran sulfate sodium-induced acute colitis.
Chang IY, Kim JN, Maeng YH, Yoon SP
Redox report : communications in free radical research18(5)165-73(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

overexpression of Msh2 did not protect the mitochondria damage. Termination of hyperglycemia failed to reverse decrease in MMR enzymes and increase in D-loop sequence variants.
Title: Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.

The following Msh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Msh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07487	NM_031058.1 Latest version!	Rattus norvegicus mutS homolog 2 (Msh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Msh2 ( NM_031058.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112320.1 Rattus norvegicus mutS homolog 2 (Msh2), mRNA.

Price & Availability↑

CloneID	ORa07487
Clone ID Related Accession (Same CDS sequence)	NM_031058.1
Accession Version	NM_031058.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA mismatch repair protein Msh2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X93591.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X93591.1, BC161846.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCAGTTC AGCCCAAGGA GACGCTGCAG TTGGAGGGCG CGGCCGAGGT GGGCTTCGTA 
CGCTTCTTTG AGGGCATGCC GGAGAAGCCG AGCACCACGG TCGGCCTCTT CGACCGCGGC 
GACTTTTACA CCGCGCACGG CGAGGACGCG CTGCTGGCGG CCCGCGAGGT GTTCAAGACC 
CAAGGCGTGA TCAAGTACAT GGGGCCGGCA GGGGCAAAGA CCCTGCAGAC TGTTGTGCTG 
AGTAAGATGA ATTTTGAGTC TTTCGTGAAA GATCTTCTTC TGGTTCGTCA CTATAGAGTT 
GAAGTTTATA AGAATAAAGC TGGAAATAAG GCATCTAAGG AGAACGACTG GTATTTGGCA 
TATAAGGCTT CTCCTGGCAA TCTTTCTCAG TTTGAAGACA TCCTGTTTGG TAACAATGAC 
ATGGCCACTT CCATTGGCAT TATGGGTATT AAACTGTCTA CGGTTGATGG TCAGAGACAG 
GTTGGAGTTG GGGATGTGGA TTCCACCCAG AGAAAGCTAG GATTGTGTGA GTTCCCTGAC 
AACGATCAGT TCTCCAATCT CGAGGCTCTT CTGATTCAGA TTGGACCAAA GGAATGCATT 
TTACCAGGCG GAGAGACTGC TGGAGACATG GGGAAACTGA GGCAGGTTAT ACAGAGAGGA 
GGGATTCTGA TCACAGAAAG AAAGAGAATC GACTTTTCCA CAAAAGACAT CTACCAGGAT 
CTCAACCGGT TACTGAAAGG CAGAAAAGGA GAGCAGATGA ACAGCGCTGT CTTACCAGAG 
ATGGAGAATC AGGTTGCAGT TTCATCGTTG TCTGCAGTGA TCAAGTTCCT AGAACTCTTA 
TCAGATGATT CGAATTTTGG GCAGTTTGAA CTGGCGACTT TTGACTTCAG CCAGTACATG 
AAGTTAGACA TGGCAGCAGT TAGAGCCCTC AACCTTTTCC AGGGTTCTGT TGAAGACACC 
ACAGGCTCTC AGTCTCTGGC TGCATTCTTG AATAAATGCA AAACTGCTCA AGGACAAAGG 
CTGGTTAGCC AGTGGATCAA ACAGCCGCTC ATGGATAAAA ACAGGATTGA AGAGAGATTA 
AATTTAGTGG AAGCTTTTGT TGAAGATTCA GAATTGAGGA GAGCTCTACA GGAGGATTTA 
CTTCGCCGAT TTCCAGATCT TAACCGGCTT GCCAAGAAAT TTCAGAGACA AGCAGCGAAT 
TTACAAGATT GTTACCGACT GTATCAGGGT GTGAAACAGC TTCCCAACGT CATCCAGGCT 
CTGGAGAAAT ACCAAGGAAG ACACCAGGCA TTGTTGTTGG CAGTTTTTGT GACTCCTCTT 
ACTGATCTTC GTTCTGATTT TTCAAAATTT CAAGAAAAGA TAGAAACGAC TTTAGATATG 
GATCAGGTGG AGAACCACGA ATTCCTTGTA AAACCTTCAT TTGATCCTAA CCTGAGTGAG 
CTAAGAGAAG TCATGGATGG TCTGGAGAAG AAGATGCAGT CCACCTTAAT AAGTGCAGCG 
CGGGGTCTTG GATTGGACCC TGGCAAACAG ATTAAATTGG ACTCCAGTGC ACAGTTTGGG 
TATTACTTTC GTGTAACCTG CAAGGAAGAG AAAGTCCTCC GCAACAACAA GAACTTCAGC 
ACCGTGGATA TCCAGAAGAA TGGCGTTAAA TTCACCAACA GTGAATTGTC TTCTTTAAAT 
GAAGAATACA CTAAGAACAA AGGAGAGTAT GAGGAGGCCC AGGATGCCAT TGTTAAAGAA 
ATCGTCAATA TTTCCTCAGG CTACGTGGAG CCAATGCAGA CCGTCAATGA CGTGCTAGCT 
CACTTAGATG CCGTCGTTAG TTTTGCTCAT GTGTCAAACG CAGCTCCTGT CCCCTACGTG 
CGACCGGTCA TCTTGGAGAA AGGAAAAGGA AGAATTATAG TGAAAGCCTC CAGGCATGCT 
TGTGTTGAAG TTCAACATGA CGTTGCTTTT ATTCCAAACG ATGTGCACTT TGAAAAAGAT 
AAACAGATGT TCCACATCAT TACCGGGCCG AACATGGGAG GAAAGTCAAC ATACATCCGT 
CAGACGGGGG TGATTGTGCT CATGGCCCAA ATTGGGTGTT TTGTGCCGTG TGAGTCAGCA 
GAGGTGTCCA TTGTGGATTG CATCTTGGCT CGAGTCGGGG CTGGTGACAG TCAGCTGAAA 
GGCGTCTCCA CATTCATGGC TGAAATGCTG GAAACTGCTT CTATCCTCAG GTCGGCAACC 
AAAGATTCCT TAATAATCAT TGATGAGCTG GGAAGAGGAA CCTCTACATA CGACGGCTTT 
GGGTTAGCAT GGGCCATATC GGAGTACATC GCAACGAACA TTGGTGCCTT TTGCATGTTT 
GCCACCCATT TTCATGAACT TACCGCTTTG GCCAGTCAGA TACCAACCGT TAACAATCTC 
CACGTCACAG CGCTGACTAC CGAAGAGACC CTGACTATGC TTTACCAAGT GAAAACAGGT 
GTCTGTGATC AGAGTTTCGG GATTCATGTG GCTGAACTCG CTAATTTCCC TAGGCATGTG 
ATAGAGTGCG CCAAGCAGAA GGCTCTGGAG CTTGAGGAGT TTCAGAGCAT TGGGACCTCA 
CAGGGACACG ATGAAACCCA GCCAGCTGCA AAGAGGCGCT GCCTGGAAAG AGAGCAAGGT 
GAGAAGATTA TTCTGGAGTT CCTGTCCAAG GTCAAGCAAG TGCCCTTCAC TGACTTGTCG 
GAGGAGAGCG TCTCAGTGAA GCTGAAGCAA CTGAAAGCTG AGGTGCTGGC GAAGAACAAC 
AGCTTTGTAA ATGAAATCAT CTCACGGGTA AAGGCTCCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112320.1
CDS	1..2802
Translation	MAVQPKETLQLEGAAEVGFVRFFEGMPEKPSTTVGLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKTLQTVVLSKMNFESFVKDLLLVRHYRVEVYKNKAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMATSIGIMGIKLSTVDGQRQVGVGDVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECILPGGETAGDMGKLRQVIQRGGILITERKRIDFSTKDIYQDLNRLLKGRKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAAFLNKCKTAQGQRLVSQWIKQPLMDKNRIEERLNLVEAFVEDSELRRALQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGVKQLPNVIQALEKYQGRHQALLLAVFVTPLTDLRSDFSKFQEKIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKNKGEYEEAQDAIVKEIVNISSGYVEPMQTVNDVLAHLDAVVSFAHVSNAAPVPYVRPVILEKGKGRIIVKASRHACVEVQHDVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATNIGAFCMFATHFHELTALASQIPTVNNLHVTALTTEETLTMLYQVKTGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQSIGTSQGHDETQPAAKRRCLEREQGEKIILEFLSKVKQVPFTDLSEESVSVKLKQLKAEVLAKNNSFVNEIISRVKAP

Target ORF information:

RefSeq Version	NM_031058.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mutS homolog 2 (Msh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031058.1

ORF Insert Sequence:

ATGGCAGTTC AGCCCAAGGA GACGCTGCAG TTGGAGGGCG CGGCCGAGGT GGGCTTCGTA 
CGCTTCTTTG AGGGCATGCC GGAGAAGCCG AGCACCACGG TCGGCCTCTT CGACCGCGGC 
GACTTTTACA CCGCGCACGG CGAGGACGCG CTGCTGGCGG CCCGCGAGGT GTTCAAGACC 
CAAGGCGTGA TCAAGTACAT GGGGCCGGCA GGGGCAAAGA CCCTGCAGAC TGTTGTGCTG 
AGTAAGATGA ATTTTGAGTC TTTCGTGAAA GATCTTCTTC TGGTTCGTCA CTATAGAGTT 
GAAGTTTATA AGAATAAAGC TGGAAATAAG GCATCTAAGG AGAACGACTG GTATTTGGCA 
TATAAGGCTT CTCCTGGCAA TCTTTCTCAG TTTGAAGACA TCCTGTTTGG TAACAATGAC 
ATGGCCACTT CCATTGGCAT TATGGGTATT AAACTGTCTA CGGTTGATGG TCAGAGACAG 
GTTGGAGTTG GGGATGTGGA TTCCACCCAG AGAAAGCTAG GATTGTGTGA GTTCCCTGAC 
AACGATCAGT TCTCCAATCT CGAGGCTCTT CTGATTCAGA TTGGACCAAA GGAATGCATT 
TTACCAGGCG GAGAGACTGC TGGAGACATG GGGAAACTGA GGCAGGTTAT ACAGAGAGGA 
GGGATTCTGA TCACAGAAAG AAAGAGAATC GACTTTTCCA CAAAAGACAT CTACCAGGAT 
CTCAACCGGT TACTGAAAGG CAGAAAAGGA GAGCAGATGA ACAGCGCTGT CTTACCAGAG 
ATGGAGAATC AGGTTGCAGT TTCATCGTTG TCTGCAGTGA TCAAGTTCCT AGAACTCTTA 
TCAGATGATT CGAATTTTGG GCAGTTTGAA CTGGCGACTT TTGACTTCAG CCAGTACATG 
AAGTTAGACA TGGCAGCAGT TAGAGCCCTC AACCTTTTCC AGGGTTCTGT TGAAGACACC 
ACAGGCTCTC AGTCTCTGGC TGCATTCTTG AATAAATGCA AAACTGCTCA AGGACAAAGG 
CTGGTTAGCC AGTGGATCAA ACAGCCGCTC ATGGATAAAA ACAGGATTGA AGAGAGATTA 
AATTTAGTGG AAGCTTTTGT TGAAGATTCA GAATTGAGGA GAGCTCTACA GGAGGATTTA 
CTTCGCCGAT TTCCAGATCT TAACCGGCTT GCCAAGAAAT TTCAGAGACA AGCAGCGAAT 
TTACAAGATT GTTACCGACT GTATCAGGGT GTGAAACAGC TTCCCAACGT CATCCAGGCT 
CTGGAGAAAT ACCAAGGAAG ACACCAGGCA TTGTTGTTGG CAGTTTTTGT GACTCCTCTT 
ACTGATCTTC GTTCTGATTT TTCAAAATTT CAAGAAAAGA TAGAAACGAC TTTAGATATG 
GATCAGGTGG AGAACCACGA ATTCCTTGTA AAACCTTCAT TTGATCCTAA CCTGAGTGAG 
CTAAGAGAAG TCATGGATGG TCTGGAGAAG AAGATGCAGT CCACCTTAAT AAGTGCAGCG 
CGGGGTCTTG GATTGGACCC TGGCAAACAG ATTAAATTGG ACTCCAGTGC ACAGTTTGGG 
TATTACTTTC GTGTAACCTG CAAGGAAGAG AAAGTCCTCC GCAACAACAA GAACTTCAGC 
ACCGTGGATA TCCAGAAGAA TGGCGTTAAA TTCACCAACA GTGAATTGTC TTCTTTAAAT 
GAAGAATACA CTAAGAACAA AGGAGAGTAT GAGGAGGCCC AGGATGCCAT TGTTAAAGAA 
ATCGTCAATA TTTCCTCAGG CTACGTGGAG CCAATGCAGA CCGTCAATGA CGTGCTAGCT 
CACTTAGATG CCGTCGTTAG TTTTGCTCAT GTGTCAAACG CAGCTCCTGT CCCCTACGTG 
CGACCGGTCA TCTTGGAGAA AGGAAAAGGA AGAATTATAG TGAAAGCCTC CAGGCATGCT 
TGTGTTGAAG TTCAACATGA CGTTGCTTTT ATTCCAAACG ATGTGCACTT TGAAAAAGAT 
AAACAGATGT TCCACATCAT TACCGGGCCG AACATGGGAG GAAAGTCAAC ATACATCCGT 
CAGACGGGGG TGATTGTGCT CATGGCCCAA ATTGGGTGTT TTGTGCCGTG TGAGTCAGCA 
GAGGTGTCCA TTGTGGATTG CATCTTGGCT CGAGTCGGGG CTGGTGACAG TCAGCTGAAA 
GGCGTCTCCA CATTCATGGC TGAAATGCTG GAAACTGCTT CTATCCTCAG GTCGGCAACC 
AAAGATTCCT TAATAATCAT TGATGAGCTG GGAAGAGGAA CCTCTACATA CGACGGCTTT 
GGGTTAGCAT GGGCCATATC GGAGTACATC GCAACGAACA TTGGTGCCTT TTGCATGTTT 
GCCACCCATT TTCATGAACT TACCGCTTTG GCCAGTCAGA TACCAACCGT TAACAATCTC 
CACGTCACAG CGCTGACTAC CGAAGAGACC CTGACTATGC TTTACCAAGT GAAAACAGGT 
GTCTGTGATC AGAGTTTCGG GATTCATGTG GCTGAACTCG CTAATTTCCC TAGGCATGTG 
ATAGAGTGCG CCAAGCAGAA GGCTCTGGAG CTTGAGGAGT TTCAGAGCAT TGGGACCTCA 
CAGGGACACG ATGAAACCCA GCCAGCTGCA AAGAGGCGCT GCCTGGAAAG AGAGCAAGGT 
GAGAAGATTA TTCTGGAGTT CCTGTCCAAG GTCAAGCAAG TGCCCTTCAC TGACTTGTCG 
GAGGAGAGCG TCTCAGTGAA GCTGAAGCAA CTGAAAGCTG AGGTGCTGGC GAAGAACAAC 
AGCTTTGTAA ATGAAATCAT CTCACGGGTA AAGGCTCCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MCM9 Is Required for Mammalian DNA Mismatch Repair.
Molecular cell59(5)831-9(2015 Sep)
Traver S,Coulombe P,Peiffer I,Hutchins JR,Kitzmann M,Latreille D,M?chali M

Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.
Investigative ophthalmology & visual science55(10)6960-7(2014 Sep)
Mishra M,Kowluru RA

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.
Molecular cell50(3)323-32(2013 May)
Ghodgaonkar MM,Lazzaro F,Olivera-Pimentel M,Artola-Bor?n M,Cejka P,Reijns MA,Jackson AP,Plevani P,Muzi-Falconi M,Jiricny J

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS?.
Cell153(3)590-600(2013 Apr)
Li F,Mao G,Tong D,Huang J,Gu L,Yang W,Li GM

Apurinic/apyrimidinic endonuclease 1, the sensitive marker for DNA deterioration in dextran sulfate sodium-induced acute colitis.
Redox report : communications in free radical research18(5)165-73(2013)
Chang IY,Kim JN,Maeng YH,Yoon SP

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Msh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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