Ryr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ryr2
Entrez Gene ID	689560
Full Name	ryanodine receptor 2
Synonyms	RYR-2,RyR
General protein information	Preferred Names ryanodine receptor 2 Names ryanodine receptor 2 cardiac muscle ryanodine receptor cardiac muscle ryanodine receptor-calcium release channel cardiac-type ryaodine receptor ryanodine receptor 2, cardiac ryanodine receptor type II type 2 ryanodine receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.1
Summary	may play a role in associative memory and heart function in diabetic rats [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191043.1	NP_001177972.1	ryanodine receptor 2 isoform 2
NM_032078.2	NP_114467.1	ryanodine receptor 2 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	RYR2	XP_419553.4
Pan troglodytes (chimpanzee)	RYR2	XP_514296.4
Canis lupus familiaris (dog)	RYR2	XP_005618836.1
Xenopus tropicalis (tropical clawed frog)	ryr1	XP_004917163.1
	RYR2	XP_002808310.1
Bos taurus (cattle)	LOC537376	XP_005226298.1
Danio rerio (zebrafish)	ryr1b	NP_001096041.1
Drosophila melanogaster (fruit fly)	Rya-r44F	NP_001246207.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010750	XP_318561.3
Caenorhabditis elegans (roundworm)	unc-68	NP_001256074.1
Homo sapiens (human)	RYR2	NP_001026.2
Danio rerio (zebrafish)	ryr1a	XP_001923294.4
Mus musculus (house mouse)	Ryr2	NP_076357.2
Rattus norvegicus (Norway rat)	Ryr2	NP_114467.1

Gene Ontology
Bibliography

Related articles in PubMed

Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory.
More J, Bruna B, Lobos P, Galaz JL, Figueroa P, Namias S, Sanchez G, Barrientos G, Valdes JL, Paula-Lima AC, Hidalgo C, Adasme T
Antioxidants & redox signaling(2018 Jan)

Ryanodine Receptor Type 2 Plays a Role in the Development of Cardiac Fibrosis under Mechanical Stretch Through TGF?-1.
Ding Z, Yuan J, Liang Y, Wu J, Gong H, Ye Y, Jiang G, Yin P, Li Y, Zhang G, Yang C, Guo J, Chen Z, Wang X, Weng L, Zou Y
International heart journal58(6)957-961(2017 Dec)

Dysregulated Zn
Reilly-O'Donnell B, Robertson GB, Karumbi A, McIntyre C, Bal W, Nishi M, Takeshima H, Stewart AJ, Pitt SJ
The Journal of biological chemistry292(32)13361-13373(2017 08)

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC
Circulation. Arrhythmia and electrophysiology9(8)(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RyR-2 regulated TGFbeta1 expression in mechanically stretched cardiomyocytes, and TGFbeta1 promoted collagen formation of cardiac fibroblasts by a paracrine mechanism.
Title: Ryanodine Receptor Type 2 Plays a Role in the Development of Cardiac Fibrosis under Mechanical Stretch Through TGF?-1.

Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23)
Title: Dysregulated Zn

redox modification of RyR2 synergistically with CaMKII phosphorylation modulates reperfusion arrhythmias.
Title: Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.

RyR2-gated Ca(2+) store contributes to SOCE in pulmonary artery smooth muscle cells; however, store-depletion alone is insufficient but requires a specific RyR conformation modifiable by ryanodine binding to activate Ca(2+) entry.
Title: Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes.

Results suggest that RyR2 play an important role in spinal cord injury through NOX2-mediated regulation of redox state and thus mitochondrial and ER dysfunction and inflammation as well.
Title: Ryanodine Receptor 2 Plays a Critical Role in Spinal Cord Injury via Induction of Oxidative Stress.

The following Ryr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ryr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12597	NM_032078.2 Latest version!	Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	Quote Price
ORa12617	NM_001191043.1 Latest version!	Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	Quote Price

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ryr2 ( NM_032078.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114467.1 Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12597
Clone ID Related Accession (Same CDS sequence)	NM_032078.2
Accession Version	NM_032078.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 14862bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	ryanodine receptor 2 isoform 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU346200.2. On Apr 22, 2010 this sequence version replaced NM_032078.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU346200.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGATG CGGGCGAAGG CGAGGACGAG ATCCAGTTCC TGAGAACTGA TGATGAGGTG 
GTTCTACAGT GCACCGCAAC CATCCACAAA GAGCAGCAGA AGCTGTGCTT GGCTGCAGGA 
GGATTTGGCA ACAGACTTTG CTTTTTGGAG TCTACTTCCA ATTCTAAGAA TGTCCCCCCG 
GACCTGTCCA TCTGCACCTT TGTGCTGGAG CAGTCCCTGT CAGTACGGGC CCTGCAGGAG 
ATGCTAGCCA ACACAGTGGA AAAGTCAGAA GGGAAGTTCA TGATGAAGAC TGCTCAAGGT 
GGAGGCCACC GGACACTCCT CTATGGACAC GCCATACTAC TACGCCATTC CTACAGTGGT 
ATGTATCTCT GCTGTCTCTC CACCTCCCGG TCTTCCACCG ACAAACTGGC CTTTGATGTT 
GGCCTTCAAG AGGATACCAC AGGGGAGGCT TGCTGGTGGA CCATACATCC TGCCTCTAAG 
CAGAGATCAG AAGGAGAAAA GGTGCGGGTT GGAGACGACC TCATATTGGT CAGCGTGTCC 
TCAGAAAGGT ACTTGCACTT GTCATACGGC AACAGCAGCT GGCGTGTAGA CGCAGCCTTC 
CAGCAGACCC TCTGGAGCGT GGCCCCTATC AGCTCAGGAA GTGAAGCAGC CCAAGGGTAT 
CTCATTGGTG GTGATGTTCT CCGGCTGCTA CATGGACACA TGGATGAATG TCTCACTGTT 
CCTTCAGGAG AACATGGTGA AGAACAGCGG AGAACAGTCC ATTATGAAGG TGGTGCTGTA 
TCAGTTCATG CCCGCTCCCT CTGGAGACTA GAGACCCTAA GAGTCGCGTG GAGTGGAAGT 
CACATAAGAT GGGGCCAGCC ATTCCGACTG CGGCACGTCA CGACAGGAAA ATACTTAAGC 
CTCATGGAAG ACAAGAACCT TCTACTCATG GACAAAGAAA AAGCTGATGT AAAATCAACG 
GCGTTTGCCT TCCGGTCTTC CAAGGAAAAA TTGGATGCAG GTGTAAGGAA AGAAGTCGAT 
GGCATGGGAA CCTCAGAAAT CAAGTATGGA GACTCCATTT GCTATATACA ACATGTGGAC 
ACGGGCCTGC GGCTAACCTA CCAGGCCGTG GATGTCAAAT CAGCACGAAT GGGATCCATA 
CAGCGTAAGG CTATCATGCA CCACGAAGGC CACATGGATG ACGGCTTGAA CTTATCCAGA 
TCGCAGCACG AGGAGTCCCG CACTGCCCGT GTCATCCGGA GCACAGTGTT TCTCTTCAAT 
AGGTTCATAA GGGGCCTGGA TGCTCTCAGC AAGAGAGCGA AGCTGCCCAC TGTTGACTTG 
CCCATCGAGT CTGTGAGCCT GAGTTTGCAG GACCTCATCG GCTACTTCCA CCCCCCAGAC 
GAGCACCTGG AGCACGAGGA CAAGCAGAAC AGGCTGCGAG CCCTGAAGAA CCGGCAGAAT 
CTCTTCCAGG AAGAGGGAAT GATCAACCTG GTTCTGGAGT GCATCGACCG CCTCCATGTC 
TACAGCAGTG CAGCCCACTT TGCAGACGTT GCAGGACGAG AAGCGGGGGA GTCTTGGAAA 
TCCATCCTGA ATTCTCTGTA TGAGTTGCTG GCGGCTCTAA TTAGAGGAAA TCGTAAAAAC 
TGTGCTCAAT TTTCTGGCTC CCTCGACTGG CTGATCAGCA GACTGGAGAG ACTGGAAGCG 
TCCTCTGGTA TCCTGGAGGT CCTCCACTGT GTGTTAGTGG AGAGCCCGGA AGCTCTGAAT 
ATCATCAAAG AAGGACACAT CAAGTCCATT ATTTCCCTTT TAGACAAGCA TGGGAGAAAC 
CACAAGGTCC TGGATGTGCT GTGTTCTCTC TGTGTGTGCC ATGGAGTTGC CGTCCGTTCT 
AATCAGCATC TCATCTGTGA TAACCTCCTG CCGGGACGAG ACCTCTTACT GCAGACCCGG 
CTTGTGAATC ATGTCAGCAG CATGAGGCCT AATATTTTCC TGGGTGTCAG CGAAGGATCA 
GCACAGTATA AGAAGTGGTA CTACGAGCTC ATGGTGGACC ACACGGAACC CTTTGTGACC 
GCAGAAGCCA CTCACCTGCG AGTGGGCTGG GCTTCCACTG AAGGGTATTC CCCGTACCCA 
GGTGGGGGTG AAGAGTGGGG TGGCAATGGC GTTGGTGATG ACCTCTTCTC CTATGGGTTT 
GATGGCCTTC ACCTCTGGTC AGGTTGTATA GCTCGAACAG TGAGCTCCCC CAACCAGCAC 
CTGCTGAGAA CTGATGATGT CATAAGTTGC TGTTTAGATC TAAGTGCCCC GAGCATCTCG 
TTTCGCATTA ATGGACAACC TGTGCAAGGG ATGTTTGAGA ACTTCAATAT CGATGGCCTG 
TTCTTTCCGG TTGTCAGTTT CTCTGCAGGA ATAAAGGTTC GCTTTTTGCT TGGGGGGAGA 
CACGGAGAAT TCAAATTTCT CCCTCCACCG GGCTATGCAG CTTGCTATGA AGCTGTTTTG 
CCCAAAGAGA AATTGAAGGT GGAACACAGC CGAGAATATA AGCAAGAGAG GACGTACACA 
CGAGACCTGC TGGGGCCTAC AGTGTCCCTG ACCCAAGCTG CCTTCACACC TGTTCCTGTG 
GACACCAGCC AGATTGTGTT GCCTCCTCAC CTGGAAAGGA TAAGAGAAAG ACTGGCAGAA 
AATATCCACG AGCTCTGGGT TATGAATAAA ATTGAGCTTG GCTGGCAGTA TGGTCCGGTT 
AGAGATGACA ACAAGAGACA GCACCCATGT CTGGTGGAGT TCTGCAAGCT TCCGGAACAG 
GAACGCAACT ACAATTTGCA GATGTCTCTG GAAACCCTCA AGACTTTGCT GGCATTAGGA 
TGTCATGTGG GTATAGCGGA TGAACATGCT GAAGAGAAGG TGAAGAAAAT GAAGCTGCCC 
AAGAATTACC AGCTGACCAG TGGATACAAG CCTGCCCCCA TGGATCTGAG CTTTATAAAA 
CTTACCCCGT CTCAGGAAGC AATGGTGGAC AAGTTGGCTG AAAATGCTCA CAACGTGTGG 
GCCCGGGACC GAATCCGGCA GGGCTGGACT TACGGCATCC AGCAGGATGT GAAGAACAGG 
AGAAACCCTC GTCTGGTTCC CTACACTCTT CTGGATGACA GAACCAAGAA GTCCAACAAA 
GACAGTCTCC GAGAGGCAGT GCGAACACTG CTGGGCTACG GCTACCACCT GGAAGCTCCT 
GATCAGGACC ACGCCTCAAG AGCCGAGGTG TGCAGCGGTA CTGGGGAGAG GTTCCGCATC 
TTCAGGGCAG AGAAGACCTA TGCAGTAAAG GCTGGGCGCT GGTACTTTGA ATTTGAGGCC 
GTCACTGCTG GAGACATGAG GGTGGGATGG AGCAGGCCAG GCTGCCAACC GGATCTAGAA 
CTGGGTTCTG ATGAACGTGC CTTCGCTTTT GACGGCTTTA AGGCCCAGCG GTGGCACCAG 
GGCAATGAAC ACTACGGGCG TTCTTGGCAA GCAGGTGATG TCGTGGGCTG CATGGTTGAT 
ATGAATGAAC ACACCATGAT GTTCACTCTG AACGGTGAGA TCCTGCTGGA TGACTCAGGC 
TCCGAGCTGG CTTTCAAGGA CTTTGATGTT GGTGACGGAT TCATCCCTGT GTGTAGCCTC 
GGGGTGGCAC AAGTAGGCAG GATGAACTTT GGAAAGGACG TCAGCACTTT GAAATACTTT 
ACCATCTGTG GCTTACAAGA GGGCTACGAG CCATTTGCAG TTAACACAAA TAGGGACATC 
ACCATGTGGC TGAGCAAGCG GCTTCCTCAG TTCCTCCAGG TCCCCTCAAA CCACGAACAC 
ATCGAGGTGA CCAGAATAGA TGGTACCATA GACAGTTCTC CATGTCTGAA GGTCACTCAG 
AAGTCCTTTG GTTCTCAGAA CAGCAACACA GACATCATGT TTTACCGCCT GAGTATGCCC 
ATTGAGTGTG CTGAGGTCTT CTCAAAGTCC GTGGCTGGAG GGATCCCTGG CGCCGGCTTC 
TATGGGCCCA AGAATGATTT GGAGGACTTT GATGTGGATT CTGACTTTGA GGTTCTGATG 
AAGACAGCTC ATGGTCATCT TGTGCCCGAC CGCATGGACA AGGACAAAGA GACCCCCAAG 
CCAGAATTCA ATAACCACAA AGATTATGCT CAGGAAAAGC CCTCACGCCT AAAGCAAAGA 
TTCTTACTTA GAAGGACCAA GCCAGATTAC AGCACAAGCC ATTCTGCAAG ACTCACTGAA 
GACGTCCTTG CTGATGACCG GGATGACTAT GAATATCTGA TGCAGACATC TACATACTAT 
TATTCAGTGA GGATCTTTCC TGGACAAGAA CCAGCTAACG TCTGGGTGGG CTGGATTACA 
TCTGACTTCC ACCAGTATGA CACAGGCTTC GATTTGGACA GAGTGCGCAC AGTGACAGTC 
ACCCTAGGAG ATGAAAAAGG GAAAGTGCAC GAGAGCATCA AACGCAGCAA CTGCTATATG 
GTGTGTGCGG GAGAGAGCAT GAGCCCCGGG CAAGGCCGAA ACAACAGCAA TGGCTTGGAG 
ATCGGCTGTG TGGTGGACGC TGCCAGTGGG CTGCTCACAT TCATAGCCAA CGGCAAGGAG 
CTAAGCACTT ACTATCAGGT GGAGCCAAGC ACGAAGTTAT TTCCTGCGGT TTTCGCGCAA 
GCTACAAGTC CCAATGTTTT CCAGTTTGAG TTGGGCAGAA TAAAGAATGT GATGCCTCTC 
TCAGCGGGAT TGTTTAAGAG TGAGCACAAA AACCCCGTGC CCCAGTGTCC TCCACGTCTG 
CACGTGCAGT TCCTGTCACA TGTCCTGTGG AGCCGGATGC CCAACCAGTT CCTCAAGGTG 
GACGTCTCTC GAATCAGTGA ACGCCAAGGC TGGCTGGTGC AGTGTCTGGA TCCTCTGCAG 
TTCATGTCCC TCCACATCCC CGAGGAGAAC AGATCTGTTG ATATCTTAGA GCTGACCGAG 
CAGGAGGAGT TGTTGCAGTT TCACTACCAC ACCCTCCGCC TCTACTCTGC AGTCTGTGCC 
CTTGGGAATC ACCGGGTGGC GCATGCACTG TGCAGCCACG TGGACGAACC TCAGCTGCTC 
TATGCCATTG AGAACAAGTA CATGCCTGGC TTGCTGCGAG CCGGGTACTA TGACCTGCTG 
ATTGACATCC ACCTCAGCTC CTACGCCACC GCCAGGCTCA TGATGAACAA TGAGTTCATC 
GTCCCGATGA CAGAGGAGAC AAAGAGCATC ACCCTCTTCC CTGATGAGAA CAAGAAACAT 
GGCCTCCCGG GCATAGGCCT CAGCACCTCT CTCCGCCCTC GGATGTGCTT TTCCTCCCCT 
AGTTTCGTGA GCATTAGCAA CGAATGCTAT CAGTATAGTC CCGAGTTCCC ACTGGACATC 
CTCAAGGCCA AGACCATCCA GATGCTCACA GAAGCGGTGA AGGAGGGCAG CCTCCACGCG 
CGGGATCCCG TGGGCGGGAC CACCGAGTTC CTCTTTGTGC CTCTCATCAA GCTCTTCTAC 
ACCCTGCTCA TCATGGGCAT CTTTCACAAT GAGGATTTGA AACACATCCT GCGGTTGATT 
GAGCCTAGTG TGTTTAAGGA AGCTGCCACT CCAGAGGAGG AAGGAGGTGC CCCAGAGAAG 
GAGATTAGTA TAGACGACTC TAAACTGGAA GTCAAAGAGG AAGCCAAAGC AGGCAAAAGG 
CCTAAGGAAG GCTTACTCCA GATGAAACTC CCGGAGCCTG TTAAACTACA GATGTGCCTC 
TTGCTTCAGT ACCTCTGTGA CTGCCAGGTT CGGCACCGGA TAGAAGCCAT TGTAGCCTTT 
TCAGATGACT TTGTAGCCAA ACTCCAAGAC AATCAGCGGT TCAGGTATAA TGAAGTCATG 
CAAGCCTTAA ACATGTCTGC TGCACTCACT GCCAGGAAGG AGTTCCGGTC ACCACCACAG 
GAGCAGATCA ATATGCTTCT TAATTTTAAG GATGATAAAA GTGAATGCCC CTGCCCTGAA 
GAAATCCGAG ACCAACTCCT AGATTTCCAT GAGGACCTGA TGACTCACTG TGGAATTGAA 
CTGGATGAAG ATGGATCTCT AGACGGAAGC AATGACTTAA CAATCAGAGG ACGTCTGCTG 
TCCCTGGTAG AAAAGGTGAC CTACCTGAAG AAAAAGCAAG CTGAAAAACC AGTCGCAAGT 
GACTCCAGAA AGTCCTCCAG CCTCCAGCAA CTCATTTCTG AGACTATGGT GCGGTGGGCT 
CAAGAGTCTG TCATCGAGGA CCCTGAGCTG GTGAGGGCTA TGTTTGTGCT GCTGCACCGG 
CAGTATGATG GCATTGGGGG TCTCGTTCGA GCACTGCCAA AGACCTACAC TATCAACGGC 
GTCTCTGTGG AGGACACCAT CAATCTGCTT GCATCACTTG GTCAGATCCG ATCCCTGCTG 
AGTGTGAGGA TGGGCAAAGA AGAAGAGAAG CTGATGATCC GAGGATTAGG GGATATTATG 
AATAACAAGG TGTTTTATCA GCATCCCAAT CTCATGAGGG CCCTTGGGAT GCACGAAACA 
GTGATGGAAG TCATGGTGAA CGTCCTTGGA GGTGGGGAGT CCAAGGAAAT CACCTTCCCC 
AAGATGGTGG CCAACTGCTG CCGTTTTCTC TGTTACTTCT GTCGTATAAG TAGGCAGAAT 
CAGAAAGCCA TGTTTGATCA TCTCAGTTAT TTACTGGAAA ACAGCAGTGT TGGTCTTGCC 
TCACCAGCCA TGAGAGGTTC AACTCCATTA GACGTGGCCG CAGCGTCAGT GATGGATAAC 
AATGAGCTTG CCCTTGCTCT ACGAGAGCCG GATCTGGAGA AGGTGGTTCG CTATCTGGCC 
GGCTGTGGTC TGCAGAGCTG CCAGATGCTG GTGTCTAAGG GTTACCCAGA CATTGGGTGG 
AATCCAGTTG AAGGAGAACG ATATCTTGAC TTTCTCAGAT TTGCCGTCTT CTGTAATGGG 
GAGAGTGTGG AAGAGAATGC AAATGTTGTG GTGAGGTTGC TCATCCGGAG ACCGGAGTGC 
TTTGGCCCTG CCTTGAGAGG AGAAGGTGGT AATGGTCTCC TTGCAGCCAT GGAAGAAGCC 
ATAAAAATAG CTGAGGATCC TTCTAGAGAT GGCCCCTCTC CAACCAGTGG ATCCAGCAAA 
ACCCTTGATG CGGAAGAGGA GGAAGACGAC ACCATCCACA TGGGGAACGC AATCATGACC 
TTCTACGCAG CTTTGATTGA CCTGCTTGGT CGCTGTGCTC CTGAAATGCA TTTGATTCAT 
GCTGGAAAGG GAGAAGCCAT CCGAATCAGG TCTATTTTGC GATCCCTGAT TCCATTGGGA 
GACTTGGTGG GTGTAATCAG CATTGCATTT CAGATGCCAA CAATAGCCAA AGATGGGAAG 
GTGGTGGAGC CTGACATGTC CGCGGGGTTT TGCCCAGATC ACAAGGCAGC CATGGTTTTG 
TTCCTTGACA GGGTCTATGG AATTGAGGTG CAAGATTTCC TCCTCCATCT CCTTGAGGTT 
GGCTTTCTGC CAGATCTTCG CGCTGCTGCC TCTCTAGACA CGGCTGCACT AAGTGCTACA 
GACATGGCCT TGGCCCTCAA TCGGTACCTC TGCACAGCTG TCCTGCCTTT GTTAACGAGA 
TGTGCTCCCC TGTTTGCTGG AACAGAGCAC CATGCTTCCC TCATTGACTC TCTGCTACAC 
ACTGTATATA GACTCTCTAA GGGATGTTCC CTCACCAAAG CTCAGCGGGA CTCCATAGAA 
GTGTGCCTGC TCTCTATATG TGGCCAACTG CGACCTTCTA TGATGCAGCA CCTACTCCGA 
AGGCTGGTGT TTGATGTCCC ACTGCTGAAC GAGCACGCAA AGATGCCTCT AAAGCTGCTG 
ACCAATCATT ATGAAAGATG CTGGAAATAT TACTGCCTAC CTGGAGGGTG GAGCAACTTT 
GGTGCTGCCT CGGAAGAAGA ACTTCATTTA TCAAGAAAAT TATTTTGGGG CATTTTTGAT 
GCTTTGTCTC AAAAGAAATA CGAACAAGAA CTTTTCAAAC TGGCCCTGCC TTGCCTGAGT 
GCAGTTGCGG GAGCTTTACC TCCAGACTAC ATGGAGTCAA ACTATGTCAG TATGATGGAA 
AAACAGTCAT CCATGGACTC TGAAGGGAAC TCTAACCCAC AACCTGTTGA TACCTCAAAC 
ATTACAATTC CCGAGAAGCT GGAATACTTC ATTAACAAGT ATGCGGAGCA TTCCCATGAT 
AAATGGTCTA TGGACAAGTT GGCGAATGGA TGGATTTATG GGGAAATATA TTCAGACTCT 
TCTAAGATCC AGCCACTAAT GAAGCCATAT AAACTCTTAT CTGAAAAGGA AAAAGAAATT 
TATCGTTGGC CAATCAAGGA GTCTTTAAAA ACGATGCTGG CTTGGGGTTG GAGAATTGAG 
AGGACACGGG AGGGAGACAG TATGGCCCTT TATAACCGGA CTCGGCGCAT TTCTCAGACT 
AGCCAGGTGT CTATAGATGC TGCACATGGG TATAGCCCCC GTGCTATCGA CATGAGTAAC 
GTTACCCTCT CGAGAGACCT GCATGCTATG GCGGAGATGA TGGCTGAAAA CTACCACAAC 
ATATGGGCCA AGAAAAAGAA AATGGAGCTG GAATCCAAAG GAGGAGGAAA CCACCCCCTG 
CTAGTGCCCT ACGACACACT GACAGCCAAG GAGAAAGCCA AGGACAGAGA AAAGGCCCAG 
GACATCTTCA AGTTCCTACA GATCAGTGGT TATGCTGTAT CCAGAGGGTT CAAGGACCTG 
GATCTGGACA CACCTTCCAT TGAGAAGCGA TTTGCCTACA GTTTCCTGCA GCAGCTGATC 
CGATATGTGG ACGAGGCCCA TCAGTACATC CTGGAGTTTG ACGGTGGCAG CAGAAGCAAA 
GGAGAGCATT TCCCGTACGA GCAAGAGATC AAGTTCTTCG CCAAAGTTGT TCTTCCTTTA 
ATTGATCAGT ATTTCAAAAA CCATCGCCTG TACTTCTTGT CTGCTGCAAG CAGGCCTCTT 
TGCACCGGAG GACATGCGTC CAACAAGGAG AAGGAGATGG TTACAAGCCT GTTCTGCAAA 
CTTGGAGTTC TTGTCAGGCA TAGGATTTCA CTGTTTGGGA ATGATGCTAC CTCAATTGTG 
AACTGTCTTC ATATTTTGGG TCAGACTTTG GATGCAAGGA CTGTGATGAA GACGGGTCTG 
GACAGCGTGA AAAGTGCTCT CAGGGCCTTT CTGGACAATG CGGCGGAGGA TCTGGAAAAG 
ACGATGGAAA ACCTTAAGCA GGGCCAGTTT ACTCACACCA GGAGCCAGCC CAAGGGCGTG 
ACTCAGATCA TCAACTATAC CACCGTGGCG CTCCTGCCCA TGCTCTCTTC CCTGTTTGAG 
CACATTGGCC AGCATCAGTT TGGAGAAGAT CTGATATTGG AGGATGTGCA GGTGTCTTGT 
TACAGAATTC TGACCAGCTT GTATGCCTTG GGAACCAGCA AGAGCATCTA TGTGGAAAGG 
CAACGTTCTG CACTCGGAGA ATGCCTAGCT GCCTTTGCTG GTGCCTTCCC TATCGCCTTT 
CTAGAAACCC ACCTGGACAA ACATAATGTT TACTCCATCT ACAACACCAG GTCTTCACGA 
GAAAGAGCAG CTCTCAGTTT ACCCGCAAAT GTGGAGGATG TCTGCCCAAA TATACCATCC 
CTGGAGAAGC TCATGACTGA GATCATAGAG CTGGCAGAGT CAGGAACCCG TTACACTCAG 
ATGCCACACA TGATGGGGGT GGTACTGCCC ATGTTATGCA GCTACATGTC AAGGTGGTGG 
GAGCACGGTC CTGAGAACCA TCCAGAGAGG GCTGAGATGT GCTGCACAGC GCTCAACTCA 
GAGCACATGA ACACACTGCT GGGCAACATT CTCAAGATCA TCTACAACAA CCTGGGGATT 
GATGAAGGGG CCTGGATGAA GCGCTTAGCT GTATTTTCAC AGCCAATCAT CAACAAGGTG 
AAACCTCAGC TCTTAAAAAC TCATTTCTTA CCCTTAATGG AGAAACTAAA GAAAAAGGCT 
GCCATGGTAG TGTCTGAGGA AGACCACCTA AAAGCCGAAG CCAGAGGGGA CATGTCCGAA 
GCGGAGCTGC TCATTCTAGA TGAGTTTACC ACATTGGCCA GGAATCTCTA TGCCTTCTAC 
CCACTCTTGA TCCGATTTGT GGACTATAAC AGGGCAAAGT GGCTGAAGGA ACCCAACCCA 
GAAGCAGAGG AGCTATTTCG AATGGTAGCT GAAGTCTTCA TTTACTGGTC CAAATCCCAT 
AATTTCAAAA GAGAGGAACA GAACTTTGTG GTGCAGAATG AAATCAACAA CATGTCCTTC 
CTCATCACCG ACACAAAGTC TAAGATGTCC AAGGCAGCCA TTTCTGATCA AGAGAGGAAG 
AAAATGAAGC GGAAAGGAGA CCGGTATTCT ATGCAGACAT CTTTGATTGT GGCAGCTCTG 
AAGCGATTGC TTCCCATTGG ACTGAACATC TGTGCCCCTG GGGACCAAGA GCTCATTGCT 
CTGGCCAAAA ACCGATTTAG CTTGAAAGAC ACTGAGGAGG AAGTACGTGA TGTAATCCGC 
AGTAATATAC ACTTGCAAGG CAAGCTGGAA GACCCTGCAA TCAGGTGGCA GATGGCTCTA 
TACAAAGACT TGCCAAACAG GGCAGAAGAC ACCTCAGACC CAGAGAGGAC AGTGGAGCGT 
ATCCTGGATA TAGCGAATGT GCTTTTTCAC CTTGAACAGG TGGAGCACCC TCAGAGATCA 
AAGAAAGCCG TGTGGCACAA ACTGCTCTCT AAGCAGAGAA AAAGAGCTGT TGTTGCCTGT 
TTCCGGATGG CCCCTTTGTA CAATCTGCCA AGGCATCGGG CTGTCAATCT CTTTCTTCAG 
GGATATGAAA AGTCTTGGAT TGAAACAGAA GAGCATTACT TTGAGGATAA ATTGATCGAA 
GATTTAGCGA AACCGGGGTC TGAACTCCCA GAAGAAGATG AAGCCATGAA AAGAGTTGAT 
CCTCTGCATC AGCTTATTCT TCTGTTCAGC CGCACAGCCT TAACAGAGAA ATGCAAACTG 
GAGGAAGATT TTCTGTACAT GGCGTATGCA GACATTATGG CAAAGAGTTG TCACGATGAA 
GAAGACGATG ATGGTGAAGA AGAAGTGAAG AGCTTTGAAG TCACAGGATC CCAACGCAGC 
AAGGAAAAGG AAATGGAAAA GCAGAAGCTT CTGTACCAGC AAGCCAGACT GCATGACCGC 
GGGGCTGCCG AGATGGTTCT CCAGACCTTC AGTGCCAGCA AAGGTGAAAC TGGACCAATG 
GTGGCTGCCA CTTTGAAGCT GGGTATTGCT ACTTTAAATG GTGGGAACTC CACGGTGCAG 
CAGAAGATGC TGGATTACCT GAAGGAGAAA AAAGATGTAG GCTTCTTCCA GAGCCTGGCA 
GGCCTCATGC AGTCTTGCAG TGTCCTGGAC CTGAATGCCT TTGAGAGGCA AAACAAAGCA 
GAAGGACTTG GGATGGTGAC TGAGGAAGGA TCAGGAGAGA AGGTACTTCA GGATGATGAG 
TTCACCTGTG ACCTCTTCCG ATTCCTGCAG CTGCTCTGTG AAGGACACAA CTCAGATTTT 
CAGAATTACC TGAGAACCCA GACTGGCAAC AACACCACAG TTAATATCAT CATCTCTACT 
GTGGACTACC TCCTTCGAGT GCAGGAGTCC ATTAGTGATT TCTATTGGTA CTACTCTGGC 
AAGGACATCA TAGGTGAGCA GGGCCAGCGT AACTTTTCCA AAGCCATCCA AGTGGCGAAG 
CAGGTGTTCA ACACACTCAC GGAGTACATC CAGGGTCCTT GTACCGGAAA CCAGCAGAGT 
TTGGCACACA GCAGGCTCTG GGATGCTGTT GTGGGCTTCC TTCATGTATT TGCACACATG 
CAGATGAAGC TGTCTCAGGA TTCCAGCCAG ATTGAGCTCT TAAAAGAACT GATGGATCTC 
CAAAAGGACA TGGTGGTCAT GCTGCTGTCT ATGCTAGAGG GTAATGTGGT AAACGGAACA 
ATAGGCAAGC AGATGGTGGA CATGCTTGCG GAGTCATCCA ACAACGTGGA GATGATCCTC 
AAGTTCTTTG ACATGTTTCT GAAGTTAAAG GACTTGACAT CCTCTGACAC ATTTAAAGAG 
TATGACCCTG ATGGCAAAGG CGTCATTTCC AAGAGAGACT TCCACAAAGC CATGGAGAGC 
CACAAACACT ACACCCAGTC AGAGACTGAG TTTCTGTTGT CCTGTGCAGA GACAGATGAG 
AACGAGACGC TGGATTATGA AGAGTTTGTC AAAAGGTTCC ACGAGCCTGC CAAGGACATC 
GGCTTCAACG TCGCCGTTCT GCTGACCAAC CTCTCAGAGC ACATGCCCAA TGACACGAGG 
CTGCAGACCT TCTTGGAGCT GGCAGAGAGT GTCCTCAACT ACTTCCAACC TTTCCTGGGT 
CGCATCGAGA TCATGGGCAG CGCCAAGCGC ATCGAGAGGG TCTACTTTGA GATCAGCGAA 
TCCAGCCGAA CCCAGTGGGA GAAGCCCCAG GTCAAGGAGT CCAAGAGGCA GTTCATATTC 
GATGTGGTCA ATGAGGGCGG GGAAAAGGAG AAGATGGAGC TCTTTGTGAA CTTCTGTGAG 
GACACCATCT TTGAGATGCA GCTGGCAGCT CAGATCTCAG AGTCCGGCCT GAATGAGAGG 
TCGGCAAATA AAGAGGAGAG TGAAAAGGAG AGGCCAGAGG AGCAGGCCCC ACGGATGGGC 
TTCTTCTCCC TGCTCACCGT CCAGTCAGCC CTGTTTGCAC TCAGGTACAA TGTCCTAACC 
CTTGTGAGGA TGCTCAGCCT GAAGAGCCTG AAGAAGCAGA TGAAGAGAAT GAAGAAGATG 
ACAGCGAAGG ACATGGTCTC AGCCTTCTTC TCGTCCTACT GGAGTGTGTT TGTCACCCTC 
CTACACTTCG TGGCCAGCGT CTGTAGGGGC TTCTTCCGCA TTGTCTCCAG CCTACTGCTG 
GGGGGCAGCC TGGTGGAAGG TGCTAAGAAA ATCAAAGTGG CGGAGCTTCT TGCCAACATG 
CCAGACCCTA CTCAGGATGA GGTGCGAGGA GATGAAGAGG AGGGAGAGAG GAAGCCATTA 
GAGTCAGCCC TGCCCTCTGA AGACCTAACG GACTTGAAGG AACTGACGGA GGAAAGTGAC 
CTTCTTTCAG ACATATTTGG CTTGGATCTG AAGAGAGAAG GAGGGCAGTA CAAACTAATT 
CCTCACAACC CAAATGCTGG TCTCAGTGAC CTCATGACGA ACCCCATCCC TGTCCCTGAG 
GTACAAGAAA AGTTTCAGGA GCAGAAGGTA AAAGAAGAAA AGGAAGGAAA GGAAGAAACC 
AAGTCTGAAC CGGAGAAGGC TGAGGGAGAG GATGGAGAAA AAGAAGAAAA AGCCAAAGAT 
GATAAGGGTA AACAGAAGTT GAGGCAGCTT CATACACATC GATATGGGGA GCCTGAGGTC 
CCCGAGTCAG CATTCTGGAA GAAAATCATA GCCTACCAAC AGAAGCTGCT GAACTATTTT 
GCTCGCAACT TTTACAACAT GAGAATGCTG GCCCTGTTTG TCGCCTTCGC CATCAATTTC 
ATCCTGCTCT TCTACAAGGT CTCCACTTCT TCTGTGGTTG AAGGAAAGGA GCTGCCTACC 
CGAACTTCCA GCGATGCCGC TAAAGTGACC ACCAGCCTGG ACAGCGGCCC CCACAGAATC 
ATTGCGGTTC ACTACGTCCT GGAGGAGAGT AGCGGCTACA TGGAACCCAC CTTGCGCATC 
CTAGCCATCC TCCACACCAT CATCTCCTTC TTCTGCATCA TCGGATACTA CTGCCTGAAA 
GTCCCCTTGG TTATTTTTAA GCGAGAGAAG GAAGTGGCAC GGAAGTTGGA GTTTGATGGG 
CTTTACATTA CGGAGCAGCC ATCGGAAGAC GATATCAAAG GCCAGTGGGA CAGACTGGTG 
ATCAACACAC AGTCATTTCC CAATAACTAC TGGGATAAAT TTGTTAAAAG AAAGGTAATG 
GATAAATATG GAGAGTTTTA TGGGAGAGAC AGAATCAGCG AGTTACTGGG CATGGATAAG 
GCTGCACTGG ATTTCAGCGG TGCAAGAGAG AAGAAGAAGC CCAAGAAGGA CAGTTCCTTG 
TCTGCTGTAT TGAACTCTAT TGACGTGAAG TACCAGATGT GGAAACTTGG AGTCGTGTTC 
ACAGACAATT CCTTCCTCTA CCTAGCCTGG TATATGACCA TGTCTGTTCT TGGACACTAC 
AACAACTTTT TTTTTGCTGC CCACCTCCTT GACATCGCGA TGGGCTTCAA GACCTTGAGA 
ACTATCCTGT CCTCAGTTAC CCATAATGGC AAACAGCTCG TGTTAACTGT TGGCTTGTTG 
GCTGTCGTTG TATACCTGTA CACTGTTGTG GCGTTCAATT TCTTCCGAAA ATTCTACAAT 
AAAAGCGAGG ATGGTGACAC GCCGGACATG AAGTGTGACG ACATGCTGAC GTGTTACATG 
TTCCACATGT ATGTGGGCGT CCGTGCTGGA GGGGGCATCG GTGATGAAAT TGAAGACCCA 
GCAGGAGATG AGTACGAGAT CTACCGAATC ATCTTTGATA TCACATTCTT CTTCTTTGTG 
ATTGTCATCC TTTTGGCTAT CATACAAGGT TTGATCATTG ATGCTTTTGG AGAACTCAGA 
GACCAACAAG AGCAAGTCAA GGAAGACATG GAGACCAAGT GCTTCATCTG TGGGATAGGC 
AACGACTACT TTGATACAGT GCCGCATGGC TTTGAAACCC ATACTCTACA GGAGCACAAC 
CTGGCCAACT ACCTGTTTTT TCTGATGTAC CTCATAAACA AGGATGAAAC AGAACACACG 
GGACAGGAAT CTTATGTCTG GAAGATGCAC CAAGAGAGGT GTTGGGAATT TTTCCCAGCA 
GGAGACTGTT TCCGGAAACA GTATGAGGAC CAGTTAAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114467.1
CDS	1..14862
Translation	MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAGGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNSSWRVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDAGVRKEVDGMGTSEIKYGDSICYIQHVDTGLRLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKRAKLPTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKSVAGGIPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRMDKDKETPKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMCFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILRLIEPSVFKEAATPEEEGGAPEKEISIDDSKLEVKEEAKAGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKKKQAEKPVASDSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDAEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWSNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNSNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGTRYTQMPHMMGVVLPMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARNLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEEEVRDVIRSNIHLQGKLEDPAIRWQMALYKDLPNRAEDTSDPERTVERILDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGSELPEEDEAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTFSASKGETGPMVAATLKLGIATLNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIGEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLAESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESGLNERSANKEESEKERPEEQAPRMGFFSLLTVQSALFALRYNVLTLVRMLSLKSLKKQMKRMKKMTAKDMVSAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPIPVPEVQEKFQEQKVKEEKEGKEETKSEPEKAEGEDGEKEEKAKDDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTSSDAAKVTTSLDSGPHRIIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSGAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMHQERCWEFFPAGDCFRKQYEDQLN

Target ORF information:

RefSeq Version	NM_032078.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032078.2

ORF Insert Sequence:

ATGGCTGATG CGGGCGAAGG CGAGGACGAG ATCCAGTTCC TGAGAACTGA TGATGAGGTG 
GTTCTACAGT GCACCGCAAC CATCCACAAA GAGCAGCAGA AGCTGTGCTT GGCTGCAGGA 
GGATTTGGCA ACAGACTTTG CTTTTTGGAG TCTACTTCCA ATTCTAAGAA TGTCCCCCCG 
GACCTGTCCA TCTGCACCTT TGTGCTGGAG CAGTCCCTGT CAGTACGGGC CCTGCAGGAG 
ATGCTAGCCA ACACAGTGGA AAAGTCAGAA GGGAAGTTCA TGATGAAGAC TGCTCAAGGT 
GGAGGCCACC GGACACTCCT CTATGGACAC GCCATACTAC TACGCCATTC CTACAGTGGT 
ATGTATCTCT GCTGTCTCTC CACCTCCCGG TCTTCCACCG ACAAACTGGC CTTTGATGTT 
GGCCTTCAAG AGGATACCAC AGGGGAGGCT TGCTGGTGGA CCATACATCC TGCCTCTAAG 
CAGAGATCAG AAGGAGAAAA GGTGCGGGTT GGAGACGACC TCATATTGGT CAGCGTGTCC 
TCAGAAAGGT ACTTGCACTT GTCATACGGC AACAGCAGCT GGCGTGTAGA CGCAGCCTTC 
CAGCAGACCC TCTGGAGCGT GGCCCCTATC AGCTCAGGAA GTGAAGCAGC CCAAGGGTAT 
CTCATTGGTG GTGATGTTCT CCGGCTGCTA CATGGACACA TGGATGAATG TCTCACTGTT 
CCTTCAGGAG AACATGGTGA AGAACAGCGG AGAACAGTCC ATTATGAAGG TGGTGCTGTA 
TCAGTTCATG CCCGCTCCCT CTGGAGACTA GAGACCCTAA GAGTCGCGTG GAGTGGAAGT 
CACATAAGAT GGGGCCAGCC ATTCCGACTG CGGCACGTCA CGACAGGAAA ATACTTAAGC 
CTCATGGAAG ACAAGAACCT TCTACTCATG GACAAAGAAA AAGCTGATGT AAAATCAACG 
GCGTTTGCCT TCCGGTCTTC CAAGGAAAAA TTGGATGCAG GTGTAAGGAA AGAAGTCGAT 
GGCATGGGAA CCTCAGAAAT CAAGTATGGA GACTCCATTT GCTATATACA ACATGTGGAC 
ACGGGCCTGC GGCTAACCTA CCAGGCCGTG GATGTCAAAT CAGCACGAAT GGGATCCATA 
CAGCGTAAGG CTATCATGCA CCACGAAGGC CACATGGATG ACGGCTTGAA CTTATCCAGA 
TCGCAGCACG AGGAGTCCCG CACTGCCCGT GTCATCCGGA GCACAGTGTT TCTCTTCAAT 
AGGTTCATAA GGGGCCTGGA TGCTCTCAGC AAGAGAGCGA AGCTGCCCAC TGTTGACTTG 
CCCATCGAGT CTGTGAGCCT GAGTTTGCAG GACCTCATCG GCTACTTCCA CCCCCCAGAC 
GAGCACCTGG AGCACGAGGA CAAGCAGAAC AGGCTGCGAG CCCTGAAGAA CCGGCAGAAT 
CTCTTCCAGG AAGAGGGAAT GATCAACCTG GTTCTGGAGT GCATCGACCG CCTCCATGTC 
TACAGCAGTG CAGCCCACTT TGCAGACGTT GCAGGACGAG AAGCGGGGGA GTCTTGGAAA 
TCCATCCTGA ATTCTCTGTA TGAGTTGCTG GCGGCTCTAA TTAGAGGAAA TCGTAAAAAC 
TGTGCTCAAT TTTCTGGCTC CCTCGACTGG CTGATCAGCA GACTGGAGAG ACTGGAAGCG 
TCCTCTGGTA TCCTGGAGGT CCTCCACTGT GTGTTAGTGG AGAGCCCGGA AGCTCTGAAT 
ATCATCAAAG AAGGACACAT CAAGTCCATT ATTTCCCTTT TAGACAAGCA TGGGAGAAAC 
CACAAGGTCC TGGATGTGCT GTGTTCTCTC TGTGTGTGCC ATGGAGTTGC CGTCCGTTCT 
AATCAGCATC TCATCTGTGA TAACCTCCTG CCGGGACGAG ACCTCTTACT GCAGACCCGG 
CTTGTGAATC ATGTCAGCAG CATGAGGCCT AATATTTTCC TGGGTGTCAG CGAAGGATCA 
GCACAGTATA AGAAGTGGTA CTACGAGCTC ATGGTGGACC ACACGGAACC CTTTGTGACC 
GCAGAAGCCA CTCACCTGCG AGTGGGCTGG GCTTCCACTG AAGGGTATTC CCCGTACCCA 
GGTGGGGGTG AAGAGTGGGG TGGCAATGGC GTTGGTGATG ACCTCTTCTC CTATGGGTTT 
GATGGCCTTC ACCTCTGGTC AGGTTGTATA GCTCGAACAG TGAGCTCCCC CAACCAGCAC 
CTGCTGAGAA CTGATGATGT CATAAGTTGC TGTTTAGATC TAAGTGCCCC GAGCATCTCG 
TTTCGCATTA ATGGACAACC TGTGCAAGGG ATGTTTGAGA ACTTCAATAT CGATGGCCTG 
TTCTTTCCGG TTGTCAGTTT CTCTGCAGGA ATAAAGGTTC GCTTTTTGCT TGGGGGGAGA 
CACGGAGAAT TCAAATTTCT CCCTCCACCG GGCTATGCAG CTTGCTATGA AGCTGTTTTG 
CCCAAAGAGA AATTGAAGGT GGAACACAGC CGAGAATATA AGCAAGAGAG GACGTACACA 
CGAGACCTGC TGGGGCCTAC AGTGTCCCTG ACCCAAGCTG CCTTCACACC TGTTCCTGTG 
GACACCAGCC AGATTGTGTT GCCTCCTCAC CTGGAAAGGA TAAGAGAAAG ACTGGCAGAA 
AATATCCACG AGCTCTGGGT TATGAATAAA ATTGAGCTTG GCTGGCAGTA TGGTCCGGTT 
AGAGATGACA ACAAGAGACA GCACCCATGT CTGGTGGAGT TCTGCAAGCT TCCGGAACAG 
GAACGCAACT ACAATTTGCA GATGTCTCTG GAAACCCTCA AGACTTTGCT GGCATTAGGA 
TGTCATGTGG GTATAGCGGA TGAACATGCT GAAGAGAAGG TGAAGAAAAT GAAGCTGCCC 
AAGAATTACC AGCTGACCAG TGGATACAAG CCTGCCCCCA TGGATCTGAG CTTTATAAAA 
CTTACCCCGT CTCAGGAAGC AATGGTGGAC AAGTTGGCTG AAAATGCTCA CAACGTGTGG 
GCCCGGGACC GAATCCGGCA GGGCTGGACT TACGGCATCC AGCAGGATGT GAAGAACAGG 
AGAAACCCTC GTCTGGTTCC CTACACTCTT CTGGATGACA GAACCAAGAA GTCCAACAAA 
GACAGTCTCC GAGAGGCAGT GCGAACACTG CTGGGCTACG GCTACCACCT GGAAGCTCCT 
GATCAGGACC ACGCCTCAAG AGCCGAGGTG TGCAGCGGTA CTGGGGAGAG GTTCCGCATC 
TTCAGGGCAG AGAAGACCTA TGCAGTAAAG GCTGGGCGCT GGTACTTTGA ATTTGAGGCC 
GTCACTGCTG GAGACATGAG GGTGGGATGG AGCAGGCCAG GCTGCCAACC GGATCTAGAA 
CTGGGTTCTG ATGAACGTGC CTTCGCTTTT GACGGCTTTA AGGCCCAGCG GTGGCACCAG 
GGCAATGAAC ACTACGGGCG TTCTTGGCAA GCAGGTGATG TCGTGGGCTG CATGGTTGAT 
ATGAATGAAC ACACCATGAT GTTCACTCTG AACGGTGAGA TCCTGCTGGA TGACTCAGGC 
TCCGAGCTGG CTTTCAAGGA CTTTGATGTT GGTGACGGAT TCATCCCTGT GTGTAGCCTC 
GGGGTGGCAC AAGTAGGCAG GATGAACTTT GGAAAGGACG TCAGCACTTT GAAATACTTT 
ACCATCTGTG GCTTACAAGA GGGCTACGAG CCATTTGCAG TTAACACAAA TAGGGACATC 
ACCATGTGGC TGAGCAAGCG GCTTCCTCAG TTCCTCCAGG TCCCCTCAAA CCACGAACAC 
ATCGAGGTGA CCAGAATAGA TGGTACCATA GACAGTTCTC CATGTCTGAA GGTCACTCAG 
AAGTCCTTTG GTTCTCAGAA CAGCAACACA GACATCATGT TTTACCGCCT GAGTATGCCC 
ATTGAGTGTG CTGAGGTCTT CTCAAAGTCC GTGGCTGGAG GGATCCCTGG CGCCGGCTTC 
TATGGGCCCA AGAATGATTT GGAGGACTTT GATGTGGATT CTGACTTTGA GGTTCTGATG 
AAGACAGCTC ATGGTCATCT TGTGCCCGAC CGCATGGACA AGGACAAAGA GACCCCCAAG 
CCAGAATTCA ATAACCACAA AGATTATGCT CAGGAAAAGC CCTCACGCCT AAAGCAAAGA 
TTCTTACTTA GAAGGACCAA GCCAGATTAC AGCACAAGCC ATTCTGCAAG ACTCACTGAA 
GACGTCCTTG CTGATGACCG GGATGACTAT GAATATCTGA TGCAGACATC TACATACTAT 
TATTCAGTGA GGATCTTTCC TGGACAAGAA CCAGCTAACG TCTGGGTGGG CTGGATTACA 
TCTGACTTCC ACCAGTATGA CACAGGCTTC GATTTGGACA GAGTGCGCAC AGTGACAGTC 
ACCCTAGGAG ATGAAAAAGG GAAAGTGCAC GAGAGCATCA AACGCAGCAA CTGCTATATG 
GTGTGTGCGG GAGAGAGCAT GAGCCCCGGG CAAGGCCGAA ACAACAGCAA TGGCTTGGAG 
ATCGGCTGTG TGGTGGACGC TGCCAGTGGG CTGCTCACAT TCATAGCCAA CGGCAAGGAG 
CTAAGCACTT ACTATCAGGT GGAGCCAAGC ACGAAGTTAT TTCCTGCGGT TTTCGCGCAA 
GCTACAAGTC CCAATGTTTT CCAGTTTGAG TTGGGCAGAA TAAAGAATGT GATGCCTCTC 
TCAGCGGGAT TGTTTAAGAG TGAGCACAAA AACCCCGTGC CCCAGTGTCC TCCACGTCTG 
CACGTGCAGT TCCTGTCACA TGTCCTGTGG AGCCGGATGC CCAACCAGTT CCTCAAGGTG 
GACGTCTCTC GAATCAGTGA ACGCCAAGGC TGGCTGGTGC AGTGTCTGGA TCCTCTGCAG 
TTCATGTCCC TCCACATCCC CGAGGAGAAC AGATCTGTTG ATATCTTAGA GCTGACCGAG 
CAGGAGGAGT TGTTGCAGTT TCACTACCAC ACCCTCCGCC TCTACTCTGC AGTCTGTGCC 
CTTGGGAATC ACCGGGTGGC GCATGCACTG TGCAGCCACG TGGACGAACC TCAGCTGCTC 
TATGCCATTG AGAACAAGTA CATGCCTGGC TTGCTGCGAG CCGGGTACTA TGACCTGCTG 
ATTGACATCC ACCTCAGCTC CTACGCCACC GCCAGGCTCA TGATGAACAA TGAGTTCATC 
GTCCCGATGA CAGAGGAGAC AAAGAGCATC ACCCTCTTCC CTGATGAGAA CAAGAAACAT 
GGCCTCCCGG GCATAGGCCT CAGCACCTCT CTCCGCCCTC GGATGTGCTT TTCCTCCCCT 
AGTTTCGTGA GCATTAGCAA CGAATGCTAT CAGTATAGTC CCGAGTTCCC ACTGGACATC 
CTCAAGGCCA AGACCATCCA GATGCTCACA GAAGCGGTGA AGGAGGGCAG CCTCCACGCG 
CGGGATCCCG TGGGCGGGAC CACCGAGTTC CTCTTTGTGC CTCTCATCAA GCTCTTCTAC 
ACCCTGCTCA TCATGGGCAT CTTTCACAAT GAGGATTTGA AACACATCCT GCGGTTGATT 
GAGCCTAGTG TGTTTAAGGA AGCTGCCACT CCAGAGGAGG AAGGAGGTGC CCCAGAGAAG 
GAGATTAGTA TAGACGACTC TAAACTGGAA GTCAAAGAGG AAGCCAAAGC AGGCAAAAGG 
CCTAAGGAAG GCTTACTCCA GATGAAACTC CCGGAGCCTG TTAAACTACA GATGTGCCTC 
TTGCTTCAGT ACCTCTGTGA CTGCCAGGTT CGGCACCGGA TAGAAGCCAT TGTAGCCTTT 
TCAGATGACT TTGTAGCCAA ACTCCAAGAC AATCAGCGGT TCAGGTATAA TGAAGTCATG 
CAAGCCTTAA ACATGTCTGC TGCACTCACT GCCAGGAAGG AGTTCCGGTC ACCACCACAG 
GAGCAGATCA ATATGCTTCT TAATTTTAAG GATGATAAAA GTGAATGCCC CTGCCCTGAA 
GAAATCCGAG ACCAACTCCT AGATTTCCAT GAGGACCTGA TGACTCACTG TGGAATTGAA 
CTGGATGAAG ATGGATCTCT AGACGGAAGC AATGACTTAA CAATCAGAGG ACGTCTGCTG 
TCCCTGGTAG AAAAGGTGAC CTACCTGAAG AAAAAGCAAG CTGAAAAACC AGTCGCAAGT 
GACTCCAGAA AGTCCTCCAG CCTCCAGCAA CTCATTTCTG AGACTATGGT GCGGTGGGCT 
CAAGAGTCTG TCATCGAGGA CCCTGAGCTG GTGAGGGCTA TGTTTGTGCT GCTGCACCGG 
CAGTATGATG GCATTGGGGG TCTCGTTCGA GCACTGCCAA AGACCTACAC TATCAACGGC 
GTCTCTGTGG AGGACACCAT CAATCTGCTT GCATCACTTG GTCAGATCCG ATCCCTGCTG 
AGTGTGAGGA TGGGCAAAGA AGAAGAGAAG CTGATGATCC GAGGATTAGG GGATATTATG 
AATAACAAGG TGTTTTATCA GCATCCCAAT CTCATGAGGG CCCTTGGGAT GCACGAAACA 
GTGATGGAAG TCATGGTGAA CGTCCTTGGA GGTGGGGAGT CCAAGGAAAT CACCTTCCCC 
AAGATGGTGG CCAACTGCTG CCGTTTTCTC TGTTACTTCT GTCGTATAAG TAGGCAGAAT 
CAGAAAGCCA TGTTTGATCA TCTCAGTTAT TTACTGGAAA ACAGCAGTGT TGGTCTTGCC 
TCACCAGCCA TGAGAGGTTC AACTCCATTA GACGTGGCCG CAGCGTCAGT GATGGATAAC 
AATGAGCTTG CCCTTGCTCT ACGAGAGCCG GATCTGGAGA AGGTGGTTCG CTATCTGGCC 
GGCTGTGGTC TGCAGAGCTG CCAGATGCTG GTGTCTAAGG GTTACCCAGA CATTGGGTGG 
AATCCAGTTG AAGGAGAACG ATATCTTGAC TTTCTCAGAT TTGCCGTCTT CTGTAATGGG 
GAGAGTGTGG AAGAGAATGC AAATGTTGTG GTGAGGTTGC TCATCCGGAG ACCGGAGTGC 
TTTGGCCCTG CCTTGAGAGG AGAAGGTGGT AATGGTCTCC TTGCAGCCAT GGAAGAAGCC 
ATAAAAATAG CTGAGGATCC TTCTAGAGAT GGCCCCTCTC CAACCAGTGG ATCCAGCAAA 
ACCCTTGATG CGGAAGAGGA GGAAGACGAC ACCATCCACA TGGGGAACGC AATCATGACC 
TTCTACGCAG CTTTGATTGA CCTGCTTGGT CGCTGTGCTC CTGAAATGCA TTTGATTCAT 
GCTGGAAAGG GAGAAGCCAT CCGAATCAGG TCTATTTTGC GATCCCTGAT TCCATTGGGA 
GACTTGGTGG GTGTAATCAG CATTGCATTT CAGATGCCAA CAATAGCCAA AGATGGGAAG 
GTGGTGGAGC CTGACATGTC CGCGGGGTTT TGCCCAGATC ACAAGGCAGC CATGGTTTTG 
TTCCTTGACA GGGTCTATGG AATTGAGGTG CAAGATTTCC TCCTCCATCT CCTTGAGGTT 
GGCTTTCTGC CAGATCTTCG CGCTGCTGCC TCTCTAGACA CGGCTGCACT AAGTGCTACA 
GACATGGCCT TGGCCCTCAA TCGGTACCTC TGCACAGCTG TCCTGCCTTT GTTAACGAGA 
TGTGCTCCCC TGTTTGCTGG AACAGAGCAC CATGCTTCCC TCATTGACTC TCTGCTACAC 
ACTGTATATA GACTCTCTAA GGGATGTTCC CTCACCAAAG CTCAGCGGGA CTCCATAGAA 
GTGTGCCTGC TCTCTATATG TGGCCAACTG CGACCTTCTA TGATGCAGCA CCTACTCCGA 
AGGCTGGTGT TTGATGTCCC ACTGCTGAAC GAGCACGCAA AGATGCCTCT AAAGCTGCTG 
ACCAATCATT ATGAAAGATG CTGGAAATAT TACTGCCTAC CTGGAGGGTG GAGCAACTTT 
GGTGCTGCCT CGGAAGAAGA ACTTCATTTA TCAAGAAAAT TATTTTGGGG CATTTTTGAT 
GCTTTGTCTC AAAAGAAATA CGAACAAGAA CTTTTCAAAC TGGCCCTGCC TTGCCTGAGT 
GCAGTTGCGG GAGCTTTACC TCCAGACTAC ATGGAGTCAA ACTATGTCAG TATGATGGAA 
AAACAGTCAT CCATGGACTC TGAAGGGAAC TCTAACCCAC AACCTGTTGA TACCTCAAAC 
ATTACAATTC CCGAGAAGCT GGAATACTTC ATTAACAAGT ATGCGGAGCA TTCCCATGAT 
AAATGGTCTA TGGACAAGTT GGCGAATGGA TGGATTTATG GGGAAATATA TTCAGACTCT 
TCTAAGATCC AGCCACTAAT GAAGCCATAT AAACTCTTAT CTGAAAAGGA AAAAGAAATT 
TATCGTTGGC CAATCAAGGA GTCTTTAAAA ACGATGCTGG CTTGGGGTTG GAGAATTGAG 
AGGACACGGG AGGGAGACAG TATGGCCCTT TATAACCGGA CTCGGCGCAT TTCTCAGACT 
AGCCAGGTGT CTATAGATGC TGCACATGGG TATAGCCCCC GTGCTATCGA CATGAGTAAC 
GTTACCCTCT CGAGAGACCT GCATGCTATG GCGGAGATGA TGGCTGAAAA CTACCACAAC 
ATATGGGCCA AGAAAAAGAA AATGGAGCTG GAATCCAAAG GAGGAGGAAA CCACCCCCTG 
CTAGTGCCCT ACGACACACT GACAGCCAAG GAGAAAGCCA AGGACAGAGA AAAGGCCCAG 
GACATCTTCA AGTTCCTACA GATCAGTGGT TATGCTGTAT CCAGAGGGTT CAAGGACCTG 
GATCTGGACA CACCTTCCAT TGAGAAGCGA TTTGCCTACA GTTTCCTGCA GCAGCTGATC 
CGATATGTGG ACGAGGCCCA TCAGTACATC CTGGAGTTTG ACGGTGGCAG CAGAAGCAAA 
GGAGAGCATT TCCCGTACGA GCAAGAGATC AAGTTCTTCG CCAAAGTTGT TCTTCCTTTA 
ATTGATCAGT ATTTCAAAAA CCATCGCCTG TACTTCTTGT CTGCTGCAAG CAGGCCTCTT 
TGCACCGGAG GACATGCGTC CAACAAGGAG AAGGAGATGG TTACAAGCCT GTTCTGCAAA 
CTTGGAGTTC TTGTCAGGCA TAGGATTTCA CTGTTTGGGA ATGATGCTAC CTCAATTGTG 
AACTGTCTTC ATATTTTGGG TCAGACTTTG GATGCAAGGA CTGTGATGAA GACGGGTCTG 
GACAGCGTGA AAAGTGCTCT CAGGGCCTTT CTGGACAATG CGGCGGAGGA TCTGGAAAAG 
ACGATGGAAA ACCTTAAGCA GGGCCAGTTT ACTCACACCA GGAGCCAGCC CAAGGGCGTG 
ACTCAGATCA TCAACTATAC CACCGTGGCG CTCCTGCCCA TGCTCTCTTC CCTGTTTGAG 
CACATTGGCC AGCATCAGTT TGGAGAAGAT CTGATATTGG AGGATGTGCA GGTGTCTTGT 
TACAGAATTC TGACCAGCTT GTATGCCTTG GGAACCAGCA AGAGCATCTA TGTGGAAAGG 
CAACGTTCTG CACTCGGAGA ATGCCTAGCT GCCTTTGCTG GTGCCTTCCC TATCGCCTTT 
CTAGAAACCC ACCTGGACAA ACATAATGTT TACTCCATCT ACAACACCAG GTCTTCACGA 
GAAAGAGCAG CTCTCAGTTT ACCCGCAAAT GTGGAGGATG TCTGCCCAAA TATACCATCC 
CTGGAGAAGC TCATGACTGA GATCATAGAG CTGGCAGAGT CAGGAACCCG TTACACTCAG 
ATGCCACACA TGATGGGGGT GGTACTGCCC ATGTTATGCA GCTACATGTC AAGGTGGTGG 
GAGCACGGTC CTGAGAACCA TCCAGAGAGG GCTGAGATGT GCTGCACAGC GCTCAACTCA 
GAGCACATGA ACACACTGCT GGGCAACATT CTCAAGATCA TCTACAACAA CCTGGGGATT 
GATGAAGGGG CCTGGATGAA GCGCTTAGCT GTATTTTCAC AGCCAATCAT CAACAAGGTG 
AAACCTCAGC TCTTAAAAAC TCATTTCTTA CCCTTAATGG AGAAACTAAA GAAAAAGGCT 
GCCATGGTAG TGTCTGAGGA AGACCACCTA AAAGCCGAAG CCAGAGGGGA CATGTCCGAA 
GCGGAGCTGC TCATTCTAGA TGAGTTTACC ACATTGGCCA GGAATCTCTA TGCCTTCTAC 
CCACTCTTGA TCCGATTTGT GGACTATAAC AGGGCAAAGT GGCTGAAGGA ACCCAACCCA 
GAAGCAGAGG AGCTATTTCG AATGGTAGCT GAAGTCTTCA TTTACTGGTC CAAATCCCAT 
AATTTCAAAA GAGAGGAACA GAACTTTGTG GTGCAGAATG AAATCAACAA CATGTCCTTC 
CTCATCACCG ACACAAAGTC TAAGATGTCC AAGGCAGCCA TTTCTGATCA AGAGAGGAAG 
AAAATGAAGC GGAAAGGAGA CCGGTATTCT ATGCAGACAT CTTTGATTGT GGCAGCTCTG 
AAGCGATTGC TTCCCATTGG ACTGAACATC TGTGCCCCTG GGGACCAAGA GCTCATTGCT 
CTGGCCAAAA ACCGATTTAG CTTGAAAGAC ACTGAGGAGG AAGTACGTGA TGTAATCCGC 
AGTAATATAC ACTTGCAAGG CAAGCTGGAA GACCCTGCAA TCAGGTGGCA GATGGCTCTA 
TACAAAGACT TGCCAAACAG GGCAGAAGAC ACCTCAGACC CAGAGAGGAC AGTGGAGCGT 
ATCCTGGATA TAGCGAATGT GCTTTTTCAC CTTGAACAGG TGGAGCACCC TCAGAGATCA 
AAGAAAGCCG TGTGGCACAA ACTGCTCTCT AAGCAGAGAA AAAGAGCTGT TGTTGCCTGT 
TTCCGGATGG CCCCTTTGTA CAATCTGCCA AGGCATCGGG CTGTCAATCT CTTTCTTCAG 
GGATATGAAA AGTCTTGGAT TGAAACAGAA GAGCATTACT TTGAGGATAA ATTGATCGAA 
GATTTAGCGA AACCGGGGTC TGAACTCCCA GAAGAAGATG AAGCCATGAA AAGAGTTGAT 
CCTCTGCATC AGCTTATTCT TCTGTTCAGC CGCACAGCCT TAACAGAGAA ATGCAAACTG 
GAGGAAGATT TTCTGTACAT GGCGTATGCA GACATTATGG CAAAGAGTTG TCACGATGAA 
GAAGACGATG ATGGTGAAGA AGAAGTGAAG AGCTTTGAAG TCACAGGATC CCAACGCAGC 
AAGGAAAAGG AAATGGAAAA GCAGAAGCTT CTGTACCAGC AAGCCAGACT GCATGACCGC 
GGGGCTGCCG AGATGGTTCT CCAGACCTTC AGTGCCAGCA AAGGTGAAAC TGGACCAATG 
GTGGCTGCCA CTTTGAAGCT GGGTATTGCT ACTTTAAATG GTGGGAACTC CACGGTGCAG 
CAGAAGATGC TGGATTACCT GAAGGAGAAA AAAGATGTAG GCTTCTTCCA GAGCCTGGCA 
GGCCTCATGC AGTCTTGCAG TGTCCTGGAC CTGAATGCCT TTGAGAGGCA AAACAAAGCA 
GAAGGACTTG GGATGGTGAC TGAGGAAGGA TCAGGAGAGA AGGTACTTCA GGATGATGAG 
TTCACCTGTG ACCTCTTCCG ATTCCTGCAG CTGCTCTGTG AAGGACACAA CTCAGATTTT 
CAGAATTACC TGAGAACCCA GACTGGCAAC AACACCACAG TTAATATCAT CATCTCTACT 
GTGGACTACC TCCTTCGAGT GCAGGAGTCC ATTAGTGATT TCTATTGGTA CTACTCTGGC 
AAGGACATCA TAGGTGAGCA GGGCCAGCGT AACTTTTCCA AAGCCATCCA AGTGGCGAAG 
CAGGTGTTCA ACACACTCAC GGAGTACATC CAGGGTCCTT GTACCGGAAA CCAGCAGAGT 
TTGGCACACA GCAGGCTCTG GGATGCTGTT GTGGGCTTCC TTCATGTATT TGCACACATG 
CAGATGAAGC TGTCTCAGGA TTCCAGCCAG ATTGAGCTCT TAAAAGAACT GATGGATCTC 
CAAAAGGACA TGGTGGTCAT GCTGCTGTCT ATGCTAGAGG GTAATGTGGT AAACGGAACA 
ATAGGCAAGC AGATGGTGGA CATGCTTGCG GAGTCATCCA ACAACGTGGA GATGATCCTC 
AAGTTCTTTG ACATGTTTCT GAAGTTAAAG GACTTGACAT CCTCTGACAC ATTTAAAGAG 
TATGACCCTG ATGGCAAAGG CGTCATTTCC AAGAGAGACT TCCACAAAGC CATGGAGAGC 
CACAAACACT ACACCCAGTC AGAGACTGAG TTTCTGTTGT CCTGTGCAGA GACAGATGAG 
AACGAGACGC TGGATTATGA AGAGTTTGTC AAAAGGTTCC ACGAGCCTGC CAAGGACATC 
GGCTTCAACG TCGCCGTTCT GCTGACCAAC CTCTCAGAGC ACATGCCCAA TGACACGAGG 
CTGCAGACCT TCTTGGAGCT GGCAGAGAGT GTCCTCAACT ACTTCCAACC TTTCCTGGGT 
CGCATCGAGA TCATGGGCAG CGCCAAGCGC ATCGAGAGGG TCTACTTTGA GATCAGCGAA 
TCCAGCCGAA CCCAGTGGGA GAAGCCCCAG GTCAAGGAGT CCAAGAGGCA GTTCATATTC 
GATGTGGTCA ATGAGGGCGG GGAAAAGGAG AAGATGGAGC TCTTTGTGAA CTTCTGTGAG 
GACACCATCT TTGAGATGCA GCTGGCAGCT CAGATCTCAG AGTCCGGCCT GAATGAGAGG 
TCGGCAAATA AAGAGGAGAG TGAAAAGGAG AGGCCAGAGG AGCAGGCCCC ACGGATGGGC 
TTCTTCTCCC TGCTCACCGT CCAGTCAGCC CTGTTTGCAC TCAGGTACAA TGTCCTAACC 
CTTGTGAGGA TGCTCAGCCT GAAGAGCCTG AAGAAGCAGA TGAAGAGAAT GAAGAAGATG 
ACAGCGAAGG ACATGGTCTC AGCCTTCTTC TCGTCCTACT GGAGTGTGTT TGTCACCCTC 
CTACACTTCG TGGCCAGCGT CTGTAGGGGC TTCTTCCGCA TTGTCTCCAG CCTACTGCTG 
GGGGGCAGCC TGGTGGAAGG TGCTAAGAAA ATCAAAGTGG CGGAGCTTCT TGCCAACATG 
CCAGACCCTA CTCAGGATGA GGTGCGAGGA GATGAAGAGG AGGGAGAGAG GAAGCCATTA 
GAGTCAGCCC TGCCCTCTGA AGACCTAACG GACTTGAAGG AACTGACGGA GGAAAGTGAC 
CTTCTTTCAG ACATATTTGG CTTGGATCTG AAGAGAGAAG GAGGGCAGTA CAAACTAATT 
CCTCACAACC CAAATGCTGG TCTCAGTGAC CTCATGACGA ACCCCATCCC TGTCCCTGAG 
GTACAAGAAA AGTTTCAGGA GCAGAAGGTA AAAGAAGAAA AGGAAGGAAA GGAAGAAACC 
AAGTCTGAAC CGGAGAAGGC TGAGGGAGAG GATGGAGAAA AAGAAGAAAA AGCCAAAGAT 
GATAAGGGTA AACAGAAGTT GAGGCAGCTT CATACACATC GATATGGGGA GCCTGAGGTC 
CCCGAGTCAG CATTCTGGAA GAAAATCATA GCCTACCAAC AGAAGCTGCT GAACTATTTT 
GCTCGCAACT TTTACAACAT GAGAATGCTG GCCCTGTTTG TCGCCTTCGC CATCAATTTC 
ATCCTGCTCT TCTACAAGGT CTCCACTTCT TCTGTGGTTG AAGGAAAGGA GCTGCCTACC 
CGAACTTCCA GCGATGCCGC TAAAGTGACC ACCAGCCTGG ACAGCGGCCC CCACAGAATC 
ATTGCGGTTC ACTACGTCCT GGAGGAGAGT AGCGGCTACA TGGAACCCAC CTTGCGCATC 
CTAGCCATCC TCCACACCAT CATCTCCTTC TTCTGCATCA TCGGATACTA CTGCCTGAAA 
GTCCCCTTGG TTATTTTTAA GCGAGAGAAG GAAGTGGCAC GGAAGTTGGA GTTTGATGGG 
CTTTACATTA CGGAGCAGCC ATCGGAAGAC GATATCAAAG GCCAGTGGGA CAGACTGGTG 
ATCAACACAC AGTCATTTCC CAATAACTAC TGGGATAAAT TTGTTAAAAG AAAGGTAATG 
GATAAATATG GAGAGTTTTA TGGGAGAGAC AGAATCAGCG AGTTACTGGG CATGGATAAG 
GCTGCACTGG ATTTCAGCGG TGCAAGAGAG AAGAAGAAGC CCAAGAAGGA CAGTTCCTTG 
TCTGCTGTAT TGAACTCTAT TGACGTGAAG TACCAGATGT GGAAACTTGG AGTCGTGTTC 
ACAGACAATT CCTTCCTCTA CCTAGCCTGG TATATGACCA TGTCTGTTCT TGGACACTAC 
AACAACTTTT TTTTTGCTGC CCACCTCCTT GACATCGCGA TGGGCTTCAA GACCTTGAGA 
ACTATCCTGT CCTCAGTTAC CCATAATGGC AAACAGCTCG TGTTAACTGT TGGCTTGTTG 
GCTGTCGTTG TATACCTGTA CACTGTTGTG GCGTTCAATT TCTTCCGAAA ATTCTACAAT 
AAAAGCGAGG ATGGTGACAC GCCGGACATG AAGTGTGACG ACATGCTGAC GTGTTACATG 
TTCCACATGT ATGTGGGCGT CCGTGCTGGA GGGGGCATCG GTGATGAAAT TGAAGACCCA 
GCAGGAGATG AGTACGAGAT CTACCGAATC ATCTTTGATA TCACATTCTT CTTCTTTGTG 
ATTGTCATCC TTTTGGCTAT CATACAAGGT TTGATCATTG ATGCTTTTGG AGAACTCAGA 
GACCAACAAG AGCAAGTCAA GGAAGACATG GAGACCAAGT GCTTCATCTG TGGGATAGGC 
AACGACTACT TTGATACAGT GCCGCATGGC TTTGAAACCC ATACTCTACA GGAGCACAAC 
CTGGCCAACT ACCTGTTTTT TCTGATGTAC CTCATAAACA AGGATGAAAC AGAACACACG 
GGACAGGAAT CTTATGTCTG GAAGATGCAC CAAGAGAGGT GTTGGGAATT TTTCCCAGCA 
GGAGACTGTT TCCGGAAACA GTATGAGGAC CAGTTAAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ryr2 ( NM_001191043.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001177972.1 Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant 2, mRNA.

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CloneID	ORa12617
Clone ID Related Accession (Same CDS sequence)	NM_001191043.1
Accession Version	NM_001191043.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 14844bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	ryanodine receptor 2 isoform 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB204523.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB204523.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGATG CGGGCGAAGG CGAGGACGAG ATCCAGTTCC TGAGAACTGA TGATGAGGTG 
GTTCTACAGT GCACCGCAAC CATCCACAAA GAGCAGCAGA AGCTGTGCTT GGCAGCAGAA 
GGATTTGGCA ACAGACTTTG CTTTTTGGAG TCTACTTCCA ATTCTAAGAA TGTCCCCCCG 
GACCTGTCCA TCTGCACCTT TGTGCTGGAG CAGTCCCTGT CAGTACGGGC CCTGCAGGAG 
ATGCTGGCCA ACACAGTGGA AAAGTCAGAA GGGAAGTTCA TGATGAAGAC TGCTCAAGGT 
GGAGGCCACC GGACACTCCT CTATGGACAC GCCATACTAC TACGCCATTC CTACAGTGGT 
ATGTATCTCT GCTGTCTCTC CACCTCCCGG TCTTCCACCG ACAAACTGGC CTTTGATGTT 
GGCCTTCAAG AGGATACCAC AGGGGAGGCT TGCTGGTGGA CCATACATCC TGCCTCTAAG 
CAGAGATCAG AAGGAGAAAA GGTGCGGGTT GGAGACGACC TCATATTGGT CAGCGTGTCC 
TCAGAAAGGT ACTTGCACTT GTCATACGGC AACAGCAGCT GGCGTGTAGA CGCAGCCTTC 
CAGCAGACCC TCTGGAGCGT GGCCCCTATC AGCTCAGGAA GTGAAGCAGC CCAAGGGTAT 
CTCATTGGTG GTGATGTTCT CCGGCTGCTA CATGGACACA TGGATGAATG TCTCACTGTT 
CCTTCAGGAG AACATGGTGA AGAACAGCGG AGAACAGTCC ATTATGAAGG TGGTGCTGTA 
TCAGTTCATG CCCGCTCCCT CTGGAGACTA GAGACCCTAA GAGTCGCGTG GAGTGGAAGT 
CACATAAGAT GGGGCCAGCC ATTCCGACTG CGGCACGTCA CGACAGGAAA ATACTTAAGC 
CTCATGGAAG ACAAGAACCT TCTACTCATG GACAAAGAAA AAGCTGATGT AAAATCAACG 
GCGTTTGCCT TCCGGTCTTC CAANGAAAAA TTGGATGCAG GTGTAAGGAA AGAAGTCGAT 
GGCATGGGAA CCTCAGAAAT CAAGTATGGA GACTCCATTT GCTATATACA ACATGTGGAC 
ACAGGCCTGT GGCTAACCTA CCAGGCCGTG GATGTCAAAT CAGCACGAAT GGGATCCATA 
CAGCGTAAGG CTATCATGCA CCACGAAGGC CACATGGATG ACGGCTTGAA CTTATCCAGA 
TCGCAGCACG AGGAGTCCCG CACTGCCCGT GTCATCCGGA GCACAGTGTT TCTCTTCAAT 
AGGTTCATAA GGGGCCTGGA TGCTCTCAGC AAGAGAGCGA AGCTGCCCAC TGTTGACTTG 
CCCATCGAGT CTGTGAGCCT GAGTNTGCAG GACCTCATCG GCTACTTCCA CCCCCCAGAC 
GAGCACCTGG AGCACGAGGA CAAGCAGAAC AGGCTGCGAG CCCTGAAGAA CCGGCAGAAT 
CTCTTCCAGG AAGAGGGAAT GATCAACCTG GTTCTGGAGT GCATCGACCG CCTCCATGTC 
TACAGCAGTG CAGCCCACTT TGCAGACGTT GCAGGACGAG AAGCGGGGGA GTCTTGGAAA 
TCCATCCTGA ATTCTCTGTA TGAGTTGCTG GCGGCTCTAA TTAGAGGAAA TCGTAAAAAC 
TGTGCTCAAT TTTCTGGCTC CCTCGACTGG CTGATCAGCA GACTGGAGAG ACTGGAAGCG 
TCCTCTGGTA TCCTGGAGGT CCTCCACTGT GTGTTAGTGG AGAGCCCGGA AGCTCTGAAT 
ATCATCAAAG AAGGACACAT CAAGTCCATT ATTTCCCTTT TAGACAAGCA TGGGAGAAAC 
CACAAGGTCC TGGATGTGCT GTGTTCTCTC TGTGTGTGCC ATGGAGTTGC CGTCCGTTCT 
AATCAGCATC TCATCTGTGA TAACCTCCTG CCGGGACGAG ACCTCTTACT GCAGACCCGG 
CTTGTGAATC ATGTCAGCAG CATGAGGCCT AATATTTTCC TGGGTGTCAG CGAAGGATCA 
GCACAGTATA AGAAGTGGTA CTACGAGCTC ATGGTGGACC ACACGGAACC CTTTGTGACC 
GCAGAAGCCA CTCACCTGCG AGTGGGCTGG GCTTCCACTG AAGGGTATTC CCCGTACCCA 
GGTGGGGGTG AAGAGTGGGG TGGCAATGGC GTTGGTGATG ACCTCTTCTC CTATGGGTTT 
GATGGCCTTC ACCTCTGGTC AGGTTGTATA GCTCGAACAG TGAGCTCCCC CAACCAGCAC 
CTGCTGAGAA CTGATGATGT CATAAGTTGC TGTTTAGATC TAAGTGCCCC GAGCATCTCG 
TTTCGCATTA ATGGACAACC TGTGCAAGGG ATGTTTGAGA ACTTCAATAT CGATGGCCTG 
TTCTTTCCGG TTGTCAGTTT CTCTGCAGGA ATAAAGGTTC GCTTTTTGCT TGGGGGGAGA 
CACGGAGAAT TCAAATTTCT CCCTCCACCG GGCTATGCAG CTTGCTATGA AGCTGTTTTG 
CCCAAAGAGA AATTGAAGGT GGAACACAGC CGAGAATATA AGCAAGAGAG GACGTACACA 
CGAGACCTGC TGGGGCCTAC AGTGTCCCTG ACCCAAGCTG CCTTCACACC TGTTCCTGTG 
GACACCAGCC AGATTGTGTT GCCTCCTCAC CTGGAAAGGA TAAGAGAAAG ACTGGCAGAA 
AATATCCACG AGCTCTGGGT TATGAATAAA ATTGAGCTTG GCTGGCAGTA TGGTCCGGTT 
AGAGATGACA ACAAGAGACA GCACCCATGT CTGGTGGAGT TCTGCAAGCT TCCGGAACAG 
GAACGCAACT ACAATTTGCA GATGTCTCTG GAAACCCTCA AGACTTTGCT GGCATTAGGA 
TGTCATGTGG GTATAGCGGA TGAACATGCT GAAGAGAAGG TGAAGAAAAT GAAGCTGCCC 
AAGAATTACC AGCTGACCAG TGGATACAAG CCTGCCCCCA TGGATCTGAG CTTTATAAAA 
CTTACCCCGT CTCAGGAAGC AATGGTGGAC AAGTTGGCTG AAAATGCTCA CAACGTGTGG 
GCCCGGGACC GAATCCGGCA GGGCTGGACT TACGGCATCC AGCAGGATGT GAAGAACAGG 
AGAAACCCTC GTCTGGTTCC CTACACTCTT CTGGATGACA GAACCAAGAA GTCCAACAAA 
GACAGTCTCC GAGAGGCAGT GCGAACACTG CTGGGCTACG GCTACCACCT GGAAGCTCCN 
GATCAGGACC ACGCCTCAAG AGCCGAGGTG TGCAGCGGTA CTGGGGAGAG GTTCCGCATC 
TTCAGGGCAG AGAAGACCTA TGCAGTAAAG GCTGGGCGCT GGTACTTTGA ATTTGAGGCC 
GTCACTGCTG GAGACATGAG GGTGGGATGG AGCAGGCCAG GCTGCCAACC GGATCTAGAA 
CTGGGTTCTG ATGAACGTGC CTTCGCTTTT GACGGCTTTA AGGCCCAGCG GTGGCACCAG 
GGCAATGAAC ACTACGGGCG TTCTTGGCAA GCAGGTGATG TCGTGGGCTG CATGGTTGAT 
ATGAACGAAC ACACCATGAT GTTCACTCTG AACGGTGAGA TCCTGCTGGA TGACTCGGGC 
TCCGAGCTGG CTTTCAAGGA CTTTGATGTT GGTGACGGAT TCATCCCTGT GTGTAGCCTC 
GGGGTGGCAC AAGTAGGCAG GATGAACTTT GGAAAGGACG TCAGCACTTT GAAATACTTT 
ACCATCTGTG GCTTACAAGA GGGCTACGAG CCATTTGCAG TTAACACAAA TAGGGACATC 
ACCATGTGGC TGAGCAAGCG GCTTCCTCAG TTCCTCCAGG TCCCCTCAAA CCACGAACAC 
ATCGAGGTGA CCAGAATAGA TGGTACCATA GACAGTTCTC CATGTCTGAA GGTCACTCAG 
AAGTCCTTTG GTTCTCAGAA CAGCAACACA GACATCATGT TTTACCGCCT GAGTATGCCC 
ATTGAGTGTG CTGAGGTCTT CTCAAAGTCC GTGGCTGGAG GGATCCCTGG CGCCGGCTTC 
TATGGGCCCA AGAATGATTT GGAGGACTTT GATGTGGATT CTGACTTTGA GGTTCTGATG 
AAGACAGCTC ATGGTCATCT TGTGCCCGAC CGCATGGACA AGGACAAAGA GACCCCCAAG 
CCAGAATTCA ATAACCACAA AGATTATGCT CAGGAAAAGC CCTCACGCCT AAAGCAAAGA 
TTCTTACTTA GAAGGACCAA GCCAGATTAC AGCACAAGCC ATTCTGCAAG ACTCACTGAA 
GACGTCCTTG CTGATGACCG GGATGACTAT GAATATCTGA TGCAGACATC TACATACTAT 
TATTCAGTGA GGATCTTTCC TGGACAAGAA CCAGCTAACG TCTGGGTGGG CTGGATTACA 
TCTGACTTCC ACCAGTATGA CACAGGCTTC GATTTGGACA GAGTGCGCAC AGTGACAGTC 
ACCCTAGGAG ATGAAAAAGG GAAAGTGCAC GAGAGCATCA AACGCAGCAA CTGCTATATG 
GTGTGTGCGG GAGAGAGCAT GAGCCCCGGG CAAGGCCGAA ACAACAGCAA TGGCTTGGAG 
ATCGGCTGTG TGGTGGACGC TGCCAGTGGG CTGCTCACAT TCATAGCCAA CGGCAAGGAG 
CTAAGCACTT ACTATCAGGT GGAGCCAAGC ACGAAGTTAT TTCCTGCGGT TTTCGCGCAA 
GCTACAAGTC CCAATGTTTT CCAGTTTGAG TTGGGCAGAA TAAAGAATGT GATGCCTCTC 
TCAGCGGGAT TGTTTAAGAG TGAGCACAAA AACCCCGTGC CCCAGTGTCC TCCACGTCTG 
CACGTGCAGT TCCTGTCACA TGTCCTGTGG AGCCGGATGC CCAACCAGTT CCTCAAGGTG 
GATGTCTCTC GAATCAGTGA ACGCCAAGGC TGGCTGGTGC AGTGTCTGGA TCCTCTGCAG 
TTCATGTCCC TCCACATCCC CGAGGAGAAC AGATCTGTTG ATATCTTAGA GCTGACCGAG 
CAGGAGGAGT TGTTGCAGTT TCACTACCAC ACCCTCCGCC TCTACTCTGC AGTCTGTGCC 
CTTGGGAATC ACCGGGTGGC GCATGCACTG TGCAGCCACG TGGACGAACC TCAGCTGCTC 
TATGCCATTG AGAACAAGTA CATGCCTGGC TTGCTGCGAG CCGGGTACTA TGACCTGCTG 
ATTGACATCC ACCTCAGCTC CTACGCCACC GCCAGGCTCA TGATGAACAA TGAGTTCATC 
GTCCCGATGA CAGAGGAGAC AAAGAGCATC ACCCTCTTCC CTGATGAGAA CAAGAAACAT 
GGCCTCCCGG GCATAGGCCT CAGCACCTCT CTCCGCCCTC GGATGTGCTT TTCCTCCCCT 
AGTTTCGTGA GCATTAGCAA CGAATGCTAT CAGTATAGTC CCGAGTTCCC ACTGGACATC 
CTCAAGGCCA AGACCATCCA GATGCTCACA GAAGCGGTGA AGGAGGGCAG CCTCCACGCG 
CGGGATCCCG TGGGCGGGAC CACCGAGTTC CTCTTTGTGC CTCTCATCAA GCTCTTCTAC 
ACCCTGCTCA TCATGGGCAT CTTTCACAAT GAGGATTTGA AACACATCCT GCAGTTGATT 
GAGCCTAGTG TGTTTAAGGA AGCTGCCACT CCAGAGGAGG AAGGAGGTGC CCCAGAGAAG 
GAGATTAGTA TAGATGACTC TAAACTGGAA GTCAAAGAGG AAGCCAAAGC AGGCAAAAGG 
CCTAAGGAAG GTTTACTCCA GATGAAACTC CCGGAGCCTG TTAAACTACA GATGTGCCTC 
TTGCTTCAGT ACCTCTGTGA CTGCCAGGTT CGGCACCGGA TAGAAGCCAT TGTAGCCTTT 
TCAGATGACT TTGTAGCCAA ACTCCAAGAC AATCAGCGGT TCAGGTATAA TGAAGTCATG 
CAAGCCTTAA ACATGTCTGC TGCACTCACT GCCAGGAAAA CCAAGGAGTT CCGGTCACCA 
CCACAGGAGC AGATCAATAT GCTTCTCAAT TTTAAGGATG ATAAAAGTGA ATGCCCCTGC 
CCTGAAGAAA TCCGAGACCA ACTCCTAGAT TTCCATGAGG ACCTGATGAC TCACTGTGGA 
ATTGAACTGG ATGAAGATGG ATCTCTAGAC GGAAGCAATG ACTTAACAAT CAGAGGACGT 
CTGCTGTCCC TGGTAGAAAA GGTGACCTAC CTGAAGAAAA AGCAAGCTGA AAAACCAGTC 
GCAAGTGACT CCAGAAAGTC CTCCAGCCTC CAGCAACTCA TTTCTGAGAC TATGGTGCGG 
TGGGCTCAAG AGTCTGTCAT CGAGGACCCT GAGCTGGTGA GGGCTATGTT TGTGCTGCTG 
CACCGGCAGT ATGATGGCAT TGGGGGTCTC GTTCGAGCAC TGCCAAAGAC CTACACTATC 
AACGGCGTCT CTGTGGAGGA CACCATCAAT CTGCTTGCAT CACTTGGTCA GATCCGATCC 
CTGCTGAGTG TGAGGATGGG CAAAGAAGAA GAGAAGCTGA TGATCCGAGG ATTAGGGGAT 
ATTATGAATA ACAAGGTGTT TTATCAGCAT CCCAATCTCA TGAGGGCCCT TGGGATGCAC 
GAAACAGTGA TGGAAGTCAT GGTGAACGTC CTTGGAGGTG GGGAGTCCAA GGAAATCACC 
TTCCCCAAGA TGGTGGCCAA CTGCTGCCGT TTTCTCTGTT ACTTCTGTCG TATAAGTAGG 
CAGAATCAGA AAGCCATGTT TGATCATCTC AGTTATTTAC TGGAAAACAG CAGTGTTGGT 
CTTGCCTCAC CAGCCATGAG AGGTTCAACT CCATTAGACG TGGCCGCAGC GTCAGTGATG 
GATAACAATG AGCTTGCCCT TGCTCTACGA GAGCCGGATC TGGAGAAGGT GGTTCGCTAT 
CTGGCCGGCT GTGGTCTGCA GAGCTGCCAG ATGCTGGTGT CTAAGGGTTA CCCAGACATT 
GGGTGGAATC CAGTTGAAGG AGAACGATAT CTTGACTTTC TCAGATTTGC CGTCTTCTGT 
AATGGGGAGA GTGTGGAAGA GAATGCAAAT GTTGTGGTGA GGTTGCTCAT CCGGAGACCG 
GAGTGCTTTG GCCCTGCCTT GAGAGGAGAA GGTGGTAATG GTCTCCTTGC AGCCATGGAA 
GAAGCCATAA AAATAGCTGA GGATCCTTCT AGAGATGGCC CCTCTCCAAC CAGTGGATCC 
AGCAAAACCC TTGATGCGGA AGAGGAGGAA GACGACACCA TCCACATGGG GAACGCAATC 
ATGACCTTCT ACGCAGCTTT GATTGACCTG CTTGGTCGCT GTGCTCCTGA AATGCATTTG 
ATTCATGCTG GAAAGGGAGA AGCCATCCGA ATCAGGTCTA TTTTGCGATC CCTGATTCCA 
TTGGGAGACT TGGTGGGTGT AATCAGCATT GCATTTCAGA TGCCAACAAT AGCCAAAGAT 
GGGAAGGTGG TGGAGCCTGA CATGTCCGCG GGGTTTTGCC CAGATCACAA GGCAGCCATG 
GTTTTGTTCC TTGACAGGGT CTATGGAATT GAGGTGCAAG ATTTCCTCCT CCATCTCCTT 
GAGGTTGGCT TTCTGCCAGA TCTTCGCGCT GCTGCCTCTC TAGACACGGC TGCACTAAGT 
GCTACAGACA TGGCCTTGGC CCTCAATCGG TACCTCTGCA CAGCTGTCCT GCCTTTGTTA 
ACGAGATGTG CTCCCCTGTT TGCTGGAACA GAGCACCATG CTTCCCTCAT TGACTCTCTG 
CTACACACTG TATATAGACT CTCTAAGGGA TGTTCCCTCA CCAAAGCTCA GCGGGACTCC 
ATAGAAGTGT GCCTGCTCTC TATATGTGGC CAACTGCGAC CTTCTATGAT GCAGCACCTA 
CTCCGAAGGC TGGTGTTTGA TGTCCCACTG CTGAACGAGC ACGCAAAGAT GCCTCTAAAG 
CTGCTGACCA ATCATTATGA AAGATGCTGG AAATATTACT GCCTACCTGG AGGGTGGAGC 
AACTTTGGTG CTGCCTCGGA AGAAGAACTT CATTTATCAA GAAAATTATT TTGGGGCATT 
TTTGATGCTT TGTCTCAAAA GAAATACGAA CAAGAACTTT TCAAACTGGC CCTGCCTTGC 
CTGAGTGCAG TTGCGGGAGC TTTACCTCCA GACTACATGG AGTCAAACTA TGTCAGTATG 
ATGGAAAAAC AGTCATCCAT GGACTCTGAA GGGAACTTTA ACCCACAACC TGTTGATACC 
TCAAACATTA CAATTCCCGA GAAGCTGGAA TACTTCATTA ACAAGTATGC GGAGCATTCC 
CATGATAAAT GGTCTATGGA CAAGTTGGCG AATGGATGGA TTTATGGGGA AATATATTCA 
GACTCTTCTA AGATCCAGCC ACTAATGAAG CCATATAAAC TCTTATCTGA AAAGGAAAAA 
GAAATTTATC GTTGGCCAAT CAAGGAGTCT TTAAAAACGA TGCTGGCTTG GGGTTGGAGA 
ATTGAGAGGA CACGGGAGGG AGACAGTATG GCCCTTTATA ACCGGACTCG GCGCATTTCT 
CAGACTAGCC AGGTGTCTAT AGATGCTGCA CATGGGTATA GCCCCCGTGC TATCGACATG 
AGTAACGTTA CCCTCTCGAG AGACCTGCAT GCTATGGCGG AGATGATGGC TGAAAACTAC 
CACAACATAT GGGCCAAGAA AAAGAAAATG GAGCTGGAAT CCAAAGGAGG AGGAAACCAC 
CCCCTGCTAG TGCCCTATGA CACACTGACA GCCAAGGAGA AAGCCAAGGA CAGAGAAAAG 
GCCCAGGACA TCTTCAAGTT CCTACAGATC AGTGGTTATG CTGTATCCAG AGGGTTCAAG 
GACCTGGATC TGGACACACC TTCCATTGAG AAGCGATTTG CCTACAGTTT CCTGCAGCAG 
CTGATCCGAT ATGTGGACGA GGCCCATCAG TACATCCTGG AGTTTGACGG TGGCAGCAGA 
AGCAAAGGAG AGCATTTCCC GTACGAGCAA GAGATCAAGT TCTTCGCCAA AGTTGTTCTT 
CCTTTAATTG ATCAGTATTT CAAAAACCAT CGCCTGTACT TCTTGTCTGC TGCAAGCAGG 
CCTCTTTGCA CCGGAGGACA TGCGTCCAAC AAGGAGAAGG AGATGGTTAC AAGCCTGTTC 
TGCAAACTTG GAGTTCTTGT CAGGCATAGG ATTTCACTGT TTGGGAATGA TGCTACCTCA 
ATTGTGAACT GTCTTCATAT TTTGGGTCAG ACTTTGGATG CAAGGACTGT GATGAAGACG 
GGTCTGGACA GCGTGAAAAG TGCTCTCAGG GCCTTTCTGG ACAATGCGGC GGAGGATCTG 
GAAAAGACGA TGGAAAACCT TAAGCAGGGC CAGTTTACTC ACACCAGGAG CCAGCCCAAG 
GGCGTGACTC AGATCATCAA CTATACCACC GTGGCGCTCC TGCCCATGCT CTCTTCCCTG 
TTTGAGCACA TTGGCCAGCA TCAGTTTGGA GAAGATCTGA TATTGGAGGA TGTGCAGGTG 
TCTTGTTACA GAATTCTGAC CAGCTTGTAT GCCTTGGGAA CCAGCAAGAG CATCTATGTG 
GAAAGGCAAC GTTCTGCACT CGGAGAATGC CTAGCTGCCT TTGCTGGTGC CTTCCCTATC 
GCCTTTCTAG AAACCCACCT GGACAAACAT AATGTTTACT CCATCTACAA CACCAGGTCT 
TCACGAGAAA GAGCAGCTCT CAGTTTACCC GCAAATGTGG AGGATGTCTG CCCAAATATA 
CCATCCCTGG AGAAGCTCAT GACTGAGATC ATAGAGCTGG CAGAGTCAGG AATCCGTTAC 
ACTCAGATGC CACACATGAT GGAGGTGGTA CTGCCCATGT TATGCAGCTA CATGTCAAGG 
TGGTGGGAGC ACGGTCCTGA GAACCATCCA GAGAGGGCTG AGATGTGCTG CACAGCGCTC 
AACTCAGAGC ACATGAACAC ACTGCTGGGC AACATTCTCA AGATCATCTA CAACAACCTG 
GGGATTGATG AAGGGGCCTG GATGAAGCGC TTAGCTGTAT TTTCACAGCC AATCATCAAC 
AAGGTGAAAC CTCAGCTCTT AAAAACTCAT TTCTTACCCT TAATGGAGAA ACTAAAGAAA 
AAGGCTGCCA TGGTAGTGTC TGAGGAAGAC CACCTAAAAG CCGAAGCCAG AGGGGACATG 
TCCGAAGCGG AGCTGCTCAT TCTAGATGAG TTTACCACAT TGGCCAGGGA TCTCTATGCC 
TTCTACCCAC TCTTGATCCG ATTTGTGGAC TATAACAGGG CAAAGTGGCT GAAGGAACCC 
AACCCAGAAG CAGAGGAGCT ATTTCGAATG GTAGCTGAAG TCTTCATTTA CTGGTCCAAA 
TCCCATAATT TCAAAAGAGA GGAACAGAAC TTTGTGGTGC AGAATGAAAT CAACAACATG 
TCCTTCCTCA TCACCGACAC AAAGTCTAAG ATGTCCAAGG CAGCCATTTC TGATCAAGAG 
AGGAAGAAAA TGAAGCGGAA AGGAGACCGG TATTCTATGC AGACATCTTT GATTGTGGCA 
GCTCTGAAGC GATTGCTTCC CATTGGACTG AACATCTGTG CCCCTGGGGA CCAAGAGCTC 
ATTGCTCTGG CCAAAAACCG ATTTAGCTTG AAAGACACTG AGGAGGAAGT ACGTGATGTA 
ATCCGCAGTA ATATACACTT GCAAGGCAAG CTGGAAGACC CTGCAATCAG GTGGCAGATG 
GCTCTATACA AAGACTTGCC AAACAGGGCA GAAGACACCT CAGACCCAGA GAGGACAGTG 
GAGCGTGTCC TGGATATAGC GAATGTGCTT TTTCACCTTG AACAGGTGGA GCACCCTCAG 
AGATCAAAGA AAGCCGTGTG GCACAAACTG CTCTCTAAGC AGAGAAAAAG AGCTGTTGTT 
GCCTGTTTCC GGATGGCCCC TTTGTACAAT CTGCCAAGGC ATCGGGCTGT CAATCTTTTT 
CTTCAGGGAT ATGAAAAGTC TTGGATTGAA ACAGAAGAGC ATTACTTTGA GGATAAATTG 
ATCGAAGATT TAGCGAAACC GGGGTCTGAA CTCCCAGAAG AAGATGAAGC CATGAAAAGA 
GTTGATCCTC TGCATCAGCT TATTCTTCTG TTCAGCCGCA CAGCCTTAAC AGAGAAATGC 
AAACTGGAGG AAGATTTTCT GTACATGGCG TATGCAGACA TTATGGCAAA GAGTTGTCAC 
GATGAAGAAG ACGATGATGG TGAAGAAGAA GTGAAGAGCT TTGAAGAAAA GGAAATGGAA 
AAGCAGAAGC TTCTGTACCA GCAAGCCAGA CTGCATGACC GCGGGGCTGC CGAGATGGTT 
CTCCAGACCT TCAGTGCCAG CAAAGGTGAA ACTGGACCAA TGGTGGCTGC CACTTTGAAG 
CTGGGTATTG CTATTTTAAA TGGTGGGAAC TCCACGGTGC AGCAGAAGAT GCTGGATTAC 
CTGAAGGAGA AAAAAGATGT AGGCTTCTTC CAGAGCCTGG CAGGCCTCAT GCAGTCTTGC 
AGTGTCCTGG ACCTGAATGC CTTTGAGAGG CAAAACAAAG CAGAAGGACT TGGGATGGTG 
ACTGAGGAAG GATCAGGAGA GAAGGTACTG CAGGATGATG AGTTCACCTG TGACCTCTTC 
CGATTCCTGC AGCTGCTCTG TGAAGGACAC AACTCAGATT TTCAGAATTA CCTGAGAACC 
CAGACTGGCA ACAACACCAC AGTTAATATC ATCATCTCTA CTGTGGACTA CCTCCTTCGA 
GTGCAGGAGT CCATTAGTGA TTTCTATTGG TACTACTCTG GCAAGGACAT CATAGATGAG 
CAGGGCCAGC GTAACTTTTC CAAAGCCATC CAAGTGGCGA AGCAGGTGTT CAACACACTC 
ACGGAGTACA TCCAGGGTCC TTGTACCGGA AACCAGCAGA GTTTGGCACA CAGCAGGCTC 
TGGGATGCTG TTGTGGGCTT CCTTCATGTA TTTGCACACA TGCAGATGAA GCTGTCTCAG 
GATTCCAGCC AGATTGAGCT CTTAAAAGAA CTGATGGATC TCCAAAAGGA CATGGTGGTC 
ATGCTGCTGT CTATGCTAGA AGGTAATGTG GTAAACGGAA CAATAGGCAA GCAGATGGTG 
GACATGCTTG TGGAGTCATC CAACAACGTG GAGATGATCC TCAAGTTCTT TGACATGTTT 
CTGAAGCTAA AGGACTTGAC ATCCTCTGAC ACATTTAAAG AGTATGACCC TGATGGCAAA 
GGCGTCATTT CCAAGAGAGA CTTCCACAAA GCCATGGAGA GCCACAAACA CTACACCCAG 
TCAGAGACTG AGTTTCTGTT GTCCTGTGCA GAGACAGATG AGAACGAGAC GCTGGATTAT 
GAAGAGTTTG TCAAAAGGTT CCACGAGCCT GCCAAGGACA TCGGCTTCAA CGTCGCCGTT 
CTGCTGACCA ACCTCTCAGA GCACATGCCC AATGACACGA GGCTGCAGAC CTTCTTGGAG 
CTGGCAGAGA GTGTCCTCAA CTACTTCCAA CCTTTCCTGG GTCGCATCGA GATCATGGGC 
AGCGCCAAGC GCATCGAGAG GGTCTACTTT GAGATCAGCG AATCCAGCCG AACCCAGTGG 
GAGAAGCCCC AGGTCAAGGA GTCCAAGAGG CAGTTCATAT TCGATGTGGT CAATGAGGGC 
GGGGAAAAGG AGAAGATGGA GCTCTTTGTG AACTTCTGTG AGGACACCAT CTTTGAGATG 
CAGCTGGCAG CTCAGATCTC AGAGTCCGAC CTGAATGAGA GGTCGGCAAA TAAAGAGGAG 
AGTGAAAAGG AGAGGCCAGA GGAGCAGGCC CCACGGATGG GCTTCTTCTC CCTGCTCACC 
GTCCAGTCAG CCCTGTTTGC ACTCAGGTAC AATGTCCTAA CCCTTGTGAG GATGCTCAGC 
CTGAAGAGCC TGAAGAAGCA GATGAAGAGA ATGAAGAAGA TGACAGTGAA GGACATGGTC 
TCAGCCTTCT TCTCGTCCTA CTGGAGTGTG TTTGTCACCC TCCTACACTT TGTGGCCAGC 
GTCTGTAGGG GCTTCTTCCG CATTGTCTCC AGCCTACTGC TGGGGGGCAG CCTGGTGGAA 
GGTGCTAAGA AAATCAAAGT GGCGGAGCTT CTTGCCAACA TGCCAGACCC TACTCAGGAT 
GAGGTGCGAG GAGATGAAGA GGAGGGAGAG AGGAAGCCAT TAGAGTCAGC CCTGCCCTCT 
GAAGACCTAA CAGACTTGAA GGAACTGACG GAGGAAAGTG ACCTTCTTTC AGACATATTT 
GGCTTGGATC TGAAGAGAGA AGGAGGGCAG TACAAACTAA TTCCTCACAA CCCAAATGCT 
GGTCTCAGTG ACCTCATGAC GAACCCCATC CCTGTCCCTG AGGTACAAGA AAAGTTTCAG 
GAGCAGAAGG TAAAAGAAGA AAAGGAAGGA AAGGAAGAAA CCAAGTCTGA ACCGGAGAAG 
GCTGAGGGAG AGGATGGAGA AAAAGAAGAA AAAGCCAAAG ATGATAAGGG TAAACAGAAG 
TTGAGGCAGC TTCATACACA TCGATATGGG GAGCCTGAGG TCCCCGAGTC AGCATTCTGG 
AAGAAAATCA TAGCCTACCA ACAGAAGCTG CTGAACTATT TTGCTCGCAA CTTTTACAAC 
ATGAGAATGC TGGCCCTGTT TGTCGCCTTC GCCATCAATT TCATCCTGCT CTTCTACAAG 
GTCTCCACTT CTTCTGTGGT TGAAGGAAAG GAGCTGCCTA CCCGAACTTC CAGCGATGCC 
GCTAAAGTGA CCACCAGCCT GGACAGCAGC CCCCACAGAA TCATTGCGGT TCACTACGTC 
CTGGAGGAGA GTAGCGGCTA CATGGAACCC ACCCTGCGCA TCCTAGCCAT CCTCCACACC 
ATCATCTCCT TCTTCTGCAT CATCGGATAC TACTGCCTGA AAGTCCCCTT GGTTATTTTT 
AAGCGAGAGA AGGAAGTGGC ACGGAAGTTG GAGTTTGATG GGCTTTACAT TACGGAGCAG 
CCATCGGAAG ACGATATCAA AGGCCAGTGG GACAGACTGG TGATCAACAC ACAGTCATTT 
CCCAATAACT ACTGGGATAA ATTTGTTAAA AGAAAGGTAA TGGATAAATA TGGAGAGTTT 
TATGGGAGAG ACAGAATCAG CGAGTTACTG GGCATGGATA AGGCTGCACT GGATTTCAGC 
GATGCAAGAG AGAAGAAGAA GCCCAAGAAG GACAGTTCCT TGTCTGCTGT ATTGAACTCT 
ATTGACGTGA AGTACCAGAT GTGGAAACTT GGAGTCGTGT TCACAGACAA TTCCTTCCTC 
TACCTAGCCT GGTATATGAC CATGTCTGTT CTTGGACACT ACAACAACTT TTTTTTTGCT 
GCCCACCTCC TTGACATCGC GATGGGCTTC AAGACCTTGA GAACTATCCT GTCCTCAGTT 
ACCCATAATG GCAAACAGCT CGTGTTAACT GTTGGCTTGT TGGCTGTTGT TGTATACCTG 
TACACTGTTG TGGCGTTCAA TTTCTTCCGA AAATTCTACA ATAAAAGCGA GGATGGTGAC 
ACGCCGGACA TGAAGTGTGA CGACATGCTG ACGTGTTACA TGTTCCACAT GTATGTGGGC 
GTCCGTGCTG GAGGGGGCAT CGGTGATGAA ATTGAAGACC CAGCAGGAGA TGAGTACGAG 
ATCTACCGAA TCATCTTTGA TATCACATTC TTCTTCTTTG TGATTGTCAT CCTTTTGGCT 
ATCATACAAG GTTTGATCAT TGATGCTTTT GGAGAACTCA GAGATCAACA AGAGCAAGTC 
AAGGAAGACA TGGAGACCAA GTGCTTCATC TGTGGGATAG GCAACGACTA CTTTGATACA 
GTGCCGCATG GCTTTGAAAC CCATACTCTA CAGGAGCACA ACCTGGCCAA CTACCTGTTT 
TTTCTGATGT ACCTCATAAA CAAGGATGAA ACAGAACACA CGGGACAGGA ATCTTATGTC 
TGGAAGATGT ACCAAGAGAG GTGTTGGGAA TTTTTCCCAG CAGGAGACTG TTTCCGGAAA 
CAGTATGAGG ACCAGTTAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177972.1
CDS	95..14938
Translation	MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNSSWRVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSnullEKLDAGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKRAKLPTVDLPIESVSLSnullQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAnullDQDHASRAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKSVAGGIPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRMDKDKETPKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMCFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEEGGAPEKEISIDDSKLEVKEEAKAGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKKKQAEKPVASDSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDAEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWSNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPHMMEVVLPMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEEEVRDVIRSNIHLQGKLEDPAIRWQMALYKDLPNRAEDTSDPERTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGSELPEEDEAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTFSASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQAPRMGFFSLLTVQSALFALRYNVLTLVRMLSLKSLKKQMKRMKKMTVKDMVSAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPIPVPEVQEKFQEQKVKEEKEGKEETKSEPEKAEGEDGEKEEKAKDDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTSSDAAKVTTSLDSSPHRIIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN

Target ORF information:

RefSeq Version	NM_001191043.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ryanodine receptor 2 (Ryr2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191043.1

ORF Insert Sequence:

ATGGCTGATG CGGGCGAAGG CGAGGACGAG ATCCAGTTCC TGAGAACTGA TGATGAGGTG 
GTTCTACAGT GCACCGCAAC CATCCACAAA GAGCAGCAGA AGCTGTGCTT GGCAGCAGAA 
GGATTTGGCA ACAGACTTTG CTTTTTGGAG TCTACTTCCA ATTCTAAGAA TGTCCCCCCG 
GACCTGTCCA TCTGCACCTT TGTGCTGGAG CAGTCCCTGT CAGTACGGGC CCTGCAGGAG 
ATGCTGGCCA ACACAGTGGA AAAGTCAGAA GGGAAGTTCA TGATGAAGAC TGCTCAAGGT 
GGAGGCCACC GGACACTCCT CTATGGACAC GCCATACTAC TACGCCATTC CTACAGTGGT 
ATGTATCTCT GCTGTCTCTC CACCTCCCGG TCTTCCACCG ACAAACTGGC CTTTGATGTT 
GGCCTTCAAG AGGATACCAC AGGGGAGGCT TGCTGGTGGA CCATACATCC TGCCTCTAAG 
CAGAGATCAG AAGGAGAAAA GGTGCGGGTT GGAGACGACC TCATATTGGT CAGCGTGTCC 
TCAGAAAGGT ACTTGCACTT GTCATACGGC AACAGCAGCT GGCGTGTAGA CGCAGCCTTC 
CAGCAGACCC TCTGGAGCGT GGCCCCTATC AGCTCAGGAA GTGAAGCAGC CCAAGGGTAT 
CTCATTGGTG GTGATGTTCT CCGGCTGCTA CATGGACACA TGGATGAATG TCTCACTGTT 
CCTTCAGGAG AACATGGTGA AGAACAGCGG AGAACAGTCC ATTATGAAGG TGGTGCTGTA 
TCAGTTCATG CCCGCTCCCT CTGGAGACTA GAGACCCTAA GAGTCGCGTG GAGTGGAAGT 
CACATAAGAT GGGGCCAGCC ATTCCGACTG CGGCACGTCA CGACAGGAAA ATACTTAAGC 
CTCATGGAAG ACAAGAACCT TCTACTCATG GACAAAGAAA AAGCTGATGT AAAATCAACG 
GCGTTTGCCT TCCGGTCTTC CAANGAAAAA TTGGATGCAG GTGTAAGGAA AGAAGTCGAT 
GGCATGGGAA CCTCAGAAAT CAAGTATGGA GACTCCATTT GCTATATACA ACATGTGGAC 
ACAGGCCTGT GGCTAACCTA CCAGGCCGTG GATGTCAAAT CAGCACGAAT GGGATCCATA 
CAGCGTAAGG CTATCATGCA CCACGAAGGC CACATGGATG ACGGCTTGAA CTTATCCAGA 
TCGCAGCACG AGGAGTCCCG CACTGCCCGT GTCATCCGGA GCACAGTGTT TCTCTTCAAT 
AGGTTCATAA GGGGCCTGGA TGCTCTCAGC AAGAGAGCGA AGCTGCCCAC TGTTGACTTG 
CCCATCGAGT CTGTGAGCCT GAGTNTGCAG GACCTCATCG GCTACTTCCA CCCCCCAGAC 
GAGCACCTGG AGCACGAGGA CAAGCAGAAC AGGCTGCGAG CCCTGAAGAA CCGGCAGAAT 
CTCTTCCAGG AAGAGGGAAT GATCAACCTG GTTCTGGAGT GCATCGACCG CCTCCATGTC 
TACAGCAGTG CAGCCCACTT TGCAGACGTT GCAGGACGAG AAGCGGGGGA GTCTTGGAAA 
TCCATCCTGA ATTCTCTGTA TGAGTTGCTG GCGGCTCTAA TTAGAGGAAA TCGTAAAAAC 
TGTGCTCAAT TTTCTGGCTC CCTCGACTGG CTGATCAGCA GACTGGAGAG ACTGGAAGCG 
TCCTCTGGTA TCCTGGAGGT CCTCCACTGT GTGTTAGTGG AGAGCCCGGA AGCTCTGAAT 
ATCATCAAAG AAGGACACAT CAAGTCCATT ATTTCCCTTT TAGACAAGCA TGGGAGAAAC 
CACAAGGTCC TGGATGTGCT GTGTTCTCTC TGTGTGTGCC ATGGAGTTGC CGTCCGTTCT 
AATCAGCATC TCATCTGTGA TAACCTCCTG CCGGGACGAG ACCTCTTACT GCAGACCCGG 
CTTGTGAATC ATGTCAGCAG CATGAGGCCT AATATTTTCC TGGGTGTCAG CGAAGGATCA 
GCACAGTATA AGAAGTGGTA CTACGAGCTC ATGGTGGACC ACACGGAACC CTTTGTGACC 
GCAGAAGCCA CTCACCTGCG AGTGGGCTGG GCTTCCACTG AAGGGTATTC CCCGTACCCA 
GGTGGGGGTG AAGAGTGGGG TGGCAATGGC GTTGGTGATG ACCTCTTCTC CTATGGGTTT 
GATGGCCTTC ACCTCTGGTC AGGTTGTATA GCTCGAACAG TGAGCTCCCC CAACCAGCAC 
CTGCTGAGAA CTGATGATGT CATAAGTTGC TGTTTAGATC TAAGTGCCCC GAGCATCTCG 
TTTCGCATTA ATGGACAACC TGTGCAAGGG ATGTTTGAGA ACTTCAATAT CGATGGCCTG 
TTCTTTCCGG TTGTCAGTTT CTCTGCAGGA ATAAAGGTTC GCTTTTTGCT TGGGGGGAGA 
CACGGAGAAT TCAAATTTCT CCCTCCACCG GGCTATGCAG CTTGCTATGA AGCTGTTTTG 
CCCAAAGAGA AATTGAAGGT GGAACACAGC CGAGAATATA AGCAAGAGAG GACGTACACA 
CGAGACCTGC TGGGGCCTAC AGTGTCCCTG ACCCAAGCTG CCTTCACACC TGTTCCTGTG 
GACACCAGCC AGATTGTGTT GCCTCCTCAC CTGGAAAGGA TAAGAGAAAG ACTGGCAGAA 
AATATCCACG AGCTCTGGGT TATGAATAAA ATTGAGCTTG GCTGGCAGTA TGGTCCGGTT 
AGAGATGACA ACAAGAGACA GCACCCATGT CTGGTGGAGT TCTGCAAGCT TCCGGAACAG 
GAACGCAACT ACAATTTGCA GATGTCTCTG GAAACCCTCA AGACTTTGCT GGCATTAGGA 
TGTCATGTGG GTATAGCGGA TGAACATGCT GAAGAGAAGG TGAAGAAAAT GAAGCTGCCC 
AAGAATTACC AGCTGACCAG TGGATACAAG CCTGCCCCCA TGGATCTGAG CTTTATAAAA 
CTTACCCCGT CTCAGGAAGC AATGGTGGAC AAGTTGGCTG AAAATGCTCA CAACGTGTGG 
GCCCGGGACC GAATCCGGCA GGGCTGGACT TACGGCATCC AGCAGGATGT GAAGAACAGG 
AGAAACCCTC GTCTGGTTCC CTACACTCTT CTGGATGACA GAACCAAGAA GTCCAACAAA 
GACAGTCTCC GAGAGGCAGT GCGAACACTG CTGGGCTACG GCTACCACCT GGAAGCTCCN 
GATCAGGACC ACGCCTCAAG AGCCGAGGTG TGCAGCGGTA CTGGGGAGAG GTTCCGCATC 
TTCAGGGCAG AGAAGACCTA TGCAGTAAAG GCTGGGCGCT GGTACTTTGA ATTTGAGGCC 
GTCACTGCTG GAGACATGAG GGTGGGATGG AGCAGGCCAG GCTGCCAACC GGATCTAGAA 
CTGGGTTCTG ATGAACGTGC CTTCGCTTTT GACGGCTTTA AGGCCCAGCG GTGGCACCAG 
GGCAATGAAC ACTACGGGCG TTCTTGGCAA GCAGGTGATG TCGTGGGCTG CATGGTTGAT 
ATGAACGAAC ACACCATGAT GTTCACTCTG AACGGTGAGA TCCTGCTGGA TGACTCGGGC 
TCCGAGCTGG CTTTCAAGGA CTTTGATGTT GGTGACGGAT TCATCCCTGT GTGTAGCCTC 
GGGGTGGCAC AAGTAGGCAG GATGAACTTT GGAAAGGACG TCAGCACTTT GAAATACTTT 
ACCATCTGTG GCTTACAAGA GGGCTACGAG CCATTTGCAG TTAACACAAA TAGGGACATC 
ACCATGTGGC TGAGCAAGCG GCTTCCTCAG TTCCTCCAGG TCCCCTCAAA CCACGAACAC 
ATCGAGGTGA CCAGAATAGA TGGTACCATA GACAGTTCTC CATGTCTGAA GGTCACTCAG 
AAGTCCTTTG GTTCTCAGAA CAGCAACACA GACATCATGT TTTACCGCCT GAGTATGCCC 
ATTGAGTGTG CTGAGGTCTT CTCAAAGTCC GTGGCTGGAG GGATCCCTGG CGCCGGCTTC 
TATGGGCCCA AGAATGATTT GGAGGACTTT GATGTGGATT CTGACTTTGA GGTTCTGATG 
AAGACAGCTC ATGGTCATCT TGTGCCCGAC CGCATGGACA AGGACAAAGA GACCCCCAAG 
CCAGAATTCA ATAACCACAA AGATTATGCT CAGGAAAAGC CCTCACGCCT AAAGCAAAGA 
TTCTTACTTA GAAGGACCAA GCCAGATTAC AGCACAAGCC ATTCTGCAAG ACTCACTGAA 
GACGTCCTTG CTGATGACCG GGATGACTAT GAATATCTGA TGCAGACATC TACATACTAT 
TATTCAGTGA GGATCTTTCC TGGACAAGAA CCAGCTAACG TCTGGGTGGG CTGGATTACA 
TCTGACTTCC ACCAGTATGA CACAGGCTTC GATTTGGACA GAGTGCGCAC AGTGACAGTC 
ACCCTAGGAG ATGAAAAAGG GAAAGTGCAC GAGAGCATCA AACGCAGCAA CTGCTATATG 
GTGTGTGCGG GAGAGAGCAT GAGCCCCGGG CAAGGCCGAA ACAACAGCAA TGGCTTGGAG 
ATCGGCTGTG TGGTGGACGC TGCCAGTGGG CTGCTCACAT TCATAGCCAA CGGCAAGGAG 
CTAAGCACTT ACTATCAGGT GGAGCCAAGC ACGAAGTTAT TTCCTGCGGT TTTCGCGCAA 
GCTACAAGTC CCAATGTTTT CCAGTTTGAG TTGGGCAGAA TAAAGAATGT GATGCCTCTC 
TCAGCGGGAT TGTTTAAGAG TGAGCACAAA AACCCCGTGC CCCAGTGTCC TCCACGTCTG 
CACGTGCAGT TCCTGTCACA TGTCCTGTGG AGCCGGATGC CCAACCAGTT CCTCAAGGTG 
GATGTCTCTC GAATCAGTGA ACGCCAAGGC TGGCTGGTGC AGTGTCTGGA TCCTCTGCAG 
TTCATGTCCC TCCACATCCC CGAGGAGAAC AGATCTGTTG ATATCTTAGA GCTGACCGAG 
CAGGAGGAGT TGTTGCAGTT TCACTACCAC ACCCTCCGCC TCTACTCTGC AGTCTGTGCC 
CTTGGGAATC ACCGGGTGGC GCATGCACTG TGCAGCCACG TGGACGAACC TCAGCTGCTC 
TATGCCATTG AGAACAAGTA CATGCCTGGC TTGCTGCGAG CCGGGTACTA TGACCTGCTG 
ATTGACATCC ACCTCAGCTC CTACGCCACC GCCAGGCTCA TGATGAACAA TGAGTTCATC 
GTCCCGATGA CAGAGGAGAC AAAGAGCATC ACCCTCTTCC CTGATGAGAA CAAGAAACAT 
GGCCTCCCGG GCATAGGCCT CAGCACCTCT CTCCGCCCTC GGATGTGCTT TTCCTCCCCT 
AGTTTCGTGA GCATTAGCAA CGAATGCTAT CAGTATAGTC CCGAGTTCCC ACTGGACATC 
CTCAAGGCCA AGACCATCCA GATGCTCACA GAAGCGGTGA AGGAGGGCAG CCTCCACGCG 
CGGGATCCCG TGGGCGGGAC CACCGAGTTC CTCTTTGTGC CTCTCATCAA GCTCTTCTAC 
ACCCTGCTCA TCATGGGCAT CTTTCACAAT GAGGATTTGA AACACATCCT GCAGTTGATT 
GAGCCTAGTG TGTTTAAGGA AGCTGCCACT CCAGAGGAGG AAGGAGGTGC CCCAGAGAAG 
GAGATTAGTA TAGATGACTC TAAACTGGAA GTCAAAGAGG AAGCCAAAGC AGGCAAAAGG 
CCTAAGGAAG GTTTACTCCA GATGAAACTC CCGGAGCCTG TTAAACTACA GATGTGCCTC 
TTGCTTCAGT ACCTCTGTGA CTGCCAGGTT CGGCACCGGA TAGAAGCCAT TGTAGCCTTT 
TCAGATGACT TTGTAGCCAA ACTCCAAGAC AATCAGCGGT TCAGGTATAA TGAAGTCATG 
CAAGCCTTAA ACATGTCTGC TGCACTCACT GCCAGGAAAA CCAAGGAGTT CCGGTCACCA 
CCACAGGAGC AGATCAATAT GCTTCTCAAT TTTAAGGATG ATAAAAGTGA ATGCCCCTGC 
CCTGAAGAAA TCCGAGACCA ACTCCTAGAT TTCCATGAGG ACCTGATGAC TCACTGTGGA 
ATTGAACTGG ATGAAGATGG ATCTCTAGAC GGAAGCAATG ACTTAACAAT CAGAGGACGT 
CTGCTGTCCC TGGTAGAAAA GGTGACCTAC CTGAAGAAAA AGCAAGCTGA AAAACCAGTC 
GCAAGTGACT CCAGAAAGTC CTCCAGCCTC CAGCAACTCA TTTCTGAGAC TATGGTGCGG 
TGGGCTCAAG AGTCTGTCAT CGAGGACCCT GAGCTGGTGA GGGCTATGTT TGTGCTGCTG 
CACCGGCAGT ATGATGGCAT TGGGGGTCTC GTTCGAGCAC TGCCAAAGAC CTACACTATC 
AACGGCGTCT CTGTGGAGGA CACCATCAAT CTGCTTGCAT CACTTGGTCA GATCCGATCC 
CTGCTGAGTG TGAGGATGGG CAAAGAAGAA GAGAAGCTGA TGATCCGAGG ATTAGGGGAT 
ATTATGAATA ACAAGGTGTT TTATCAGCAT CCCAATCTCA TGAGGGCCCT TGGGATGCAC 
GAAACAGTGA TGGAAGTCAT GGTGAACGTC CTTGGAGGTG GGGAGTCCAA GGAAATCACC 
TTCCCCAAGA TGGTGGCCAA CTGCTGCCGT TTTCTCTGTT ACTTCTGTCG TATAAGTAGG 
CAGAATCAGA AAGCCATGTT TGATCATCTC AGTTATTTAC TGGAAAACAG CAGTGTTGGT 
CTTGCCTCAC CAGCCATGAG AGGTTCAACT CCATTAGACG TGGCCGCAGC GTCAGTGATG 
GATAACAATG AGCTTGCCCT TGCTCTACGA GAGCCGGATC TGGAGAAGGT GGTTCGCTAT 
CTGGCCGGCT GTGGTCTGCA GAGCTGCCAG ATGCTGGTGT CTAAGGGTTA CCCAGACATT 
GGGTGGAATC CAGTTGAAGG AGAACGATAT CTTGACTTTC TCAGATTTGC CGTCTTCTGT 
AATGGGGAGA GTGTGGAAGA GAATGCAAAT GTTGTGGTGA GGTTGCTCAT CCGGAGACCG 
GAGTGCTTTG GCCCTGCCTT GAGAGGAGAA GGTGGTAATG GTCTCCTTGC AGCCATGGAA 
GAAGCCATAA AAATAGCTGA GGATCCTTCT AGAGATGGCC CCTCTCCAAC CAGTGGATCC 
AGCAAAACCC TTGATGCGGA AGAGGAGGAA GACGACACCA TCCACATGGG GAACGCAATC 
ATGACCTTCT ACGCAGCTTT GATTGACCTG CTTGGTCGCT GTGCTCCTGA AATGCATTTG 
ATTCATGCTG GAAAGGGAGA AGCCATCCGA ATCAGGTCTA TTTTGCGATC CCTGATTCCA 
TTGGGAGACT TGGTGGGTGT AATCAGCATT GCATTTCAGA TGCCAACAAT AGCCAAAGAT 
GGGAAGGTGG TGGAGCCTGA CATGTCCGCG GGGTTTTGCC CAGATCACAA GGCAGCCATG 
GTTTTGTTCC TTGACAGGGT CTATGGAATT GAGGTGCAAG ATTTCCTCCT CCATCTCCTT 
GAGGTTGGCT TTCTGCCAGA TCTTCGCGCT GCTGCCTCTC TAGACACGGC TGCACTAAGT 
GCTACAGACA TGGCCTTGGC CCTCAATCGG TACCTCTGCA CAGCTGTCCT GCCTTTGTTA 
ACGAGATGTG CTCCCCTGTT TGCTGGAACA GAGCACCATG CTTCCCTCAT TGACTCTCTG 
CTACACACTG TATATAGACT CTCTAAGGGA TGTTCCCTCA CCAAAGCTCA GCGGGACTCC 
ATAGAAGTGT GCCTGCTCTC TATATGTGGC CAACTGCGAC CTTCTATGAT GCAGCACCTA 
CTCCGAAGGC TGGTGTTTGA TGTCCCACTG CTGAACGAGC ACGCAAAGAT GCCTCTAAAG 
CTGCTGACCA ATCATTATGA AAGATGCTGG AAATATTACT GCCTACCTGG AGGGTGGAGC 
AACTTTGGTG CTGCCTCGGA AGAAGAACTT CATTTATCAA GAAAATTATT TTGGGGCATT 
TTTGATGCTT TGTCTCAAAA GAAATACGAA CAAGAACTTT TCAAACTGGC CCTGCCTTGC 
CTGAGTGCAG TTGCGGGAGC TTTACCTCCA GACTACATGG AGTCAAACTA TGTCAGTATG 
ATGGAAAAAC AGTCATCCAT GGACTCTGAA GGGAACTTTA ACCCACAACC TGTTGATACC 
TCAAACATTA CAATTCCCGA GAAGCTGGAA TACTTCATTA ACAAGTATGC GGAGCATTCC 
CATGATAAAT GGTCTATGGA CAAGTTGGCG AATGGATGGA TTTATGGGGA AATATATTCA 
GACTCTTCTA AGATCCAGCC ACTAATGAAG CCATATAAAC TCTTATCTGA AAAGGAAAAA 
GAAATTTATC GTTGGCCAAT CAAGGAGTCT TTAAAAACGA TGCTGGCTTG GGGTTGGAGA 
ATTGAGAGGA CACGGGAGGG AGACAGTATG GCCCTTTATA ACCGGACTCG GCGCATTTCT 
CAGACTAGCC AGGTGTCTAT AGATGCTGCA CATGGGTATA GCCCCCGTGC TATCGACATG 
AGTAACGTTA CCCTCTCGAG AGACCTGCAT GCTATGGCGG AGATGATGGC TGAAAACTAC 
CACAACATAT GGGCCAAGAA AAAGAAAATG GAGCTGGAAT CCAAAGGAGG AGGAAACCAC 
CCCCTGCTAG TGCCCTATGA CACACTGACA GCCAAGGAGA AAGCCAAGGA CAGAGAAAAG 
GCCCAGGACA TCTTCAAGTT CCTACAGATC AGTGGTTATG CTGTATCCAG AGGGTTCAAG 
GACCTGGATC TGGACACACC TTCCATTGAG AAGCGATTTG CCTACAGTTT CCTGCAGCAG 
CTGATCCGAT ATGTGGACGA GGCCCATCAG TACATCCTGG AGTTTGACGG TGGCAGCAGA 
AGCAAAGGAG AGCATTTCCC GTACGAGCAA GAGATCAAGT TCTTCGCCAA AGTTGTTCTT 
CCTTTAATTG ATCAGTATTT CAAAAACCAT CGCCTGTACT TCTTGTCTGC TGCAAGCAGG 
CCTCTTTGCA CCGGAGGACA TGCGTCCAAC AAGGAGAAGG AGATGGTTAC AAGCCTGTTC 
TGCAAACTTG GAGTTCTTGT CAGGCATAGG ATTTCACTGT TTGGGAATGA TGCTACCTCA 
ATTGTGAACT GTCTTCATAT TTTGGGTCAG ACTTTGGATG CAAGGACTGT GATGAAGACG 
GGTCTGGACA GCGTGAAAAG TGCTCTCAGG GCCTTTCTGG ACAATGCGGC GGAGGATCTG 
GAAAAGACGA TGGAAAACCT TAAGCAGGGC CAGTTTACTC ACACCAGGAG CCAGCCCAAG 
GGCGTGACTC AGATCATCAA CTATACCACC GTGGCGCTCC TGCCCATGCT CTCTTCCCTG 
TTTGAGCACA TTGGCCAGCA TCAGTTTGGA GAAGATCTGA TATTGGAGGA TGTGCAGGTG 
TCTTGTTACA GAATTCTGAC CAGCTTGTAT GCCTTGGGAA CCAGCAAGAG CATCTATGTG 
GAAAGGCAAC GTTCTGCACT CGGAGAATGC CTAGCTGCCT TTGCTGGTGC CTTCCCTATC 
GCCTTTCTAG AAACCCACCT GGACAAACAT AATGTTTACT CCATCTACAA CACCAGGTCT 
TCACGAGAAA GAGCAGCTCT CAGTTTACCC GCAAATGTGG AGGATGTCTG CCCAAATATA 
CCATCCCTGG AGAAGCTCAT GACTGAGATC ATAGAGCTGG CAGAGTCAGG AATCCGTTAC 
ACTCAGATGC CACACATGAT GGAGGTGGTA CTGCCCATGT TATGCAGCTA CATGTCAAGG 
TGGTGGGAGC ACGGTCCTGA GAACCATCCA GAGAGGGCTG AGATGTGCTG CACAGCGCTC 
AACTCAGAGC ACATGAACAC ACTGCTGGGC AACATTCTCA AGATCATCTA CAACAACCTG 
GGGATTGATG AAGGGGCCTG GATGAAGCGC TTAGCTGTAT TTTCACAGCC AATCATCAAC 
AAGGTGAAAC CTCAGCTCTT AAAAACTCAT TTCTTACCCT TAATGGAGAA ACTAAAGAAA 
AAGGCTGCCA TGGTAGTGTC TGAGGAAGAC CACCTAAAAG CCGAAGCCAG AGGGGACATG 
TCCGAAGCGG AGCTGCTCAT TCTAGATGAG TTTACCACAT TGGCCAGGGA TCTCTATGCC 
TTCTACCCAC TCTTGATCCG ATTTGTGGAC TATAACAGGG CAAAGTGGCT GAAGGAACCC 
AACCCAGAAG CAGAGGAGCT ATTTCGAATG GTAGCTGAAG TCTTCATTTA CTGGTCCAAA 
TCCCATAATT TCAAAAGAGA GGAACAGAAC TTTGTGGTGC AGAATGAAAT CAACAACATG 
TCCTTCCTCA TCACCGACAC AAAGTCTAAG ATGTCCAAGG CAGCCATTTC TGATCAAGAG 
AGGAAGAAAA TGAAGCGGAA AGGAGACCGG TATTCTATGC AGACATCTTT GATTGTGGCA 
GCTCTGAAGC GATTGCTTCC CATTGGACTG AACATCTGTG CCCCTGGGGA CCAAGAGCTC 
ATTGCTCTGG CCAAAAACCG ATTTAGCTTG AAAGACACTG AGGAGGAAGT ACGTGATGTA 
ATCCGCAGTA ATATACACTT GCAAGGCAAG CTGGAAGACC CTGCAATCAG GTGGCAGATG 
GCTCTATACA AAGACTTGCC AAACAGGGCA GAAGACACCT CAGACCCAGA GAGGACAGTG 
GAGCGTGTCC TGGATATAGC GAATGTGCTT TTTCACCTTG AACAGGTGGA GCACCCTCAG 
AGATCAAAGA AAGCCGTGTG GCACAAACTG CTCTCTAAGC AGAGAAAAAG AGCTGTTGTT 
GCCTGTTTCC GGATGGCCCC TTTGTACAAT CTGCCAAGGC ATCGGGCTGT CAATCTTTTT 
CTTCAGGGAT ATGAAAAGTC TTGGATTGAA ACAGAAGAGC ATTACTTTGA GGATAAATTG 
ATCGAAGATT TAGCGAAACC GGGGTCTGAA CTCCCAGAAG AAGATGAAGC CATGAAAAGA 
GTTGATCCTC TGCATCAGCT TATTCTTCTG TTCAGCCGCA CAGCCTTAAC AGAGAAATGC 
AAACTGGAGG AAGATTTTCT GTACATGGCG TATGCAGACA TTATGGCAAA GAGTTGTCAC 
GATGAAGAAG ACGATGATGG TGAAGAAGAA GTGAAGAGCT TTGAAGAAAA GGAAATGGAA 
AAGCAGAAGC TTCTGTACCA GCAAGCCAGA CTGCATGACC GCGGGGCTGC CGAGATGGTT 
CTCCAGACCT TCAGTGCCAG CAAAGGTGAA ACTGGACCAA TGGTGGCTGC CACTTTGAAG 
CTGGGTATTG CTATTTTAAA TGGTGGGAAC TCCACGGTGC AGCAGAAGAT GCTGGATTAC 
CTGAAGGAGA AAAAAGATGT AGGCTTCTTC CAGAGCCTGG CAGGCCTCAT GCAGTCTTGC 
AGTGTCCTGG ACCTGAATGC CTTTGAGAGG CAAAACAAAG CAGAAGGACT TGGGATGGTG 
ACTGAGGAAG GATCAGGAGA GAAGGTACTG CAGGATGATG AGTTCACCTG TGACCTCTTC 
CGATTCCTGC AGCTGCTCTG TGAAGGACAC AACTCAGATT TTCAGAATTA CCTGAGAACC 
CAGACTGGCA ACAACACCAC AGTTAATATC ATCATCTCTA CTGTGGACTA CCTCCTTCGA 
GTGCAGGAGT CCATTAGTGA TTTCTATTGG TACTACTCTG GCAAGGACAT CATAGATGAG 
CAGGGCCAGC GTAACTTTTC CAAAGCCATC CAAGTGGCGA AGCAGGTGTT CAACACACTC 
ACGGAGTACA TCCAGGGTCC TTGTACCGGA AACCAGCAGA GTTTGGCACA CAGCAGGCTC 
TGGGATGCTG TTGTGGGCTT CCTTCATGTA TTTGCACACA TGCAGATGAA GCTGTCTCAG 
GATTCCAGCC AGATTGAGCT CTTAAAAGAA CTGATGGATC TCCAAAAGGA CATGGTGGTC 
ATGCTGCTGT CTATGCTAGA AGGTAATGTG GTAAACGGAA CAATAGGCAA GCAGATGGTG 
GACATGCTTG TGGAGTCATC CAACAACGTG GAGATGATCC TCAAGTTCTT TGACATGTTT 
CTGAAGCTAA AGGACTTGAC ATCCTCTGAC ACATTTAAAG AGTATGACCC TGATGGCAAA 
GGCGTCATTT CCAAGAGAGA CTTCCACAAA GCCATGGAGA GCCACAAACA CTACACCCAG 
TCAGAGACTG AGTTTCTGTT GTCCTGTGCA GAGACAGATG AGAACGAGAC GCTGGATTAT 
GAAGAGTTTG TCAAAAGGTT CCACGAGCCT GCCAAGGACA TCGGCTTCAA CGTCGCCGTT 
CTGCTGACCA ACCTCTCAGA GCACATGCCC AATGACACGA GGCTGCAGAC CTTCTTGGAG 
CTGGCAGAGA GTGTCCTCAA CTACTTCCAA CCTTTCCTGG GTCGCATCGA GATCATGGGC 
AGCGCCAAGC GCATCGAGAG GGTCTACTTT GAGATCAGCG AATCCAGCCG AACCCAGTGG 
GAGAAGCCCC AGGTCAAGGA GTCCAAGAGG CAGTTCATAT TCGATGTGGT CAATGAGGGC 
GGGGAAAAGG AGAAGATGGA GCTCTTTGTG AACTTCTGTG AGGACACCAT CTTTGAGATG 
CAGCTGGCAG CTCAGATCTC AGAGTCCGAC CTGAATGAGA GGTCGGCAAA TAAAGAGGAG 
AGTGAAAAGG AGAGGCCAGA GGAGCAGGCC CCACGGATGG GCTTCTTCTC CCTGCTCACC 
GTCCAGTCAG CCCTGTTTGC ACTCAGGTAC AATGTCCTAA CCCTTGTGAG GATGCTCAGC 
CTGAAGAGCC TGAAGAAGCA GATGAAGAGA ATGAAGAAGA TGACAGTGAA GGACATGGTC 
TCAGCCTTCT TCTCGTCCTA CTGGAGTGTG TTTGTCACCC TCCTACACTT TGTGGCCAGC 
GTCTGTAGGG GCTTCTTCCG CATTGTCTCC AGCCTACTGC TGGGGGGCAG CCTGGTGGAA 
GGTGCTAAGA AAATCAAAGT GGCGGAGCTT CTTGCCAACA TGCCAGACCC TACTCAGGAT 
GAGGTGCGAG GAGATGAAGA GGAGGGAGAG AGGAAGCCAT TAGAGTCAGC CCTGCCCTCT 
GAAGACCTAA CAGACTTGAA GGAACTGACG GAGGAAAGTG ACCTTCTTTC AGACATATTT 
GGCTTGGATC TGAAGAGAGA AGGAGGGCAG TACAAACTAA TTCCTCACAA CCCAAATGCT 
GGTCTCAGTG ACCTCATGAC GAACCCCATC CCTGTCCCTG AGGTACAAGA AAAGTTTCAG 
GAGCAGAAGG TAAAAGAAGA AAAGGAAGGA AAGGAAGAAA CCAAGTCTGA ACCGGAGAAG 
GCTGAGGGAG AGGATGGAGA AAAAGAAGAA AAAGCCAAAG ATGATAAGGG TAAACAGAAG 
TTGAGGCAGC TTCATACACA TCGATATGGG GAGCCTGAGG TCCCCGAGTC AGCATTCTGG 
AAGAAAATCA TAGCCTACCA ACAGAAGCTG CTGAACTATT TTGCTCGCAA CTTTTACAAC 
ATGAGAATGC TGGCCCTGTT TGTCGCCTTC GCCATCAATT TCATCCTGCT CTTCTACAAG 
GTCTCCACTT CTTCTGTGGT TGAAGGAAAG GAGCTGCCTA CCCGAACTTC CAGCGATGCC 
GCTAAAGTGA CCACCAGCCT GGACAGCAGC CCCCACAGAA TCATTGCGGT TCACTACGTC 
CTGGAGGAGA GTAGCGGCTA CATGGAACCC ACCCTGCGCA TCCTAGCCAT CCTCCACACC 
ATCATCTCCT TCTTCTGCAT CATCGGATAC TACTGCCTGA AAGTCCCCTT GGTTATTTTT 
AAGCGAGAGA AGGAAGTGGC ACGGAAGTTG GAGTTTGATG GGCTTTACAT TACGGAGCAG 
CCATCGGAAG ACGATATCAA AGGCCAGTGG GACAGACTGG TGATCAACAC ACAGTCATTT 
CCCAATAACT ACTGGGATAA ATTTGTTAAA AGAAAGGTAA TGGATAAATA TGGAGAGTTT 
TATGGGAGAG ACAGAATCAG CGAGTTACTG GGCATGGATA AGGCTGCACT GGATTTCAGC 
GATGCAAGAG AGAAGAAGAA GCCCAAGAAG GACAGTTCCT TGTCTGCTGT ATTGAACTCT 
ATTGACGTGA AGTACCAGAT GTGGAAACTT GGAGTCGTGT TCACAGACAA TTCCTTCCTC 
TACCTAGCCT GGTATATGAC CATGTCTGTT CTTGGACACT ACAACAACTT TTTTTTTGCT 
GCCCACCTCC TTGACATCGC GATGGGCTTC AAGACCTTGA GAACTATCCT GTCCTCAGTT 
ACCCATAATG GCAAACAGCT CGTGTTAACT GTTGGCTTGT TGGCTGTTGT TGTATACCTG 
TACACTGTTG TGGCGTTCAA TTTCTTCCGA AAATTCTACA ATAAAAGCGA GGATGGTGAC 
ACGCCGGACA TGAAGTGTGA CGACATGCTG ACGTGTTACA TGTTCCACAT GTATGTGGGC 
GTCCGTGCTG GAGGGGGCAT CGGTGATGAA ATTGAAGACC CAGCAGGAGA TGAGTACGAG 
ATCTACCGAA TCATCTTTGA TATCACATTC TTCTTCTTTG TGATTGTCAT CCTTTTGGCT 
ATCATACAAG GTTTGATCAT TGATGCTTTT GGAGAACTCA GAGATCAACA AGAGCAAGTC 
AAGGAAGACA TGGAGACCAA GTGCTTCATC TGTGGGATAG GCAACGACTA CTTTGATACA 
GTGCCGCATG GCTTTGAAAC CCATACTCTA CAGGAGCACA ACCTGGCCAA CTACCTGTTT 
TTTCTGATGT ACCTCATAAA CAAGGATGAA ACAGAACACA CGGGACAGGA ATCTTATGTC 
TGGAAGATGT ACCAAGAGAG GTGTTGGGAA TTTTTCCCAG CAGGAGACTG TTTCCGGAAA 
CAGTATGAGG ACCAGTTAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory.
Antioxidants & redox signaling(2018 Jan)
More J,Bruna B,Lobos P,Galaz JL,Figueroa P,Namias S,Sanchez G,Barrientos G,Valdes JL,Paula-Lima AC,Hidalgo C,Adasme T

Ryanodine Receptor Type 2 Plays a Role in the Development of Cardiac Fibrosis under Mechanical Stretch Through TGF?-1.
International heart journal58(6)957-961(2017 Dec)
Ding Z,Yuan J,Liang Y,Wu J,Gong H,Ye Y,Jiang G,Yin P,Li Y,Zhang G,Yang C,Guo J,Chen Z,Wang X,Weng L,Zou Y

Dysregulated Zn
The Journal of biological chemistry292(32)13361-13373(2017 08)
Reilly-O'Donnell B,Robertson GB,Karumbi A,McIntyre C,Bal W,Nishi M,Takeshima H,Stewart AJ,Pitt SJ

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Circulation. Arrhythmia and electrophysiology9(8)(2016 Aug)
Gomez-Hurtado N,Boczek NJ,Kryshtal DO,Johnson CN,Sun J,Nitu FR,Cornea RL,Chazin WJ,Calvert ML,Tester DJ,Ackerman MJ,Knollmann BC

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Ryr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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