Ap2a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ap2a2
Entrez Gene ID	81637
Full Name	adaptor-related protein complex 2, alpha 2 subunit
General protein information	Preferred Names adaptor-related protein complex 2, alpha 2 subunit Names AP-2 complex subunit alpha-2 100 kDa coated vesicle protein C adapter-related protein complex 2 alpha-2 subunit adapter-related protein complex 2 subunit alpha-2 adaptor protein complex AP-2 subunit alpha-2 adaptor protein complex AP-2, alpha 2 subunit adaptor-related protein complex 2 subunit alpha-2 alpha-adaptin C alpha2-adaptin clathrin assembly protein complex 2 alpha-C large chain plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	alpha c large chain of the clathrin associated protein complex [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031008.2	NP_112270.2	AP-2 complex subunit alpha-2
XM_008760010.2	XP_008758232.1	AP-2 complex subunit alpha-2 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	AP2A2	NP_001012914.1
Drosophila melanogaster (fruit fly)	alpha-Adaptin	NP_476819.2
Caenorhabditis elegans (roundworm)	apa-2	NP_509572.1
Neurospora crassa	NCU03440	XP_956726.1
Arabidopsis thaliana (thale cress)	alpha-ADR	NP_197669.1
Pan troglodytes (chimpanzee)	AP2A2	XP_003951843.1
Rattus norvegicus (Norway rat)	Ap2a2	NP_112270.2
Anopheles gambiae (African malaria mosquito)	AP2A_ANOGA	XP_310153.4
Arabidopsis thaliana (thale cress)	AT5G22780	NP_197670.1
Homo sapiens (human)	AP2A2	NP_001229766.1
	AP2A2	XP_001116794.2
Schizosaccharomyces pombe (fission yeast)	apl3	NP_595595.1
Magnaporthe oryzae (rice blast fungus)	MGG_09493	XP_003712251.1
Canis lupus familiaris (dog)	AP2A2	XP_005631788.1
Xenopus tropicalis (tropical clawed frog)	ap2a2	NP_001001209.1
Bos taurus (cattle)	AP2A2	NP_001069170.1
Mus musculus (house mouse)	Ap2a2	NP_031485.3

Gene Ontology
Bibliography

Related articles in PubMed

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, P?rez-Ota?o I, Padovani A, Giustetto M, Gardoni F, Di Luca M
The Journal of clinical investigation123(6)2523-38(2013 Jun)

Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells.
Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M
The Journal of neuroscience : the official journal of the Society for Neuroscience33(22)9508-19(2013 May)

Synaptic vesicle endocytosis.
Saheki Y, De Camilli P
Cold Spring Harbor perspectives in biology4(9)a005645(2012 Sep)

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G
Blood119(11)2510-22(2012 Mar)

Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor ?3 subunit.
Smith KR, Muir J, Rao Y, Browarski M, Gruenig MC, Sheehan DF, Haucke V, Kittler JT
The Journal of neuroscience : the official journal of the Society for Neuroscience32(7)2485-98(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AP2 binding to three ariginine residues motif in the GABA(A)R beta3-subunit regulates GABA(A)R residency time at endocytic zones, steady-state synaptic receptor levels, and pathological loss of GABA(A)Rs from synapses during simulated ischemia.
Title: Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor ?3 subunit.

alpha-AP-2 has a role in directing myosin VI-dependent endocytosis of CFTR; myosin VI is involved in membrane invagination and coated pit formation in enterocytes
Title: Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.

AP-2 binds to unique sites on the C-terminus of NMDA receptor subunit NR2B and has an antagonistic functional consequence that is independent of the ability of PSD-95 to cluster receptors on the plasma membrane.
Title: Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression.

The following Ap2a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ap2a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13443	NM_031008.2 Latest version!	Rattus norvegicus adaptor related protein complex 2 subunit alpha 2 (Ap2a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$552.30 $789.00
ORa23621	XM_008760010.2 Latest version!	Rattus norvegicus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ap2a2 ( NM_031008.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112270.2 Rattus norvegicus adaptor related protein complex 2 subunit alpha 2 (Ap2a2), mRNA.

Price & Availability↑

CloneID	ORa13443
Clone ID Related Accession (Same CDS sequence)	NM_031008.2
Accession Version	NM_031008.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2820bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	AP-2 complex subunit alpha-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081786.1. On Dec 8, 2007 this sequence version replaced NM_031008.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGCCG TATCCAAGGG GGAGGGGATG CGAGGCCTAG CGGTCTTCAT CTCCGATATC 
CGTAACTGTA AAAGTAAAGA AGCTGAAATA AAGAGGATAA ATAAGGAGCT GGCAAATATT 
AGATCAAAAT TTAAAGGTGA CAAGGCTCTT GATGGCTACA GTAAGAAGAA GTATGTCTGC 
AAGTTACTCT TCATCTTTCT CCTTGGTCAT GACATTGACT TTGGACACAT GGAAGCTGTG 
AATCTTCTGA GCTCAAACAG ATACACGGAA AAGCAGATCG GCTACCTTTT CATCTCTGTA 
TTGGTGAATT CAAATAGTGA ACTGATCCGG TTGATTAACA ATGCCATCAA GAATGACCTG 
GCCAGCCGCA ATCCTACATT TATGGGTCTG GCCCTGCACT GCATCGCCAA TGTGGGTAGC 
CGTGAGATGG CAGAGGCCTT CGCTGGAGAG ATCCCCAAGA TCCTGGTGGC AGGAGATACC 
ATGGACAGTG TGAAGCAGAG CGCAGCCCTG TGCTTGTTGC GCCTGTACAG GACGTCACCT 
GACCTAGTTC CTATGGGCGA CTGGACATCC CGTGTGGTAC ACCTCCTCAA TGACCAGCAC 
TTGGGTGTAG TGACTGCCGC AACTAGCCTC ATCACCACAC TGGCCCAGAA GAATCCTGAG 
GAGTTCAAGA CCTCTGTCTC TCTAGCTGTC TCTCGACTGA GCAGAATTGT GACGTCCGCG 
TCAACAGATC TTCAGGATTA TACTTACTAC TTTGTCCCGG CTCCTTGGCT GTCAGTCAAA 
CTTCTGAGAC TGCTGCAGTG CTACCCACCC CCAGAAGACC CTGCGGTGCG TGGCCGCCTG 
ACTGAGTGCT TGGAGACCAT CCTGAATAAG GCCCAGGAGC CCCCCAAGTC CAAGAAAGTC 
CAGCATTCAA ATGCCAAGAA CGCTGTGCTG TTTGAGGCCA TCAGCCTCAT CATCCACCAT 
GACAGTGAGC CCAACCTCCT GGTCCGTGCC TGCAACCAGC TGGGCCAGTT CCTGCAGCAT 
CGGGAGACAA ACCTGCGCTA CCTGGCTCTG GAGAGCATGT GCACACTGGC CAGCTCTGAG 
TTCTCTCACG AGGCTGTCAA GACCCACATC GAGACTGTCA TCAATGCCTT GAAGACGGAA 
CGAGATGTGA GTGTGCGGCA GCGGGCAGTG GACCTGCTCT ACGCCATGTG CGACCGAAGC 
AACGCCCAGC AGATTGTGGC TGAGATGCTG AGCTACCTAG AAACAGCTGA CTACTCCATC 
CGGGAGGAAA TTGTGCTGAA GGTGGCCATC CTTGCTGAGA AGTATGCAGT GGACTACACT 
TGGTATGTGG ACACCATCCT CAACCTCATC CGCATTGCAG GCGACTATGT GAGCGAAGAG 
GTGTGGTACC GCGTCATCCA GATTGTCATC AATCGCGATG ATGTGCAGGG TTATGCTGCC 
AAGACGGTGT TTGAGGCATT GCAGGCTCCA GCATGTCATG AGAACTTGGT CAAAGTGGGC 
GGCTACATCC TGGGCGAGTT TGGAAACTTG ATAGCGGGAG ACCCACGATC CAGCCCTCTG 
ATCCAGTTCA ACCTGCTCCA CTCCAAGTTC CACTTGTGCA GCGTCCCCAC TCGGGCACTC 
CTGCTGTCCA CCTACATCAA GTTCGTGAAC CTCTTTCCAG AGGTAAAGGC TACCATTCAG 
GACGTGCTGC GCAGTGACAG CCAACTGAAG AACGCAGATG TGGAGCTGCA GCAGCGGGCT 
GTGGAGTACC TGCGACTGAG TACTGTTGCC AGCACTGATA TCCTGGCAAC TGTCCTGGAA 
GAAATGCCAC CCTTCCCTGA GCGTGAGTCC TCCATCTTGG CCAAGCTGAA GAAGAAGAAG 
GGCCCAAGCA CAGTGACTGA CCTGGAGGAG ACCAAGCGTG AGCGAAGCAT CGATGTGAAT 
GGGGGCCCCG AACCCGTTCC AGCCAGCACC AGTGCTGCGT CCACACCTTC TCCATCAGCA 
GACCTGCTGG GTCTGGGGGC CGTTCCCCCT GCTCCCACAG GGCCCCCTCC CACCTCTGGC 
GGTGGGTTAC TGGTGGACGT GTTCTCAGAC TCAGCTTCTG CAGTTGCACC TCTTGCACCC 
GGCTCTGAAG ACAACTTTGC CAGGTTTGTT TGTAAAAACA ATGGTGTGTT GTTTGAAAAC 
CAGCTGCTTC AAATTGGACT GAAGTCAGAA TTTCGGCAGA ATTTAGGTCG AATGTTCATA 
TTTTATGGTA ACAAGACCTC CACGCAGTTC CTAAACTTCA CTCCAACACT AATCTGTGCT 
GACGACCTTC AGACTAATCT GAACCTGCAG ACTAAGCCCG TGGACCCAAC TGTGGATGGG 
GGCGCACAGG TGCAACAGGT GGTCAACATT GAGTGTATAT CTGATTTCAC AGAGGCACCT 
GTCCTCAACA TCCAGTTCAG GTATGGTGGT ACCTTCCAGA ATGTGTCTGT TAAGCTTCCC 
ATCACTCTCA ACAAATTTTT CCAGCCCACA GAAATGGCTT CTCAGGATTT CTTTCAACGT 
TGGAAGCAGT TGAGCAATCC ACAGCAAGAA GTGCAGAATA TCTTCAAAGC AAAGCATCCG 
ATGGACACAG AAATCACTAA AGCGAAGATT ATTGGATTTG GTTCTGCGCT CCTGGAAGAA 
GTTGATCCAA ACCCTGCAAA TTTTGTGGGT GCTGGCATAA TACATACCAA AACCACCCAG 
ATCGGCTGCT TGTTGCGCCT GGAGCCAAAC CTGCAAGCTC AGATGTACAG ACTCACCTTG 
CGTACCAGCA AAGACACCGT CTCTCAGAGA CTATGTGAAT TGCTGTCGGA ACAGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112270.2
CDS	81..2900
Translation	MPAVSKGEGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSDSQLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEETKRERSIDVNGGPEPVPASTSAASTPSPSADLLGLGAVPPAPTGPPPTSGGGLLVDVFSDSASAVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTVDGGAQVQQVVNIECISDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEITKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQMYRLTLRTSKDTVSQRLCELLSEQF

Target ORF information:

RefSeq Version	NM_031008.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adaptor related protein complex 2 subunit alpha 2 (Ap2a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031008.2

ORF Insert Sequence:

ATGCCGGCCG TATCCAAGGG GGAGGGGATG CGAGGCCTAG CGGTCTTCAT CTCCGATATC 
CGTAACTGTA AAAGTAAAGA AGCTGAAATA AAGAGGATAA ATAAGGAGCT GGCAAATATT 
AGATCAAAAT TTAAAGGTGA CAAGGCTCTT GATGGCTACA GTAAGAAGAA GTATGTCTGC 
AAGTTACTCT TCATCTTTCT CCTTGGTCAT GACATTGACT TTGGACACAT GGAAGCTGTG 
AATCTTCTGA GCTCAAACAG ATACACGGAA AAGCAGATCG GCTACCTTTT CATCTCTGTA 
TTGGTGAATT CAAATAGTGA ACTGATCCGG TTGATTAACA ATGCCATCAA GAATGACCTG 
GCCAGCCGCA ATCCTACATT TATGGGTCTG GCCCTGCACT GCATCGCCAA TGTGGGTAGC 
CGTGAGATGG CAGAGGCCTT CGCTGGAGAG ATCCCCAAGA TCCTGGTGGC AGGAGATACC 
ATGGACAGTG TGAAGCAGAG CGCAGCCCTG TGCTTGTTGC GCCTGTACAG GACGTCACCT 
GACCTAGTTC CTATGGGCGA CTGGACATCC CGTGTGGTAC ACCTCCTCAA TGACCAGCAC 
TTGGGTGTAG TGACTGCCGC AACTAGCCTC ATCACCACAC TGGCCCAGAA GAATCCTGAG 
GAGTTCAAGA CCTCTGTCTC TCTAGCTGTC TCTCGACTGA GCAGAATTGT GACGTCCGCG 
TCAACAGATC TTCAGGATTA TACTTACTAC TTTGTCCCGG CTCCTTGGCT GTCAGTCAAA 
CTTCTGAGAC TGCTGCAGTG CTACCCACCC CCAGAAGACC CTGCGGTGCG TGGCCGCCTG 
ACTGAGTGCT TGGAGACCAT CCTGAATAAG GCCCAGGAGC CCCCCAAGTC CAAGAAAGTC 
CAGCATTCAA ATGCCAAGAA CGCTGTGCTG TTTGAGGCCA TCAGCCTCAT CATCCACCAT 
GACAGTGAGC CCAACCTCCT GGTCCGTGCC TGCAACCAGC TGGGCCAGTT CCTGCAGCAT 
CGGGAGACAA ACCTGCGCTA CCTGGCTCTG GAGAGCATGT GCACACTGGC CAGCTCTGAG 
TTCTCTCACG AGGCTGTCAA GACCCACATC GAGACTGTCA TCAATGCCTT GAAGACGGAA 
CGAGATGTGA GTGTGCGGCA GCGGGCAGTG GACCTGCTCT ACGCCATGTG CGACCGAAGC 
AACGCCCAGC AGATTGTGGC TGAGATGCTG AGCTACCTAG AAACAGCTGA CTACTCCATC 
CGGGAGGAAA TTGTGCTGAA GGTGGCCATC CTTGCTGAGA AGTATGCAGT GGACTACACT 
TGGTATGTGG ACACCATCCT CAACCTCATC CGCATTGCAG GCGACTATGT GAGCGAAGAG 
GTGTGGTACC GCGTCATCCA GATTGTCATC AATCGCGATG ATGTGCAGGG TTATGCTGCC 
AAGACGGTGT TTGAGGCATT GCAGGCTCCA GCATGTCATG AGAACTTGGT CAAAGTGGGC 
GGCTACATCC TGGGCGAGTT TGGAAACTTG ATAGCGGGAG ACCCACGATC CAGCCCTCTG 
ATCCAGTTCA ACCTGCTCCA CTCCAAGTTC CACTTGTGCA GCGTCCCCAC TCGGGCACTC 
CTGCTGTCCA CCTACATCAA GTTCGTGAAC CTCTTTCCAG AGGTAAAGGC TACCATTCAG 
GACGTGCTGC GCAGTGACAG CCAACTGAAG AACGCAGATG TGGAGCTGCA GCAGCGGGCT 
GTGGAGTACC TGCGACTGAG TACTGTTGCC AGCACTGATA TCCTGGCAAC TGTCCTGGAA 
GAAATGCCAC CCTTCCCTGA GCGTGAGTCC TCCATCTTGG CCAAGCTGAA GAAGAAGAAG 
GGCCCAAGCA CAGTGACTGA CCTGGAGGAG ACCAAGCGTG AGCGAAGCAT CGATGTGAAT 
GGGGGCCCCG AACCCGTTCC AGCCAGCACC AGTGCTGCGT CCACACCTTC TCCATCAGCA 
GACCTGCTGG GTCTGGGGGC CGTTCCCCCT GCTCCCACAG GGCCCCCTCC CACCTCTGGC 
GGTGGGTTAC TGGTGGACGT GTTCTCAGAC TCAGCTTCTG CAGTTGCACC TCTTGCACCC 
GGCTCTGAAG ACAACTTTGC CAGGTTTGTT TGTAAAAACA ATGGTGTGTT GTTTGAAAAC 
CAGCTGCTTC AAATTGGACT GAAGTCAGAA TTTCGGCAGA ATTTAGGTCG AATGTTCATA 
TTTTATGGTA ACAAGACCTC CACGCAGTTC CTAAACTTCA CTCCAACACT AATCTGTGCT 
GACGACCTTC AGACTAATCT GAACCTGCAG ACTAAGCCCG TGGACCCAAC TGTGGATGGG 
GGCGCACAGG TGCAACAGGT GGTCAACATT GAGTGTATAT CTGATTTCAC AGAGGCACCT 
GTCCTCAACA TCCAGTTCAG GTATGGTGGT ACCTTCCAGA ATGTGTCTGT TAAGCTTCCC 
ATCACTCTCA ACAAATTTTT CCAGCCCACA GAAATGGCTT CTCAGGATTT CTTTCAACGT 
TGGAAGCAGT TGAGCAATCC ACAGCAAGAA GTGCAGAATA TCTTCAAAGC AAAGCATCCG 
ATGGACACAG AAATCACTAA AGCGAAGATT ATTGGATTTG GTTCTGCGCT CCTGGAAGAA 
GTTGATCCAA ACCCTGCAAA TTTTGTGGGT GCTGGCATAA TACATACCAA AACCACCCAG 
ATCGGCTGCT TGTTGCGCCT GGAGCCAAAC CTGCAAGCTC AGATGTACAG ACTCACCTTG 
CGTACCAGCA AAGACACCGT CTCTCAGAGA CTATGTGAAT TGCTGTCGGA ACAGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ap2a2 ( XM_008760010.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758232.1 Rattus norvegicus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23621
Clone ID Related Accession (Same CDS sequence)	XM_008760010.2
Accession Version	XM_008760010.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2817bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	AP-2 complex subunit alpha-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760010.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGCCG TATCCAAGGG GGAGGGGATG CGAGGCCTAG CGGTCTTCAT CTCCGATATC 
CGTAACTGTA AAAGTAAAGA AGCTGAAATA AAGAGGATAA ATAAGGAGCT GGCAAATATT 
AGATCAAAAT TTAAAGGTGA CAAGGCTCTT GATGGCTACA GTAAGAAGAA GTATGTCTGC 
AAGTTACTCT TCATCTTTCT CCTTGGTCAT GACATTGACT TTGGACACAT GGAAGCTGTG 
AATCTTCTGA GCTCAAACAG ATACACGGAA AAGCAGATCG GCTACCTTTT CATCTCTGTA 
TTGGTGAATT CAAATAGTGA ACTGATCCGG TTGATTAACA ATGCCATCAA GAATGACCTG 
GCCAGCCGCA ATCCTACATT TATGGGTCTG GCCCTGCACT GCATCGCCAA TGTGGGTAGC 
CGTGAGATGG CAGAGGCCTT CGCTGGAGAG ATCCCCAAGA TCCTGGTGGC AGGAGATACC 
ATGGACAGTG TGAAGCAGAG CGCAGCCCTG TGCTTGTTGC GCCTGTACAG GACGTCACCT 
GACCTAGTTC CTATGGGCGA CTGGACATCC CGTGTGGTAC ACCTCCTCAA TGACCAGCAC 
TTGGGTGTAG TGACTGCCGC AACTAGCCTC ATCACCACAC TGGCCCAGAA GAATCCTGAG 
GAGTTCAAGA CCTCTGTCTC TCTAGCTGTC TCTCGACTGA GCAGAATTGT GACGTCCGCG 
TCAACAGATC TTCAGGATTA TACTTACTAC TTTGTCCCGG CTCCTTGGCT GTCAGTCAAA 
CTTCTGAGAC TGCTGCAGTG CTACCCACCC CCAGACCCTG CGGTGCGTGG CCGCCTGACT 
GAGTGCTTGG AGACCATCCT GAATAAGGCC CAGGAGCCCC CCAAGTCCAA GAAAGTCCAG 
CATTCAAATG CCAAGAACGC TGTGCTGTTT GAGGCCATCA GCCTCATCAT CCACCATGAC 
AGTGAGCCCA ACCTCCTGGT CCGTGCCTGC AACCAGCTGG GCCAGTTCCT GCAGCATCGG 
GAGACAAACC TGCGCTACCT GGCTCTGGAG AGCATGTGCA CACTGGCCAG CTCTGAGTTC 
TCTCACGAGG CTGTCAAGAC CCACATCGAG ACTGTCATCA ATGCCTTGAA GACGGAACGA 
GATGTGAGTG TGCGGCAGCG GGCAGTGGAC CTGCTCTACG CCATGTGCGA CCGAAGCAAC 
GCCCAGCAGA TTGTGGCTGA GATGCTGAGC TACCTAGAAA CAGCTGACTA CTCCATCCGG 
GAGGAAATTG TGCTGAAGGT GGCCATCCTT GCTGAGAAGT ATGCAGTGGA CTACACTTGG 
TATGTGGACA CCATCCTCAA CCTCATCCGC ATTGCAGGCG ACTATGTGAG CGAAGAGGTG 
TGGTACCGCG TCATCCAGAT TGTCATCAAT CGCGATGATG TGCAGGGTTA TGCTGCCAAG 
ACGGTGTTTG AGGCATTGCA GGCTCCAGCA TGTCATGAGA ACTTGGTCAA AGTGGGCGGC 
TACATCCTGG GCGAGTTTGG AAACTTGATA GCGGGAGACC CACGATCCAG CCCTCTGATC 
CAGTTCAACC TGCTCCACTC CAAGTTCCAC TTGTGCAGCG TCCCCACTCG GGCACTCCTG 
CTGTCCACCT ACATCAAGTT CGTGAACCTC TTTCCAGAGG TAAAGGCTAC CATTCAGGAC 
GTGCTGCGCA GTGACAGCCA ACTGAAGAAC GCAGATGTGG AGCTGCAGCA GCGGGCTGTG 
GAGTACCTGC GACTGAGTAC TGTTGCCAGC ACTGATATCC TGGCAACTGT CCTGGAAGAA 
ATGCCACCCT TCCCTGAGCG TGAGTCCTCC ATCTTGGCCA AGCTGAAGAA GAAGAAGGGC 
CCAAGCACAG TGACTGACCT GGAGGAGACC AAGCGTGAGC GAAGCATCGA TGTGAATGGG 
GGCCCCGAAC CCGTTCCAGC CAGCACCAGT GCTGCGTCCA CACCTTCTCC ATCAGCAGAC 
CTGCTGGGTC TGGGGGCCGT TCCCCCTGCT CCCACAGGGC CCCCTCCCAC CTCTGGCGGT 
GGGTTACTGG TGGACGTGTT CTCAGACTCA GCTTCTGCAG TTGCACCTCT TGCACCCGGC 
TCTGAAGACA ACTTTGCCAG GTTTGTTTGT AAAAACAATG GTGTGTTGTT TGAAAACCAG 
CTGCTTCAAA TTGGACTGAA GTCAGAATTT CGGCAGAATT TAGGTCGAAT GTTCATATTT 
TATGGTAACA AGACCTCCAC GCAGTTCCTA AACTTCACTC CAACACTAAT CTGTGCTGAC 
GACCTTCAGA CTAATCTGAA CCTGCAGACT AAGCCCGTGG ACCCAACTGT GGATGGGGGC 
GCACAGGTGC AACAGGTGGT CAACATTGAG TGTATATCTG ATTTCACAGA GGCACCTGTC 
CTCAACATCC AGTTCAGGTA TGGTGGTACC TTCCAGAATG TGTCTGTTAA GCTTCCCATC 
ACTCTCAACA AATTTTTCCA GCCCACAGAA ATGGCTTCTC AGGATTTCTT TCAACGTTGG 
AAGCAGTTGA GCAATCCACA GCAAGAAGTG CAGAATATCT TCAAAGCAAA GCATCCGATG 
GACACAGAAA TCACTAAAGC GAAGATTATT GGATTTGGTT CTGCGCTCCT GGAAGAAGTT 
GATCCAAACC CTGCAAATTT TGTGGGTGCT GGCATAATAC ATACCAAAAC CACCCAGATC 
GGCTGCTTGT TGCGCCTGGA GCCAAACCTG CAAGCTCAGA TGTACAGACT CACCTTGCGT 
ACCAGCAAAG ACACCGTCTC TCAGAGACTA TGTGAATTGC TGTCGGAACA GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758232.1
CDS	148..2964
Translation	MPAVSKGEGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSDSQLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEETKRERSIDVNGGPEPVPASTSAASTPSPSADLLGLGAVPPAPTGPPPTSGGGLLVDVFSDSASAVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTVDGGAQVQQVVNIECISDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEITKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQMYRLTLRTSKDTVSQRLCELLSEQF

Target ORF information:

RefSeq Version	XM_008760010.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760010.2

ORF Insert Sequence:

ATGCCGGCCG TATCCAAGGG GGAGGGGATG CGAGGCCTAG CGGTCTTCAT CTCCGATATC 
CGTAACTGTA AAAGTAAAGA AGCTGAAATA AAGAGGATAA ATAAGGAGCT GGCAAATATT 
AGATCAAAAT TTAAAGGTGA CAAGGCTCTT GATGGCTACA GTAAGAAGAA GTATGTCTGC 
AAGTTACTCT TCATCTTTCT CCTTGGTCAT GACATTGACT TTGGACACAT GGAAGCTGTG 
AATCTTCTGA GCTCAAACAG ATACACGGAA AAGCAGATCG GCTACCTTTT CATCTCTGTA 
TTGGTGAATT CAAATAGTGA ACTGATCCGG TTGATTAACA ATGCCATCAA GAATGACCTG 
GCCAGCCGCA ATCCTACATT TATGGGTCTG GCCCTGCACT GCATCGCCAA TGTGGGTAGC 
CGTGAGATGG CAGAGGCCTT CGCTGGAGAG ATCCCCAAGA TCCTGGTGGC AGGAGATACC 
ATGGACAGTG TGAAGCAGAG CGCAGCCCTG TGCTTGTTGC GCCTGTACAG GACGTCACCT 
GACCTAGTTC CTATGGGCGA CTGGACATCC CGTGTGGTAC ACCTCCTCAA TGACCAGCAC 
TTGGGTGTAG TGACTGCCGC AACTAGCCTC ATCACCACAC TGGCCCAGAA GAATCCTGAG 
GAGTTCAAGA CCTCTGTCTC TCTAGCTGTC TCTCGACTGA GCAGAATTGT GACGTCCGCG 
TCAACAGATC TTCAGGATTA TACTTACTAC TTTGTCCCGG CTCCTTGGCT GTCAGTCAAA 
CTTCTGAGAC TGCTGCAGTG CTACCCACCC CCAGACCCTG CGGTGCGTGG CCGCCTGACT 
GAGTGCTTGG AGACCATCCT GAATAAGGCC CAGGAGCCCC CCAAGTCCAA GAAAGTCCAG 
CATTCAAATG CCAAGAACGC TGTGCTGTTT GAGGCCATCA GCCTCATCAT CCACCATGAC 
AGTGAGCCCA ACCTCCTGGT CCGTGCCTGC AACCAGCTGG GCCAGTTCCT GCAGCATCGG 
GAGACAAACC TGCGCTACCT GGCTCTGGAG AGCATGTGCA CACTGGCCAG CTCTGAGTTC 
TCTCACGAGG CTGTCAAGAC CCACATCGAG ACTGTCATCA ATGCCTTGAA GACGGAACGA 
GATGTGAGTG TGCGGCAGCG GGCAGTGGAC CTGCTCTACG CCATGTGCGA CCGAAGCAAC 
GCCCAGCAGA TTGTGGCTGA GATGCTGAGC TACCTAGAAA CAGCTGACTA CTCCATCCGG 
GAGGAAATTG TGCTGAAGGT GGCCATCCTT GCTGAGAAGT ATGCAGTGGA CTACACTTGG 
TATGTGGACA CCATCCTCAA CCTCATCCGC ATTGCAGGCG ACTATGTGAG CGAAGAGGTG 
TGGTACCGCG TCATCCAGAT TGTCATCAAT CGCGATGATG TGCAGGGTTA TGCTGCCAAG 
ACGGTGTTTG AGGCATTGCA GGCTCCAGCA TGTCATGAGA ACTTGGTCAA AGTGGGCGGC 
TACATCCTGG GCGAGTTTGG AAACTTGATA GCGGGAGACC CACGATCCAG CCCTCTGATC 
CAGTTCAACC TGCTCCACTC CAAGTTCCAC TTGTGCAGCG TCCCCACTCG GGCACTCCTG 
CTGTCCACCT ACATCAAGTT CGTGAACCTC TTTCCAGAGG TAAAGGCTAC CATTCAGGAC 
GTGCTGCGCA GTGACAGCCA ACTGAAGAAC GCAGATGTGG AGCTGCAGCA GCGGGCTGTG 
GAGTACCTGC GACTGAGTAC TGTTGCCAGC ACTGATATCC TGGCAACTGT CCTGGAAGAA 
ATGCCACCCT TCCCTGAGCG TGAGTCCTCC ATCTTGGCCA AGCTGAAGAA GAAGAAGGGC 
CCAAGCACAG TGACTGACCT GGAGGAGACC AAGCGTGAGC GAAGCATCGA TGTGAATGGG 
GGCCCCGAAC CCGTTCCAGC CAGCACCAGT GCTGCGTCCA CACCTTCTCC ATCAGCAGAC 
CTGCTGGGTC TGGGGGCCGT TCCCCCTGCT CCCACAGGGC CCCCTCCCAC CTCTGGCGGT 
GGGTTACTGG TGGACGTGTT CTCAGACTCA GCTTCTGCAG TTGCACCTCT TGCACCCGGC 
TCTGAAGACA ACTTTGCCAG GTTTGTTTGT AAAAACAATG GTGTGTTGTT TGAAAACCAG 
CTGCTTCAAA TTGGACTGAA GTCAGAATTT CGGCAGAATT TAGGTCGAAT GTTCATATTT 
TATGGTAACA AGACCTCCAC GCAGTTCCTA AACTTCACTC CAACACTAAT CTGTGCTGAC 
GACCTTCAGA CTAATCTGAA CCTGCAGACT AAGCCCGTGG ACCCAACTGT GGATGGGGGC 
GCACAGGTGC AACAGGTGGT CAACATTGAG TGTATATCTG ATTTCACAGA GGCACCTGTC 
CTCAACATCC AGTTCAGGTA TGGTGGTACC TTCCAGAATG TGTCTGTTAA GCTTCCCATC 
ACTCTCAACA AATTTTTCCA GCCCACAGAA ATGGCTTCTC AGGATTTCTT TCAACGTTGG 
AAGCAGTTGA GCAATCCACA GCAAGAAGTG CAGAATATCT TCAAAGCAAA GCATCCGATG 
GACACAGAAA TCACTAAAGC GAAGATTATT GGATTTGGTT CTGCGCTCCT GGAAGAAGTT 
GATCCAAACC CTGCAAATTT TGTGGGTGCT GGCATAATAC ATACCAAAAC CACCCAGATC 
GGCTGCTTGT TGCGCCTGGA GCCAAACCTG CAAGCTCAGA TGTACAGACT CACCTTGCGT 
ACCAGCAAAG ACACCGTCTC TCAGAGACTA TGTGAATTGC TGTCGGAACA GTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
The Journal of clinical investigation123(6)2523-38(2013 Jun)
Marcello E,Saraceno C,Musardo S,Vara H,de la Fuente AG,Pelucchi S,Di Marino D,Borroni B,Tramontano A,P?rez-Ota?o I,Padovani A,Giustetto M,Gardoni F,Di Luca M

Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(22)9508-19(2013 May)
Duncker SV,Franz C,Kuhn S,Schulte U,Campanelli D,Brandt N,Hirt B,Fakler B,Blin N,Ruth P,Engel J,Marcotti W,Zimmermann U,Knipper M

Synaptic vesicle endocytosis.
Cold Spring Harbor perspectives in biology4(9)a005645(2012 Sep)
Saheki Y,De Camilli P

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
Blood119(11)2510-22(2012 Mar)
Ting SB,Deneault E,Hope K,Cellot S,Chagraoui J,Mayotte N,Dorn JF,Laverdure JP,Harvey M,Hawkins ED,Russell SM,Maddox PS,Iscove NN,Sauvageau G

Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor ?3 subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(7)2485-98(2012 Feb)
Smith KR,Muir J,Rao Y,Browarski M,Gruenig MC,Sheehan DF,Haucke V,Kittler JT

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Ap2a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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