Ogg1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ogg1
Entrez Gene ID	81528
Full Name	8-oxoguanine DNA glycosylase
General protein information	Preferred Names 8-oxoguanine DNA glycosylase Names N-glycosylase/DNA lyase 8-oxoguanine DNA-glycosylase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	DNA repair enzyme that cleaves out mutagenic 7,8-dihydro-8-oxoguanine (8-oxoG) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017592906.1	XP_017448395.1	N-glycosylase/DNA lyase isoform X1
XM_008763198.2	XP_008761420.1	N-glycosylase/DNA lyase isoform X2
NM_030870.1	NP_110497.1	N-glycosylase/DNA lyase

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ogg1	NP_035087.3
Rattus norvegicus (Norway rat)	Ogg1	NP_110497.1
Pan troglodytes (chimpanzee)	OGG1	XP_003309654.1
Drosophila melanogaster (fruit fly)	Ogg1	NP_572499.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001854	XP_321213.4
Saccharomyces cerevisiae (baker's yeast)	OGG1	NP_013651.1
Neurospora crassa	NCU03040	XP_964045.2
Homo sapiens (human)	OGG1	NP_002533.1
Canis lupus familiaris (dog)	OGG1	XP_541781.2
Bos taurus (cattle)	OGG1	NP_001073754.2
Gallus gallus (chicken)	OGG1	NP_001264767.1
Eremothecium gossypii	AGOS_AER127C	NP_984986.1
	OGG1	XP_001096322.1
Danio rerio (zebrafish)	ogg1	NP_001116780.1
Magnaporthe oryzae (rice blast fungus)	MGG_00347	XP_003718736.1
Arabidopsis thaliana (thale cress)	OGG1	NP_173590.1
Kluyveromyces lactis	KLLA0B05159g	XP_451764.1
Xenopus tropicalis (tropical clawed frog)	ogg1	XP_004914171.1

Gene Ontology
Bibliography

Related articles in PubMed

The 8-oxo-deoxyguanosine glycosylase increases its migration to mitochondria in compensated cardiac hypertrophy.
Vela-Guajardo JE, P?rez-Trevi?o P, Rivera-?lvarez I, Gonz?lez-Mondellini FA, Altamirano J, Garc?a N
Journal of the American Society of Hypertension : JASH11(10)660-672(2017 Oct)

Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa.
Farias JG, Zepeda A, Castillo R, Figueroa E, Ademoyero OT, Pulgar VM
Andrologia(2017 Jul)

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.
Pastukh VM, Gorodnya OM, Gillespie MN, Ruchko MV
Free radical biology & medicine9678-88(2016 07)

Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia.
Jin L, Yang H, Fu J, Xue X, Yao L, Qiao L
Molecular medicine reports11(6)4079-86(2015 Jun)

Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Kumar P, Rao GN, Pal BB, Pal A
The international journal of biochemistry & cell biology53302-19(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ogg1 overexpression also reduced binding of mitochondrial transcription factor A (TFAM) to both regulatory and coding regions of the mitochondrial genome without altering total abundance of TFAM in either control or hypoxic cells. These observations suggest that oxidative DNA modifications in the D-loop region during hypoxia are important for increased TFAM binding and ensuing replication of the mitochondrial genome.
Title: Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.

Oxidative DNA damage occurred in lung epithelial cells during earlystage bronchopulmonary dysplasia, as confirmed by in vitro and in vivo hyperoxia exposure experiments, and the increased expression of OGG1 was associated with this process.
Title: Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia.

glucose induces apoptosis and inhibits proliferation of glial cells, which may be mediated by the phosphorylation of tuberin, down regulation of 8-oxoG-DNA glycosylase and 8-hydroxydeoxyguanosine accumulation via activation of Akt and ERK1/2MAPK pathways
Title: Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.

Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Title: Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.

high-running capacity is associated with increased hippocampal function, and SIRT1 level/activity and inversely correlates with acetylated Ogg1 levels
Title: Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair.

The following Ogg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ogg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13150	NM_030870.1 Latest version!	Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43706	XM_008763198.2 Latest version!	Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa61015	XM_017592906.1 Latest version!	Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ogg1 ( NM_030870.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110497.1 Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), mRNA.

Price & Availability↑

CloneID	ORa13150
Clone ID Related Accession (Same CDS sequence)	NM_030870.1
Accession Version	NM_030870.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	N-glycosylase/DNA lyase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF029690.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF029690.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTATTCA GTTCCAGCCT GTCTAGCAGC ATGAGACATC GCACCCTAAC CTCCAGCCCG 
GCCCTCTGGG CCTCTATTCC GTGTCCACGC TCTGAGCTGC GTCTGGACCT GGTTTTAGCT 
TCTGGACAGT CCTTCCGGTG GAGGGAGCAA AGCCCTGCTC ACTGGAGTGG AGTGCTGGCA 
GATCAAGTGT GGACACTGAC TCAGACCGAG GATCAGCTCT ATTGCACTGT GTACCGAGGA 
GACAAGGGCC AGGTCGGCAG GCCTACCCTA GAGGAGCTGG AAACCTTACA CAAGTACTTT 
CAGCTAGATG TCAGCCTGAC TCAGCTCTAT AGCCACTGGG CTTCGGTGGA CTCTCACTTC 
CAAAGTGTGG CTCAGAAATT CCAAGGTGTG AGGCTGCTGA GACAAGACCC CACTGAATGC 
CTTTTCTCTT TCATCTGTTC TTCCAACAAC AACATTGCTC GCATCACTGG CATGGTGGAA 
CGGCTGTGCC AGGCCTTTGG ACCTCGACTC GTTCAGCTTG ATGATGTCAC TTATCATGGC 
TTCCCAAACC TTCATGCCCT GGCTGGTCCA GAAGTAGAGA CCCACCTCAG GAAGTTGGGC 
CTGGGGTACC GTGCCCGCTA TGTATGTGCC AGTGCTAAAG CCATCCTAGA AGAGCAAGGT 
GGGCCGGCTT GGCTGCAGCA GCTTCGAGTG GCCTCTTATG AAGAGGCCCA CAAGGCCCTC 
TGCACCCTGC CTGGAGTGGG CACCAAGGTG GCTGACTGCA TCTGCTTAAT GGCCCTGGAC 
AAACCCCAGG CTGTGCCTGT GGACATCCAT GTGTGGCAGA TTGCCCATCG TGACTACGGC 
TGGCAGCCTA AGACATCGCA GACTAAGGGC CCGAGCCCTC TGGCCAACAA AGAACTGGGA 
AACTTTTTCC GGAATCTGTG GGGACCTTAT GCTGGCTGGG CCCAAGCAGT GCTGTTCAGT 
GCTGACCTTC GTCAACAAAA CCTGTCTCGG GAGCCACCAG CAAAGCGCAA AAAGGGATCT 
AAGAAGACAG AAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110497.1
CDS	34..1071
Translation	MLFSSSLSSSMRHRTLTSSPALWASIPCPRSELRLDLVLASGQSFRWREQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDKGQVGRPTLEELETLHKYFQLDVSLTQLYSHWASVDSHFQSVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLVQLDDVTYHGFPNLHALAGPEVETHLRKLGLGYRARYVCASAKAILEEQGGPAWLQQLRVASYEEAHKALCTLPGVGTKVADCICLMALDKPQAVPVDIHVWQIAHRDYGWQPKTSQTKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQQNLSREPPAKRKKGSKKTEG

Target ORF information:

RefSeq Version	NM_030870.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030870.1

ORF Insert Sequence:

ATGTTATTCA GTTCCAGCCT GTCTAGCAGC ATGAGACATC GCACCCTAAC CTCCAGCCCG 
GCCCTCTGGG CCTCTATTCC GTGTCCACGC TCTGAGCTGC GTCTGGACCT GGTTTTAGCT 
TCTGGACAGT CCTTCCGGTG GAGGGAGCAA AGCCCTGCTC ACTGGAGTGG AGTGCTGGCA 
GATCAAGTGT GGACACTGAC TCAGACCGAG GATCAGCTCT ATTGCACTGT GTACCGAGGA 
GACAAGGGCC AGGTCGGCAG GCCTACCCTA GAGGAGCTGG AAACCTTACA CAAGTACTTT 
CAGCTAGATG TCAGCCTGAC TCAGCTCTAT AGCCACTGGG CTTCGGTGGA CTCTCACTTC 
CAAAGTGTGG CTCAGAAATT CCAAGGTGTG AGGCTGCTGA GACAAGACCC CACTGAATGC 
CTTTTCTCTT TCATCTGTTC TTCCAACAAC AACATTGCTC GCATCACTGG CATGGTGGAA 
CGGCTGTGCC AGGCCTTTGG ACCTCGACTC GTTCAGCTTG ATGATGTCAC TTATCATGGC 
TTCCCAAACC TTCATGCCCT GGCTGGTCCA GAAGTAGAGA CCCACCTCAG GAAGTTGGGC 
CTGGGGTACC GTGCCCGCTA TGTATGTGCC AGTGCTAAAG CCATCCTAGA AGAGCAAGGT 
GGGCCGGCTT GGCTGCAGCA GCTTCGAGTG GCCTCTTATG AAGAGGCCCA CAAGGCCCTC 
TGCACCCTGC CTGGAGTGGG CACCAAGGTG GCTGACTGCA TCTGCTTAAT GGCCCTGGAC 
AAACCCCAGG CTGTGCCTGT GGACATCCAT GTGTGGCAGA TTGCCCATCG TGACTACGGC 
TGGCAGCCTA AGACATCGCA GACTAAGGGC CCGAGCCCTC TGGCCAACAA AGAACTGGGA 
AACTTTTTCC GGAATCTGTG GGGACCTTAT GCTGGCTGGG CCCAAGCAGT GCTGTTCAGT 
GCTGACCTTC GTCAACAAAA CCTGTCTCGG GAGCCACCAG CAAAGCGCAA AAAGGGATCT 
AAGAAGACAG AAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ogg1 ( XM_008763198.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008761420.1 Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa43706
Clone ID Related Accession (Same CDS sequence)	XM_008763198.2
Accession Version	XM_008763198.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	N-glycosylase/DNA lyase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008763198.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTATTCA GTTCCAGCCT GTCTAGCAGC ATGAGACATC GCACCCTAAC CTCCAGCCCG 
GCCCTCTGGG CCTCTATTCC GTGTCCACGC TCTGAGCTGC GTCTGGACCT GGTTTTAGCT 
TCTGGACAGT CCTTCCGGTG GAGGGAGCAA AGCCCTGCTC ACTGGAGTGG AGTGCTGGCA 
GATCAAGTGT GGACACTGAC TCAGACCGAG GATCAGCTCT ATTGCACTGT GTACCGAGGA 
GACAAGGGCC AGGTCGGCAG GCCTACCCTA GAGGAGCTGG AAACCTTACA CAAGTACTTT 
CAGCTAGATG TCAGCCTGAC TCAGCTCTAT AGCCACTGGG CTTCGGTGGA CTCTCACTTC 
CAAAGTGTGG CTCAGAAATT CCAAGGTGTG AGGCTGCTGA GACAAGACCC CACTGAATGC 
CTTTTCTCTT TCATCTGTTC TTCCAACAAC AACATTGCTC GCATCACTGG CATGGTGGAA 
CGGCTGTGCC AGGCCTTTGG ACCTCGACTC GTTCAGCTTG ATGATGTCAC TTATCATGGC 
TTCCCAAACC TTCATGCCCT GGCTGGTCCA GAAGTAGAGA CCCACCTCAG GAAGTTGGGC 
CTGGGGTACC GTGCCCGCTA TGTATGTGCC AGTGCTAAAG CCATCCTAGA AGAGCAAGGT 
GGGCCGGCTT GGCTGCAGCA GCTTCGAGTG GCCTCTTATG AAGAGGCCCA CAAGGCCCTC 
TGCACCCTGC CTGGAGTGGG CACCAAGGTG GCTGACTGCA TCTGCTTAAT GGCCCTGGAC 
AAACCCCAGG CTGTGCCTGT GGACATCCAT GTGTGGCAGA TTGCCCATCG TGACTACGGC 
TGGCAGCCTA AGACATCGCA GACTAAGGGC CCGAGCCCTC TGGCCAACAA AGAACTGGGA 
AACTTTTTCC GGAATCTGTG GGGACCTTAT GCTGGCTGGG CCCAAGCAAC CCCATATGCC 
CCTTCCCATA GGTGCTGTTC AGTGCTGACC TTCGTCAACA AAACCTGTCT CGGGAGCCAC 
CAGCAAAGCG CAAAAAGGGA TCTAAGAAGA CAGAAGGCTA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008761420.1
CDS	249..1313
Translation	MLFSSSLSSSMRHRTLTSSPALWASIPCPRSELRLDLVLASGQSFRWREQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDKGQVGRPTLEELETLHKYFQLDVSLTQLYSHWASVDSHFQSVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLVQLDDVTYHGFPNLHALAGPEVETHLRKLGLGYRARYVCASAKAILEEQGGPAWLQQLRVASYEEAHKALCTLPGVGTKVADCICLMALDKPQAVPVDIHVWQIAHRDYGWQPKTSQTKGPSPLANKELGNFFRNLWGPYAGWAQATPYAPSHRCCSVLTFVNKTCLGSHQQSAKRDLRRQKAR

Target ORF information:

RefSeq Version	XM_008763198.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008763198.2

ORF Insert Sequence:

ATGTTATTCA GTTCCAGCCT GTCTAGCAGC ATGAGACATC GCACCCTAAC CTCCAGCCCG 
GCCCTCTGGG CCTCTATTCC GTGTCCACGC TCTGAGCTGC GTCTGGACCT GGTTTTAGCT 
TCTGGACAGT CCTTCCGGTG GAGGGAGCAA AGCCCTGCTC ACTGGAGTGG AGTGCTGGCA 
GATCAAGTGT GGACACTGAC TCAGACCGAG GATCAGCTCT ATTGCACTGT GTACCGAGGA 
GACAAGGGCC AGGTCGGCAG GCCTACCCTA GAGGAGCTGG AAACCTTACA CAAGTACTTT 
CAGCTAGATG TCAGCCTGAC TCAGCTCTAT AGCCACTGGG CTTCGGTGGA CTCTCACTTC 
CAAAGTGTGG CTCAGAAATT CCAAGGTGTG AGGCTGCTGA GACAAGACCC CACTGAATGC 
CTTTTCTCTT TCATCTGTTC TTCCAACAAC AACATTGCTC GCATCACTGG CATGGTGGAA 
CGGCTGTGCC AGGCCTTTGG ACCTCGACTC GTTCAGCTTG ATGATGTCAC TTATCATGGC 
TTCCCAAACC TTCATGCCCT GGCTGGTCCA GAAGTAGAGA CCCACCTCAG GAAGTTGGGC 
CTGGGGTACC GTGCCCGCTA TGTATGTGCC AGTGCTAAAG CCATCCTAGA AGAGCAAGGT 
GGGCCGGCTT GGCTGCAGCA GCTTCGAGTG GCCTCTTATG AAGAGGCCCA CAAGGCCCTC 
TGCACCCTGC CTGGAGTGGG CACCAAGGTG GCTGACTGCA TCTGCTTAAT GGCCCTGGAC 
AAACCCCAGG CTGTGCCTGT GGACATCCAT GTGTGGCAGA TTGCCCATCG TGACTACGGC 
TGGCAGCCTA AGACATCGCA GACTAAGGGC CCGAGCCCTC TGGCCAACAA AGAACTGGGA 
AACTTTTTCC GGAATCTGTG GGGACCTTAT GCTGGCTGGG CCCAAGCAAC CCCATATGCC 
CCTTCCCATA GGTGCTGTTC AGTGCTGACC TTCGTCAACA AAACCTGTCT CGGGAGCCAC 
CAGCAAAGCG CAAAAAGGGA TCTAAGAAGA CAGAAGGCTA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ogg1 ( XM_017592906.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448395.1 Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61015
Clone ID Related Accession (Same CDS sequence)	XM_017592906.1
Accession Version	XM_017592906.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	N-glycosylase/DNA lyase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAGGT GGAGGGAGCA AAGCCCTGCT CACTGGAGTG GAGTGCTGGC AGATCAAGTG 
TGGACACTGA CTCAGACCGA GGATCAGCTC TATTGCACTG TGTACCGAGG AGACAAGGGC 
CAGGTCGGCA GGCCTACCCT AGAGGAGCTG GAAACCTTAC ACAAGTACTT TCAGCTAGAT 
GTCAGCCTGA CTCAGCTCTA TAGCCACTGG GCTTCGGTGG ACTCTCACTT CCAAAGTGTG 
GCTCAGAAAT TCCAAGGTGT GAGGCTGCTG AGACAAGACC CCACTGAATG CCTTTTCTCT 
TTCATCTGTT CTTCCAACAA CAACATTGCT CGCATCACTG GCATGGTGGA ACGGCTGTGC 
CAGGCCTTTG GACCTCGACT CGTTCAGCTT GATGATGTCA CTTATCATGG CTTCCCAAAC 
CTTCATGCCC TGGCTGGTCC AGAAGTAGAG ACCCACCTCA GGAAGTTGGG CCTGGGGTAC 
CGTGCCCGCT ATGTATGTGC CAGTGCTAAA GCCATCCTAG AAGAGCAAGG TGGGCCGGCT 
TGGCTGCAGC AGCTTCGAGT GGCCTCTTAT GAAGAGGCCC ACAAGGCCCT CTGCACCCTG 
CCTGGAGTGG GCACCAAGGT GGCTGACTGC ATCTGCTTAA TGGCCCTGGA CAAACCCCAG 
GCTGTGCCTG TGGACATCCA TGTGTGGCAG ATTGCCCATC GTGACTACGG CTGGCAGCCT 
AAGACATCGC AGACTAAGGG CCCGAGCCCT CTGGCCAACA AAGAACTGGG AAACTTTTTC 
CGGAATCTGT GGGGACCTTA TGCTGGCTGG GCCCAAGCAG TGCTGTTCAG TGCTGACCTT 
CGTCAACAAA ACCTGTCTCG GGAGCCACCA GCAAAGCGCA AAAAGGGATC TAAGAAGACA 
GAAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448395.1
CDS	108..1016
Translation	MPRWREQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDKGQVGRPTLEELETLHKYFQLDVSLTQLYSHWASVDSHFQSVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLVQLDDVTYHGFPNLHALAGPEVETHLRKLGLGYRARYVCASAKAILEEQGGPAWLQQLRVASYEEAHKALCTLPGVGTKVADCICLMALDKPQAVPVDIHVWQIAHRDYGWQPKTSQTKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQQNLSREPPAKRKKGSKKTEG

Target ORF information:

RefSeq Version	XM_017592906.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 8-oxoguanine DNA glycosylase (Ogg1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592906.1

ORF Insert Sequence:

ATGCCCAGGT GGAGGGAGCA AAGCCCTGCT CACTGGAGTG GAGTGCTGGC AGATCAAGTG 
TGGACACTGA CTCAGACCGA GGATCAGCTC TATTGCACTG TGTACCGAGG AGACAAGGGC 
CAGGTCGGCA GGCCTACCCT AGAGGAGCTG GAAACCTTAC ACAAGTACTT TCAGCTAGAT 
GTCAGCCTGA CTCAGCTCTA TAGCCACTGG GCTTCGGTGG ACTCTCACTT CCAAAGTGTG 
GCTCAGAAAT TCCAAGGTGT GAGGCTGCTG AGACAAGACC CCACTGAATG CCTTTTCTCT 
TTCATCTGTT CTTCCAACAA CAACATTGCT CGCATCACTG GCATGGTGGA ACGGCTGTGC 
CAGGCCTTTG GACCTCGACT CGTTCAGCTT GATGATGTCA CTTATCATGG CTTCCCAAAC 
CTTCATGCCC TGGCTGGTCC AGAAGTAGAG ACCCACCTCA GGAAGTTGGG CCTGGGGTAC 
CGTGCCCGCT ATGTATGTGC CAGTGCTAAA GCCATCCTAG AAGAGCAAGG TGGGCCGGCT 
TGGCTGCAGC AGCTTCGAGT GGCCTCTTAT GAAGAGGCCC ACAAGGCCCT CTGCACCCTG 
CCTGGAGTGG GCACCAAGGT GGCTGACTGC ATCTGCTTAA TGGCCCTGGA CAAACCCCAG 
GCTGTGCCTG TGGACATCCA TGTGTGGCAG ATTGCCCATC GTGACTACGG CTGGCAGCCT 
AAGACATCGC AGACTAAGGG CCCGAGCCCT CTGGCCAACA AAGAACTGGG AAACTTTTTC 
CGGAATCTGT GGGGACCTTA TGCTGGCTGG GCCCAAGCAG TGCTGTTCAG TGCTGACCTT 
CGTCAACAAA ACCTGTCTCG GGAGCCACCA GCAAAGCGCA AAAAGGGATC TAAGAAGACA 
GAAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The 8-oxo-deoxyguanosine glycosylase increases its migration to mitochondria in compensated cardiac hypertrophy.
Journal of the American Society of Hypertension : JASH11(10)660-672(2017 Oct)
Vela-Guajardo JE,P?rez-Trevi?o P,Rivera-?lvarez I,Gonz?lez-Mondellini FA,Altamirano J,Garc?a N

Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa.
Andrologia(2017 Jul)
Farias JG,Zepeda A,Castillo R,Figueroa E,Ademoyero OT,Pulgar VM

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.
Free radical biology & medicine9678-88(2016 07)
Pastukh VM,Gorodnya OM,Gillespie MN,Ruchko MV

Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia.
Molecular medicine reports11(6)4079-86(2015 Jun)
Jin L,Yang H,Fu J,Xue X,Yao L,Qiao L

Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
The international journal of biochemistry & cell biology53302-19(2014 Aug)
Kumar P,Rao GN,Pal BB,Pal A