Pcdh15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pcdh15
Entrez Gene ID	690865
Full Name	protocadherin related 15
General protein information	Preferred Names protocadherin related 15 Names protocadherin-15 protocadherin 15
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271377.1	NP_001258306.1	protocadherin-15 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PCDH15	XP_003433494.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002310	XP_312660.5
Mus musculus (house mouse)	Pcdh15	NP_001136214.1
Danio rerio (zebrafish)	pcdh15b	NP_001012504.1
Drosophila melanogaster (fruit fly)	Cad99C	NP_001189311.1
Rattus norvegicus (Norway rat)	Pcdh15	NP_001258306.1
Danio rerio (zebrafish)	pcdh15a	NP_001012500.1
Homo sapiens (human)	PCDH15	NP_001136241.1
Pan troglodytes (chimpanzee)	PCDH15	XP_507798.3
	PCDH15	XP_002805772.1
Bos taurus (cattle)	LOC100140108	XP_005225407.1
Gallus gallus (chicken)	PCDH15	NP_001038119.1
Caenorhabditis elegans (roundworm)	cdh-5	NP_501487.1
Xenopus tropicalis (tropical clawed frog)	pcdh15	XP_004916517.1

Gene Ontology
Bibliography

Related articles in PubMed

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A, Petit C
The Journal of cell biology212(2)231-44(2016 Jan)

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.
Xiong W, Grillet N, Elledge HM, Wagner TF, Zhao B, Johnson KR, Kazmierczak P, M?ller U
Cell151(6)1283-95(2012 Dec)

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG
The Journal of biological chemistry287(45)37628-46(2012 Nov)

Sensing sound: molecules that orchestrate mechanotransduction by hair cells.
Kazmierczak P, M?ller U
Trends in neurosciences35(4)220-9(2012 Apr)

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain.
Webb SW, Grillet N, Andrade LR, Xiong W, Swarthout L, Della Santina CC, Kachar B, M?ller U
Development (Cambridge, England)138(8)1607-17(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Since the rat is more advantageous for clinical and pharmacological studies than the mouse, the KCI rat strain may be a better disease model for Pcdh15-deficit USH1F and DFNB23.
Title: Characterization of the Kyoto circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene.

The following Pcdh15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pcdh15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41740	NM_001271377.1 Latest version!	Rattus norvegicus protocadherin related 15 (Pcdh15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pcdh15 ( NM_001271377.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258306.1 Rattus norvegicus protocadherin related 15 (Pcdh15), mRNA.

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CloneID	ORa41740
Clone ID Related Accession (Same CDS sequence)	NM_001271377.1
Accession Version	NM_001271377.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5376bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-30
Organism	Rattus norvegicus(Norway rat)
Product	protocadherin-15 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01100289.1, AAHX01100280.1, AAHX01100277.1, AAHX01100275.1, AAHX01100273.1, AAHX01100272.1, AAHX01100270.1, AAHX01100268.1, AAHX01100267.1, AAHX01100265.1, AAHX01100264.1, AAHX01100263.1, AAHX01100261.1 and AAHX01100260.1. On or before Sep 20, 2012 this sequence version replaced XM_002725815.1, XM_002725816.1, XM_002725817.1, XM_002725818.1, XM_002725819.1, XM_002725820.1, XM_002725821.1, XM_002725822.1, XM_002725823.1, XM_003753459.1, XM_002725824.1, XM_002728937.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTCCCCAC AGTTTGCTCT GTGGAAGTGT ATGCCCCATG GGATCCTCCT TGCCTCACTC 
TTGATAGTCA GCTGGGGCCA ATATGATGAT GACTGGCAAT ATGAGGATTG TAAACTAGCT 
AGGGGAGGAC CACCAGCTAC CATTGTGGCC ATTGATGAAG AGAGTCGGAA TGGTACAATT 
CTGGTGGACA ACATGTTGAT TAAGGGGACT GCCGGAGGAC CAGACCCCAC CATAGAGCTC 
TCTTTAAAGG ACAACGTGGA CTACTGGGTG TTACTGGACC CCGTTAAGCA GATGCTTTTC 
CTCAACAGTA CCGGAAGAGT TCTGGATAGA GACCCACCGA TGAACATACA CTCCATTGTA 
GTCCAAGTCC AGTGTGTCAA CAAGAAGGTT GGCACAGTGA TCTATCATGA AGTACGCATC 
GTGGTGCGGG ACCGGAATGA CAACTCACCC ACATTCAAGC ATGAGAGCTA CTATGCCACC 
GTGAATGAGC TCACTCCGGT CGGCACCACA ATATTCACGG GGTTTGCGGG AGACAACGGA 
GCCACAGACA TAGACGATGG CCCTAACGGA CAGATAGAAT ACGTCATTCA GTACAACCCA 
GAAGATCCGA CATCCAATGA CACCTTCGAA ATTCCACTCA TGTTGACTGG CAACGTGGTG 
CTGAGGAAAA GACTCAACTA CGAGGATAAG ACTCGCTACT ACGTCATCAT CCAAGCTAAT 
GACCGTGCAC AAAATCTGAA TGAGAGGCGA ACAACTACTA CCACCCTCAC AGTAGACGTT 
CTAGATGGAG ATGATCTGGG ACCAATGTTT CTGCCCTGTG TTCTTGTGCC AAATACCCGT 
GACTGCCGTC CACTCACCTA TCAAGCTGCC ATTCCTGAAC TGAGGACTCC GGAAGAACTG 
AACCCTATTT TGGTGACCCC ACCTATCCAA GCCATTGACC AGGACCGAAA CATCCAACCA 
CCATCTGATC GACCTGGCAT CCTCTACTCC ATTCTTGTTG GCACCCCTGA GGATTACCCC 
CGCTTCCTCC ACATGCATCC CAGGACTGCA GAACTCACTC TCCTGGAGCC AGTAAACAGA 
GACTTCCATC AAAAGTTTGA TTTGGTTATT AAGGCCGAAC AGGACAATGG CCACCCGCTG 
CCTGCCTTTG CTAGTCTACA CATCGAGATA CTGGACGAAA ATAATCAGAG TCCATACTTT 
ACAATGCCCA GCTATCAAGG GTACATTCTG GAATCTGCCC CAGTGGGAGC CACCATTTCT 
GAGAGCCTGA ACTTAACCAC GCCTCTGAGA ATTGTAGCTC TGGACAAAGA CATAGAAGAC 
GTGCCACCTG GTGGAGTTCC TACAAAGGAC CCGGAGCTCC ACCTTTTCCT GAATGATTAC 
ACCTCGGTCT TCACCGTGAC ACCCACCGGT ATCACCCGCT ACCTCACCCT GCTTCAACCT 
GTGGACAGGG AGGAACAGCA AACCTATACC TTTCTGATAA CAGCGTTCGA TGGCGTGCAG 
GAGAGCGAGC CAGTGGTGGT CAATATCCGA GTGATGGATG CCAATGACAA CACGCCCACC 
TTCCCTGAGA TCTCCTACAA TGTCTATGTT TACACGGACA TGAGTCCCGG GGACAGTGTC 
ATCCAGCTGA CTGCAGTGGA CGCTGATGAA GGCTCTAACG GGGAGATCTC CTATGAAATA 
CTAGTGGGCA GCAAGGGAGA CTTCGTGATC AACAGGACCA CGGGGCTGGT GAGCATCGCG 
CCAGGAGTGG AGCTGGTCGT GGGACAGACG TATGCGCTCA CGGTACAGGC TTCGGACAAC 
GCCCCGCCCG CAGAGAGAAG GCACTCCATC TGCACGGTGT ACATCGAGGT GCTGCCTCCC 
AACAACCAGA GCCCTCCGCG TTTCCCACAG CTGATGTACA GTCTGGAAGT CAGCGAAGCC 
ATGAGGATCG GCGCGGTTTT ATTAAATCTA CAGGCAACTG ATCGAGAGGG AGACCCAATC 
ACATATGCCA TCGAGAATGG AGACCCTCAG CGAGTTTTTA ATCTTTCAGA AACCACAGGG 
ATTCTCAGCC TAGGGAAGGC TCTAGATCGA GAGAGCACGG ACCGCTACAT CCTCATCGTC 
ACAGCCTCAG ATGGCAGGCC AGATGGAACC TCAACTGCCA CTGTGAACAT AGTGGTGACA 
GACGTCAATG ATAACGCTCC CGTGTTCGAT CCCTATCTGC CCAGGAACCT CTCTGTGGTG 
GAGGAAGAGG CCAATGCCTT TGTGGGTCAA GTCCGGGCGA CAGACCCAGA TGCTGGGATA 
AATGGCCAAG TGCACTACAG CCTGGGGAAT TTCAACAACC TCTTCCGCAT CACGTCCAAC 
GGGAGCATTT ACACAGCCGT GAAGCTGAAC AGGGAAGCCA GGGACCACTA TGAACTGGTT 
GTTGTGGCAA CAGATGGAGC TGTACACCCT CGACATTCAA CTCTGACACT GTACATCAAG 
GTGTTGGACA TTGACGATAA CAGCCCTGTT TTTACCAATT CAACGTACAC GGTTGTTGTT 
GAAGAGAACC TGCCAGCCGG GACCGCCTTC CTTCAAATAG AGGCCAAGGA TGTTGATCTT 
GGAGCCAATG TGTCCTATCG GATCAGAAGC CCGGAAGTGA AGCACCTCTT TGCACTGCAT 
CCATTTACTG GGGAATTGTC TCTTCTGAGG AGTTTGGATT ATGAGGCCTT TCCCGACCAA 
GAGGCAAGCA TCACGTTCTT GGTGGAGGCC TTTGATATTT ATGGGACGAT GCCACCCGGT 
ATAGCAACGG TCACAGTAAT TGTGAAGGAC ATGAATGACT ACCCTCCGGT GTTTAGCAAA 
CGCATCTACA AGGGGATGGT GGCTCCAGAT GCCGTCAAGG GGACACCAAT TACCACTGTT 
TATGCTGAAG ACGCAGACCC ACCAGGGTTG CCAGCAAGTC GGGTGAGGTA CCGAGTGGAT 
GATGTGCAGT TTCCATACCC GGCCAGTATT TTTGACGTAG AGGAAGATTC TGGAAGAGTA 
ATAACCCGTG TTAATCTTAA TGAAGAGCCT ACAACAATTT TTAAGCTGGT GGTTGTGGCT 
TTTGATGATG GTGAACCTGT GATGTCCAGC AGTGCCACTG TGAGAATTCT TGTCTTACAT 
CCTGGAGAGA TCCCACGCTT CACCCAAGAG GAATACAGAC CTCCTCCTGT GAGCGAGCTT 
GCTGCCAGAG GGACTGTAGT AGGCGTCATT TCTGCTGCCG CCATCAATCA GAGCATCGTG 
TACTCCATTG TGGCAGGAAA TGAGGACGAT AAATTTGGAA TCAACAATGT CACTGGCGTC 
ATCTATGTGA ATTCCCCACT GGATTACGAG ACAAGGACTA GCTATGTGCT CCGGGTGCAA 
GCAGATTCTC TGGAAGTGGT CCTCGCCAAT CTCCGAGTCC CTTCAAAAAG CAATACAGCT 
AAGGTGTACA TTGAGATTCA GGATGAAAAC GATCACCCCC CAGTGTTCCA GAAGAAATTC 
TACATTGGAG GTGTGTCTGA AGACGCGAGG ATGTTCACGT CTGTGCTCAG AGTGAAGGCC 
ACTGACAGGG ACACAGGAAA TTATAGCGCC ATGGCCTACA GACTCATCAT ACCACCGATT 
AAAGAGGGCA AAGAGGGGTT TGTGGTGGAA ACATACACGG GGCTCATCAA GACAGCCATG 
CTCTTCCACA ATATGAGAAG ATCCTACTTC AAGTTTCAAG TGATTGCAAC CGACGACTAC 
GGGAAGGGGT TGAGCGGGAA AGCGGACGTA CTGGTCTCCG TGGTCAATCA ACTGGATATG 
CAGGTCATTG TCTCCAATGT GCCCCCTACA TTAGTGGAAA AGAAGATAGA AGATCTTACA 
GAGATTTTGG ATCGCTATGT TCAGGAGCAA ATTCCTGGTG CCAAAGTTGT TGTAGAGTCC 
ATTGGTGCCC GGCGCCATGG AGACGCCTTC TCCCTAGAAG ACTATAGCAA GTGTGACCTG 
ACCGTCTATG CCATCGACCC TCAGACCAAC AGAGCCATCG ACAGAAATGA GCTTTTTAAG 
TTCCTGGACG GCAAACTGCT TGATATCAAT AAAGACTTCC AGCCGTATTA CGGGGAAGGA 
GGACGCATCC TGGAGATTCG GACTCCCGAA GCAGTGACGA GCATCAAGAA GCGAGGAGAG 
AGCTTGGGGT ACACAGAAGG GGCCTTGCTG GCCTTGGCCT TCATCATTAT CCTCTGCTGC 
ATCCCAGCCA TCTTGGTCGT CTTAGTGAGC TACCGACAAT TTAAAGTACG CCAGGCTGAG 
TGCACGAAGA CTGCAAGGAT TCAGTCTGCT ATGCCTGCAG CCAAGCCTGC AGCTCCTGTA 
CCTGCTGCGC CCCCACCACC GCCGCCGCCA CCACCACCAG GAGCACATCT CTATGAAGAA 
CTGGGAGAGA GCGCCATGCA TAAGTATGAG ATGCCCCAGT ATGGAAGTCG CCGCCGACTG 
CTGCCACCTG CTGGACAGGA GGAATACGGC GAAGTCATTG GTGAAGCTGA AGAGGAGTAT 
GAAGAGGAAG AGGTAAGTCC AGAGAAAGTT AAAAAGCCCA AAGTTGAAAT TAGAGAGCCT 
AGTGAGGAAG AGGTGGTAGT CACCGTTGAG AAGCCACCAG CGGCTGAGCC CACCTACCCG 
ACGTGGAAGA GAGCCAGGAT CTTCCCAATG ATCTTTAAGA AAGTCAGGGG TCTCGCTGAG 
AAAAGAGGCA TTGACCTTGA GGGCGAGGAG TGGAGGAGGC GCCTTGAGGA AGAAGACAAG 
GACTATCTCC AACTGACTCT AGACCAGGAG GAAGCCACGG AGAGCACCGT GGAGTCAGAG 
GAGGAGTCCA GCGACTACAC GGAATACACA GAAACCGAGT CTGAGTTCAG CGAGTCCGAG 
ACCACTGAAG AATCCGAGTC GGAGACCCCA TCTGAGGAGG CAGAGGAAAG CTCGACCCCG 
GAGTCAGAGG AGTCTGAGTC CACCGAGTCA GAGGGAGAGA AGGCAAGGAA AAACATCGTG 
CTAGCAAGAA GAAGACCCGT GGTAGAAGAA ATCCAAGAAG TGAAGGGTAA GAAAGAGGAG 
CCGCCTGTAG AGCAGGAAGA AGAGCCCCCG GGGGAGGAGG AAGAACGGCC AGAGGAAGGA 
GAAGAAAGCG AAGCAGCTCC CATGGATGAA TCCACAGACC TGGAGGCTCA GGATGTCCCA 
GAGGAGGGCA GCGCAGAATC AGCCTCGGTG GAGAGGGGCG TGGAAAGTGA GGAGGAATCG 
GAGTCAGAAG TGAGCAGTAG CAGCAGCAGC AGCAGCAGTG AGAGCCTCTC TGGAGGCCCC 
TGGGGGTTCC AGGTACCAGA GTATGACAGG AGGAAGGAGG AAGATGCCAA GAAATCTCCA 
GGCGCAAACT CCGAAGGATA CAACACAGCC CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258306.1
CDS	1..5376
Translation	MSPQFALWKCMPHGILLASLLIVSWGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFAGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFLHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDVPPGGVPTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYNVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGSKGDFVINRTTGLVSIAPGVELVVGQTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAVLLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTAFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVYSIVAGNEDDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFTSVLRVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQSAMPAAKPAAPVPAAPPPPPPPPPPGAHLYEELGESAMHKYEMPQYGSRRRLLPPAGQEEYGEVIGEAEEEYEEEEVSPEKVKKPKVEIREPSEEEVVVTVEKPPAAEPTYPTWKRARIFPMIFKKVRGLAEKRGIDLEGEEWRRRLEEEDKDYLQLTLDQEEATESTVESEEESSDYTEYTETESEFSESETTEESESETPSEEAEESSTPESEESESTESEGEKARKNIVLARRRPVVEEIQEVKGKKEEPPVEQEEEPPGEEEERPEEGEESEAAPMDESTDLEAQDVPEEGSAESASVERGVESEEESESEVSSSSSSSSSESLSGGPWGFQVPEYDRRKEEDAKKSPGANSEGYNTAL

Target ORF information:

RefSeq Version	NM_001271377.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protocadherin related 15 (Pcdh15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271377.1

ORF Insert Sequence:

ATGTCCCCAC AGTTTGCTCT GTGGAAGTGT ATGCCCCATG GGATCCTCCT TGCCTCACTC 
TTGATAGTCA GCTGGGGCCA ATATGATGAT GACTGGCAAT ATGAGGATTG TAAACTAGCT 
AGGGGAGGAC CACCAGCTAC CATTGTGGCC ATTGATGAAG AGAGTCGGAA TGGTACAATT 
CTGGTGGACA ACATGTTGAT TAAGGGGACT GCCGGAGGAC CAGACCCCAC CATAGAGCTC 
TCTTTAAAGG ACAACGTGGA CTACTGGGTG TTACTGGACC CCGTTAAGCA GATGCTTTTC 
CTCAACAGTA CCGGAAGAGT TCTGGATAGA GACCCACCGA TGAACATACA CTCCATTGTA 
GTCCAAGTCC AGTGTGTCAA CAAGAAGGTT GGCACAGTGA TCTATCATGA AGTACGCATC 
GTGGTGCGGG ACCGGAATGA CAACTCACCC ACATTCAAGC ATGAGAGCTA CTATGCCACC 
GTGAATGAGC TCACTCCGGT CGGCACCACA ATATTCACGG GGTTTGCGGG AGACAACGGA 
GCCACAGACA TAGACGATGG CCCTAACGGA CAGATAGAAT ACGTCATTCA GTACAACCCA 
GAAGATCCGA CATCCAATGA CACCTTCGAA ATTCCACTCA TGTTGACTGG CAACGTGGTG 
CTGAGGAAAA GACTCAACTA CGAGGATAAG ACTCGCTACT ACGTCATCAT CCAAGCTAAT 
GACCGTGCAC AAAATCTGAA TGAGAGGCGA ACAACTACTA CCACCCTCAC AGTAGACGTT 
CTAGATGGAG ATGATCTGGG ACCAATGTTT CTGCCCTGTG TTCTTGTGCC AAATACCCGT 
GACTGCCGTC CACTCACCTA TCAAGCTGCC ATTCCTGAAC TGAGGACTCC GGAAGAACTG 
AACCCTATTT TGGTGACCCC ACCTATCCAA GCCATTGACC AGGACCGAAA CATCCAACCA 
CCATCTGATC GACCTGGCAT CCTCTACTCC ATTCTTGTTG GCACCCCTGA GGATTACCCC 
CGCTTCCTCC ACATGCATCC CAGGACTGCA GAACTCACTC TCCTGGAGCC AGTAAACAGA 
GACTTCCATC AAAAGTTTGA TTTGGTTATT AAGGCCGAAC AGGACAATGG CCACCCGCTG 
CCTGCCTTTG CTAGTCTACA CATCGAGATA CTGGACGAAA ATAATCAGAG TCCATACTTT 
ACAATGCCCA GCTATCAAGG GTACATTCTG GAATCTGCCC CAGTGGGAGC CACCATTTCT 
GAGAGCCTGA ACTTAACCAC GCCTCTGAGA ATTGTAGCTC TGGACAAAGA CATAGAAGAC 
GTGCCACCTG GTGGAGTTCC TACAAAGGAC CCGGAGCTCC ACCTTTTCCT GAATGATTAC 
ACCTCGGTCT TCACCGTGAC ACCCACCGGT ATCACCCGCT ACCTCACCCT GCTTCAACCT 
GTGGACAGGG AGGAACAGCA AACCTATACC TTTCTGATAA CAGCGTTCGA TGGCGTGCAG 
GAGAGCGAGC CAGTGGTGGT CAATATCCGA GTGATGGATG CCAATGACAA CACGCCCACC 
TTCCCTGAGA TCTCCTACAA TGTCTATGTT TACACGGACA TGAGTCCCGG GGACAGTGTC 
ATCCAGCTGA CTGCAGTGGA CGCTGATGAA GGCTCTAACG GGGAGATCTC CTATGAAATA 
CTAGTGGGCA GCAAGGGAGA CTTCGTGATC AACAGGACCA CGGGGCTGGT GAGCATCGCG 
CCAGGAGTGG AGCTGGTCGT GGGACAGACG TATGCGCTCA CGGTACAGGC TTCGGACAAC 
GCCCCGCCCG CAGAGAGAAG GCACTCCATC TGCACGGTGT ACATCGAGGT GCTGCCTCCC 
AACAACCAGA GCCCTCCGCG TTTCCCACAG CTGATGTACA GTCTGGAAGT CAGCGAAGCC 
ATGAGGATCG GCGCGGTTTT ATTAAATCTA CAGGCAACTG ATCGAGAGGG AGACCCAATC 
ACATATGCCA TCGAGAATGG AGACCCTCAG CGAGTTTTTA ATCTTTCAGA AACCACAGGG 
ATTCTCAGCC TAGGGAAGGC TCTAGATCGA GAGAGCACGG ACCGCTACAT CCTCATCGTC 
ACAGCCTCAG ATGGCAGGCC AGATGGAACC TCAACTGCCA CTGTGAACAT AGTGGTGACA 
GACGTCAATG ATAACGCTCC CGTGTTCGAT CCCTATCTGC CCAGGAACCT CTCTGTGGTG 
GAGGAAGAGG CCAATGCCTT TGTGGGTCAA GTCCGGGCGA CAGACCCAGA TGCTGGGATA 
AATGGCCAAG TGCACTACAG CCTGGGGAAT TTCAACAACC TCTTCCGCAT CACGTCCAAC 
GGGAGCATTT ACACAGCCGT GAAGCTGAAC AGGGAAGCCA GGGACCACTA TGAACTGGTT 
GTTGTGGCAA CAGATGGAGC TGTACACCCT CGACATTCAA CTCTGACACT GTACATCAAG 
GTGTTGGACA TTGACGATAA CAGCCCTGTT TTTACCAATT CAACGTACAC GGTTGTTGTT 
GAAGAGAACC TGCCAGCCGG GACCGCCTTC CTTCAAATAG AGGCCAAGGA TGTTGATCTT 
GGAGCCAATG TGTCCTATCG GATCAGAAGC CCGGAAGTGA AGCACCTCTT TGCACTGCAT 
CCATTTACTG GGGAATTGTC TCTTCTGAGG AGTTTGGATT ATGAGGCCTT TCCCGACCAA 
GAGGCAAGCA TCACGTTCTT GGTGGAGGCC TTTGATATTT ATGGGACGAT GCCACCCGGT 
ATAGCAACGG TCACAGTAAT TGTGAAGGAC ATGAATGACT ACCCTCCGGT GTTTAGCAAA 
CGCATCTACA AGGGGATGGT GGCTCCAGAT GCCGTCAAGG GGACACCAAT TACCACTGTT 
TATGCTGAAG ACGCAGACCC ACCAGGGTTG CCAGCAAGTC GGGTGAGGTA CCGAGTGGAT 
GATGTGCAGT TTCCATACCC GGCCAGTATT TTTGACGTAG AGGAAGATTC TGGAAGAGTA 
ATAACCCGTG TTAATCTTAA TGAAGAGCCT ACAACAATTT TTAAGCTGGT GGTTGTGGCT 
TTTGATGATG GTGAACCTGT GATGTCCAGC AGTGCCACTG TGAGAATTCT TGTCTTACAT 
CCTGGAGAGA TCCCACGCTT CACCCAAGAG GAATACAGAC CTCCTCCTGT GAGCGAGCTT 
GCTGCCAGAG GGACTGTAGT AGGCGTCATT TCTGCTGCCG CCATCAATCA GAGCATCGTG 
TACTCCATTG TGGCAGGAAA TGAGGACGAT AAATTTGGAA TCAACAATGT CACTGGCGTC 
ATCTATGTGA ATTCCCCACT GGATTACGAG ACAAGGACTA GCTATGTGCT CCGGGTGCAA 
GCAGATTCTC TGGAAGTGGT CCTCGCCAAT CTCCGAGTCC CTTCAAAAAG CAATACAGCT 
AAGGTGTACA TTGAGATTCA GGATGAAAAC GATCACCCCC CAGTGTTCCA GAAGAAATTC 
TACATTGGAG GTGTGTCTGA AGACGCGAGG ATGTTCACGT CTGTGCTCAG AGTGAAGGCC 
ACTGACAGGG ACACAGGAAA TTATAGCGCC ATGGCCTACA GACTCATCAT ACCACCGATT 
AAAGAGGGCA AAGAGGGGTT TGTGGTGGAA ACATACACGG GGCTCATCAA GACAGCCATG 
CTCTTCCACA ATATGAGAAG ATCCTACTTC AAGTTTCAAG TGATTGCAAC CGACGACTAC 
GGGAAGGGGT TGAGCGGGAA AGCGGACGTA CTGGTCTCCG TGGTCAATCA ACTGGATATG 
CAGGTCATTG TCTCCAATGT GCCCCCTACA TTAGTGGAAA AGAAGATAGA AGATCTTACA 
GAGATTTTGG ATCGCTATGT TCAGGAGCAA ATTCCTGGTG CCAAAGTTGT TGTAGAGTCC 
ATTGGTGCCC GGCGCCATGG AGACGCCTTC TCCCTAGAAG ACTATAGCAA GTGTGACCTG 
ACCGTCTATG CCATCGACCC TCAGACCAAC AGAGCCATCG ACAGAAATGA GCTTTTTAAG 
TTCCTGGACG GCAAACTGCT TGATATCAAT AAAGACTTCC AGCCGTATTA CGGGGAAGGA 
GGACGCATCC TGGAGATTCG GACTCCCGAA GCAGTGACGA GCATCAAGAA GCGAGGAGAG 
AGCTTGGGGT ACACAGAAGG GGCCTTGCTG GCCTTGGCCT TCATCATTAT CCTCTGCTGC 
ATCCCAGCCA TCTTGGTCGT CTTAGTGAGC TACCGACAAT TTAAAGTACG CCAGGCTGAG 
TGCACGAAGA CTGCAAGGAT TCAGTCTGCT ATGCCTGCAG CCAAGCCTGC AGCTCCTGTA 
CCTGCTGCGC CCCCACCACC GCCGCCGCCA CCACCACCAG GAGCACATCT CTATGAAGAA 
CTGGGAGAGA GCGCCATGCA TAAGTATGAG ATGCCCCAGT ATGGAAGTCG CCGCCGACTG 
CTGCCACCTG CTGGACAGGA GGAATACGGC GAAGTCATTG GTGAAGCTGA AGAGGAGTAT 
GAAGAGGAAG AGGTAAGTCC AGAGAAAGTT AAAAAGCCCA AAGTTGAAAT TAGAGAGCCT 
AGTGAGGAAG AGGTGGTAGT CACCGTTGAG AAGCCACCAG CGGCTGAGCC CACCTACCCG 
ACGTGGAAGA GAGCCAGGAT CTTCCCAATG ATCTTTAAGA AAGTCAGGGG TCTCGCTGAG 
AAAAGAGGCA TTGACCTTGA GGGCGAGGAG TGGAGGAGGC GCCTTGAGGA AGAAGACAAG 
GACTATCTCC AACTGACTCT AGACCAGGAG GAAGCCACGG AGAGCACCGT GGAGTCAGAG 
GAGGAGTCCA GCGACTACAC GGAATACACA GAAACCGAGT CTGAGTTCAG CGAGTCCGAG 
ACCACTGAAG AATCCGAGTC GGAGACCCCA TCTGAGGAGG CAGAGGAAAG CTCGACCCCG 
GAGTCAGAGG AGTCTGAGTC CACCGAGTCA GAGGGAGAGA AGGCAAGGAA AAACATCGTG 
CTAGCAAGAA GAAGACCCGT GGTAGAAGAA ATCCAAGAAG TGAAGGGTAA GAAAGAGGAG 
CCGCCTGTAG AGCAGGAAGA AGAGCCCCCG GGGGAGGAGG AAGAACGGCC AGAGGAAGGA 
GAAGAAAGCG AAGCAGCTCC CATGGATGAA TCCACAGACC TGGAGGCTCA GGATGTCCCA 
GAGGAGGGCA GCGCAGAATC AGCCTCGGTG GAGAGGGGCG TGGAAAGTGA GGAGGAATCG 
GAGTCAGAAG TGAGCAGTAG CAGCAGCAGC AGCAGCAGTG AGAGCCTCTC TGGAGGCCCC 
TGGGGGTTCC AGGTACCAGA GTATGACAGG AGGAAGGAGG AAGATGCCAA GAAATCTCCA 
GGCGCAAACT CCGAAGGATA CAACACAGCC CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
The Journal of cell biology212(2)231-44(2016 Jan)
Lelli A,Michel V,Boutet de Monvel J,Cortese M,Bosch-Grau M,Aghaie A,Perfettini I,Dupont T,Avan P,El-Amraoui A,Petit C

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.
Cell151(6)1283-95(2012 Dec)
Xiong W,Grillet N,Elledge HM,Wagner TF,Zhao B,Johnson KR,Kazmierczak P,M?ller U

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
The Journal of biological chemistry287(45)37628-46(2012 Nov)
Ramakrishnan NA,Drescher MJ,Khan KM,Hatfield JS,Drescher DG

Sensing sound: molecules that orchestrate mechanotransduction by hair cells.
Trends in neurosciences35(4)220-9(2012 Apr)
Kazmierczak P,M?ller U

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain.
Development (Cambridge, England)138(8)1607-17(2011 Apr)
Webb SW,Grillet N,Andrade LR,Xiong W,Swarthout L,Della Santina CC,Kachar B,M?ller U

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Pcdh15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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