Gpr17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr17
Entrez Gene ID	767613
Full Name	G protein-coupled receptor 17
General protein information	Preferred Names G protein-coupled receptor 17 Names uracil nucleotide/cysteinyl leukotriene receptor UDP/CysLT receptor gpr17
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001071777.1	NP_001065245.1	uracil nucleotide/cysteinyl leukotriene receptor
XM_006254604.3	XP_006254666.1	uracil nucleotide/cysteinyl leukotriene receptor isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	gpr17	XP_004917917.1
Canis lupus familiaris (dog)	GPR17	XP_005631925.1
Rattus norvegicus (Norway rat)	Gpr17	NP_001065245.1
Homo sapiens (human)	GPR17	NP_001154887.1
Mus musculus (house mouse)	Gpr17	NP_001020552.1
Danio rerio (zebrafish)	si:ch73-194h10.4	XP_005166015.1
Pan troglodytes (chimpanzee)	GPR17	XP_003309280.1
	GPR17	XP_001089260.1
Bos taurus (cattle)	GPR17	NP_001075939.1
Gallus gallus (chicken)	GPR17	XP_001231870.1

Gene Ontology
Bibliography

Related articles in PubMed

Zhenbao pill protects against acute spinal cord injury via
He Y, Lv B, Huan Y, Liu B, Li Y, Jia L, Qu C, Wang D, Yu H, Yuan H
Bioscience reports38(1)(2018 Feb)

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.
Simon K, Merten N, Schr?der R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E
Molecular pharmacology91(5)518-532(2017 May)

A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro.
Boccazzi M, Lecca D, Marangon D, Guagnini F, Abbracchio MP, Ceruti S
Purinergic signalling12(4)661-672(2016 Dec)

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via G?i/o and Its Downstream Effector Molecules.
Simon K, Hennen S, Merten N, Bl?ttermann S, Gillard M, Kostenis E, Gomeza J
The Journal of biological chemistry291(2)705-18(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.
Title: The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.

These data show a co-localization between neuronal markers and GPR17 in vitro, and suggest that, besides its involvement in oligodendrogenesis, GPR17 can drive the fate of neural precursor cells by instructing precursors towards the neuronal lineage.
Title: A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro.

stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway.
Title: The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via G?i/o and Its Downstream Effector Molecules.

Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17.
Title: Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells
Title: The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells.

The following Gpr17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00052	NM_001071777.1 Latest version!	Rattus norvegicus G protein-coupled receptor 17 (Gpr17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa00052	XM_006254604.3 Latest version!	Rattus norvegicus G protein-coupled receptor 17 (Gpr17), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr17 ( NM_001071777.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001065245.1 Rattus norvegicus G protein-coupled receptor 17 (Gpr17), mRNA.

Price & Availability↑

CloneID	ORa00052
Clone ID Related Accession (Same CDS sequence)	NM_001071777.1 , XM_006254604.3
Accession Version	NM_001071777.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	uracil nucleotide/cysteinyl leukotriene receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ777767.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ777767.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATGGCC TCGAGACAGC CCTACCGAGT CTGACTGACA ATGCCTCCCT GGCTTACTCT 
GAACAATGTG GCCAAGAGAC GCCCCTGGAG AACATGCTCT TCGCCTGCTT CTACCTCCTG 
GACTTCATCC TAGCTTTTGT GGGCAACGCT CTGGCCCTCT GGCTTTTCAT CTGGGATCAC 
AAGTCAGGCA CTCCGGCCAA CGTGTTCCTA ATGCACCTGG CTGTGGCCGA CTTGTCCTGT 
GTGCTGGTCC TGCCTACCCG GTTGGTTTAT CACTTCTCTG GCAATCACTG GCCTTTTGGG 
GAAATCCCGT GCCGACTCAC TGGCTTCCTC TTCTACCTGA ATATGTACGC CAGCATCTAC 
TTCCTCACCT GCATCAGTGC TGACCGGTTC CTGGCCATTG TGCACCCAGT CAAGTCCCTC 
AAGCTTCGAA GACCTCTCTA TGCCCACCTG GCCTGCGCCT TCCTGTGGAT CGTGGTGGCC 
GTGGCTATGG CCCCACTGCT AGTGAGTCCG CAGACTGTGC AGACCAACCA CACGGTTGTC 
TGCCTGCAAC TGTACCGGGA GAAGGCCTCC CATCATGCCC TGGCTTCCCT GGCTGTGGCT 
TTTACCTTCC CCTTCATCAC CACGGTCACC TGCTACCTGC TGATCATTCG CAGCCTCCGC 
CAGGGTCCCC GTATAGAGAA GCACCTCAAG AATAAAGCCG TCCGCATGAT TGCTATGGTT 
CTGGCCATCT TCCTGATTTG TTTTGTGCCC TACCACATCC ACCGTTCAGT CTATGTGCTT 
CACTACCGCG GTGGTGGGAC TTCGTGCTCA GCTCAGCGTG CCCTGGCCCT AGGGAACCGG 
ATCACCTCCT GCCTCACCAG CCTCAACGGG GCCCTGGATC CAGTCATGTA CTTCTTTGTG 
GCTGAGAAAT TCCGCCACGC CTTGTGCAAC TTGCTCTGCA GCAAACGACT CACAGGTCCT 
CCTCCCAGCT TTGAAGGGAA AACCAACGAG AGCTCCCTGA GCGCTCGGTC TGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001065245.1
CDS	1..1020
Translation	MDGLETALPSLTDNASLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCSAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL

Target ORF information:

RefSeq Version	NM_001071777.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 17 (Gpr17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001071777.1

ORF Insert Sequence:

ATGGATGGCC TCGAGACAGC CCTACCGAGT CTGACTGACA ATGCCTCCCT GGCTTACTCT 
GAACAATGTG GCCAAGAGAC GCCCCTGGAG AACATGCTCT TCGCCTGCTT CTACCTCCTG 
GACTTCATCC TAGCTTTTGT GGGCAACGCT CTGGCCCTCT GGCTTTTCAT CTGGGATCAC 
AAGTCAGGCA CTCCGGCCAA CGTGTTCCTA ATGCACCTGG CTGTGGCCGA CTTGTCCTGT 
GTGCTGGTCC TGCCTACCCG GTTGGTTTAT CACTTCTCTG GCAATCACTG GCCTTTTGGG 
GAAATCCCGT GCCGACTCAC TGGCTTCCTC TTCTACCTGA ATATGTACGC CAGCATCTAC 
TTCCTCACCT GCATCAGTGC TGACCGGTTC CTGGCCATTG TGCACCCAGT CAAGTCCCTC 
AAGCTTCGAA GACCTCTCTA TGCCCACCTG GCCTGCGCCT TCCTGTGGAT CGTGGTGGCC 
GTGGCTATGG CCCCACTGCT AGTGAGTCCG CAGACTGTGC AGACCAACCA CACGGTTGTC 
TGCCTGCAAC TGTACCGGGA GAAGGCCTCC CATCATGCCC TGGCTTCCCT GGCTGTGGCT 
TTTACCTTCC CCTTCATCAC CACGGTCACC TGCTACCTGC TGATCATTCG CAGCCTCCGC 
CAGGGTCCCC GTATAGAGAA GCACCTCAAG AATAAAGCCG TCCGCATGAT TGCTATGGTT 
CTGGCCATCT TCCTGATTTG TTTTGTGCCC TACCACATCC ACCGTTCAGT CTATGTGCTT 
CACTACCGCG GTGGTGGGAC TTCGTGCTCA GCTCAGCGTG CCCTGGCCCT AGGGAACCGG 
ATCACCTCCT GCCTCACCAG CCTCAACGGG GCCCTGGATC CAGTCATGTA CTTCTTTGTG 
GCTGAGAAAT TCCGCCACGC CTTGTGCAAC TTGCTCTGCA GCAAACGACT CACAGGTCCT 
CCTCCCAGCT TTGAAGGGAA AACCAACGAG AGCTCCCTGA GCGCTCGGTC TGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpr17 ( XM_006254604.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254666.1 Rattus norvegicus G protein-coupled receptor 17 (Gpr17), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00052
Clone ID Related Accession (Same CDS sequence)	NM_001071777.1 , XM_006254604.3
Accession Version	XM_006254604.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	uracil nucleotide/cysteinyl leukotriene receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254604.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGGCC TCGAGACAGC CCTACCGAGT CTGACTGACA ATGCCTCCCT GGCTTACTCT 
GAACAATGTG GCCAAGAGAC GCCCCTGGAG AACATGCTCT TCGCCTGCTT CTACCTCCTG 
GACTTCATCC TAGCTTTTGT GGGCAACGCT CTGGCCCTCT GGCTTTTCAT CTGGGATCAC 
AAGTCAGGCA CTCCGGCCAA CGTGTTCCTA ATGCACCTGG CTGTGGCCGA CTTGTCCTGT 
GTGCTGGTCC TGCCTACCCG GTTGGTTTAT CACTTCTCTG GCAATCACTG GCCTTTTGGG 
GAAATCCCGT GCCGACTCAC TGGCTTCCTC TTCTACCTGA ATATGTACGC CAGCATCTAC 
TTCCTCACCT GCATCAGTGC TGACCGGTTC CTGGCCATTG TGCACCCAGT CAAGTCCCTC 
AAGCTTCGAA GACCTCTCTA TGCCCACCTG GCCTGCGCCT TCCTGTGGAT CGTGGTGGCC 
GTGGCTATGG CCCCACTGCT AGTGAGTCCG CAGACTGTGC AGACCAACCA CACGGTTGTC 
TGCCTGCAAC TGTACCGGGA GAAGGCCTCC CATCATGCCC TGGCTTCCCT GGCTGTGGCT 
TTTACCTTCC CCTTCATCAC CACGGTCACC TGCTACCTGC TGATCATTCG CAGCCTCCGC 
CAGGGTCCCC GTATAGAGAA GCACCTCAAG AATAAAGCCG TCCGCATGAT TGCTATGGTT 
CTGGCCATCT TCCTGATTTG TTTTGTGCCC TACCACATCC ACCGTTCAGT CTATGTGCTT 
CACTACCGCG GTGGTGGGAC TTCGTGCTCA GCTCAGCGTG CCCTGGCCCT AGGGAACCGG 
ATCACCTCCT GCCTCACCAG CCTCAACGGG GCCCTGGATC CAGTCATGTA CTTCTTTGTG 
GCTGAGAAAT TCCGCCACGC CTTGTGCAAC TTGCTCTGCA GCAAACGACT CACAGGTCCT 
CCTCCCAGCT TTGAAGGGAA AACCAACGAG AGCTCCCTGA GCGCTCGGTC TGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254666.1
CDS	2429..3448
Translation	MDGLETALPSLTDNASLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCSAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL

Target ORF information:

RefSeq Version	XM_006254604.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 17 (Gpr17), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254604.3

ORF Insert Sequence:

ATGGATGGCC TCGAGACAGC CCTACCGAGT CTGACTGACA ATGCCTCCCT GGCTTACTCT 
GAACAATGTG GCCAAGAGAC GCCCCTGGAG AACATGCTCT TCGCCTGCTT CTACCTCCTG 
GACTTCATCC TAGCTTTTGT GGGCAACGCT CTGGCCCTCT GGCTTTTCAT CTGGGATCAC 
AAGTCAGGCA CTCCGGCCAA CGTGTTCCTA ATGCACCTGG CTGTGGCCGA CTTGTCCTGT 
GTGCTGGTCC TGCCTACCCG GTTGGTTTAT CACTTCTCTG GCAATCACTG GCCTTTTGGG 
GAAATCCCGT GCCGACTCAC TGGCTTCCTC TTCTACCTGA ATATGTACGC CAGCATCTAC 
TTCCTCACCT GCATCAGTGC TGACCGGTTC CTGGCCATTG TGCACCCAGT CAAGTCCCTC 
AAGCTTCGAA GACCTCTCTA TGCCCACCTG GCCTGCGCCT TCCTGTGGAT CGTGGTGGCC 
GTGGCTATGG CCCCACTGCT AGTGAGTCCG CAGACTGTGC AGACCAACCA CACGGTTGTC 
TGCCTGCAAC TGTACCGGGA GAAGGCCTCC CATCATGCCC TGGCTTCCCT GGCTGTGGCT 
TTTACCTTCC CCTTCATCAC CACGGTCACC TGCTACCTGC TGATCATTCG CAGCCTCCGC 
CAGGGTCCCC GTATAGAGAA GCACCTCAAG AATAAAGCCG TCCGCATGAT TGCTATGGTT 
CTGGCCATCT TCCTGATTTG TTTTGTGCCC TACCACATCC ACCGTTCAGT CTATGTGCTT 
CACTACCGCG GTGGTGGGAC TTCGTGCTCA GCTCAGCGTG CCCTGGCCCT AGGGAACCGG 
ATCACCTCCT GCCTCACCAG CCTCAACGGG GCCCTGGATC CAGTCATGTA CTTCTTTGTG 
GCTGAGAAAT TCCGCCACGC CTTGTGCAAC TTGCTCTGCA GCAAACGACT CACAGGTCCT 
CCTCCCAGCT TTGAAGGGAA AACCAACGAG AGCTCCCTGA GCGCTCGGTC TGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zhenbao pill protects against acute spinal cord injury via
Bioscience reports38(1)(2018 Feb)
He Y,Lv B,Huan Y,Liu B,Li Y,Jia L,Qu C,Wang D,Yu H,Yuan H

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.
Molecular pharmacology91(5)518-532(2017 May)
Simon K,Merten N,Schr?der R,Hennen S,Preis P,Schmitt NK,Peters L,Schrage R,Vermeiren C,Gillard M,Mohr K,Gomeza J,Kostenis E

A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro.
Purinergic signalling12(4)661-672(2016 Dec)
Boccazzi M,Lecca D,Marangon D,Guagnini F,Abbracchio MP,Ceruti S

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via G?i/o and Its Downstream Effector Molecules.
The Journal of biological chemistry291(2)705-18(2016 Jan)
Simon K,Hennen S,Merten N,Bl?ttermann S,Gillard M,Kostenis E,Gomeza J

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Gpr17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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