Gabbr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabbr1
Entrez Gene ID	81657
Full Name	gamma-aminobutyric acid type B receptor subunit 1
General protein information	Preferred Names gamma-aminobutyric acid type B receptor subunit 1 Names gamma-aminobutyric acid type B receptor subunit 1 GABA-B receptor 1 GABA-B-R1 GABA-BR1 GABABR1 gamma-aminobutyric acid (GABA) B receptor 1 gb1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	metabotropic G-protein-coupled receptor for gamma-aminobutyric acid (GABA) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006255879.3	XP_006255941.1	gamma-aminobutyric acid type B receptor subunit 1 isoform X1
NM_031028.3	NP_112290.2	gamma-aminobutyric acid type B receptor subunit 1 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gabbr1b	XP_005170159.1
Anopheles gambiae (African malaria mosquito)	GPRGBB1	XP_319474.3
Homo sapiens (human)	GABBR1	NP_001461.1
Xenopus tropicalis (tropical clawed frog)	gabbr1	NP_001107291.1
Mus musculus (house mouse)	Gabbr1	NP_062312.3
Danio rerio (zebrafish)	gabbr1a	XP_694497.5
Caenorhabditis elegans (roundworm)	gbb-1	NP_741740.2
Pan troglodytes (chimpanzee)	GABBR1	XP_527324.4
	GABBR1	XP_001097474.2
Canis lupus familiaris (dog)	GABBR1	XP_005640226.1
Bos taurus (cattle)	GABBR1	NP_001156747.1
Rattus norvegicus (Norway rat)	Gabbr1	NP_112290.2
Drosophila melanogaster (fruit fly)	GABA-B-R1	NP_001246033.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of GABAB receptor activation on spatial cognitive function and hippocampal neurones in rat models of type 2 diabetes mellitus.
Cai XJ, Wang L, Hu CM
Bioscience reports38(1)(2018 Feb)

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA
Wright R, Newey SE, Ilie A, Wefelmeyer W, Raimondo JV, Ginham R, Mcllhinney RAJ, Akerman CJ
The Journal of neuroscience : the official journal of the Society for Neuroscience37(22)5447-5462(2017 May)

Calcium Release from Stores Inhibits GIRK.
Kramer PF, Williams JT
Cell reports17(12)3246-3255(2016 12)

Lys-63-linked Ubiquitination of ?-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.
Zemoura K, Tr?mpler C, Benke D
The Journal of biological chemistry291(41)21682-21693(2016 Oct)

GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.
Ainsworth M, Lee S, Kaiser M, Simonotto J, Kopell NJ, Whittington MA
Proceedings of the National Academy of Sciences of the United States of America113(19)E2721-9(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We demonstrate that GABABR activation can regulate KCC2 at the cell surface in a manner that alters intracellular chloride and the reversal potential for the GABAAR. Our data therefore support an additional mechanism by which GABABRs are able to modulate fast synaptic inhibition.
Title: Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA

Transient activation of mGluRs decreased the GIRK current evoked by GABAB and D2 receptors, although less efficaciously for D2.
Title: Calcium Release from Stores Inhibits GIRK.

sustained activation of glutamate receptors, a condition occurring in brain ischemia that down-regulates GABAB receptors, considerably increased the expression of MIB2 and Lys-63-linked ubiquitination of GABAB receptors. Interfering with Lys-63-linked ubiquitination by overexpressing ubiquitin mutants or GABAB1 mutants deficient in Lys-63-linked ubiquitination prevented glutamate-induced down-regulation of the receptors.
Title: Lys-63-linked Ubiquitination of ?-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.

Both synaptic processes were critically dependent on activation of GABAB receptors and, together, appeared to temporally segregate the cortical representation. These data suggest that adaptation to repetitive sensory input dramatically alters the spatiotemporal properties of the neocortical response in a manner that may both refine and minimize cortical output simultaneously.
Title: GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.

ANG II/AT1R/HoxD10/miR-7b/GABBR1 pathway in the PVN contributes to sympathoexcitation and deterioration of cardiac function in heart failure.
Title: Sympathoexcitation in Rats With Chronic Heart Failure Depends on Homeobox D10 and MicroRNA-7b Inhibiting GABBR1 Translation in Paraventricular Nucleus.

The following Gabbr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabbr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13431	NM_031028.3 Latest version!	Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$566.30 $809.00
ORa39095	XM_006255879.3 Latest version!	Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabbr1 ( NM_031028.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112290.2 Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), mRNA.

Price & Availability↑

CloneID	ORa13431
Clone ID Related Accession (Same CDS sequence)	NM_031028.3
Accession Version	NM_031028.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2883bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid type B receptor subunit 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX883052.1. On Oct 20, 2009 this sequence version replaced NM_031028.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y10369.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCTGCTGC TGCTGCTGGT GCCTCTCTTC CTCCGCCCCC TGGGCGCTGG CGGGGCGCAG 
ACCCCCAACG CCACCTCGGA AGGTTGCCAG ATTATACATC CGCCCTGGGA AGGTGGCATC 
AGGTACCGTG GCTTGACTCG CGACCAGGTG AAGGCCATCA ACTTCCTGCC TGTGGACTAT 
GAGATCGAAT ATGTGTGCCG AGGGGAGCGC GAGGTGGTGG GGCCCAAGGT GCGCAAATGC 
CTGGCCAACG GCTCCTGGAC GGATATGGAC ACACCCAGCC GCTGTGTCCG AATCTGCTCC 
AAGTCTTATT TGACCCTGGA AAATGGGAAG GTTTTCCTGA CGGGTGGGGA CCTCCCAGCT 
CTGGATGGAG CCCGGGTGGA GTTCCGATGT GACCCCGACT TCCATCTGGT GGGCAGCTCC 
CGGAGCGTCT GTAGTCAGGG CCAGTGGAGC ACCCCCAAGC CCCACTGCCA GGTGAATCGA 
ACGCCACACT CAGAACGGCG TGCAGTATAC ATCGGGGCGC TGTTTCCCAT GAGCGGGGGC 
TGGCCGGGGG GCCAGGCCTG CCAGCCCGCG GTGGAGATGG CGCTGGAGGA CGTTAACAGC 
CGCAGAGACA TCCTGCCGGA CTACGAGCTC AAGCTTATCC ACCACGACAG CAAGTGTGAC 
CCAGGGCAAG CCACCAAGTA CTTGTACGAA CTACTCTACA ATGACCCCAT CAAGATCATT 
CTCATGCCTG GCTGTAGTTC TGTCTCCACA CTTGTAGCTG AGGCTGCCCG GATGTGGAAC 
CTTATTGTGC TCTCATATGG CTCCAGTTCA CCAGCCTTGT CAAACCGACA GCGGTTTCCC 
ACGTTCTTCC GGACGCATCC ATCCGCCACA CTCCACAATC CCACCCGGGT GAAACTCTTC 
GAAAAGTGGG GCTGGAAGAA GATCGCTACC ATCCAACAGA CCACCGAGGT CTTCACCTCA 
ACGCTGGATG ACCTGGAGGA GCGAGTGAAA GAGGCTGGGA TCGAGATCAC TTTCCGACAG 
AGTTTCTTCT CGGATCCAGC TGTGCCTGTT AAAAACCTGA AGCGTCAAGA TGCTCGAATC 
ATCGTGGGAC TTTTCTATGA GACGGAAGCC CGGAAAGTTT TTTGTGAGGT CTATAAGGAA 
AGGCTCTTTG GGAAGAAGTA CGTCTGGTTC CTCATCGGGT GGTATGCTGA CAACTGGTTC 
AAGACCTATG ACCCGTCAAT CAATTGTACA GTGGAAGAAA TGACCGAGGC GGTGGAGGGC 
CACATCACCA CGGAGATTGT CATGCTGAAC CCTGCCAACA CCCGAAGCAT TTCCAACATG 
ACGTCACAGG AATTTGTGGA GAAACTAACC AAGCGGCTGA AAAGACACCC CGAGGAGACT 
GGAGGCTTCC AGGAGGCACC ACTGGCCTAT GATGCTATCT GGGCCTTGGC TTTGGCCTTG 
AACAAGACGT CTGGAGGAGG TGGTCGTTCC GGCGTGCGCC TGGAGGACTT TAACTACAAC 
AACCAGACCA TTACAGACCA GATCTACCGG GCCATGAACT CCTCCTCCTT TGAGGGCGTT 
TCTGGCCATG TGGTCTTTGA TGCCAGCGGC TCCCGGATGG CATGGACACT TATCGAGCAG 
CTACAGGGCG GCAGCTACAA GAAGATCGGC TACTACGACA GCACCAAGGA TGATCTTTCC 
TGGTCCAAAA CGGACAAGTG GATTGGAGGG TCTCCCCCAG CTGACCAGAC CTTGGTCATC 
AAGACATTCC GTTTCCTGTC TCAGAAACTC TTTATCTCCG TCTCAGTTCT CTCCAGCCTG 
GGCATTGTTC TTGCTGTTGT CTGTCTGTCC TTTAACATCT ACAACTCCCA CGTTCGTTAT 
ATCCAGAACT CCCAGCCCAA CCTGAACAAT CTGACTGCTG TGGGCTGCTC ACTGGCACTG 
GCTGCTGTCT TCCCTCTCGG GCTGGATGGT TACCACATAG GGAGAAGCCA GTTCCCGTTT 
GTCTGCCAGG CCCGCCTTTG GCTCTTGGGC TTGGGCTTTA GTCTGGGCTA TGGCTCTATG 
TTCACCAAGA TCTGGTGGGT CCACACAGTC TTCACGAAGA AGGAGGAGAA GAAGGAGTGG 
AGGAAGACCC TAGAGCCCTG GAAACTCTAT GCCACTGTGG GCCTGCTGGT GGGCATGGAT 
GTCCTGACTC TTGCCATCTG GCAGATTGTG GACCCCTTGC ACCGAACCAT TGAGACTTTT 
GCCAAGGAGG AACCAAAGGA AGACATCGAT GTCTCCATTC TGCCCCAGTT GGAGCACTGC 
AGCTCCAAGA AGATGAATAC GTGGCTTGGC ATTTTCTATG GTTACAAGGG GCTGCTGCTG 
CTGCTGGGAA TCTTTCTTGC TTACGAAACC AAGAGCGTGT CCACTGAAAA GATCAATGAC 
CACAGGGCCG TGGGCATGGC TATCTACAAT GTCGCGGTCC TGTGTCTCAT CACTGCTCCT 
GTGACCATGA TCCTTTCCAG TCAGCAGGAC GCAGCCTTTG CCTTTGCCTC TCTGGCCATC 
GTGTTCTCTT CCTACATCAC TCTGGTTGTG CTCTTTGTGC CCAAGATGCG CAGGCTGATC 
ACCCGAGGGG AATGGCAGTC TGAAACGCAG GACACCATGA AAACAGGATC ATCCACCAAC 
AACAACGAGG AAGAGAAGTC CCGACTGTTG GAGAAGGAAA ACCGAGAACT GGAAAAGATC 
ATCGCTGAGA AAGAGGAGCG CGTCTCTGAA CTGCGCCATC AGCTCCAGTC TCGGCAGCAA 
CTCCGCTCAC GGCGCCACCC CCCAACACCC CCAGATCCCT CTGGGGGCCT TCCCAGGGGA 
CCCTCTGAGC CCCCTGACCG GCTTAGCTGT GATGGGAGTC GAGTACATTT GCTTTACAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112290.2
CDS	210..3092
Translation	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK

Target ORF information:

RefSeq Version	NM_031028.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031028.3

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGGT GCCTCTCTTC CTCCGCCCCC TGGGCGCTGG CGGGGCGCAG 
ACCCCCAACG CCACCTCGGA AGGTTGCCAG ATTATACATC CGCCCTGGGA AGGTGGCATC 
AGGTACCGTG GCTTGACTCG CGACCAGGTG AAGGCCATCA ACTTCCTGCC TGTGGACTAT 
GAGATCGAAT ATGTGTGCCG AGGGGAGCGC GAGGTGGTGG GGCCCAAGGT GCGCAAATGC 
CTGGCCAACG GCTCCTGGAC GGATATGGAC ACACCCAGCC GCTGTGTCCG AATCTGCTCC 
AAGTCTTATT TGACCCTGGA AAATGGGAAG GTTTTCCTGA CGGGTGGGGA CCTCCCAGCT 
CTGGATGGAG CCCGGGTGGA GTTCCGATGT GACCCCGACT TCCATCTGGT GGGCAGCTCC 
CGGAGCGTCT GTAGTCAGGG CCAGTGGAGC ACCCCCAAGC CCCACTGCCA GGTGAATCGA 
ACGCCACACT CAGAACGGCG TGCAGTATAC ATCGGGGCGC TGTTTCCCAT GAGCGGGGGC 
TGGCCGGGGG GCCAGGCCTG CCAGCCCGCG GTGGAGATGG CGCTGGAGGA CGTTAACAGC 
CGCAGAGACA TCCTGCCGGA CTACGAGCTC AAGCTTATCC ACCACGACAG CAAGTGTGAC 
CCAGGGCAAG CCACCAAGTA CTTGTACGAA CTACTCTACA ATGACCCCAT CAAGATCATT 
CTCATGCCTG GCTGTAGTTC TGTCTCCACA CTTGTAGCTG AGGCTGCCCG GATGTGGAAC 
CTTATTGTGC TCTCATATGG CTCCAGTTCA CCAGCCTTGT CAAACCGACA GCGGTTTCCC 
ACGTTCTTCC GGACGCATCC ATCCGCCACA CTCCACAATC CCACCCGGGT GAAACTCTTC 
GAAAAGTGGG GCTGGAAGAA GATCGCTACC ATCCAACAGA CCACCGAGGT CTTCACCTCA 
ACGCTGGATG ACCTGGAGGA GCGAGTGAAA GAGGCTGGGA TCGAGATCAC TTTCCGACAG 
AGTTTCTTCT CGGATCCAGC TGTGCCTGTT AAAAACCTGA AGCGTCAAGA TGCTCGAATC 
ATCGTGGGAC TTTTCTATGA GACGGAAGCC CGGAAAGTTT TTTGTGAGGT CTATAAGGAA 
AGGCTCTTTG GGAAGAAGTA CGTCTGGTTC CTCATCGGGT GGTATGCTGA CAACTGGTTC 
AAGACCTATG ACCCGTCAAT CAATTGTACA GTGGAAGAAA TGACCGAGGC GGTGGAGGGC 
CACATCACCA CGGAGATTGT CATGCTGAAC CCTGCCAACA CCCGAAGCAT TTCCAACATG 
ACGTCACAGG AATTTGTGGA GAAACTAACC AAGCGGCTGA AAAGACACCC CGAGGAGACT 
GGAGGCTTCC AGGAGGCACC ACTGGCCTAT GATGCTATCT GGGCCTTGGC TTTGGCCTTG 
AACAAGACGT CTGGAGGAGG TGGTCGTTCC GGCGTGCGCC TGGAGGACTT TAACTACAAC 
AACCAGACCA TTACAGACCA GATCTACCGG GCCATGAACT CCTCCTCCTT TGAGGGCGTT 
TCTGGCCATG TGGTCTTTGA TGCCAGCGGC TCCCGGATGG CATGGACACT TATCGAGCAG 
CTACAGGGCG GCAGCTACAA GAAGATCGGC TACTACGACA GCACCAAGGA TGATCTTTCC 
TGGTCCAAAA CGGACAAGTG GATTGGAGGG TCTCCCCCAG CTGACCAGAC CTTGGTCATC 
AAGACATTCC GTTTCCTGTC TCAGAAACTC TTTATCTCCG TCTCAGTTCT CTCCAGCCTG 
GGCATTGTTC TTGCTGTTGT CTGTCTGTCC TTTAACATCT ACAACTCCCA CGTTCGTTAT 
ATCCAGAACT CCCAGCCCAA CCTGAACAAT CTGACTGCTG TGGGCTGCTC ACTGGCACTG 
GCTGCTGTCT TCCCTCTCGG GCTGGATGGT TACCACATAG GGAGAAGCCA GTTCCCGTTT 
GTCTGCCAGG CCCGCCTTTG GCTCTTGGGC TTGGGCTTTA GTCTGGGCTA TGGCTCTATG 
TTCACCAAGA TCTGGTGGGT CCACACAGTC TTCACGAAGA AGGAGGAGAA GAAGGAGTGG 
AGGAAGACCC TAGAGCCCTG GAAACTCTAT GCCACTGTGG GCCTGCTGGT GGGCATGGAT 
GTCCTGACTC TTGCCATCTG GCAGATTGTG GACCCCTTGC ACCGAACCAT TGAGACTTTT 
GCCAAGGAGG AACCAAAGGA AGACATCGAT GTCTCCATTC TGCCCCAGTT GGAGCACTGC 
AGCTCCAAGA AGATGAATAC GTGGCTTGGC ATTTTCTATG GTTACAAGGG GCTGCTGCTG 
CTGCTGGGAA TCTTTCTTGC TTACGAAACC AAGAGCGTGT CCACTGAAAA GATCAATGAC 
CACAGGGCCG TGGGCATGGC TATCTACAAT GTCGCGGTCC TGTGTCTCAT CACTGCTCCT 
GTGACCATGA TCCTTTCCAG TCAGCAGGAC GCAGCCTTTG CCTTTGCCTC TCTGGCCATC 
GTGTTCTCTT CCTACATCAC TCTGGTTGTG CTCTTTGTGC CCAAGATGCG CAGGCTGATC 
ACCCGAGGGG AATGGCAGTC TGAAACGCAG GACACCATGA AAACAGGATC ATCCACCAAC 
AACAACGAGG AAGAGAAGTC CCGACTGTTG GAGAAGGAAA ACCGAGAACT GGAAAAGATC 
ATCGCTGAGA AAGAGGAGCG CGTCTCTGAA CTGCGCCATC AGCTCCAGTC TCGGCAGCAA 
CTCCGCTCAC GGCGCCACCC CCCAACACCC CCAGATCCCT CTGGGGGCCT TCCCAGGGGA 
CCCTCTGAGC CCCCTGACCG GCTTAGCTGT GATGGGAGTC GAGTACATTT GCTTTACAAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gabbr1 ( XM_006255879.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006255941.1 Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa39095
Clone ID Related Accession (Same CDS sequence)	XM_006255879.3
Accession Version	XM_006255879.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2976bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid type B receptor subunit 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006255879.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCTGC TGCTGCTGGT GCCTCTCTTC CTCCGCCCCC TGGGCGCTGG CGGGGCGCAG 
ACCCCCAACG CCACCTCGGA AGGTTGCCAG ATTATACATC CGCCCTGGGA AGGTGGCATC 
AGGTACCGTG GCTTGACTCG CGACCAGGTG AAGGCCATCA ACTTCCTGCC TGTGGACTAT 
GAGATCGAAT ATGTGTGCCG AGGGGAGCGC GAGGTGGTGG GGCCCAAGGT GCGCAAATGC 
CTGGCCAACG GCTCCTGGAC GGATATGGAC ACACCCAGCC GCTGTGTCCG AATCTGCTCC 
AAGTCTTATT TGACCCTGGA AAATGGGAAG GTTTTCCTGA CGGGTGGGGA CCTCCCAGCT 
CTGGATGGAG CCCGGGTGGA GTTCCGATGT GACCCCGACT TCCATCTGGT GGGCAGCTCC 
CGGAGCGTCT GTAGTCAGGG CCAGTGGAGC ACCCCCAAGC CCCACTGCCA GGTGAATCGA 
ACGCCACACT CAGAACGGCG TGCAGTATAC ATCGGGGCGC TGTTTCCCAT GAGCGGGGGC 
TGGCCGGGGG GCCAGGCCTG CCAGCCCGCG GTGGAGATGG CGCTGGAGGA CGTTAACAGC 
CGCAGAGACA TCCTGCCGGA CTACGAGCTC AAGCTTATCC ACCACGACAG CAAGTGTGAC 
CCAGGGCAAG CCACCAAGTA CTTGTACGAA CTACTCTACA ATGACCCCAT CAAGATCATT 
CTCATGCCTG GCTGTAGTTC TGTCTCCACA CTTGTAGCTG AGGCTGCCCG GATGTGGAAC 
CTTATTGTGC TCTCATATGG CTCCAGTTCA CCAGCCTTGT CAAACCGACA GCGGTTTCCC 
ACGTTCTTCC GGACGCATCC ATCCGCCACA CTCCACAATC CCACCCGGGT GAAACTCTTC 
GAAAAGTGGG GCTGGAAGAA GATCGCTACC ATCCAACAGA CCACCGAGGT CTTCACCTCA 
ACGCTGGATG ACCTGGAGGA GCGAGTGAAA GAGGCTGGGA TCGAGATCAC TTTCCGACAG 
AGTTTCTTCT CGGATCCAGC TGTGCCTGTT AAAAACCTGA AGCGTCAAGA TGCTCGAATC 
ATCGTGGGAC TTTTCTATGA GACGGAAGCC CGGAAAGTTT TTTGTGAGGT CTATAAGGAA 
AGGCTCTTTG GGAAGAAGTA CGTCTGGTTC CTCATCGGGT GGTATGCTGA CAACTGGTTC 
AAGACCTATG ACCCGTCAAT CAATTGTACA GTGGAAGAAA TGACCGAGGC GGTGGAGGGC 
CACATCACCA CGGAGATTGT CATGCTGAAC CCTGCCAACA CCCGAAGCAT TTCCAACATG 
ACGTCACAGG AATTTGTGGA GAAACTAACC AAGCGGCTGA AAAGACACCC CGAGGAGACT 
GGAGGCTTCC AGGAGGCACC ACTGGCCTAT GATGCTATCT GGGCCTTGGC TTTGGCCTTG 
AACAAGACGT CTGGAGGAGG TGGTCGTTCC GGCGTGCGCC TGGAGGACTT TAACTACAAC 
AACCAGACCA TTACAGACCA GATCTACCGG GCCATGAACT CCTCCTCCTT TGAGGGCGTT 
TCTGGCCATG TGGTCTTTGA TGCCAGCGGC TCCCGGATGG CATGGACACT TATCGAGCAG 
CTACAGGGCG GCAGCTACAA GAAGATCGGC TACTACGACA GCACCAAGGA TGATCTTTCC 
TGGTCCAAAA CGGACAAGTG GATTGGAGGG TCTCCCCCAG CTGACCAGAC CTTGGTCATC 
AAGACATTCC GTTTCCTGTC TCAGAAACTC TTTATCTCCG TCTCAGTTCT CTCCAGCCTG 
GGCATTGTTC TTGCTGTTGT CTGTCTGTCC TTTAACATCT ACAACTCCCA CGTTCGTTAT 
ATCCAGAACT CCCAGCCCAA CCTGAACAAT CTGACTGCTG TGGGCTGCTC ACTGGCACTG 
GCTGCTGTCT TCCCTCTCGG GCTGGATGGT TACCACATAG GGAGAAGCCA GTTCCCGTTT 
GTCTGCCAGG CCCGCCTTTG GCTCTTGGGC TTGGGCTTTA GTCTGGGCTA TGGCTCTATG 
TTCACCAAGA TCTGGTGGGT CCACACAGTC TTCACGAAGA AGGAGGAGAA GAAGGAGTGG 
AGGAAGACCC TAGAGCCCTG GAAACTCTAT GCCACTGTGG GCCTGCTGGT GGGCATGGAT 
GTCCTGACTC TTGCCATCTG GCAGATTGTG GACCCCTTGC ACCGAACCAT TGAGACTTTT 
GCCAAGGAGG AACCAAAGGA AGACATCGAT GTCTCCATTC TGCCCCAGTT GGAGCACTGC 
AGCTCCAAGA AGATGAATAC GTGGCTTGGA GAGCTTTGGT CTTTTGCTGT GAGTAGTGAT 
GTTCAGCGGA GGGCCACTGT AGGCGGTGAC TCACCCATCT GTGTCTGGCC AGCTCCTGAG 
AGCATTTTCT ATGGTTACAA GGGGCTGCTG CTGCTGCTGG GAATCTTTCT TGCTTACGAA 
ACCAAGAGCG TGTCCACTGA AAAGATCAAT GACCACAGGG CCGTGGGCAT GGCTATCTAC 
AATGTCGCGG TCCTGTGTCT CATCACTGCT CCTGTGACCA TGATCCTTTC CAGTCAGCAG 
GACGCAGCCT TTGCCTTTGC CTCTCTGGCC ATCGTGTTCT CTTCCTACAT CACTCTGGTT 
GTGCTCTTTG TGCCCAAGAT GCGCAGGCTG ATCACCCGAG GGGAATGGCA GTCTGAAACG 
CAGGACACCA TGAAAACAGG ATCATCCACC AACAACAACG AGGAAGAGAA GTCCCGACTG 
TTGGAGAAGG AAAACCGAGA ACTGGAAAAG ATCATCGCTG AGAAAGAGGA GCGCGTCTCT 
GAACTGCGCC ATCAGCTCCA GTCTCGGCAG CAACTCCGCT CACGGCGCCA CCCCCCAACA 
CCCCCAGATC CCTCTGGGGG CCTTCCCAGG GGACCCTCTG AGCCCCCTGA CCGGCTTAGC 
TGTGATGGGA GTCGAGTACA TTTGCTTTAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006255941.1
CDS	315..3290
Translation	MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK

Target ORF information:

RefSeq Version	XM_006255879.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006255879.3

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGGT GCCTCTCTTC CTCCGCCCCC TGGGCGCTGG CGGGGCGCAG 
ACCCCCAACG CCACCTCGGA AGGTTGCCAG ATTATACATC CGCCCTGGGA AGGTGGCATC 
AGGTACCGTG GCTTGACTCG CGACCAGGTG AAGGCCATCA ACTTCCTGCC TGTGGACTAT 
GAGATCGAAT ATGTGTGCCG AGGGGAGCGC GAGGTGGTGG GGCCCAAGGT GCGCAAATGC 
CTGGCCAACG GCTCCTGGAC GGATATGGAC ACACCCAGCC GCTGTGTCCG AATCTGCTCC 
AAGTCTTATT TGACCCTGGA AAATGGGAAG GTTTTCCTGA CGGGTGGGGA CCTCCCAGCT 
CTGGATGGAG CCCGGGTGGA GTTCCGATGT GACCCCGACT TCCATCTGGT GGGCAGCTCC 
CGGAGCGTCT GTAGTCAGGG CCAGTGGAGC ACCCCCAAGC CCCACTGCCA GGTGAATCGA 
ACGCCACACT CAGAACGGCG TGCAGTATAC ATCGGGGCGC TGTTTCCCAT GAGCGGGGGC 
TGGCCGGGGG GCCAGGCCTG CCAGCCCGCG GTGGAGATGG CGCTGGAGGA CGTTAACAGC 
CGCAGAGACA TCCTGCCGGA CTACGAGCTC AAGCTTATCC ACCACGACAG CAAGTGTGAC 
CCAGGGCAAG CCACCAAGTA CTTGTACGAA CTACTCTACA ATGACCCCAT CAAGATCATT 
CTCATGCCTG GCTGTAGTTC TGTCTCCACA CTTGTAGCTG AGGCTGCCCG GATGTGGAAC 
CTTATTGTGC TCTCATATGG CTCCAGTTCA CCAGCCTTGT CAAACCGACA GCGGTTTCCC 
ACGTTCTTCC GGACGCATCC ATCCGCCACA CTCCACAATC CCACCCGGGT GAAACTCTTC 
GAAAAGTGGG GCTGGAAGAA GATCGCTACC ATCCAACAGA CCACCGAGGT CTTCACCTCA 
ACGCTGGATG ACCTGGAGGA GCGAGTGAAA GAGGCTGGGA TCGAGATCAC TTTCCGACAG 
AGTTTCTTCT CGGATCCAGC TGTGCCTGTT AAAAACCTGA AGCGTCAAGA TGCTCGAATC 
ATCGTGGGAC TTTTCTATGA GACGGAAGCC CGGAAAGTTT TTTGTGAGGT CTATAAGGAA 
AGGCTCTTTG GGAAGAAGTA CGTCTGGTTC CTCATCGGGT GGTATGCTGA CAACTGGTTC 
AAGACCTATG ACCCGTCAAT CAATTGTACA GTGGAAGAAA TGACCGAGGC GGTGGAGGGC 
CACATCACCA CGGAGATTGT CATGCTGAAC CCTGCCAACA CCCGAAGCAT TTCCAACATG 
ACGTCACAGG AATTTGTGGA GAAACTAACC AAGCGGCTGA AAAGACACCC CGAGGAGACT 
GGAGGCTTCC AGGAGGCACC ACTGGCCTAT GATGCTATCT GGGCCTTGGC TTTGGCCTTG 
AACAAGACGT CTGGAGGAGG TGGTCGTTCC GGCGTGCGCC TGGAGGACTT TAACTACAAC 
AACCAGACCA TTACAGACCA GATCTACCGG GCCATGAACT CCTCCTCCTT TGAGGGCGTT 
TCTGGCCATG TGGTCTTTGA TGCCAGCGGC TCCCGGATGG CATGGACACT TATCGAGCAG 
CTACAGGGCG GCAGCTACAA GAAGATCGGC TACTACGACA GCACCAAGGA TGATCTTTCC 
TGGTCCAAAA CGGACAAGTG GATTGGAGGG TCTCCCCCAG CTGACCAGAC CTTGGTCATC 
AAGACATTCC GTTTCCTGTC TCAGAAACTC TTTATCTCCG TCTCAGTTCT CTCCAGCCTG 
GGCATTGTTC TTGCTGTTGT CTGTCTGTCC TTTAACATCT ACAACTCCCA CGTTCGTTAT 
ATCCAGAACT CCCAGCCCAA CCTGAACAAT CTGACTGCTG TGGGCTGCTC ACTGGCACTG 
GCTGCTGTCT TCCCTCTCGG GCTGGATGGT TACCACATAG GGAGAAGCCA GTTCCCGTTT 
GTCTGCCAGG CCCGCCTTTG GCTCTTGGGC TTGGGCTTTA GTCTGGGCTA TGGCTCTATG 
TTCACCAAGA TCTGGTGGGT CCACACAGTC TTCACGAAGA AGGAGGAGAA GAAGGAGTGG 
AGGAAGACCC TAGAGCCCTG GAAACTCTAT GCCACTGTGG GCCTGCTGGT GGGCATGGAT 
GTCCTGACTC TTGCCATCTG GCAGATTGTG GACCCCTTGC ACCGAACCAT TGAGACTTTT 
GCCAAGGAGG AACCAAAGGA AGACATCGAT GTCTCCATTC TGCCCCAGTT GGAGCACTGC 
AGCTCCAAGA AGATGAATAC GTGGCTTGGA GAGCTTTGGT CTTTTGCTGT GAGTAGTGAT 
GTTCAGCGGA GGGCCACTGT AGGCGGTGAC TCACCCATCT GTGTCTGGCC AGCTCCTGAG 
AGCATTTTCT ATGGTTACAA GGGGCTGCTG CTGCTGCTGG GAATCTTTCT TGCTTACGAA 
ACCAAGAGCG TGTCCACTGA AAAGATCAAT GACCACAGGG CCGTGGGCAT GGCTATCTAC 
AATGTCGCGG TCCTGTGTCT CATCACTGCT CCTGTGACCA TGATCCTTTC CAGTCAGCAG 
GACGCAGCCT TTGCCTTTGC CTCTCTGGCC ATCGTGTTCT CTTCCTACAT CACTCTGGTT 
GTGCTCTTTG TGCCCAAGAT GCGCAGGCTG ATCACCCGAG GGGAATGGCA GTCTGAAACG 
CAGGACACCA TGAAAACAGG ATCATCCACC AACAACAACG AGGAAGAGAA GTCCCGACTG 
TTGGAGAAGG AAAACCGAGA ACTGGAAAAG ATCATCGCTG AGAAAGAGGA GCGCGTCTCT 
GAACTGCGCC ATCAGCTCCA GTCTCGGCAG CAACTCCGCT CACGGCGCCA CCCCCCAACA 
CCCCCAGATC CCTCTGGGGG CCTTCCCAGG GGACCCTCTG AGCCCCCTGA CCGGCTTAGC 
TGTGATGGGA GTCGAGTACA TTTGCTTTAC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of GABAB receptor activation on spatial cognitive function and hippocampal neurones in rat models of type 2 diabetes mellitus.
Bioscience reports38(1)(2018 Feb)
Cai XJ,Wang L,Hu CM

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA
The Journal of neuroscience : the official journal of the Society for Neuroscience37(22)5447-5462(2017 May)
Wright R,Newey SE,Ilie A,Wefelmeyer W,Raimondo JV,Ginham R,Mcllhinney RAJ,Akerman CJ

Calcium Release from Stores Inhibits GIRK.
Cell reports17(12)3246-3255(2016 12)
Kramer PF,Williams JT

Lys-63-linked Ubiquitination of ?-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.
The Journal of biological chemistry291(41)21682-21693(2016 Oct)
Zemoura K,Tr?mpler C,Benke D

GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.
Proceedings of the National Academy of Sciences of the United States of America113(19)E2721-9(2016 May)
Ainsworth M,Lee S,Kaiser M,Simonotto J,Kopell NJ,Whittington MA

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Gabbr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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