Sumo2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sumo2
Entrez Gene ID	690244
Full Name	small ubiquitin-like modifier 2
Synonyms	Smt3A,Smt3h2
General protein information	Preferred Names small ubiquitin-like modifier 2 Names small ubiquitin-related modifier 2 SMT3 homolog 2 SMT3 suppressor of mif two 3 homolog 2 SUMO-2 sentrin-2 ubiquitin-like protein SMT3A ubiquitin-like protein SMT3B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	LDH isozyme which show evolutionary relationships among vertebrate [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133594.2	NP_598278.1	small ubiquitin-related modifier 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SUMO2	XP_511671.2
Mus musculus (house mouse)	Sumo2	NP_579932.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001701	XP_321390.3
Homo sapiens (human)	SUMO2	NP_008868.3
Bos taurus (cattle)	SUMO2	NP_777194.1
Danio rerio (zebrafish)	sumo2b	NP_001003422.1
Xenopus tropicalis (tropical clawed frog)	sumo2	NP_001016406.1
Canis lupus familiaris (dog)	SUMO2	NP_001239218.1
Rattus norvegicus (Norway rat)	Sumo2	NP_598278.1
	LOC694763	XP_001082298.1
Gallus gallus (chicken)	SUMO2	NP_001074186.1

Gene Ontology
Bibliography

Related articles in PubMed

High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.
Zhou X, Gao C, Huang W, Yang M, Chen G, Jiang L, Gou F, Feng H, Ai N, Xu Y
BioMed research international2014782625(2014)

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.
Richard P, Feng S, Manley JL
Genes & development27(20)2227-32(2013 Oct)

Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.
Wang L, Ma Q, Yang W, Mackensen GB, Paschen W
Journal of neurochemistry123(3)349-59(2012 Nov)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells.
Title: High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.

Exposure to moderate 30 degrees C hypothermia in rats is sufficient to markedly modify the pattern and subcellular localization of SUMO2/3 in neurons; hypothermia triggers nuclear translocation of the SUMO-conjugating enzyme Ubc9.
Title: Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.

disruption of the retinoic acid receptor alpha gene in the testis resulted in alteration of SUMO-2/3 subcellular localization
Title: Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis.

Studies identified SUMO-2 modification as a novel posttranslational regulatory mechanism controlling the ATRA-dependent RARA subcellular localization and transcription.
Title: Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity.

the effects of silencing SUMO2/3 expression on the cellular transcription pattern and cell proliferation were studied.
Title: Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.

The following Sumo2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sumo2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01026	NM_133594.2 Latest version!	Rattus norvegicus small ubiquitin-like modifier 2 (Sumo2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sumo2 ( NM_133594.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598278.1 Rattus norvegicus small ubiquitin-like modifier 2 (Sumo2), mRNA.

Price & Availability↑

CloneID	ORa01026
Clone ID Related Accession (Same CDS sequence)	NM_133594.2
Accession Version	NM_133594.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Rattus norvegicus(Norway rat)
Product	small ubiquitin-related modifier 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF976332.1 and BC078746.1. On Oct 31, 2008 this sequence version replaced NM_133594.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00632252, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGACG AGAAACCCAA GGAAGGAGTC AAGACTGAGA ACAACGATCA TATTAATTTG 
AAGGTGGCGG GACAGGATGG TTCTGTGGTG CAGTTTAAGA TTAAGAGGCA TACACCACTT 
AGTAAACTAA TGAAAGCCTA TTGTGAACGG CAGGGTTTGT CAATGAGGCA GATCAGATTC 
CGGTTTGATG GGCAACCAAT CAACGAAACA GACACACCTG CACAGTTGGA AATGGAGGAT 
GAAGATACGA TTGATGTGTT CCAGCAGCAG ACAGGAGGCG TCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598278.1
CDS	161..448
Translation	MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY

Target ORF information:

RefSeq Version	NM_133594.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus small ubiquitin-like modifier 2 (Sumo2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133594.2

ORF Insert Sequence:

ATGGCCGACG AGAAACCCAA GGAAGGAGTC AAGACTGAGA ACAACGATCA TATTAATTTG 
AAGGTGGCGG GACAGGATGG TTCTGTGGTG CAGTTTAAGA TTAAGAGGCA TACACCACTT 
AGTAAACTAA TGAAAGCCTA TTGTGAACGG CAGGGTTTGT CAATGAGGCA GATCAGATTC 
CGGTTTGATG GGCAACCAAT CAACGAAACA GACACACCTG CACAGTTGGA AATGGAGGAT 
GAAGATACGA TTGATGTGTT CCAGCAGCAG ACAGGAGGCG TCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.
BioMed research international2014782625(2014)
Zhou X,Gao C,Huang W,Yang M,Chen G,Jiang L,Gou F,Feng H,Ai N,Xu Y

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.
Genes & development27(20)2227-32(2013 Oct)
Richard P,Feng S,Manley JL

Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.
Journal of neurochemistry123(3)349-59(2012 Nov)
Wang L,Ma Q,Yang W,Mackensen GB,Paschen W

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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Sumo2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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