Agtr1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Agtr1b
Entrez Gene ID	81638
Full Name	angiotensin II receptor, type 1b
Synonyms	AT1,AT1B,AT3,AT₁R,Agtr1
General protein information	Preferred Names angiotensin II receptor, type 1b Names type-1B angiotensin II receptor Angiotensin II receptor, type 1 (AT1B) angiotensin II receptor, type-1 angiotensin II type-1 receptor angiotensin II type-1B receptor angiotensin receptor 1 angiotensin receptor 1b
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q24
Summary	G-protein coupled receptor for angiotensin II; has a role in blood pressure regulation, electrolyte balance and cardiac function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008760879.2	XP_008759101.1	type-1B angiotensin II receptor isoform X1
NM_031009.2	NP_112271.2	type-1B angiotensin II receptor
XM_006232187.2	XP_006232249.1	type-1B angiotensin II receptor isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Agtr1b	NP_780295.2
Rattus norvegicus (Norway rat)	Agtr1b	NP_112271.2
Danio rerio (zebrafish)	agtr1b	XP_005162585.1
Danio rerio (zebrafish)	agtr1a	XP_005163432.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells.
Garrido-Gil P, Rodriguez-Perez AI, Fernandez-Rodriguez P, Lanciego JL, Labandeira-Garcia JL
Brain structure & function222(6)2559-2571(2017 Aug)

Aging-related dysregulation of dopamine and angiotensin receptor interaction.
Villar-Cheda B, Dominguez-Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira-Garcia JL
Neurobiology of aging35(7)1726-38(2014 Jul)

Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction.
Li Z, Cao Y, Li L, Liang Y, Tian X, Mo N, Liu Y, Li M, Chui D, Guo X
Biochemical and biophysical research communications449(1)74-80(2014 Jun)

Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys.
Razga Z, Kovacs G, B?di N, Talapka P, Nyengaard JR
BioMed research international2014947506(2014)

Tissue renin-angiotensin system in the intervertebral disc.
Morimoto R, Akeda K, Iida R, Nishimura A, Tsujii M, Obata S, Kasai Y, Uchida A, Sudo A
Spine38(3)E129-36(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A counterregulatory interaction between dopamine and the angiotensin receptor was observed.
Title: Aging-related dysregulation of dopamine and angiotensin receptor interaction.

The enhanced downregulation of the AT1-B receptors in the renin-positive SMCs in the arterioles may result in an enhanced level of renin granulation in the arterioles.
Title: Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys.

Data indicate that mRNA of tissue renin-angiotensin system (tRAS) components angiotensin converting enzyme, Ang II, Ang II receptor type 1, Ang II receptor type 2, and Cathepsin D in intervertebral disc (IVD) was clearly confirmed BY RT-PCR.
Title: Tissue renin-angiotensin system in the intervertebral disc.

Data indicate tjat AT1 receptor blockade completely abrogated AT1-AA-induced TNF-alpha secretion, caspase-3 activation, and cardiomyocyte apoptosis.
Title: Angiotensin II type I receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-?.

alterations in both D1R (diminished) and AT(1)R (exaggerated) functions are necessary for the development of age-associated hypertension, as seen in old FBN rats.
Title: Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.

The following Agtr1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Agtr1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07368	NM_031009.2 Latest version!	Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa07368	XM_006232187.2 Latest version!	Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa07368	XM_008760879.2 Latest version!	Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Agtr1b ( NM_031009.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112271.2 Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), mRNA.

Price & Availability↑

CloneID	ORa07368
Clone ID Related Accession (Same CDS sequence)	XM_008760879.2 , NM_031009.2 , XM_006232187.2
Accession Version	NM_031009.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	type-1B angiotensin II receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB730850.1, AABR07009599.1, AC094053.9 and M87003.1. On Nov 18, 2005 this sequence version replaced NM_031009.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M87003.1, CB730850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN02642595 [ECO:0000348] ##Evidence-Data-END##

ATGACCCTTA ACTCCTCTAC TGAAGATGGA ATTAAAAGAA TCCAAGATGA CTGCCCCAAG 
GCTGGCAGGC ACAATTACAT ATTTGTCATG ATCCCTACTC TCTACAGCAT CATCTTTGTG 
GTGGGAATAT TTGGAAACAG CTTGGTGGTG ATTGTCATTT ACTTTTACAT GAAGCTAAAG 
ACTGTGGCCA GTGTTTTTCT TCTGAATCTT GCCCTGGCTG ATTTATGCTT TTTGTTGACT 
TTGCCACTGT GGGCAGTCTA TACCGCTATG GAATACCGAT GGCCCTTCGG CAACCACCTA 
TGTAAGATCG CTTCTGCCAG CGTCAGTTTC AATCTCTATG CCAGTGTGTT TCTGCTCACG 
TGTCTCAGCA TCGATCGCTA CCTGGCCATT GTCCACCCAA TGAAGTCTCG CCTCCGCCGC 
ACGATGCTGG TAGCCAAAGT CACCTGCATC ATCATCTGGC TAATGGCTGG CTTGGCCAGT 
TTGCCAGCCG TCATCTACCG AAACGTATAT TTCATCGAGA ACACCAATAT CACAGTTTGC 
GCTTTTCATT ATGAATCTCA GAACTCAACA CTCCCCATTG GACTGGGTCT AACAAAGAAC 
ATTCTGGGCT TCGTGTTCCC TTTCCTTATC ATTCTCACCA GCTATACTCT TATTTGGAAA 
GCCCTAAAGA AGGCTTATAA AATTCAGAAG AACACGCCAA GAAATGATGA CATCTTTAGG 
ATAATTATGG CGATTGTGCT TTTCTTCTTC TTTTCCTGGG TTCCCCACCA AATATTCACT 
TTTCTGGATG TGCTCATTCA GCTGGGCATT ATCCGTGACT GTGAAATTGC TGACATTGTG 
GACACCGCTA TGCCCATCAC CATCTGCATA GCTTATTTTA ACAATTGCCT GAATCCTCTG 
TTTTATGGCT TTCTGGGGAA AAAATTTAAA AAATATTTCC TCCAGCTTCT GAAATACATT 
CCCCCAACGG CCAAGTCACA CGCAGGCTTG TCAACAAAAA TGAGCACTCT TTCCTACCGC 
CCTTCAGATA ACATGAGTTC ATCTGCCAAA AAGTCTGCAT CTTTTTTTGA AGTGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112271.2
CDS	166..1245
Translation	MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE

Target ORF information:

RefSeq Version	NM_031009.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031009.2

ORF Insert Sequence:

ATGACCCTTA ACTCCTCTAC TGAAGATGGA ATTAAAAGAA TCCAAGATGA CTGCCCCAAG 
GCTGGCAGGC ACAATTACAT ATTTGTCATG ATCCCTACTC TCTACAGCAT CATCTTTGTG 
GTGGGAATAT TTGGAAACAG CTTGGTGGTG ATTGTCATTT ACTTTTACAT GAAGCTAAAG 
ACTGTGGCCA GTGTTTTTCT TCTGAATCTT GCCCTGGCTG ATTTATGCTT TTTGTTGACT 
TTGCCACTGT GGGCAGTCTA TACCGCTATG GAATACCGAT GGCCCTTCGG CAACCACCTA 
TGTAAGATCG CTTCTGCCAG CGTCAGTTTC AATCTCTATG CCAGTGTGTT TCTGCTCACG 
TGTCTCAGCA TCGATCGCTA CCTGGCCATT GTCCACCCAA TGAAGTCTCG CCTCCGCCGC 
ACGATGCTGG TAGCCAAAGT CACCTGCATC ATCATCTGGC TAATGGCTGG CTTGGCCAGT 
TTGCCAGCCG TCATCTACCG AAACGTATAT TTCATCGAGA ACACCAATAT CACAGTTTGC 
GCTTTTCATT ATGAATCTCA GAACTCAACA CTCCCCATTG GACTGGGTCT AACAAAGAAC 
ATTCTGGGCT TCGTGTTCCC TTTCCTTATC ATTCTCACCA GCTATACTCT TATTTGGAAA 
GCCCTAAAGA AGGCTTATAA AATTCAGAAG AACACGCCAA GAAATGATGA CATCTTTAGG 
ATAATTATGG CGATTGTGCT TTTCTTCTTC TTTTCCTGGG TTCCCCACCA AATATTCACT 
TTTCTGGATG TGCTCATTCA GCTGGGCATT ATCCGTGACT GTGAAATTGC TGACATTGTG 
GACACCGCTA TGCCCATCAC CATCTGCATA GCTTATTTTA ACAATTGCCT GAATCCTCTG 
TTTTATGGCT TTCTGGGGAA AAAATTTAAA AAATATTTCC TCCAGCTTCT GAAATACATT 
CCCCCAACGG CCAAGTCACA CGCAGGCTTG TCAACAAAAA TGAGCACTCT TTCCTACCGC 
CCTTCAGATA ACATGAGTTC ATCTGCCAAA AAGTCTGCAT CTTTTTTTGA AGTGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Agtr1b ( XM_008760879.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008759101.1 Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa07368
Clone ID Related Accession (Same CDS sequence)	XM_008760879.2 , NM_031009.2 , XM_006232187.2
Accession Version	XM_008760879.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	type-1B angiotensin II receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760879.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCTTA ACTCCTCTAC TGAAGATGGA ATTAAAAGAA TCCAAGATGA CTGCCCCAAG 
GCTGGCAGGC ACAATTACAT ATTTGTCATG ATCCCTACTC TCTACAGCAT CATCTTTGTG 
GTGGGAATAT TTGGAAACAG CTTGGTGGTG ATTGTCATTT ACTTTTACAT GAAGCTAAAG 
ACTGTGGCCA GTGTTTTTCT TCTGAATCTT GCCCTGGCTG ATTTATGCTT TTTGTTGACT 
TTGCCACTGT GGGCAGTCTA TACCGCTATG GAATACCGAT GGCCCTTCGG CAACCACCTA 
TGTAAGATCG CTTCTGCCAG CGTCAGTTTC AATCTCTATG CCAGTGTGTT TCTGCTCACG 
TGTCTCAGCA TCGATCGCTA CCTGGCCATT GTCCACCCAA TGAAGTCTCG CCTCCGCCGC 
ACGATGCTGG TAGCCAAAGT CACCTGCATC ATCATCTGGC TAATGGCTGG CTTGGCCAGT 
TTGCCAGCCG TCATCTACCG AAACGTATAT TTCATCGAGA ACACCAATAT CACAGTTTGC 
GCTTTTCATT ATGAATCTCA GAACTCAACA CTCCCCATTG GACTGGGTCT AACAAAGAAC 
ATTCTGGGCT TCGTGTTCCC TTTCCTTATC ATTCTCACCA GCTATACTCT TATTTGGAAA 
GCCCTAAAGA AGGCTTATAA AATTCAGAAG AACACGCCAA GAAATGATGA CATCTTTAGG 
ATAATTATGG CGATTGTGCT TTTCTTCTTC TTTTCCTGGG TTCCCCACCA AATATTCACT 
TTTCTGGATG TGCTCATTCA GCTGGGCATT ATCCGTGACT GTGAAATTGC TGACATTGTG 
GACACCGCTA TGCCCATCAC CATCTGCATA GCTTATTTTA ACAATTGCCT GAATCCTCTG 
TTTTATGGCT TTCTGGGGAA AAAATTTAAA AAATATTTCC TCCAGCTTCT GAAATACATT 
CCCCCAACGG CCAAGTCACA CGCAGGCTTG TCAACAAAAA TGAGCACTCT TTCCTACCGC 
CCTTCAGATA ACATGAGTTC ATCTGCCAAA AAGTCTGCAT CTTTTTTTGA AGTGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008759101.1
CDS	341..1420
Translation	MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE

Target ORF information:

RefSeq Version	XM_008760879.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760879.2

ORF Insert Sequence:

ATGACCCTTA ACTCCTCTAC TGAAGATGGA ATTAAAAGAA TCCAAGATGA CTGCCCCAAG 
GCTGGCAGGC ACAATTACAT ATTTGTCATG ATCCCTACTC TCTACAGCAT CATCTTTGTG 
GTGGGAATAT TTGGAAACAG CTTGGTGGTG ATTGTCATTT ACTTTTACAT GAAGCTAAAG 
ACTGTGGCCA GTGTTTTTCT TCTGAATCTT GCCCTGGCTG ATTTATGCTT TTTGTTGACT 
TTGCCACTGT GGGCAGTCTA TACCGCTATG GAATACCGAT GGCCCTTCGG CAACCACCTA 
TGTAAGATCG CTTCTGCCAG CGTCAGTTTC AATCTCTATG CCAGTGTGTT TCTGCTCACG 
TGTCTCAGCA TCGATCGCTA CCTGGCCATT GTCCACCCAA TGAAGTCTCG CCTCCGCCGC 
ACGATGCTGG TAGCCAAAGT CACCTGCATC ATCATCTGGC TAATGGCTGG CTTGGCCAGT 
TTGCCAGCCG TCATCTACCG AAACGTATAT TTCATCGAGA ACACCAATAT CACAGTTTGC 
GCTTTTCATT ATGAATCTCA GAACTCAACA CTCCCCATTG GACTGGGTCT AACAAAGAAC 
ATTCTGGGCT TCGTGTTCCC TTTCCTTATC ATTCTCACCA GCTATACTCT TATTTGGAAA 
GCCCTAAAGA AGGCTTATAA AATTCAGAAG AACACGCCAA GAAATGATGA CATCTTTAGG 
ATAATTATGG CGATTGTGCT TTTCTTCTTC TTTTCCTGGG TTCCCCACCA AATATTCACT 
TTTCTGGATG TGCTCATTCA GCTGGGCATT ATCCGTGACT GTGAAATTGC TGACATTGTG 
GACACCGCTA TGCCCATCAC CATCTGCATA GCTTATTTTA ACAATTGCCT GAATCCTCTG 
TTTTATGGCT TTCTGGGGAA AAAATTTAAA AAATATTTCC TCCAGCTTCT GAAATACATT 
CCCCCAACGG CCAAGTCACA CGCAGGCTTG TCAACAAAAA TGAGCACTCT TTCCTACCGC 
CCTTCAGATA ACATGAGTTC ATCTGCCAAA AAGTCTGCAT CTTTTTTTGA AGTGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Agtr1b ( XM_006232187.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232249.1 Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa07368
Clone ID Related Accession (Same CDS sequence)	XM_008760879.2 , NM_031009.2 , XM_006232187.2
Accession Version	XM_006232187.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	type-1B angiotensin II receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006232187.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCTTA ACTCCTCTAC TGAAGATGGA ATTAAAAGAA TCCAAGATGA CTGCCCCAAG 
GCTGGCAGGC ACAATTACAT ATTTGTCATG ATCCCTACTC TCTACAGCAT CATCTTTGTG 
GTGGGAATAT TTGGAAACAG CTTGGTGGTG ATTGTCATTT ACTTTTACAT GAAGCTAAAG 
ACTGTGGCCA GTGTTTTTCT TCTGAATCTT GCCCTGGCTG ATTTATGCTT TTTGTTGACT 
TTGCCACTGT GGGCAGTCTA TACCGCTATG GAATACCGAT GGCCCTTCGG CAACCACCTA 
TGTAAGATCG CTTCTGCCAG CGTCAGTTTC AATCTCTATG CCAGTGTGTT TCTGCTCACG 
TGTCTCAGCA TCGATCGCTA CCTGGCCATT GTCCACCCAA TGAAGTCTCG CCTCCGCCGC 
ACGATGCTGG TAGCCAAAGT CACCTGCATC ATCATCTGGC TAATGGCTGG CTTGGCCAGT 
TTGCCAGCCG TCATCTACCG AAACGTATAT TTCATCGAGA ACACCAATAT CACAGTTTGC 
GCTTTTCATT ATGAATCTCA GAACTCAACA CTCCCCATTG GACTGGGTCT AACAAAGAAC 
ATTCTGGGCT TCGTGTTCCC TTTCCTTATC ATTCTCACCA GCTATACTCT TATTTGGAAA 
GCCCTAAAGA AGGCTTATAA AATTCAGAAG AACACGCCAA GAAATGATGA CATCTTTAGG 
ATAATTATGG CGATTGTGCT TTTCTTCTTC TTTTCCTGGG TTCCCCACCA AATATTCACT 
TTTCTGGATG TGCTCATTCA GCTGGGCATT ATCCGTGACT GTGAAATTGC TGACATTGTG 
GACACCGCTA TGCCCATCAC CATCTGCATA GCTTATTTTA ACAATTGCCT GAATCCTCTG 
TTTTATGGCT TTCTGGGGAA AAAATTTAAA AAATATTTCC TCCAGCTTCT GAAATACATT 
CCCCCAACGG CCAAGTCACA CGCAGGCTTG TCAACAAAAA TGAGCACTCT TTCCTACCGC 
CCTTCAGATA ACATGAGTTC ATCTGCCAAA AAGTCTGCAT CTTTTTTTGA AGTGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232249.1
CDS	1250..2329
Translation	MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE

Target ORF information:

RefSeq Version	XM_006232187.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232187.2

ORF Insert Sequence:

ATGACCCTTA ACTCCTCTAC TGAAGATGGA ATTAAAAGAA TCCAAGATGA CTGCCCCAAG 
GCTGGCAGGC ACAATTACAT ATTTGTCATG ATCCCTACTC TCTACAGCAT CATCTTTGTG 
GTGGGAATAT TTGGAAACAG CTTGGTGGTG ATTGTCATTT ACTTTTACAT GAAGCTAAAG 
ACTGTGGCCA GTGTTTTTCT TCTGAATCTT GCCCTGGCTG ATTTATGCTT TTTGTTGACT 
TTGCCACTGT GGGCAGTCTA TACCGCTATG GAATACCGAT GGCCCTTCGG CAACCACCTA 
TGTAAGATCG CTTCTGCCAG CGTCAGTTTC AATCTCTATG CCAGTGTGTT TCTGCTCACG 
TGTCTCAGCA TCGATCGCTA CCTGGCCATT GTCCACCCAA TGAAGTCTCG CCTCCGCCGC 
ACGATGCTGG TAGCCAAAGT CACCTGCATC ATCATCTGGC TAATGGCTGG CTTGGCCAGT 
TTGCCAGCCG TCATCTACCG AAACGTATAT TTCATCGAGA ACACCAATAT CACAGTTTGC 
GCTTTTCATT ATGAATCTCA GAACTCAACA CTCCCCATTG GACTGGGTCT AACAAAGAAC 
ATTCTGGGCT TCGTGTTCCC TTTCCTTATC ATTCTCACCA GCTATACTCT TATTTGGAAA 
GCCCTAAAGA AGGCTTATAA AATTCAGAAG AACACGCCAA GAAATGATGA CATCTTTAGG 
ATAATTATGG CGATTGTGCT TTTCTTCTTC TTTTCCTGGG TTCCCCACCA AATATTCACT 
TTTCTGGATG TGCTCATTCA GCTGGGCATT ATCCGTGACT GTGAAATTGC TGACATTGTG 
GACACCGCTA TGCCCATCAC CATCTGCATA GCTTATTTTA ACAATTGCCT GAATCCTCTG 
TTTTATGGCT TTCTGGGGAA AAAATTTAAA AAATATTTCC TCCAGCTTCT GAAATACATT 
CCCCCAACGG CCAAGTCACA CGCAGGCTTG TCAACAAAAA TGAGCACTCT TTCCTACCGC 
CCTTCAGATA ACATGAGTTC ATCTGCCAAA AAGTCTGCAT CTTTTTTTGA AGTGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells.
Brain structure & function222(6)2559-2571(2017 Aug)
Garrido-Gil P,Rodriguez-Perez AI,Fernandez-Rodriguez P,Lanciego JL,Labandeira-Garcia JL

Aging-related dysregulation of dopamine and angiotensin receptor interaction.
Neurobiology of aging35(7)1726-38(2014 Jul)
Villar-Cheda B,Dominguez-Meijide A,Valenzuela R,Granado N,Moratalla R,Labandeira-Garcia JL

Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction.
Biochemical and biophysical research communications449(1)74-80(2014 Jun)
Li Z,Cao Y,Li L,Liang Y,Tian X,Mo N,Liu Y,Li M,Chui D,Guo X

Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys.
BioMed research international2014947506(2014)
Razga Z,Kovacs G,B?di N,Talapka P,Nyengaard JR

Tissue renin-angiotensin system in the intervertebral disc.
Spine38(3)E129-36(2013 Feb)
Morimoto R,Akeda K,Iida R,Nishimura A,Tsujii M,Obata S,Kasai Y,Uchida A,Sudo A

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Agtr1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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