Pdgfc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdgfc
Entrez Gene ID	79429
Full Name	platelet derived growth factor C
Synonyms	SCDGF
General protein information	Preferred Names platelet derived growth factor C Names platelet-derived growth factor C PDGF-C VEGF-E fallotein platelet-derived growth factor, C polypeptide rScdfg spinal cord-derived growth factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q33-q34
Summary	expressed in the embryonic spinal cord floor plate and ventricular zone, adult expression is localized to motoneurons in several regions of the brain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031317.1	NP_112607.1	platelet-derived growth factor C precursor

Pathways from BioSystems

Homologies

	PDGFC	XP_001093265.1
Bos taurus (cattle)	PDGFC	XP_005217744.1
Mus musculus (house mouse)	Pdgfc	NP_064355.1
Rattus norvegicus (Norway rat)	Pdgfc	NP_112607.1
Homo sapiens (human)	PDGFC	NP_057289.1
Pan troglodytes (chimpanzee)	PDGFC	XP_001140766.1
Danio rerio (zebrafish)	LOC560564	XP_689054.3
Canis lupus familiaris (dog)	PDGFC	XP_539783.3
Gallus gallus (chicken)	PDGFC	NP_990052.1
Xenopus tropicalis (tropical clawed frog)	pdgfc	XP_002934792.2

Gene Ontology
Bibliography

Related articles in PubMed

Mesenchymal Stem Cells Suppress Chronic Rejection in Heterotopic Small Intestine Transplant Rat Models Via Inhibition of CD68, Transforming Growth Factor- ?1, and Platelet-Derived Growth Factor Expression.
Li F, Cao J, Zhao Z, Li C, Qi F, Liu T
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation15(2)213-221(2017 Apr)

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.
Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, Andersson P, Nakamura M, N?slund E, Yl?-Herttuala S, Sun M, Iwamoto H, Li X, Liu Y, Samani NJ, Cao Y
Nature communications712152(2016 Aug)

Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.
Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, Betsholtz C
Molecular and cellular biology33(20)4030-40(2013 Oct)

Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29.
Kwiecinski M, Elfimova N, Noetel A, T?x U, Steffen HM, Hacker U, Nischt R, Dienes HP, Odenthal M
Laboratory investigation; a journal of technical methods and pathology92(7)978-87(2012 Jul)

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.
Pogribny IP, Starlard-Davenport A, Tryndyak VP, Han T, Ross SA, Rusyn I, Beland FA
Laboratory investigation; a journal of technical methods and pathology90(10)1437-46(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mesenchymal stem cells could inhibit the process of chronic rejection of small intestine transplant. The mechanisms may include the inhibited function of these cells on lymphocyte proliferation, reduced infiltration of macrophages, and reduced expression of transforming growth factor beta1 and platelet-derived growth factor C.
Title: Mesenchymal Stem Cells Suppress Chronic Rejection in Heterotopic Small Intestine Transplant Rat Models Via Inhibition of CD68, Transforming Growth Factor- ?1, and Platelet-Derived Growth Factor Expression.

After experimental liver fibrosis, induced by bile-duct occlusion, miR-29 expression was shown to be reduced, but IGF-I and PDGF-C expression was upregulated, correlating inversely to the miR-29 pattern.
Title: Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29.

PDGFR (platelet derived growth factor receptor)-alpha mRNA Is Upregulated in Acutely-Rejecting, and PDGF-A and PDGF-C mRNAis upregulated in Chronically-Rejecting Cardiac Allografts
Title: PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.

might be involved in the pathogenesis of periapical lesions
Title: Expression of a novel PDGF isoform, PDGF-C, in experimental periapical lesions.

ATII induction of PDGF-C transcription is mediated by the angiotensin type 1 receptor and through an Egr-1-binding element in the PDGF-C promoter.
Title: Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation.

The following Pdgfc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdgfc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07803	NM_031317.1 Latest version!	Rattus norvegicus platelet derived growth factor C (Pdgfc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdgfc ( NM_031317.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112607.1 Rattus norvegicus platelet derived growth factor C (Pdgfc), mRNA.

Price & Availability↑

CloneID	ORa07803
Clone ID Related Accession (Same CDS sequence)	NM_031317.1
Accession Version	NM_031317.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	platelet-derived growth factor C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB033830.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB033830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTCCTCC TCGGCCTCCT CCTGCTGACA TCTGCCCTGG CCGGCCAGAG AACCGGGACT 
CGGGCTGAGT CCAACCTGAG CAGCAAGTTG CAGCTCTCCA GCGACAAGGA GCAGAACGGA 
GTGCAAGATC CCCGGCATGA GAGAGTTGTC ACTATATCTG GTAATGGGAG CATCCACAGC 
CCGAAGTTTC CTCATACCTA CCCAAGAAAT ACGGTGCTGG TCTGGAGATT AGTGGCAGTA 
GATGAAAATG TGCGGATCCA GCTGACATTT GATGAGAGAT TTGGGCTGGA AGACCCAGAG 
GACGATCTAT GCAAGTATGA TTTTGTAGAA GTTGAGGAGC CCAGTGATGG AAGTGTATTA 
GGACGCTGGT GTGGTTCTGG GACTGTGCCA GGAAAGCAGA CTTCTAAAGG AAATCATATC 
AGGATAAGAT TTGTATCTGA TGAGTATTTC CCATCTGAAC CCGGATTCTG CATCCACTAC 
AGTATTATCA TGCCACAAGT CACAGAAACT ACGAGTCCTT CAGTGTTGCC CCCTTCAGCT 
TTGTCATTGG ACCTGCTCAA TAATGCTGTG ACTGCCTTCA GTACTGTGGA AGAGCTGATT 
CGGTTCCTAG AGCCAGATCG ATGGCAGATA GACTTGGACA GCCTCTACAA GCCAACATGG 
CCGCTTTTGG GCAAAGCTTT CCTGTATGGG AAAAAAAGCA AAGCGGTGAA TCTGAACCTT 
CTCAAAGAAG AGGTAAAACT TTACAGCTGC ACACCCCGGA ACTTCTCTGT GTCCATACGG 
GAAGAGCTAA AGAGGACAGA CACCATATTC TGGCCAGGTT GTCTCCTGGT CAAGCGCTGT 
GGAGGAAATT GTGCCTGTTG CCTCCATAAT TGCAATGAAT GTCAGTGTGT CCCACGTAAA 
GTTACAAAAA AGTACCATGA GGTCCTTCAG TTGAGACCAA AAATTGGAGT CAAGGGATTG 
CATAAGTCGC TCACCGATGT GGCCCTGGAA CACCATGAGG AATGTGACTG TGTGTGTAGA 
GGAAACACAG AAGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112607.1
CDS	1..1038
Translation	MLLLGLLLLTSALAGQRTGTRAESNLSSKLQLSSDKEQNGVQDPRHERVVTISGNGSIHSPKFPHTYPRNTVLVWRLVAVDENVRIQLTFDERFGLEDPEDDLCKYDFVEVEEPSDGSVLGRWCGSGTVPGKQTSKGNHIRIRFVSDEYFPSEPGFCIHYSIIMPQVTETTSPSVLPPSALSLDLLNNAVTAFSTVEELIRFLEPDRWQIDLDSLYKPTWPLLGKAFLYGKKSKAVNLNLLKEEVKLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPRKVTKKYHEVLQLRPKIGVKGLHKSLTDVALEHHEECDCVCRGNTEG

Target ORF information:

RefSeq Version	NM_031317.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus platelet derived growth factor C (Pdgfc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031317.1

ORF Insert Sequence:

ATGCTCCTCC TCGGCCTCCT CCTGCTGACA TCTGCCCTGG CCGGCCAGAG AACCGGGACT 
CGGGCTGAGT CCAACCTGAG CAGCAAGTTG CAGCTCTCCA GCGACAAGGA GCAGAACGGA 
GTGCAAGATC CCCGGCATGA GAGAGTTGTC ACTATATCTG GTAATGGGAG CATCCACAGC 
CCGAAGTTTC CTCATACCTA CCCAAGAAAT ACGGTGCTGG TCTGGAGATT AGTGGCAGTA 
GATGAAAATG TGCGGATCCA GCTGACATTT GATGAGAGAT TTGGGCTGGA AGACCCAGAG 
GACGATCTAT GCAAGTATGA TTTTGTAGAA GTTGAGGAGC CCAGTGATGG AAGTGTATTA 
GGACGCTGGT GTGGTTCTGG GACTGTGCCA GGAAAGCAGA CTTCTAAAGG AAATCATATC 
AGGATAAGAT TTGTATCTGA TGAGTATTTC CCATCTGAAC CCGGATTCTG CATCCACTAC 
AGTATTATCA TGCCACAAGT CACAGAAACT ACGAGTCCTT CAGTGTTGCC CCCTTCAGCT 
TTGTCATTGG ACCTGCTCAA TAATGCTGTG ACTGCCTTCA GTACTGTGGA AGAGCTGATT 
CGGTTCCTAG AGCCAGATCG ATGGCAGATA GACTTGGACA GCCTCTACAA GCCAACATGG 
CCGCTTTTGG GCAAAGCTTT CCTGTATGGG AAAAAAAGCA AAGCGGTGAA TCTGAACCTT 
CTCAAAGAAG AGGTAAAACT TTACAGCTGC ACACCCCGGA ACTTCTCTGT GTCCATACGG 
GAAGAGCTAA AGAGGACAGA CACCATATTC TGGCCAGGTT GTCTCCTGGT CAAGCGCTGT 
GGAGGAAATT GTGCCTGTTG CCTCCATAAT TGCAATGAAT GTCAGTGTGT CCCACGTAAA 
GTTACAAAAA AGTACCATGA GGTCCTTCAG TTGAGACCAA AAATTGGAGT CAAGGGATTG 
CATAAGTCGC TCACCGATGT GGCCCTGGAA CACCATGAGG AATGTGACTG TGTGTGTAGA 
GGAAACACAG AAGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mesenchymal Stem Cells Suppress Chronic Rejection in Heterotopic Small Intestine Transplant Rat Models Via Inhibition of CD68, Transforming Growth Factor- ?1, and Platelet-Derived Growth Factor Expression.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation15(2)213-221(2017 Apr)
Li F,Cao J,Zhao Z,Li C,Qi F,Liu T

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.
Nature communications712152(2016 Aug)
Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,N?slund E,Yl?-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y

Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.
Molecular and cellular biology33(20)4030-40(2013 Oct)
Andrae J,Ehrencrona H,Gallini R,Lal M,Ding H,Betsholtz C

Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29.
Laboratory investigation; a journal of technical methods and pathology92(7)978-87(2012 Jul)
Kwiecinski M,Elfimova N,Noetel A,T?x U,Steffen HM,Hacker U,Nischt R,Dienes HP,Odenthal M

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.
Laboratory investigation; a journal of technical methods and pathology90(10)1437-46(2010 Oct)
Pogribny IP,Starlard-Davenport A,Tryndyak VP,Han T,Ross SA,Rusyn I,Beland FA