Mmp14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp14
Entrez Gene ID	81707
Full Name	matrix metallopeptidase 14
Synonyms	Mt1-mmp
General protein information	Preferred Names matrix metallopeptidase 14 Names matrix metalloproteinase-14 MMP-14 MT-MMP 1 MT1MMP MTMMP1 matrix metallopeptidase 14 (membrane-inserted) matrix metalloproteinase 14 membrane-inserted membrane type 1-matrix metalloproteinase membrane-type matrix metalloproteinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p13
Summary	enzyme which is an activator of progelatinase A [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031056.1	NP_112318.1	matrix metalloproteinase-14 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mmp14b	NP_919395.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006904	XP_001688107.1
Pan troglodytes (chimpanzee)	MMP14	XP_001157686.1
Bos taurus (cattle)	MMP14	NP_776815.1
Mus musculus (house mouse)	Mmp14	NP_032634.3
Caenorhabditis elegans (roundworm)	H36L18.1	NP_510112.2
Xenopus tropicalis (tropical clawed frog)	mmp14	NP_001025559.1
Homo sapiens (human)	MMP14	NP_004986.1
	MMP14	XP_001100232.1
Rattus norvegicus (Norway rat)	Mmp14	NP_112318.1
Danio rerio (zebrafish)	mmp14a	NP_919397.1
Drosophila melanogaster (fruit fly)	Mmp1	NP_726473.2
Canis lupus familiaris (dog)	MMP14	XP_856947.1

Gene Ontology
Bibliography

Related articles in PubMed

MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy.
Yan D, Liu X, Hua L, Wu K, Sha X, Zhao J, Yang C, Zhang C, Shi J, Wu X
Pathology, research and practice212(12)1119-1125(2016 Dec)

MT1-MMP and its potential role in the vertebrate intestinal morphogenesis.
Camargo KC, Gomes JR, Loddi MM, de Sordi R, Costa-Ayub CL, Soares MA
Acta histochemica118(7)729-735(2016 Sep)

Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.
Ji ML, Zhang XJ, Shi PL, Lu J, Wang SZ, Chang Q, Chen H, Wang C
Journal of molecular medicine (Berlin, Germany)94(4)457-68(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expression of MMP-14 was different between cardiac isografts and allografts. MMP-14 could interact with CD44 in allografts.
Title: MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy.

that MT1-MMP contributes to intestinal development, particularly to villi morphogenesis
Title: MT1-MMP and its potential role in the vertebrate intestinal morphogenesis.

Downregulation of miR-193a-3p promoted loss of type II collagen by directly targeting MMP14 in IDD. miR-193a-3p inhibited IDD in vitro and in vivo. miR-193a-3p may be a promising candidate for prevention of degenerative disc disease.
Title: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.

the endothelium under ANGII stimulation acts as a novel and key activator of latent pro-MT1MMP and pro-MMP2 in smooth muscle cells of rat aorta
Title: A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta.

Heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGFR transactivation.
Title: Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation.

The following Mmp14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12914	NM_031056.1 Latest version!	Rattus norvegicus matrix metallopeptidase 14 (Mmp14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp14 ( NM_031056.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112318.1 Rattus norvegicus matrix metallopeptidase 14 (Mmp14), mRNA.

Price & Availability↑

CloneID	ORa12914
Clone ID Related Accession (Same CDS sequence)	NM_031056.1
Accession Version	NM_031056.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	matrix metalloproteinase-14 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X91785.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X91785.1, BC072509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCCCG CCCCTCGACC CTCCCGCAGC CTCCTGCTCC CCCTGCTCAC GCTCGGCACC 
ACGCTCGCCT CCCTCGGCTG GGCCCAAAGC AGCAACTTCA GCCCCGAAGC TTGGCTGCAG 
CAGTATGGCT ACCTACCTCC AGGGGACCTG CGTACCCACA CACAACGCTC ACCCCAGTCA 
CTCTCAGCTG CCATTGCCGC CATGCAAAGG TTCTATGGTT TACAAGTGAC AGGCAAGGCC 
GATTCGGACA CGATGAAGGC TATGAGGCGC CCTCGCTGTG GTGTTCCAGA TAAGTTTGGG 
ACTGAGATCA AGGCCAATGT TCGGAGGAAG CGCTATGCCA TTCAGGGCCT CAAGTGGCAG 
CATAATGAGA TCACTTTCTG CATCCAGAAT TATACCCCCA AGGTGGGCGA GTATGCCACA 
TTCGAGGCCA TTCGGAAAGC CTTCCGAGTA TGGGAGAGTG CCACGCCACT GCGCTTCCGA 
GAAGTGCCCT ATGCCTACAT CCGGGAGGGT CATGAGAAGC AGGCTGACAT CATGATCTTG 
TTTGCTGAGG GTTTCCATGG CGACAGCACA CCCTTTGATG GTGAAGGAGG CTTCCTGGCT 
CATGCCTATT TCCCAGGCCC CAATATCGGA GGGGATACCC ACTTTGATTC TGCTGAGCCC 
TGGACTGTCC AAAATGAGGA TCTAAATGGG AATGACATCT TCTTGGTGGC TGTGCATGAG 
TTGGGGCATG CCCTAGGCCT GGAACATTCC AACGACCCCT CCGCCATCAT GGCTCCCTTT 
TACCAGTGGA TGGACACCGA GAACTTCGTG TTGCCTGATG ACGATCGCCG CGGCATCCAG 
CAACTTTATG GAAGCAAGTC AGGGTCACCC ACAAAGATGC CCCCTCAACC CAGAACCACC 
TCTAGGCCCT CTGTCCCAGA TAAGCCCAGA AACCCCACCT ATGGGCCCAA CATCTGTGAT 
GGGAACTTTG ACACCGTGGC CATGCTCCGA GGAGAGATGT TTGTCTTCAA GGAGCGATGG 
TTCTGGCGGG TGAGGAATAA CCAAGTGATG GACGGATACC CAATGCCCAT TGGCCAATTC 
TGGAGGGGCC TGCCTGCATC CATCAACACT GCCTATGAGA GGAAGGATGG CAAATTTGTT 
TTCTTCAAAG GAGATAAGCA CTGGGTGTTT GACGAAGCTT CCCTGGAACC CGGATACCCC 
AAGCACATTA AGGAGCTGGG CCGAGGACTG CCCACGGACA AGATTGATGC AGCTCTCTTC 
TGGATGCCCA ACGGGAAGAC CTACTTCTTC CGGGGAAATA AGTACTACCG CTTCAATGAG 
GAGTTCAGGG CAGTGGACAG CGAATACCCC AAAAACATCA AAGTCTGGGA AGGAATCCCT 
GAGTCTCCCA GAGGCTCATT CATGGGTAGC GATGAAGTCT TCACATACTT CTACAAAGGG 
AACAAATACT GGAAATTCAA CAACCAGAAG CTGAAGGTAG AGCCAGGGTA CCCCAAGTCA 
GCTCTGCGGG ACTGGATGGG CTGCCCTTCG GGGGGCCGGC CCGACGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT CGAGGTGGAT GAGGAGGGCA GCGGAGCCGT GAGTGCAGCT 
GCTGTCGTTC TGCCGGTGCT GCTGCTGCTC CTGGTACTGG CAGTGGGCCT TGCTGTCTTC 
TTCTTTAGAC GCCATGGGAC ACCCAAGCGA CTGCTTTACT GCCAGCGTTC ACTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112318.1
CDS	164..1912
Translation	MSPAPRPSRSLLLPLLTLGTTLASLGWAQSSNFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLQVTGKADSDTMKAMRRPRCGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSKSGSPTKMPPQPRTTSRPSVPDKPRNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV

Target ORF information:

RefSeq Version	NM_031056.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 14 (Mmp14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031056.1

ORF Insert Sequence:

ATGTCTCCCG CCCCTCGACC CTCCCGCAGC CTCCTGCTCC CCCTGCTCAC GCTCGGCACC 
ACGCTCGCCT CCCTCGGCTG GGCCCAAAGC AGCAACTTCA GCCCCGAAGC TTGGCTGCAG 
CAGTATGGCT ACCTACCTCC AGGGGACCTG CGTACCCACA CACAACGCTC ACCCCAGTCA 
CTCTCAGCTG CCATTGCCGC CATGCAAAGG TTCTATGGTT TACAAGTGAC AGGCAAGGCC 
GATTCGGACA CGATGAAGGC TATGAGGCGC CCTCGCTGTG GTGTTCCAGA TAAGTTTGGG 
ACTGAGATCA AGGCCAATGT TCGGAGGAAG CGCTATGCCA TTCAGGGCCT CAAGTGGCAG 
CATAATGAGA TCACTTTCTG CATCCAGAAT TATACCCCCA AGGTGGGCGA GTATGCCACA 
TTCGAGGCCA TTCGGAAAGC CTTCCGAGTA TGGGAGAGTG CCACGCCACT GCGCTTCCGA 
GAAGTGCCCT ATGCCTACAT CCGGGAGGGT CATGAGAAGC AGGCTGACAT CATGATCTTG 
TTTGCTGAGG GTTTCCATGG CGACAGCACA CCCTTTGATG GTGAAGGAGG CTTCCTGGCT 
CATGCCTATT TCCCAGGCCC CAATATCGGA GGGGATACCC ACTTTGATTC TGCTGAGCCC 
TGGACTGTCC AAAATGAGGA TCTAAATGGG AATGACATCT TCTTGGTGGC TGTGCATGAG 
TTGGGGCATG CCCTAGGCCT GGAACATTCC AACGACCCCT CCGCCATCAT GGCTCCCTTT 
TACCAGTGGA TGGACACCGA GAACTTCGTG TTGCCTGATG ACGATCGCCG CGGCATCCAG 
CAACTTTATG GAAGCAAGTC AGGGTCACCC ACAAAGATGC CCCCTCAACC CAGAACCACC 
TCTAGGCCCT CTGTCCCAGA TAAGCCCAGA AACCCCACCT ATGGGCCCAA CATCTGTGAT 
GGGAACTTTG ACACCGTGGC CATGCTCCGA GGAGAGATGT TTGTCTTCAA GGAGCGATGG 
TTCTGGCGGG TGAGGAATAA CCAAGTGATG GACGGATACC CAATGCCCAT TGGCCAATTC 
TGGAGGGGCC TGCCTGCATC CATCAACACT GCCTATGAGA GGAAGGATGG CAAATTTGTT 
TTCTTCAAAG GAGATAAGCA CTGGGTGTTT GACGAAGCTT CCCTGGAACC CGGATACCCC 
AAGCACATTA AGGAGCTGGG CCGAGGACTG CCCACGGACA AGATTGATGC AGCTCTCTTC 
TGGATGCCCA ACGGGAAGAC CTACTTCTTC CGGGGAAATA AGTACTACCG CTTCAATGAG 
GAGTTCAGGG CAGTGGACAG CGAATACCCC AAAAACATCA AAGTCTGGGA AGGAATCCCT 
GAGTCTCCCA GAGGCTCATT CATGGGTAGC GATGAAGTCT TCACATACTT CTACAAAGGG 
AACAAATACT GGAAATTCAA CAACCAGAAG CTGAAGGTAG AGCCAGGGTA CCCCAAGTCA 
GCTCTGCGGG ACTGGATGGG CTGCCCTTCG GGGGGCCGGC CCGACGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT CGAGGTGGAT GAGGAGGGCA GCGGAGCCGT GAGTGCAGCT 
GCTGTCGTTC TGCCGGTGCT GCTGCTGCTC CTGGTACTGG CAGTGGGCCT TGCTGTCTTC 
TTCTTTAGAC GCCATGGGAC ACCCAAGCGA CTGCTTTACT GCCAGCGTTC ACTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy.
Pathology, research and practice212(12)1119-1125(2016 Dec)
Yan D,Liu X,Hua L,Wu K,Sha X,Zhao J,Yang C,Zhang C,Shi J,Wu X

MT1-MMP and its potential role in the vertebrate intestinal morphogenesis.
Acta histochemica118(7)729-735(2016 Sep)
Camargo KC,Gomes JR,Loddi MM,de Sordi R,Costa-Ayub CL,Soares MA

Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.
Journal of molecular medicine (Berlin, Germany)94(4)457-68(2016 Apr)
Ji ML,Zhang XJ,Shi PL,Lu J,Wang SZ,Chang Q,Chen H,Wang C

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Mmp14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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