Nfkbib cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfkbib
Entrez Gene ID	81525
Full Name	NFKB inhibitor beta
General protein information	Preferred Names NFKB inhibitor beta Names NF-kappa-B inhibitor beta I-kappa-B-beta NF-kappa-BIB ikB-B ikB-beta ikappaBbeta nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	a stress protein inducible by hyperthermia or proteasome inhibitors [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030867.2	NP_110494.2	NF-kappa-B inhibitor beta

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Nfkbib	NP_110494.2
Pan troglodytes (chimpanzee)	NFKBIB	XP_001168499.1
Mus musculus (house mouse)	Nfkbib	NP_035038.2
	NFKBIB	XP_001085582.1
Bos taurus (cattle)	NFKBIB	NP_001069340.1
Danio rerio (zebrafish)	si:dkeyp-110c7.1	NP_001122267.1
Homo sapiens (human)	NFKBIB	NP_002494.2
Canis lupus familiaris (dog)	NFKBIB	XP_541633.1
Gallus gallus (chicken)	NFKBIB	XP_003643552.1

Gene Ontology
Bibliography

Related articles in PubMed

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells.
Gu H, Cui M, Bai Y, Chen F, Ma K, Zhou C, Guo L
Biochemical and biophysical research communications392(2)178-82(2010 Feb)

Shared principles in NF-kappaB signaling.
Hayden MS, Ghosh S
Cell132(3)344-62(2008 Feb)

Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta.
Xu S, Bayat H, Hou X, Jiang B
American journal of physiology. Cell physiology291(6)C1336-45(2006 Dec)

Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia.
Nakajima K, Matsushita Y, Tohyama Y, Kohsaka S, Kurihara T
Neuroscience letters401(3)199-202(2006 Jul)

Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins.
Jaffray C, Mendez C, Denham W, Carter G, Norman J
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract4(4)370-7; discussion 377-8(2000 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that RSK1 directly phosphorylates IkappaBbeta and contributes to the persistent activation of NF-kappaB by IL-1beta.
Title: Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta.

The following Nfkbib gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfkbib cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07246	NM_030867.2 Latest version!	Rattus norvegicus NFKB inhibitor beta (Nfkbib), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfkbib ( NM_030867.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110494.2 Rattus norvegicus NFKB inhibitor beta (Nfkbib), mRNA.

Price & Availability↑

CloneID	ORa07246
Clone ID Related Accession (Same CDS sequence)	NM_030867.2
Accession Version	NM_030867.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	NF-kappa-B inhibitor beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085729.1. On Nov 15, 2004 this sequence version replaced NM_030867.1. ##Evidence-Data-START## Transcript exon combination :: BC085729.1, FQ235103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGGG TCGCGTGCTT GGGGAAAACT GCAGACGCCG ATGAATGGTG CGACAGTGGC 
CTGGGCTCTC TAGGTCCCGA CGCAGCAGCT CCCGGAGGAC CAGGTCTGGT CGCAGAGCTT 
AGCCCAGAGC TGTCTTGGGC GCCCTTAGTC TTTGGCTACG TCACTGAGGA TGGGGACACA 
GCCCTGCACT TGGCCGTGAT ACATCAGCAC GAGCCCTTCC TGGATTTCCT CCTGGGCTTC 
TCTGCCGGCA CTGAGTACCT GGACTTGCAG AACGACCTAG GCCAAACAGC CCTGCACCTA 
GCAGCCATCC TTGGAGAGGC ATCTACAGTA GAGAAACTCT ATGCAGCTGG CGCAGGAGTG 
TTGGTGACTG AGAGAGGGGG CCACACAGCA CTGCACTTGG CCTGCCGTGT GAGGGCACAC 
ACGTGTGCAT ATGTACTGCT TCAGCCCCGT CCCAGCCACC CAAGAGATGC CTCAGATACC 
TACCTCACTC AGAGCCAGGA CCACACCCCA GACACCAGCC ATGCCCCTGT TGCCACGGAC 
CCCCAACCCA ACCCAGGGAA CGAAGAGGAG CTGCGTGATG AAGATTGGAG GCTGCAGCTA 
GAAGCTGAAA ACTATGATGG CCACACCCCA CTCCATGTAG CTGTCATCCA CAAAGATGCA 
GAGATGGTCC AACTGCTCAG GGATGCTGGG GCCGACCTCA ATAAACCGGA GCCTACGTGT 
GGCCGGACCC CTCTGCACCT GGCAGTAGAA GGCCAGGCAG CCGGCGTGCT GGCGCTTCTC 
CTCAAAGCTG GCGCTGACCC CACCGCACGC ATGTATGGGG GCCGCACCCC ACTTGGCAGT 
GCCCTGCTCC GGCCCAACCC TGTCCTCGCC CGCCTCCTCC GTGCACATGG GGCTCCTGAG 
CCCGAGGATG AGGATGATAA GCTTAGCCCT TGCAGCAACA GCAGCAGTGA CAGCGACAGT 
GACAACAGAG ATGAAGGCGA TGAATATGAT GACATCGTGG TTCACAGTCG CAGGAGCCAA 
AACCAGCCAC CTCCTTCCCC AGCAGCCAAA CCTCTTCCTG ATGACCCCAA CCCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110494.2
CDS	260..1339
Translation	MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLVAELSPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVTERGGHTALHLACRVRAHTCAYVLLQPRPSHPRDASDTYLTQSQDHTPDTSHAPVATDPQPNPGNEEELRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVQLLRDAGADLNKPEPTCGRTPLHLAVEGQAAGVLALLLKAGADPTARMYGGRTPLGSALLRPNPVLARLLRAHGAPEPEDEDDKLSPCSNSSSDSDSDNRDEGDEYDDIVVHSRRSQNQPPPSPAAKPLPDDPNPA

Target ORF information:

RefSeq Version	NM_030867.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NFKB inhibitor beta (Nfkbib), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030867.2

ORF Insert Sequence:

ATGGCCGGGG TCGCGTGCTT GGGGAAAACT GCAGACGCCG ATGAATGGTG CGACAGTGGC 
CTGGGCTCTC TAGGTCCCGA CGCAGCAGCT CCCGGAGGAC CAGGTCTGGT CGCAGAGCTT 
AGCCCAGAGC TGTCTTGGGC GCCCTTAGTC TTTGGCTACG TCACTGAGGA TGGGGACACA 
GCCCTGCACT TGGCCGTGAT ACATCAGCAC GAGCCCTTCC TGGATTTCCT CCTGGGCTTC 
TCTGCCGGCA CTGAGTACCT GGACTTGCAG AACGACCTAG GCCAAACAGC CCTGCACCTA 
GCAGCCATCC TTGGAGAGGC ATCTACAGTA GAGAAACTCT ATGCAGCTGG CGCAGGAGTG 
TTGGTGACTG AGAGAGGGGG CCACACAGCA CTGCACTTGG CCTGCCGTGT GAGGGCACAC 
ACGTGTGCAT ATGTACTGCT TCAGCCCCGT CCCAGCCACC CAAGAGATGC CTCAGATACC 
TACCTCACTC AGAGCCAGGA CCACACCCCA GACACCAGCC ATGCCCCTGT TGCCACGGAC 
CCCCAACCCA ACCCAGGGAA CGAAGAGGAG CTGCGTGATG AAGATTGGAG GCTGCAGCTA 
GAAGCTGAAA ACTATGATGG CCACACCCCA CTCCATGTAG CTGTCATCCA CAAAGATGCA 
GAGATGGTCC AACTGCTCAG GGATGCTGGG GCCGACCTCA ATAAACCGGA GCCTACGTGT 
GGCCGGACCC CTCTGCACCT GGCAGTAGAA GGCCAGGCAG CCGGCGTGCT GGCGCTTCTC 
CTCAAAGCTG GCGCTGACCC CACCGCACGC ATGTATGGGG GCCGCACCCC ACTTGGCAGT 
GCCCTGCTCC GGCCCAACCC TGTCCTCGCC CGCCTCCTCC GTGCACATGG GGCTCCTGAG 
CCCGAGGATG AGGATGATAA GCTTAGCCCT TGCAGCAACA GCAGCAGTGA CAGCGACAGT 
GACAACAGAG ATGAAGGCGA TGAATATGAT GACATCGTGG TTCACAGTCG CAGGAGCCAA 
AACCAGCCAC CTCCTTCCCC AGCAGCCAAA CCTCTTCCTG ATGACCCCAA CCCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells.
Biochemical and biophysical research communications392(2)178-82(2010 Feb)
Gu H,Cui M,Bai Y,Chen F,Ma K,Zhou C,Guo L

Shared principles in NF-kappaB signaling.
Cell132(3)344-62(2008 Feb)
Hayden MS,Ghosh S

Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta.
American journal of physiology. Cell physiology291(6)C1336-45(2006 Dec)
Xu S,Bayat H,Hou X,Jiang B

Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia.
Neuroscience letters401(3)199-202(2006 Jul)
Nakajima K,Matsushita Y,Tohyama Y,Kohsaka S,Kurihara T

Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract4(4)370-7; discussion 377-8(2000 Jul-Aug)
Jaffray C,Mendez C,Denham W,Carter G,Norman J

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Nfkbib cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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