Akr1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akr1a1
Entrez Gene ID	78959
Full Name	aldo-keto reductase family 1 member A1
Synonyms	Akr1a4
General protein information	Preferred Names aldo-keto reductase family 1 member A1 Names alcohol dehydrogenase [NADP(+)] 3-DG-reducing enzyme alcohol dehydrogenase aldehyde reductase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q35
Summary	enzyme that catalyzes the NADPH-dependent reduction of 3-deoxyglucosone; important for detoxifying 3-deoxyglucosone when it is formed through the Maillard reaction in vivo [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031000.3	NP_112262.1	aldo-keto reductase family 1 member A1

Pathways from BioSystems

Homologies

	AKR1A1	XP_001082982.1
Schizosaccharomyces pombe (fission yeast)	SPBC8E4.04	NP_596843.1
Arabidopsis thaliana (thale cress)	AT2G37760	NP_565871.1
Canis lupus familiaris (dog)	AKR1A1	NP_001239097.1
Bos taurus (cattle)	AKR1A1	NP_001069981.1
Xenopus tropicalis (tropical clawed frog)	akr1a1	NP_001016137.1
Rattus norvegicus (Norway rat)	Akr1a1	NP_112262.1
Neurospora crassa	NCU04510	XP_956921.1
Homo sapiens (human)	AKR1A1	NP_697021.1
Pan troglodytes (chimpanzee)	AKR1A1	XP_001157388.1
Mus musculus (house mouse)	Akr1a1	NP_067448.1
Gallus gallus (chicken)	AKR1A1	NP_001006539.1
Danio rerio (zebrafish)	akr1a1b	NP_001017640.1
Schizosaccharomyces pombe (fission yeast)	SPAC26F1.07	NP_594888.1
Magnaporthe oryzae (rice blast fungus)	MGG_07938	XP_003713188.1

Gene Ontology
Bibliography

Related articles in PubMed

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Kurahashi T, Kwon M, Homma T, Saito Y, Lee J, Takahashi M, Yamada K, Miyata S, Fujii J
Biochemical and biophysical research communications452(1)136-41(2014 Sep)

Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases.
Lacroix P?pin N, Chapdelaine P, Fortier MA
Prostaglandins & other lipid mediators106124-32(2013 Oct)

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P
Molecular bioSystems9(6)1108-16(2013 Jun)

In vivo role of aldehyde reductase.
Takahashi M, Miyata S, Fujii J, Inai Y, Ueyama S, Araki M, Soga T, Fujinawa R, Nishitani C, Ariki S, Shimizu T, Abe T, Ihara Y, Nishikimi M, Kozutsumi Y, Taniguchi N, Kuroki Y
Biochimica et biophysica acta1820(11)1787-96(2012 Nov)

Doxorubicin pathways: pharmacodynamics and adverse effects.
Thorn CF, Oshiro C, Marsh S, Hernandez-Boussard T, McLeod H, Klein TE, Altman RB
Pharmacogenetics and genomics21(7)440-6(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Akr1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akr1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07318	NM_031000.3 Latest version!	Rattus norvegicus aldo-keto reductase family 1 member A1 (Akr1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akr1a1 ( NM_031000.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112262.1 Rattus norvegicus aldo-keto reductase family 1 member A1 (Akr1a1), mRNA.

Price & Availability↑

CloneID	ORa07318
Clone ID Related Accession (Same CDS sequence)	NM_031000.3
Accession Version	NM_031000.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member A1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D10854.1. On Jun 10, 2007 this sequence version replaced NM_031000.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10854.1, BC059133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACGGCCT CCAGTGTCCT CCTGCACACT GGACAGAAGA TGCCTCTGAT TGGTCTGGGG 
ACATGGAAGA GTGAGCCTGG TCAGGTGAAA GCAGCTATTA AATATGCCCT TAGCGTAGGC 
TACCGCCACA TTGACTGTGC TTCTGTATAT GGCAATGAAA CTGAGATTGG AGAGGCCCTG 
AAGGAGAGTG TGGGAGCAGG CAAGGCAGTA CCTCGAGAGG AGCTGTTTGT GACCTCCAAG 
CTGTGGAATA CTAAGCACCA CCCTGAGGAT GTAGAACCTG CTGTCCGGAA GACGCTGGCT 
GATCTGCAGC TGGAGTATTT GGACCTCTAT TTGATGCATT GGCCTTATGC CTTCGAGCGG 
GGAGACAATC CCTTTCCCAA GAATGCCGAT GGAACTGTCA AATATGACTC CACTCACTAT 
AAGGAGACCT GGAAGGCTCT GGAGGCACTG GTGGCAAAGG GGCTGGTGAA AGCCTTGGGC 
TTGTCCAACT TCAGCAGTCG GCAGATAGAT GATGTCCTCA GTGTGGCCTC GGTGCGCCCA 
GCTGTCTTGC AGGTGGAATG CCATCCATAC CTGGCTCAAA ATGAGCTCAT TGCCCACTGT 
CAAGCACGAG GCTTGGAGGT GACAGCTTAC AGCCCCTTGG GTTCATCGGA TCGTGCTTGG 
CGCCACCCTG ATGAGCCAGT CCTGCTTGAG GAACCAGTTG TCTTGGCACT AGCTGAAAAA 
CATGGCCGAT CTCCAGCTCA GATCTTGCTC AGATGGCAGG TTCAGCGGAA AGTAATCTGC 
ATCCCCAAAA GCATCACTCC TTCCCGCATC CTTCAGAACA TTCAGGTATT TGATTTCACC 
TTTAGTCCAG AGGAGATGAA GCAATTAGAT GCTCTGAACA AAAATTGGCG GTATATTGTG 
CCCATGATTA CGGTGGATGG GAAGAGAGTC CCCAGAGATG CTGGACACCC TCTGTATCCC 
TTTAATGACC CATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112262.1
CDS	54..1031
Translation	MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY

Target ORF information:

RefSeq Version	NM_031000.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1 member A1 (Akr1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031000.3

ORF Insert Sequence:

ATGACGGCCT CCAGTGTCCT CCTGCACACT GGACAGAAGA TGCCTCTGAT TGGTCTGGGG 
ACATGGAAGA GTGAGCCTGG TCAGGTGAAA GCAGCTATTA AATATGCCCT TAGCGTAGGC 
TACCGCCACA TTGACTGTGC TTCTGTATAT GGCAATGAAA CTGAGATTGG AGAGGCCCTG 
AAGGAGAGTG TGGGAGCAGG CAAGGCAGTA CCTCGAGAGG AGCTGTTTGT GACCTCCAAG 
CTGTGGAATA CTAAGCACCA CCCTGAGGAT GTAGAACCTG CTGTCCGGAA GACGCTGGCT 
GATCTGCAGC TGGAGTATTT GGACCTCTAT TTGATGCATT GGCCTTATGC CTTCGAGCGG 
GGAGACAATC CCTTTCCCAA GAATGCCGAT GGAACTGTCA AATATGACTC CACTCACTAT 
AAGGAGACCT GGAAGGCTCT GGAGGCACTG GTGGCAAAGG GGCTGGTGAA AGCCTTGGGC 
TTGTCCAACT TCAGCAGTCG GCAGATAGAT GATGTCCTCA GTGTGGCCTC GGTGCGCCCA 
GCTGTCTTGC AGGTGGAATG CCATCCATAC CTGGCTCAAA ATGAGCTCAT TGCCCACTGT 
CAAGCACGAG GCTTGGAGGT GACAGCTTAC AGCCCCTTGG GTTCATCGGA TCGTGCTTGG 
CGCCACCCTG ATGAGCCAGT CCTGCTTGAG GAACCAGTTG TCTTGGCACT AGCTGAAAAA 
CATGGCCGAT CTCCAGCTCA GATCTTGCTC AGATGGCAGG TTCAGCGGAA AGTAATCTGC 
ATCCCCAAAA GCATCACTCC TTCCCGCATC CTTCAGAACA TTCAGGTATT TGATTTCACC 
TTTAGTCCAG AGGAGATGAA GCAATTAGAT GCTCTGAACA AAAATTGGCG GTATATTGTG 
CCCATGATTA CGGTGGATGG GAAGAGAGTC CCCAGAGATG CTGGACACCC TCTGTATCCC 
TTTAATGACC CATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Biochemical and biophysical research communications452(1)136-41(2014 Sep)
Kurahashi T,Kwon M,Homma T,Saito Y,Lee J,Takahashi M,Yamada K,Miyata S,Fujii J

Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases.
Prostaglandins & other lipid mediators106124-32(2013 Oct)
Lacroix P?pin N,Chapdelaine P,Fortier MA

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Molecular bioSystems9(6)1108-16(2013 Jun)
Pieragostino D,Agnifili L,Fasanella V,D'Aguanno S,Mastropasqua R,Di Ilio C,Sacchetta P,Urbani A,Del Boccio P

In vivo role of aldehyde reductase.
Biochimica et biophysica acta1820(11)1787-96(2012 Nov)
Takahashi M,Miyata S,Fujii J,Inai Y,Ueyama S,Araki M,Soga T,Fujinawa R,Nishitani C,Ariki S,Shimizu T,Abe T,Ihara Y,Nishikimi M,Kozutsumi Y,Taniguchi N,Kuroki Y

Doxorubicin pathways: pharmacodynamics and adverse effects.
Pharmacogenetics and genomics21(7)440-6(2011 Jul)
Thorn CF,Oshiro C,Marsh S,Hernandez-Boussard T,McLeod H,Klein TE,Altman RB

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Akr1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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