Igfals cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfals
Entrez Gene ID	79438
Full Name	insulin-like growth factor binding protein, acid labile subunit
Synonyms	Als
General protein information	Preferred Names insulin-like growth factor binding protein, acid labile subunit Names insulin-like growth factor-binding protein complex acid labile subunit insulin-like growth factor-binding protein complex acid labile chain
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	subunit of the ternary insulin-like growth factor-binding protein complex; involved in controlling the bioavailability of circulating insulin-like growth factors [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053329.2	NP_445781.2	insulin-like growth factor-binding protein complex acid labile subunit precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IGFALS	XP_547189.4
Mus musculus (house mouse)	Igfals	NP_032366.2
Pan troglodytes (chimpanzee)	IGFALS	XP_001172738.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007061	XP_565143.2
Gallus gallus (chicken)	IGFALS	XP_004945462.1
Xenopus tropicalis (tropical clawed frog)	igfals	XP_002940278.1
Homo sapiens (human)	IGFALS	NP_001139478.1
Rattus norvegicus (Norway rat)	Igfals	NP_445781.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007059	XP_001688062.1
	LOC722493	XP_002802399.1
Bos taurus (cattle)	IGFALS	NP_001069431.1
Danio rerio (zebrafish)	si:ch211-66h3.1	XP_003198203.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007060	XP_565144.3

Gene Ontology
Bibliography

Related articles in PubMed

A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1).
Hess O, Khayat M, Hwa V, Heath KE, Teitler A, Hritan Y, Allon-Shalev S, Tenenbaum-Rakover Y
Clinical endocrinology79(6)838-44(2013 Dec)

IGF-I-IGFBP-3-acid-labile subunit (ALS) complex in children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH).
V?lkl TM, Rauh M, Sch?fl C, D?rr HG
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society21(4)191-8(2011 Aug)

IGF system in children with congenital disorders of glycosylation.
Miller BS, Khosravi MJ, Patterson MC, Conover CA
Clinical endocrinology70(6)892-7(2009 Jun)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Noonan syndrome: relationships between genotype, growth, and growth factors.
Limal JM, Parfait B, Cabrol S, Bonnet D, Leheup B, Lyonnet S, Vidaud M, Le Bouc Y
The Journal of clinical endocrinology and metabolism91(1)300-6(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypothesize that development-dependent regulation of ALS and IGF-I during refeeding may involve a posttranscriptional hepatic response that is not growth hormone dependent
Title: Age-dependent regulation of the acid-labile subunit in response to fasting-refeeding in rats.

in sustained endotoxemia, ALS levels are regulated through modulation of hepatic insulin sensitivity.
Title: Regulation of the acid-labile subunit in sustained endotoxemia.

The following Igfals gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfals cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09293	NM_053329.2 Latest version!	Rattus norvegicus insulin-like growth factor binding protein, acid labile subunit (Igfals), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfals ( NM_053329.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445781.2 Rattus norvegicus insulin-like growth factor binding protein, acid labile subunit (Igfals), mRNA.

Price & Availability↑

CloneID	ORa09293
Clone ID Related Accession (Same CDS sequence)	NM_053329.2
Accession Version	NM_053329.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein complex acid labile subunit precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S46785.1. On Aug 7, 2005 this sequence version replaced NM_053329.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S46785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCTGA GGACAGGAGG CCCAGCCCTG GTGGTGCTTC TGGCTTTCTG GGTGGCACTG 
GGCCCCTGTC ACCTGCAGGG GACAGATCCC GGAGCGTCGG CAGATGCCGA GGGCCCCCAG 
TGCCCCGTCG CCTGTACCTG CAGCCATGAT GACTACACAG ATGAGCTCAG CGTCTTTTGC 
AGTTCAAAGA ACCTCACACA TCTGCCTGAT GACATCCCAG TCAGCACCAG AGCCCTGTGG 
CTTGATGGCA ACAACCTCTC TTCTATCCCC TCAGCGGCCT TCCAGAACCT GTCCAGCCTG 
GACTTTCTCA ACCTGCAGGG CAGCTGGCTG AGGAGCCTGG AGCCACAGGC ACTGCTGGGG 
CTGCAGAACC TCTACTATCT GCACCTGGAA CGGAACCGGC TCCGGAACCT CGCCGTGGGC 
TTGTTCACAC ACACACCGAG TCTGGCTTCA CTCAGCCTGA GCAGCAACCT CTTGGGCCGG 
CTGGAGGAAG GGCTGTTCCA GGGCCTCAGT CACCTTTGGG ACCTCAACCT GGGTTGGAAC 
AGTCTAGTGG TCCTGCCTGA CACAGTGTTC CAGGGACTGG GCAACCTCCA CGAGCTGGTG 
CTGGCTGGCA ACAAACTGAC TTACCTGCAG CCTGCGCTCT TCTGTGGCTT GGGCGAGCTG 
CGGGAGCTGG ATCTGAGCAG GAACGCACTC CGAAGCGTCA AAGCTAACGT CTTTGTACAT 
TTGCCCAGGC TGCAGAAGCT GTACCTGGAC CGGAACCTCA TTACAGCCGT GGCCCCTGGT 
GCCTTTCTGG GCATGAAGGC CCTGCGTTGG CTGGACCTGT CGCACAACCG CGTGGCTGGC 
CTCATGGAGG ACACCTTCCC AGGCCTGCTG GGCCTGCACG TCCTGCGCCT GGCACACAAT 
GCGATCGCTA GCTTGCGGCC GCGCACTTTC AAAGACCTGC ACTTCCTGGA GGAACTGCAG 
CTGGGCCACA ATCGAATCAG GCAGCTCGGG GAGAGGACAT TCGAGGGCCT GGGGCAGCTG 
GAGGTGCTGA CGCTCAATGA CAACCAGATC ACTGAGGTCA GGGTGGGCGC CTTCTCTGGC 
CTTTTCAATG TGGCGGTTAT GAATCTCTCC GGCAACTGTC TGAGGAGCCT CCCGGAGCGG 
GTGTTTCAGG GTCTGGACAA ACTGCACAGC CTGCACCTAG AGCACAGCTG CCTGGGTCAC 
GTCCGCCTGC ACACTTTTGC TGGCCTCTCA GGGCTGCGCA GGCTCTTCCT CAGGGACAAC 
AGCATCTCCA GCATCGAAGA ACAGAGCCTG GCAGGGCTTT CGGAGCTCCT GGAACTGGAT 
CTTACTACCA ACCGCCTCAC ACATCTGCCC CGCCAGCTCT TCCAGGGCCT CGGCCACCTG 
GAGTACCTGC TTCTCTCCTA CAACCAACTG ACGACTTTAT CCGCGGAGGT CCTGGGCCCT 
CTGCAGCGGG CCTTCTGGTT GGATATCTCA CACAACCACC TGGAGACGCT GGCCGAAGGC 
CTTTTCTCAT CTCTGGGGCG CGTTCGCTAC CTCAGCCTCA GGAATAACTC CTTGCAGACC 
TTTTCACCAC AGCCCGGCCT GGAGCGCCTG TGGCTTGATG CCAACCCCTG GGACTGCAGC 
TGTCCCCTCA AGGCGCTTCG AGACTTTGCC CTGCAGAACC CTGGTGTTGT CCCCCGCTTT 
GTTCAGACTG TCTGTGAGGG GGACGACTGC CAGCCGGTGT ACACCTACAA CAATATCACT 
TGCGCTGGCC CCGCCAACGT CTCGGGCCTC GACCTAAGAG ACGTTAGTGA AACACATTTT 
GTGCACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445781.2
CDS	101..1912
Translation	MALRTGGPALVVLLAFWVALGPCHLQGTDPGASADAEGPQCPVACTCSHDDYTDELSVFCSSKNLTHLPDDIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYYLHLERNRLRNLAVGLFTHTPSLASLSLSSNLLGRLEEGLFQGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALFCGLGELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAPGAFLGMKALRWLDLSHNRVAGLMEDTFPGLLGLHVLRLAHNAIASLRPRTFKDLHFLEELQLGHNRIRQLGERTFEGLGQLEVLTLNDNQITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLHLEHSCLGHVRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTTNRLTHLPRQLFQGLGHLEYLLLSYNQLTTLSAEVLGPLQRAFWLDISHNHLETLAEGLFSSLGRVRYLSLRNNSLQTFSPQPGLERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCEGDDCQPVYTYNNITCAGPANVSGLDLRDVSETHFVHC

Target ORF information:

RefSeq Version	NM_053329.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein, acid labile subunit (Igfals), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053329.2

ORF Insert Sequence:

ATGGCCCTGA GGACAGGAGG CCCAGCCCTG GTGGTGCTTC TGGCTTTCTG GGTGGCACTG 
GGCCCCTGTC ACCTGCAGGG GACAGATCCC GGAGCGTCGG CAGATGCCGA GGGCCCCCAG 
TGCCCCGTCG CCTGTACCTG CAGCCATGAT GACTACACAG ATGAGCTCAG CGTCTTTTGC 
AGTTCAAAGA ACCTCACACA TCTGCCTGAT GACATCCCAG TCAGCACCAG AGCCCTGTGG 
CTTGATGGCA ACAACCTCTC TTCTATCCCC TCAGCGGCCT TCCAGAACCT GTCCAGCCTG 
GACTTTCTCA ACCTGCAGGG CAGCTGGCTG AGGAGCCTGG AGCCACAGGC ACTGCTGGGG 
CTGCAGAACC TCTACTATCT GCACCTGGAA CGGAACCGGC TCCGGAACCT CGCCGTGGGC 
TTGTTCACAC ACACACCGAG TCTGGCTTCA CTCAGCCTGA GCAGCAACCT CTTGGGCCGG 
CTGGAGGAAG GGCTGTTCCA GGGCCTCAGT CACCTTTGGG ACCTCAACCT GGGTTGGAAC 
AGTCTAGTGG TCCTGCCTGA CACAGTGTTC CAGGGACTGG GCAACCTCCA CGAGCTGGTG 
CTGGCTGGCA ACAAACTGAC TTACCTGCAG CCTGCGCTCT TCTGTGGCTT GGGCGAGCTG 
CGGGAGCTGG ATCTGAGCAG GAACGCACTC CGAAGCGTCA AAGCTAACGT CTTTGTACAT 
TTGCCCAGGC TGCAGAAGCT GTACCTGGAC CGGAACCTCA TTACAGCCGT GGCCCCTGGT 
GCCTTTCTGG GCATGAAGGC CCTGCGTTGG CTGGACCTGT CGCACAACCG CGTGGCTGGC 
CTCATGGAGG ACACCTTCCC AGGCCTGCTG GGCCTGCACG TCCTGCGCCT GGCACACAAT 
GCGATCGCTA GCTTGCGGCC GCGCACTTTC AAAGACCTGC ACTTCCTGGA GGAACTGCAG 
CTGGGCCACA ATCGAATCAG GCAGCTCGGG GAGAGGACAT TCGAGGGCCT GGGGCAGCTG 
GAGGTGCTGA CGCTCAATGA CAACCAGATC ACTGAGGTCA GGGTGGGCGC CTTCTCTGGC 
CTTTTCAATG TGGCGGTTAT GAATCTCTCC GGCAACTGTC TGAGGAGCCT CCCGGAGCGG 
GTGTTTCAGG GTCTGGACAA ACTGCACAGC CTGCACCTAG AGCACAGCTG CCTGGGTCAC 
GTCCGCCTGC ACACTTTTGC TGGCCTCTCA GGGCTGCGCA GGCTCTTCCT CAGGGACAAC 
AGCATCTCCA GCATCGAAGA ACAGAGCCTG GCAGGGCTTT CGGAGCTCCT GGAACTGGAT 
CTTACTACCA ACCGCCTCAC ACATCTGCCC CGCCAGCTCT TCCAGGGCCT CGGCCACCTG 
GAGTACCTGC TTCTCTCCTA CAACCAACTG ACGACTTTAT CCGCGGAGGT CCTGGGCCCT 
CTGCAGCGGG CCTTCTGGTT GGATATCTCA CACAACCACC TGGAGACGCT GGCCGAAGGC 
CTTTTCTCAT CTCTGGGGCG CGTTCGCTAC CTCAGCCTCA GGAATAACTC CTTGCAGACC 
TTTTCACCAC AGCCCGGCCT GGAGCGCCTG TGGCTTGATG CCAACCCCTG GGACTGCAGC 
TGTCCCCTCA AGGCGCTTCG AGACTTTGCC CTGCAGAACC CTGGTGTTGT CCCCCGCTTT 
GTTCAGACTG TCTGTGAGGG GGACGACTGC CAGCCGGTGT ACACCTACAA CAATATCACT 
TGCGCTGGCC CCGCCAACGT CTCGGGCCTC GACCTAAGAG ACGTTAGTGA AACACATTTT 
GTGCACTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1).
Clinical endocrinology79(6)838-44(2013 Dec)
Hess O,Khayat M,Hwa V,Heath KE,Teitler A,Hritan Y,Allon-Shalev S,Tenenbaum-Rakover Y

IGF-I-IGFBP-3-acid-labile subunit (ALS) complex in children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH).
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society21(4)191-8(2011 Aug)
V?lkl TM,Rauh M,Sch?fl C,D?rr HG

IGF system in children with congenital disorders of glycosylation.
Clinical endocrinology70(6)892-7(2009 Jun)
Miller BS,Khosravi MJ,Patterson MC,Conover CA

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Noonan syndrome: relationships between genotype, growth, and growth factors.
The Journal of clinical endocrinology and metabolism91(1)300-6(2006 Jan)
Limal JM,Parfait B,Cabrol S,Bonnet D,Leheup B,Lyonnet S,Vidaud M,Le Bouc Y

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Igfals cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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