Apex1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apex1
Entrez Gene ID	79116
Full Name	apurinic/apyrimidinic endodeoxyribonuclease 1
Synonyms	APE,Apex,REF-1
General protein information	Preferred Names apurinic/apyrimidinic endodeoxyribonuclease 1 Names DNA-(apurinic or apyrimidinic site) lyase AP endonuclease 1 APEN APEX nuclease (multifunctional DNA repair enzyme) 1 APEX nuclease 1 apurinic/apyrimidinic endonuclease 1 redox factor-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p14
Summary	may play roles in DNA repair and in redox homeostasis; regulates Pax8 transcription [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006251913.1	XP_006251975.1	DNA-(apurinic or apyrimidinic site) lyase isoform X1
XM_017599805.1	XP_017455294.1	DNA-(apurinic or apyrimidinic site) lyase isoform X2
NM_024148.1	NP_077062.1	DNA-(apurinic or apyrimidinic site) lyase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	APEX1	NP_001138591.1
Mus musculus (house mouse)	Apex1	NP_033817.1
Gallus gallus (chicken)	APEX1	NP_001171688.1
Arabidopsis thaliana (thale cress)	ARP	NP_181677.1
Pan troglodytes (chimpanzee)	APEX1	NP_001074954.1
	APEX1	XP_001090240.1
Rattus norvegicus (Norway rat)	Apex1	NP_077062.1
Oryza sativa (rice)	Os01g0801000	NP_001044537.1
Bos taurus (cattle)	APEX1	NP_788782.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009587	XP_318609.4
Xenopus tropicalis (tropical clawed frog)	apex1	NP_989307.1
Homo sapiens (human)	APEX1	NP_001231178.1
Danio rerio (zebrafish)	apex1	NP_998586.1

Gene Ontology
Bibliography

Related articles in PubMed

DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.
Fehrenbacher JC, Guo C, Kelley MR, Vasko MR
Neuroscience36623-35(2017 Dec)

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.
Lee KM, Lee EO, Lee YR, Joo HK, Park MS, Kim CS, Choi S, Jeong JO, Jeon BH
International journal of molecular sciences18(10)(2017 Sep)

Ape1 protects against MPP+-induced neurotoxicity through ERK1/2 signaling in PC12 cells.
Kang B, Mu S, Yang Q, Guo S, Chen X, Guo H
Neuroreport28(1)10-16(2017 Jan)

The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.
Baek H, Lim CS, Byun HS, Cho HS, Lee YR, Shin YS, Kim HW, Jeon BH, Kim DW, Hong J, Hur GM, Park JB
Molecular brain9(1)99(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study suggest that Ape1 protects against neuron death by activating the ERK1/2 signaling pathway.
Title: Ape1 protects against MPP+-induced neurotoxicity through ERK1/2 signaling in PC12 cells.

altered expression and/or subcellular distribution of APE1/Ref-1 in activated astrocytes regulated the neuroinflammatory response to excitotoxin and endotoxin insults used in model of neurodegenerative brain diseases.
Title: The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.

In summary, APE1 is regulated at different levels after acute and chronic UUO. Thus, our results suggest that DNA repair activity is regulated in response to progressive (7 days) obstruction and that APE1 potentially could play a role in the development of fibrosis in kidney disease.
Title: Unilateral ureteral obstruction induces DNA repair by APE1.

This study suggests that a new function of GLP-1 is to elevate DNA repair by inducing the expression of the DNA repair protein APE1.
Title: Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1.

Ape1 expression was initially high and then gradually reduced along with the tooth development.
Title: Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells.

The following Apex1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apex1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13352	NM_024148.1 Latest version!	Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa13352	XM_006251913.1 Latest version!	Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa58652	XM_017599805.1 Latest version!	Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apex1 ( NM_024148.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077062.1 Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), mRNA.

Price & Availability↑

CloneID	ORa13352
Clone ID Related Accession (Same CDS sequence)	XM_006251913.1 , NM_024148.1
Accession Version	NM_024148.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	DNA-(apurinic or apyrimidinic site) lyase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D44495.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D44495.1, BC078816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCCGAAGC GGGGGAAGAG AGCGGCAGCG GAAGACGGGG AAGAACCCAA GTCCGAGCCA 
GAGACCAAGA AGAGTAAGGG GGCAGCAAAG AAAACTGAGA AGGAGGCCGC AGGAGAGGGC 
CCTGTCCTGT ATGAGGACCC TCCAGATCAG AAAACGTCAG CCAGTGGCAA ATCTGCCACA 
CTCAAGATAT GCTCCTGGAA TGTGGATGGG CTTCGAGCCT GGATTAAAAA GAAAGGCTTG 
GATTGGGTAA AGGAAGAAGC ACCAGACATC TTGTGCCTCC AAGAGACCAA ATGCTCAGAG 
AACAAACTCC CGGCTGAACT GCAAGAGCTG CCTGGACTCA CCCATCAGTA CTGGTCAGCT 
CCATCAGACA AAGAAGGATA TAGTGGTGTG GGCCTACTTT CCCGCCAATG CCCGCTCAAA 
GTCTCTTATG GCATTGGTGA GGAAGAACAT GATCAAGAAG GCCGGGTGAT TGTGGCTGAA 
TTTGAGTCCT TTATCTTGGT AACAGCCTAT GTTCCGAACG CAGGAAGGGG TCTGGTAAGA 
CTGGAGTACC GACAGCGATG GGATGAAGCC TTCAGAAAGT TTCTAAAGGA CTTGGCTTCC 
CGGAAACCTC TTGTGCTGTG TGGGGATCTC AATGTGGCTC ATGAAGAAAT AGACCTTCGT 
AACCCCAAAG GAAACAAAAA GAATGCTGGT TTTACTCCCC AGGAGCGCCA AGGCTTTGGG 
GAAATGCTAC AGGCTGTACC ACTGGCTGAC AGCTTCCGGC ATCTCTACCC CAACACTGCC 
TACGCTTATA CTTTCTGGAC TTACATGATG AATGCCCGCT CTAAGAATGT TGGTTGGCGC 
CTTGATTACT TTTTGCTGTC TCACTCTCTT TTACCTGCTT TGTGCGACAG CAAGATCCGG 
TCCAAGGCTC TTGGCAGTGA CCACTGTCCC ATCACCCTTT ACCTAGCACT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077062.1
CDS	108..1061
Translation	MPKRGKRAAAEDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSASGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFILVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEMLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

Target ORF information:

RefSeq Version	NM_024148.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024148.1

ORF Insert Sequence:

ATGCCGAAGC GGGGGAAGAG AGCGGCAGCG GAAGACGGGG AAGAACCCAA GTCCGAGCCA 
GAGACCAAGA AGAGTAAGGG GGCAGCAAAG AAAACTGAGA AGGAGGCCGC AGGAGAGGGC 
CCTGTCCTGT ATGAGGACCC TCCAGATCAG AAAACGTCAG CCAGTGGCAA ATCTGCCACA 
CTCAAGATAT GCTCCTGGAA TGTGGATGGG CTTCGAGCCT GGATTAAAAA GAAAGGCTTG 
GATTGGGTAA AGGAAGAAGC ACCAGACATC TTGTGCCTCC AAGAGACCAA ATGCTCAGAG 
AACAAACTCC CGGCTGAACT GCAAGAGCTG CCTGGACTCA CCCATCAGTA CTGGTCAGCT 
CCATCAGACA AAGAAGGATA TAGTGGTGTG GGCCTACTTT CCCGCCAATG CCCGCTCAAA 
GTCTCTTATG GCATTGGTGA GGAAGAACAT GATCAAGAAG GCCGGGTGAT TGTGGCTGAA 
TTTGAGTCCT TTATCTTGGT AACAGCCTAT GTTCCGAACG CAGGAAGGGG TCTGGTAAGA 
CTGGAGTACC GACAGCGATG GGATGAAGCC TTCAGAAAGT TTCTAAAGGA CTTGGCTTCC 
CGGAAACCTC TTGTGCTGTG TGGGGATCTC AATGTGGCTC ATGAAGAAAT AGACCTTCGT 
AACCCCAAAG GAAACAAAAA GAATGCTGGT TTTACTCCCC AGGAGCGCCA AGGCTTTGGG 
GAAATGCTAC AGGCTGTACC ACTGGCTGAC AGCTTCCGGC ATCTCTACCC CAACACTGCC 
TACGCTTATA CTTTCTGGAC TTACATGATG AATGCCCGCT CTAAGAATGT TGGTTGGCGC 
CTTGATTACT TTTTGCTGTC TCACTCTCTT TTACCTGCTT TGTGCGACAG CAAGATCCGG 
TCCAAGGCTC TTGGCAGTGA CCACTGTCCC ATCACCCTTT ACCTAGCACT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apex1 ( XM_006251913.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251975.1 Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13352
Clone ID Related Accession (Same CDS sequence)	XM_006251913.1 , NM_024148.1
Accession Version	XM_006251913.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA-(apurinic or apyrimidinic site) lyase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAAGC GGGGGAAGAG AGCGGCAGCG GAAGACGGGG AAGAACCCAA GTCCGAGCCA 
GAGACCAAGA AGAGTAAGGG GGCAGCAAAG AAAACTGAGA AGGAGGCCGC AGGAGAGGGC 
CCTGTCCTGT ATGAGGACCC TCCAGATCAG AAAACGTCAG CCAGTGGCAA ATCTGCCACA 
CTCAAGATAT GCTCCTGGAA TGTGGATGGG CTTCGAGCCT GGATTAAAAA GAAAGGCTTG 
GATTGGGTAA AGGAAGAAGC ACCAGACATC TTGTGCCTCC AAGAGACCAA ATGCTCAGAG 
AACAAACTCC CGGCTGAACT GCAAGAGCTG CCTGGACTCA CCCATCAGTA CTGGTCAGCT 
CCATCAGACA AAGAAGGATA TAGTGGTGTG GGCCTACTTT CCCGCCAATG CCCGCTCAAA 
GTCTCTTATG GCATTGGTGA GGAAGAACAT GATCAAGAAG GCCGGGTGAT TGTGGCTGAA 
TTTGAGTCCT TTATCTTGGT AACAGCCTAT GTTCCGAACG CAGGAAGGGG TCTGGTAAGA 
CTGGAGTACC GACAGCGATG GGATGAAGCC TTCAGAAAGT TTCTAAAGGA CTTGGCTTCC 
CGGAAACCTC TTGTGCTGTG TGGGGATCTC AATGTGGCTC ATGAAGAAAT AGACCTTCGT 
AACCCCAAAG GAAACAAAAA GAATGCTGGT TTTACTCCCC AGGAGCGCCA AGGCTTTGGG 
GAAATGCTAC AGGCTGTACC ACTGGCTGAC AGCTTCCGGC ATCTCTACCC CAACACTGCC 
TACGCTTATA CTTTCTGGAC TTACATGATG AATGCCCGCT CTAAGAATGT TGGTTGGCGC 
CTTGATTACT TTTTGCTGTC TCACTCTCTT TTACCTGCTT TGTGCGACAG CAAGATCCGG 
TCCAAGGCTC TTGGCAGTGA CCACTGTCCC ATCACCCTTT ACCTAGCACT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251975.1
CDS	149..1102
Translation	MPKRGKRAAAEDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSASGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFILVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEMLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

Target ORF information:

RefSeq Version	XM_006251913.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251913.1

ORF Insert Sequence:

ATGCCGAAGC GGGGGAAGAG AGCGGCAGCG GAAGACGGGG AAGAACCCAA GTCCGAGCCA 
GAGACCAAGA AGAGTAAGGG GGCAGCAAAG AAAACTGAGA AGGAGGCCGC AGGAGAGGGC 
CCTGTCCTGT ATGAGGACCC TCCAGATCAG AAAACGTCAG CCAGTGGCAA ATCTGCCACA 
CTCAAGATAT GCTCCTGGAA TGTGGATGGG CTTCGAGCCT GGATTAAAAA GAAAGGCTTG 
GATTGGGTAA AGGAAGAAGC ACCAGACATC TTGTGCCTCC AAGAGACCAA ATGCTCAGAG 
AACAAACTCC CGGCTGAACT GCAAGAGCTG CCTGGACTCA CCCATCAGTA CTGGTCAGCT 
CCATCAGACA AAGAAGGATA TAGTGGTGTG GGCCTACTTT CCCGCCAATG CCCGCTCAAA 
GTCTCTTATG GCATTGGTGA GGAAGAACAT GATCAAGAAG GCCGGGTGAT TGTGGCTGAA 
TTTGAGTCCT TTATCTTGGT AACAGCCTAT GTTCCGAACG CAGGAAGGGG TCTGGTAAGA 
CTGGAGTACC GACAGCGATG GGATGAAGCC TTCAGAAAGT TTCTAAAGGA CTTGGCTTCC 
CGGAAACCTC TTGTGCTGTG TGGGGATCTC AATGTGGCTC ATGAAGAAAT AGACCTTCGT 
AACCCCAAAG GAAACAAAAA GAATGCTGGT TTTACTCCCC AGGAGCGCCA AGGCTTTGGG 
GAAATGCTAC AGGCTGTACC ACTGGCTGAC AGCTTCCGGC ATCTCTACCC CAACACTGCC 
TACGCTTATA CTTTCTGGAC TTACATGATG AATGCCCGCT CTAAGAATGT TGGTTGGCGC 
CTTGATTACT TTTTGCTGTC TCACTCTCTT TTACCTGCTT TGTGCGACAG CAAGATCCGG 
TCCAAGGCTC TTGGCAGTGA CCACTGTCCC ATCACCCTTT ACCTAGCACT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apex1 ( XM_017599805.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455294.1 Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa58652
Clone ID Related Accession (Same CDS sequence)	XM_017599805.1
Accession Version	XM_017599805.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA-(apurinic or apyrimidinic site) lyase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCGGA TCGCTCCCCT CCCCCCAGAG CCAGAGACCA AGAAGAGTAA GGGGGCAGCA 
AAGAAAACTG AGAAGGAGGC CGCAGGAGAG GGCCCTGTCC TGTATGAGGA CCCTCCAGAT 
CAGAAAACGT CAGCCAGTGG CAAATCTGCC ACACTCAAGA TATGCTCCTG GAATGTGGAT 
GGGCTTCGAG CCTGGATTAA AAAGAAAGGC TTGGATTGGG TAAAGGAAGA AGCACCAGAC 
ATCTTGTGCC TCCAAGAGAC CAAATGCTCA GAGAACAAAC TCCCGGCTGA ACTGCAAGAG 
CTGCCTGGAC TCACCCATCA GTACTGGTCA GCTCCATCAG ACAAAGAAGG ATATAGTGGT 
GTGGGCCTAC TTTCCCGCCA ATGCCCGCTC AAAGTCTCTT ATGGCATTGG TGAGGAAGAA 
CATGATCAAG AAGGCCGGGT GATTGTGGCT GAATTTGAGT CCTTTATCTT GGTAACAGCC 
TATGTTCCGA ACGCAGGAAG GGGTCTGGTA AGACTGGAGT ACCGACAGCG ATGGGATGAA 
GCCTTCAGAA AGTTTCTAAA GGACTTGGCT TCCCGGAAAC CTCTTGTGCT GTGTGGGGAT 
CTCAATGTGG CTCATGAAGA AATAGACCTT CGTAACCCCA AAGGAAACAA AAAGAATGCT 
GGTTTTACTC CCCAGGAGCG CCAAGGCTTT GGGGAAATGC TACAGGCTGT ACCACTGGCT 
GACAGCTTCC GGCATCTCTA CCCCAACACT GCCTACGCTT ATACTTTCTG GACTTACATG 
ATGAATGCCC GCTCTAAGAA TGTTGGTTGG CGCCTTGATT ACTTTTTGCT GTCTCACTCT 
CTTTTACCTG CTTTGTGCGA CAGCAAGATC CGGTCCAAGG CTCTTGGCAG TGACCACTGT 
CCCATCACCC TTTACCTAGC ACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455294.1
CDS	43..969
Translation	MNRIAPLPPEPETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSASGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFILVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEMLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

Target ORF information:

RefSeq Version	XM_017599805.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599805.1

ORF Insert Sequence:

ATGAACCGGA TCGCTCCCCT CCCCCCAGAG CCAGAGACCA AGAAGAGTAA GGGGGCAGCA 
AAGAAAACTG AGAAGGAGGC CGCAGGAGAG GGCCCTGTCC TGTATGAGGA CCCTCCAGAT 
CAGAAAACGT CAGCCAGTGG CAAATCTGCC ACACTCAAGA TATGCTCCTG GAATGTGGAT 
GGGCTTCGAG CCTGGATTAA AAAGAAAGGC TTGGATTGGG TAAAGGAAGA AGCACCAGAC 
ATCTTGTGCC TCCAAGAGAC CAAATGCTCA GAGAACAAAC TCCCGGCTGA ACTGCAAGAG 
CTGCCTGGAC TCACCCATCA GTACTGGTCA GCTCCATCAG ACAAAGAAGG ATATAGTGGT 
GTGGGCCTAC TTTCCCGCCA ATGCCCGCTC AAAGTCTCTT ATGGCATTGG TGAGGAAGAA 
CATGATCAAG AAGGCCGGGT GATTGTGGCT GAATTTGAGT CCTTTATCTT GGTAACAGCC 
TATGTTCCGA ACGCAGGAAG GGGTCTGGTA AGACTGGAGT ACCGACAGCG ATGGGATGAA 
GCCTTCAGAA AGTTTCTAAA GGACTTGGCT TCCCGGAAAC CTCTTGTGCT GTGTGGGGAT 
CTCAATGTGG CTCATGAAGA AATAGACCTT CGTAACCCCA AAGGAAACAA AAAGAATGCT 
GGTTTTACTC CCCAGGAGCG CCAAGGCTTT GGGGAAATGC TACAGGCTGT ACCACTGGCT 
GACAGCTTCC GGCATCTCTA CCCCAACACT GCCTACGCTT ATACTTTCTG GACTTACATG 
ATGAATGCCC GCTCTAAGAA TGTTGGTTGG CGCCTTGATT ACTTTTTGCT GTCTCACTCT 
CTTTTACCTG CTTTGTGCGA CAGCAAGATC CGGTCCAAGG CTCTTGGCAG TGACCACTGT 
CCCATCACCC TTTACCTAGC ACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.
Neuroscience36623-35(2017 Dec)
Fehrenbacher JC,Guo C,Kelley MR,Vasko MR

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.
International journal of molecular sciences18(10)(2017 Sep)
Lee KM,Lee EO,Lee YR,Joo HK,Park MS,Kim CS,Choi S,Jeong JO,Jeon BH

Ape1 protects against MPP+-induced neurotoxicity through ERK1/2 signaling in PC12 cells.
Neuroreport28(1)10-16(2017 Jan)
Kang B,Mu S,Yang Q,Guo S,Chen X,Guo H

The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.
Molecular brain9(1)99(2016 12)
Baek H,Lim CS,Byun HS,Cho HS,Lee YR,Shin YS,Kim HW,Jeon BH,Kim DW,Hong J,Hur GM,Park JB

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Apex1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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