Gnrhr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gnrhr
Entrez Gene ID	81668
Full Name	gonadotropin releasing hormone receptor
Synonyms	GH1,Lhrhr
General protein information	Preferred Names gonadotropin releasing hormone receptor Names gonadotropin-releasing hormone receptor gnRH receptor gnRH-R growth hormone
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p21
Summary	induces the synthesis of pituitary gonadotropins; G-protein coupled receptor activity acts via both G(q) and G(s) signaling pathways [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031038.3	NP_112300.2	gonadotropin-releasing hormone receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GNRHR	NP_803480.1
Mus musculus (house mouse)	Gnrhr	NP_034453.1
Rattus norvegicus (Norway rat)	Gnrhr	NP_112300.2
Pan troglodytes (chimpanzee)	GNRHR	XP_526608.1
Homo sapiens (human)	GNRHR	NP_000397.1
	GNRHR	XP_001109227.1
Canis lupus familiaris (dog)	GNRHR	NP_001003121.1

Gene Ontology
Bibliography

Related articles in PubMed

The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.
Bjelobaba I, Janjic MM, Tavcar JS, Kucka M, Tomi? M, Stojilkovic SS
Molecular and cellular endocrinology437302-311(2016 Dec)

Circulating Estradiol Regulates Brain-Derived Estradiol via Actions at GnRH Receptors to Impact Memory in Ovariectomized Rats.
Nelson BS, Black KL, Daniel JM
eNeuro3(6)(2016 Nov-Dec)

Augmentation of gonadotropin-releasing hormone receptor expression in the post-lactational mammary tissues of rats.
Terashima R, Laoharatchatathanin T, Kurusu S, Kawaminami M
The Journal of reproduction and development62(5)495-499(2016 Oct)

Inside and outside the pituitary: comparative analysis of Gnrhr expression provides insight into the mechanisms underlying the evolution of gene expression.
Schang A
Journal of neuroendocrinology27(3)177-86(2015 Mar)

Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.
Wu L, Liu W, Bayaer N, Gu W, Song J
Experimental animals63(4)447-57(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.
Title: The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.

Prevention of estradiol synthesis blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory in a radial-maze task. Hippocampal GnRH receptor antagonism blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory.
Title: Circulating Estradiol Regulates Brain-Derived Estradiol via Actions at GnRH Receptors to Impact Memory in Ovariectomized Rats.

GnRH-R is expressed in the mammary tissues after weaning; GnRH is involved in the involution and tissue remodeling of post-lactating rat mammary tissues
Title: Augmentation of gonadotropin-releasing hormone receptor expression in the post-lactational mammary tissues of rats.

Gnrhr promoter sequences are mainly responsible for directing transcriptional programmes and play a predominant role over the species-specific cell environment.
Title: Inside and outside the pituitary: comparative analysis of Gnrhr expression provides insight into the mechanisms underlying the evolution of gene expression.

Downregulation of Gnrh may be involved in the development of sex hormone disorder and calcium loss.
Title: Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.

The following Gnrhr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gnrhr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12720	NM_031038.3 Latest version!	Rattus norvegicus gonadotropin releasing hormone receptor (Gnrhr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gnrhr ( NM_031038.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112300.2 Rattus norvegicus gonadotropin releasing hormone receptor (Gnrhr), mRNA.

Price & Availability↑

CloneID	ORa12720
Clone ID Related Accession (Same CDS sequence)	NM_031038.3
Accession Version	NM_031038.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	gonadotropin-releasing hormone receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB775870.1, X68980.1, L07646.1 and AC117319.7. On Oct 18, 2005 this sequence version replaced NM_031038.2. Sequence Note: This RefSeq record was created using sequences from two different strains, Sprague-Dawley and BN/SsNHsdMCW, because no single transcript from the same strain was available for the full length of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X68980.1, X76635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMEA2689604 [ECO:0000348] ##Evidence-Data-END##

ATGGCTAACA ATGCGTCTCT TGAGCAGGAC CAAAATCACT GCTCAGCCAT CAACAACAGC 
ATCCCCCTGA CACAGGGCAA GCTCCCGACT CTAACCTTAT CTGGAAAGAT CCGAGTGACG 
GTGACTTTCT TCCTTTTCCT ACTCTCTACT GCCTTCAATG CCTCTTTCTT GGTAAAGCTG 
CAGAGGTGGA CCCAGAAGAG GAAGAAAGGA AAAAAGCTCT CAAGGATGAA GGTGCTTTTA 
AAGCATTTGA CCTTAGCCAA CCTCCTTGAG ACTCTAATCG TCATGCCGCT GGATGGGATG 
TGGAACATCA CTGTTCAGTG GTATGCTGGA GAGTTCCTTT GCAAAGTTCT CAGCTATCTG 
AAGCTCTTCT CTATGTATGC CCCAGCCTTC ATGATGGTGG TGATTAGCCT GGATCGCTCC 
CTGGCCGTCA CTCAGCCCTT AGCTGTCCAA AGCAAGAGCA AGCTTGAACG GTCTATGACC 
AGCCTGGCCT GGATTCTCAG CATTGTCTTT GCGGGACCAC AGTTATATAT CTTCAGGATG 
ATCTACCTAG CCGACGGCTC TGGGCCAGCA GTTTTCTCGC AATGTGTGAC CCACTGCAGC 
TTTCCGCAAT GGTGGCATGA AGCCTTCTAC AACTTTTTCA CCTTCAGCTG CCTGTTCATC 
ATCCCTCTTC TCATCATGCT AATCTGCAAT GCCAAAATCA TCTTCGCCCT CACACGAGTC 
CTTCATCAGG ACCCACGCAA ACTACAGCTG AATCAATCCA AGAATAATAT CCCAAGAGCA 
CGGCTGAGAA CTCTAAAGAT GACAGTGGCA TTTGCCACCT CCTTTGTCAT CTGCTGGACT 
CCCTACTACG TCCTAGGAAT CTGGTACTGG TTTGATCCGG AAATGTTAAA CAGGGTGTCA 
GAGCCAGTCA ATCACTTCTT CTTTCTCTTT GCTTTTCTAA ACCCGTGCTT CGACCCACTT 
ATATATGGGT ATTTCTCTTT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112300.2
CDS	88..1071
Translation	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL

Target ORF information:

RefSeq Version	NM_031038.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gonadotropin releasing hormone receptor (Gnrhr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031038.3

ORF Insert Sequence:

ATGGCTAACA ATGCGTCTCT TGAGCAGGAC CAAAATCACT GCTCAGCCAT CAACAACAGC 
ATCCCCCTGA CACAGGGCAA GCTCCCGACT CTAACCTTAT CTGGAAAGAT CCGAGTGACG 
GTGACTTTCT TCCTTTTCCT ACTCTCTACT GCCTTCAATG CCTCTTTCTT GGTAAAGCTG 
CAGAGGTGGA CCCAGAAGAG GAAGAAAGGA AAAAAGCTCT CAAGGATGAA GGTGCTTTTA 
AAGCATTTGA CCTTAGCCAA CCTCCTTGAG ACTCTAATCG TCATGCCGCT GGATGGGATG 
TGGAACATCA CTGTTCAGTG GTATGCTGGA GAGTTCCTTT GCAAAGTTCT CAGCTATCTG 
AAGCTCTTCT CTATGTATGC CCCAGCCTTC ATGATGGTGG TGATTAGCCT GGATCGCTCC 
CTGGCCGTCA CTCAGCCCTT AGCTGTCCAA AGCAAGAGCA AGCTTGAACG GTCTATGACC 
AGCCTGGCCT GGATTCTCAG CATTGTCTTT GCGGGACCAC AGTTATATAT CTTCAGGATG 
ATCTACCTAG CCGACGGCTC TGGGCCAGCA GTTTTCTCGC AATGTGTGAC CCACTGCAGC 
TTTCCGCAAT GGTGGCATGA AGCCTTCTAC AACTTTTTCA CCTTCAGCTG CCTGTTCATC 
ATCCCTCTTC TCATCATGCT AATCTGCAAT GCCAAAATCA TCTTCGCCCT CACACGAGTC 
CTTCATCAGG ACCCACGCAA ACTACAGCTG AATCAATCCA AGAATAATAT CCCAAGAGCA 
CGGCTGAGAA CTCTAAAGAT GACAGTGGCA TTTGCCACCT CCTTTGTCAT CTGCTGGACT 
CCCTACTACG TCCTAGGAAT CTGGTACTGG TTTGATCCGG AAATGTTAAA CAGGGTGTCA 
GAGCCAGTCA ATCACTTCTT CTTTCTCTTT GCTTTTCTAA ACCCGTGCTT CGACCCACTT 
ATATATGGGT ATTTCTCTTT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.
Molecular and cellular endocrinology437302-311(2016 Dec)
Bjelobaba I,Janjic MM,Tavcar JS,Kucka M,Tomi? M,Stojilkovic SS

Circulating Estradiol Regulates Brain-Derived Estradiol via Actions at GnRH Receptors to Impact Memory in Ovariectomized Rats.
eNeuro3(6)(2016 Nov-Dec)
Nelson BS,Black KL,Daniel JM

Augmentation of gonadotropin-releasing hormone receptor expression in the post-lactational mammary tissues of rats.
The Journal of reproduction and development62(5)495-499(2016 Oct)
Terashima R,Laoharatchatathanin T,Kurusu S,Kawaminami M

Inside and outside the pituitary: comparative analysis of Gnrhr expression provides insight into the mechanisms underlying the evolution of gene expression.
Journal of neuroendocrinology27(3)177-86(2015 Mar)
Schang A

Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.
Experimental animals63(4)447-57(2014)
Wu L,Liu W,Bayaer N,Gu W,Song J

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Gnrhr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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