Marcksl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Marcksl1
Entrez Gene ID	81520
Full Name	MARCKS-like 1
Synonyms	F52,Mlp
General protein information	Preferred Names MARCKS-like 1 Names MARCKS-related protein MARCKS-like protein 1 MARCKS-related protein-like brain protein F52 mac-MARCKS macMARCKS macrophage myristoylated alanine-rich C kinase substrate myristoylated alanine-rich C kinase substrate
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	activation may induce vesicle transport in brain neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030862.2	NP_110489.1	MARCKS-related protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Marcksl1	NP_034937.1
Canis lupus familiaris (dog)	MARCKSL1	XP_854637.1
Rattus norvegicus (Norway rat)	Marcksl1	NP_110489.1
Homo sapiens (human)	MARCKSL1	NP_075385.1
Rattus norvegicus (Norway rat)	LOC100911158	XP_003750086.1
Rattus norvegicus (Norway rat)	LOC100911122	XP_003750085.1
Pan troglodytes (chimpanzee)	MARCKSL1	XP_001151702.3
	MARCKSL1	XP_002802334.1
Bos taurus (cattle)	MARCKSL1	NP_001069640.1

Gene Ontology
Bibliography

Related articles in PubMed

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.
Bj?rkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, M?g?rd M, James P, Coffey ET
Molecular and cellular biology32(17)3513-26(2012 Sep)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.
Zhao J, Izumi T, Nunomura K, Satoh S, Watanabe S
The Biochemical journal408(1)51-9(2007 Nov)

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels.
Bertaso F, Lill Y, Airas JM, Espeut J, Blahos J, Bockaert J, Fagni L, Betz H, El-Far O
Journal of neurochemistry99(1)288-98(2006 Oct)

Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons.
Yang H, Wang X, Sumners C, Raizada MK
Hypertension (Dallas, Tex. : 1979)39(2 Pt 2)567-72(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

c-Jun N-terminal kinase phosphorylation of MARCKSL1 enables it to bundle and stabilize F-actin, increase filopodium numbers and dynamics, and retard migration in neurons.
Title: c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.

PKCbeta-MARCKS signaling may be a general mechanism for the stimulation of vesicular trafficking in brain neurons.
Title: Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons.

The following Marcksl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Marcksl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42427	NM_030862.2 Latest version!	Rattus norvegicus MARCKS-like 1 (Marcksl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Marcksl1 ( NM_030862.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110489.1 Rattus norvegicus MARCKS-like 1 (Marcksl1), mRNA.

Price & Availability↑

CloneID	ORa42427
Clone ID Related Accession (Same CDS sequence)	NM_030862.2
Accession Version	NM_030862.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	MARCKS-related protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081789.1. On Oct 17, 2004 this sequence version replaced NM_030862.1. ##Evidence-Data-START## Transcript exon combination :: BC081789.1, AJ301677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCAGCC AGAGCTCCAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCGGGC 
GCTTCCCCCG CGAAGGCCAA CGGACAGGAG AATGGCCACG TGAAAAGCAA TGGAGACTTA 
ACCCCCAAGG GTGAAGGGGA GTCACCACCC GTGAACGGAG CAGATGAGGC AGCTGGGGCT 
ACTGGTGATG CCATCGAGCC AGCGCCCCCT AGCCAGGAAG CTGAGGCCAA GGGGGAGGTC 
GCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGTGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCTTC AGCCTCCTCA 
CCAACAGAGG AAGAGCAAGA GCAGGGGGAA ATCAGCGCCT GCAGTGATGA GGGCACTGCC 
CAAGAAGGGA AGGCTGCTGC CACCCCTGAG AGCCAAGAGC CCCAGGCCAA GGGGGCAGAG 
GCCAGTGCTG TCTCCAAGGG AGGAGACGCG GAAGAAGAGG CAGGGCCCCA GGCTGCAGAG 
CCATCCACTC CCTCGGGCCC AGAGAGTGGC CCCGCATCTG CCAGTGCTGA GAATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110489.1
CDS	183..782
Translation	MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLTPKGEGESPPVNGADEAAGATGDAIEPAPPSQEAEAKGEVAPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEISACSDEGTAQEGKAAATPESQEPQAKGAEASAVSKGGDAEEEAGPQAAEPSTPSGPESGPASASAENE

Target ORF information:

RefSeq Version	NM_030862.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MARCKS-like 1 (Marcksl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030862.2

ORF Insert Sequence:

ATGGGCAGCC AGAGCTCCAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCGGGC 
GCTTCCCCCG CGAAGGCCAA CGGACAGGAG AATGGCCACG TGAAAAGCAA TGGAGACTTA 
ACCCCCAAGG GTGAAGGGGA GTCACCACCC GTGAACGGAG CAGATGAGGC AGCTGGGGCT 
ACTGGTGATG CCATCGAGCC AGCGCCCCCT AGCCAGGAAG CTGAGGCCAA GGGGGAGGTC 
GCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGTGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCTTC AGCCTCCTCA 
CCAACAGAGG AAGAGCAAGA GCAGGGGGAA ATCAGCGCCT GCAGTGATGA GGGCACTGCC 
CAAGAAGGGA AGGCTGCTGC CACCCCTGAG AGCCAAGAGC CCCAGGCCAA GGGGGCAGAG 
GCCAGTGCTG TCTCCAAGGG AGGAGACGCG GAAGAAGAGG CAGGGCCCCA GGCTGCAGAG 
CCATCCACTC CCTCGGGCCC AGAGAGTGGC CCCGCATCTG CCAGTGCTGA GAATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.
Molecular and cellular biology32(17)3513-26(2012 Sep)
Bj?rkblom B,Padzik A,Mohammad H,Westerlund N,Komulainen E,Hollos P,Parviainen L,Papageorgiou AC,Iljin K,Kallioniemi O,Kallajoki M,Courtney MJ,M?g?rd M,James P,Coffey ET

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.
The Biochemical journal408(1)51-9(2007 Nov)
Zhao J,Izumi T,Nunomura K,Satoh S,Watanabe S

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels.
Journal of neurochemistry99(1)288-98(2006 Oct)
Bertaso F,Lill Y,Airas JM,Espeut J,Blahos J,Bockaert J,Fagni L,Betz H,El-Far O

Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons.
Hypertension (Dallas, Tex. : 1979)39(2 Pt 2)567-72(2002 Feb)
Yang H,Wang X,Sumners C,Raizada MK

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Marcksl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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