Fabp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp4
Entrez Gene ID	79451
Full Name	fatty acid binding protein 4
Synonyms	Albp,aP2
General protein information	Preferred Names fatty acid binding protein 4 Names fatty acid-binding protein, adipocyte A-FABP AFABP adipocyte lipid-binding protein adipocyte-type fatty acid-binding protein fatty acid binding protein 4, adipocyte
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q23
Summary	intracellular lipid-binding protein; mediates fatty acid trafficking during lipolysis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053365.1	NP_445817.1	fatty acid-binding protein, adipocyte

Pathways from BioSystems

Homologies

Homo sapiens (human)	FABP4	NP_001433.1
Gallus gallus (chicken)	FABP4	NP_989621.1
Pan troglodytes (chimpanzee)	FABP4	XP_519830.1
	FABP4	XP_001092255.1
Mus musculus (house mouse)	Fabp4	NP_077717.1
Rattus norvegicus (Norway rat)	Fabp4	NP_445817.1
Caenorhabditis elegans (roundworm)	lbp-8	NP_506444.2
Canis lupus familiaris (dog)	FABP4	XP_850162.1
Bos taurus (cattle)	FABP4	NP_776739.1
Xenopus tropicalis (tropical clawed frog)	pmp2	NP_001107544.1
Canis lupus familiaris (dog)	LOC100686507	XP_003435639.1
Caenorhabditis elegans (roundworm)	lbp-6	NP_491926.1
Caenorhabditis elegans (roundworm)	lbp-5	NP_491928.1
Caenorhabditis elegans (roundworm)	lbp-7	NP_506440.1

Gene Ontology
Bibliography

Related articles in PubMed

Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4.
Okamura Y, Otani K, Sekiguchi A, Kogane T, Kakuda C, Sakamoto Y, Kodama T, Okada M, Yamawaki H
Pflugers Archiv : European journal of physiology(2017 Apr)

Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.
Yang A, Zhang H, Sun Y, Wang Y, Yang X, Yang X, Zhang H, Guo W, Zhu G, Tian J, Jia Y, Jiang Y
Placenta4649-62(2016 Oct)

Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress.
Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Putri M, Obokata M, Sunaga H, Koitabashi N, Matsui H, Maeda K, Endo K, Tsushima Y, Yokoyama T, Kurabayashi M
PloS one9(6)e90825(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypomethylation of FABP4 was regulated by DNMT1, which was a direct target of miR-152/148a, in pre-eclampsia model
Title: Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.

Intermittent moderate exercise in the hyperphagic obese Zucker rats lasting for 10 weeks elevates adipose tissue FABP4.
Title: Aerobic training lasting for 10 weeks elevates the adipose tissue FABP4, Gi?, and adiponectin expression associated by a reduced protein oxidation.

show that AP2 interacts with bile salt export pump (BSEP) at the canalicular membrane through a tyrosine motif at the carboxyl terminus of BSEP
Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

the release of FABP4 from adipocytes may be involved in the development of cardiac contractile dysfunction of obese subjects.
Title: Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease.

In rats fed a high-fat diet, the expressions of PPARgamma and aP2 mRNA of obesity group were much higher than those of control and obesity resistant group.
Title: [Study on PPARgamma and aP2 mRNA expression of adipose tissues in obesity and obesity resistant rats].

The following Fabp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09366	NM_053365.1 Latest version!	Rattus norvegicus fatty acid binding protein 4 (Fabp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp4 ( NM_053365.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445817.1 Rattus norvegicus fatty acid binding protein 4 (Fabp4), mRNA.

Price & Availability↑

CloneID	ORa09366
Clone ID Related Accession (Same CDS sequence)	NM_053365.1
Accession Version	NM_053365.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Rattus norvegicus(Norway rat)
Product	fatty acid-binding protein, adipocyte
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF144756.1. On Jan 12, 2005 this sequence version replaced XM_346619.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF144756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGTGCGACG CCTTTGTGGG GACCTGGAAA CTCGTCTCCA GTGAGAACTT CGATGATTAC 
ATGAAAGAAG TGGGAGTTGG CTTCGCCACC AGGAAAGTGG CCGGTATGGC CAAGCCCAAC 
TTGATCATCA GCGTAGAAGG GGACTTGGTC GTCATCCGGT CAGAGAGTAC TTTTAAAAAC 
ACCGAGATTT CCTTCAAACT GGGCGTGGAA TTCGATGAAA TCACCCCAGA TGACAGGAAA 
GTGAAGAGCA TCATAACCCT GGATGGTGGG GTCCTGGTAC ATGTGCAGAA GTGGGATGGA 
AAGTCGACCA CCATAAAGAG GAGACNAGAT GGTGACAAGC TGGTGGTGGA ATGTGTCATG 
AAAGGCGTGA CTTCTACAAG AGTTTACNAA AGGGCATNAG CCAAGGGACG AGGCCCTGGA 
CTGAAATTTG CATCAAACTC TACAATAACT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445817.1
CDS	54..506
Translation	MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNLIISVEGDLVVIRSESTFKNTEISFKLGVEFDEITPDDRKVKSIITLDGGVLVHVQKWDGKSTTIKRRnullDGDKLVVECVMKGVTSTRVYnullRAnullAKGRGPGLKFASNSTIT

Target ORF information:

RefSeq Version	NM_053365.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fatty acid binding protein 4 (Fabp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053365.1

ORF Insert Sequence:

ATGTGCGACG CCTTTGTGGG GACCTGGAAA CTCGTCTCCA GTGAGAACTT CGATGATTAC 
ATGAAAGAAG TGGGAGTTGG CTTCGCCACC AGGAAAGTGG CCGGTATGGC CAAGCCCAAC 
TTGATCATCA GCGTAGAAGG GGACTTGGTC GTCATCCGGT CAGAGAGTAC TTTTAAAAAC 
ACCGAGATTT CCTTCAAACT GGGCGTGGAA TTCGATGAAA TCACCCCAGA TGACAGGAAA 
GTGAAGAGCA TCATAACCCT GGATGGTGGG GTCCTGGTAC ATGTGCAGAA GTGGGATGGA 
AAGTCGACCA CCATAAAGAG GAGACNAGAT GGTGACAAGC TGGTGGTGGA ATGTGTCATG 
AAAGGCGTGA CTTCTACAAG AGTTTACNAA AGGGCATNAG CCAAGGGACG AGGCCCTGGA 
CTGAAATTTG CATCAAACTC TACAATAACT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4.
Pflugers Archiv : European journal of physiology(2017 Apr)
Okamura Y,Otani K,Sekiguchi A,Kogane T,Kakuda C,Sakamoto Y,Kodama T,Okada M,Yamawaki H

Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.
Placenta4649-62(2016 Oct)
Yang A,Zhang H,Sun Y,Wang Y,Yang X,Yang X,Zhang H,Guo W,Zhu G,Tian J,Jia Y,Jiang Y

Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress.
PloS one9(6)e90825(2014)
Syamsunarno MR,Iso T,Yamaguchi A,Hanaoka H,Putri M,Obokata M,Sunaga H,Koitabashi N,Matsui H,Maeda K,Endo K,Tsushima Y,Yokoyama T,Kurabayashi M

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Fabp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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