Tcap cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tcap
Entrez Gene ID	688173
Full Name	titin-cap
General protein information	Preferred Names titin-cap Names telethonin LOW QUALITY PROTEIN: telethonin titin cap protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597809.1	XP_017453298.1	LOW QUALITY PROTEIN: telethonin isoform X1
NM_001271277.1	NP_001258206.1	telethonin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.
Candasamy AJ, Haworth RS, Cuello F, Ibrahim M, Aravamudhan S, Kr?ger M, Holt MR, Terracciano CM, Mayr M, Gautel M, Avkiran M
The Journal of biological chemistry289(3)1282-93(2014 Jan)

Coordinate expression of the 19S regulatory complex and evidence for ubiquitin-dependent telethonin degradation in the unloaded soleus muscle.
Heng AE, Ventadour S, Jarzaguet M, Pouch-P?lissier MN, Guezennec CY, Bigard X, Attaix D, Taillandier D
The international journal of biochemistry & cell biology40(11)2544-52(2008)

Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy.
Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A
American journal of physiology. Heart and circulatory physiology293(6)H3396-403(2007 Dec)

Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.
Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Kn?ll R, Hoshijima M, Chien KR, Kimura A
Journal of the American College of Cardiology44(11)2192-201(2004 Dec)

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.
Kn?ll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR
Cell111(7)943-55(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients.
Title: Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.

data suggest that telethonin is a substrate of the ubiquitin-proteasome system during soleus muscle atrophy.
Title: Coordinate expression of the 19S regulatory complex and evidence for ubiquitin-dependent telethonin degradation in the unloaded soleus muscle.

The following Tcap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tcap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12595	NM_001271277.1 Latest version!	Rattus norvegicus titin-cap (Tcap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa57596	XM_017597809.1 Latest version!	Rattus norvegicus titin-cap (Tcap), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tcap ( NM_001271277.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258206.1 Rattus norvegicus titin-cap (Tcap), mRNA.

Price & Availability↑

CloneID	ORa12595
Clone ID Related Accession (Same CDS sequence)	NM_001271277.1
Accession Version	NM_001271277.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Rattus norvegicus(Norway rat)
Product	telethonin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FQ216780.1 and BM384635.1. On Sep 13, 2012 this sequence version replaced XM_001081394.3. ##Evidence-Data-START## Transcript exon combination :: FQ216780.1, FQ215695.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACTT CAGAGCTGAG CTGTCAAGTG TCTGAGGAGA ACCAGGAGCG CAGGGAAGCC 
TTCTGGGCCG AGTGGAAAGA CCTGACTCTG TCTACCCGGC CGGAAGAGGG ATGCTCCCTG 
CATGAGGAGG ATACACAGAG GCATGAGACC TACCACCGGC AGGGACAGTG TCAGGCCGTG 
GTACAGCGCT CGCCATGGCT GGTGATGCGC CTGGGTATCC TCGGCCGTGG GCTGCAGGAA 
TACCAGCTGC CGTACCAGCG GGTGCTGCCG CTACCCATCT TCACCCCTAC CAAGGTGGGG 
GCCACCAAGG AGGAACGCGA GGAGACCCCC ATTCAGCTGC GGGAGCTGCT GGCCCTGGAG 
ACAGCCCTGG GCGGCCAGTG CGTGGAGCGC CAGGACGTGG CTGAGATCAC CAAGCAGCTT 
CCCCCGGTGG TGCCAGTCAG CAAACCTGGG CCCCTGCGGC GTACCCTGTC TCGGTCCATG 
TCTCAGGAAG CTCAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258206.1
CDS	26..529
Translation	MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGATKEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSMSQEAQRG

Target ORF information:

RefSeq Version	NM_001271277.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus titin-cap (Tcap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271277.1

ORF Insert Sequence:

ATGGCCACTT CAGAGCTGAG CTGTCAAGTG TCTGAGGAGA ACCAGGAGCG CAGGGAAGCC 
TTCTGGGCCG AGTGGAAAGA CCTGACTCTG TCTACCCGGC CGGAAGAGGG ATGCTCCCTG 
CATGAGGAGG ATACACAGAG GCATGAGACC TACCACCGGC AGGGACAGTG TCAGGCCGTG 
GTACAGCGCT CGCCATGGCT GGTGATGCGC CTGGGTATCC TCGGCCGTGG GCTGCAGGAA 
TACCAGCTGC CGTACCAGCG GGTGCTGCCG CTACCCATCT TCACCCCTAC CAAGGTGGGG 
GCCACCAAGG AGGAACGCGA GGAGACCCCC ATTCAGCTGC GGGAGCTGCT GGCCCTGGAG 
ACAGCCCTGG GCGGCCAGTG CGTGGAGCGC CAGGACGTGG CTGAGATCAC CAAGCAGCTT 
CCCCCGGTGG TGCCAGTCAG CAAACCTGGG CCCCTGCGGC GTACCCTGTC TCGGTCCATG 
TCTCAGGAAG CTCAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tcap ( XM_017597809.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453298.1 Rattus norvegicus titin-cap (Tcap), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57596
Clone ID Related Accession (Same CDS sequence)	XM_017597809.1
Accession Version	XM_017597809.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	LOW QUALITY PROTEIN: telethonin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 15% of CDS bases frameshifts :: corrected 2 indels ##RefSeq-Attributes-END##

ATGACTCCCT GCATGAGGAG GATAAAGAGG CATGAGACCT ACCACCGGCA GGGACAGGTG 
TCAGGCCGTG GTACAGCGCT CCCGCCATGG CTGGTGATGC GCCTGGGTAT CCTCGCCGTG 
GGCTGCAGGA ATACCAGCGC CGTCCAGCGG GTGCTGCCGC TACCATCTTC ACCCCTACCA 
AGGTGGGCCA CCAAGGAGGA ACGCGAGNGG ACCCCCATTC AGCTGCGGGA GCTGCTGGCC 
CTGGAGACAG CCCTGGGCGG CCAGTGCGTG GAGCGCCAGG ACGTGGCTGA ATCACCAAGC 
AGACTTCCCC GGNNTGTGCC AGTCACAAAA CTGGGCCCCT GCGGGCTTAC CTCTGTCTCG 
GTCATGTCTC AGGAAGCTCA GAGAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453298.1
CDS	324..713
Translation	MTPCMRRIKRHETYHRQGQVSGRGTALPPWLVMRLGILAVGCRNTSAVQRVLPLPSSPLPRWATKEEREnullTPIQLRELLALETALGGQCVERQDVAESPSRLPRnullVPVTKLGPCGLTSVSVMSQEAQRG

Target ORF information:

RefSeq Version	XM_017597809.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus titin-cap (Tcap), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597809.1

ORF Insert Sequence:

ATGACTCCCT GCATGAGGAG GATAAAGAGG CATGAGACCT ACCACCGGCA GGGACAGGTG 
TCAGGCCGTG GTACAGCGCT CCCGCCATGG CTGGTGATGC GCCTGGGTAT CCTCGCCGTG 
GGCTGCAGGA ATACCAGCGC CGTCCAGCGG GTGCTGCCGC TACCATCTTC ACCCCTACCA 
AGGTGGGCCA CCAAGGAGGA ACGCGAGNGG ACCCCCATTC AGCTGCGGGA GCTGCTGGCC 
CTGGAGACAG CCCTGGGCGG CCAGTGCGTG GAGCGCCAGG ACGTGGCTGA ATCACCAAGC 
AGACTTCCCC GGNNTGTGCC AGTCACAAAA CTGGGCCCCT GCGGGCTTAC CTCTGTCTCG 
GTCATGTCTC AGGAAGCTCA GAGAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.
The Journal of biological chemistry289(3)1282-93(2014 Jan)
Candasamy AJ,Haworth RS,Cuello F,Ibrahim M,Aravamudhan S,Kr?ger M,Holt MR,Terracciano CM,Mayr M,Gautel M,Avkiran M

Coordinate expression of the 19S regulatory complex and evidence for ubiquitin-dependent telethonin degradation in the unloaded soleus muscle.
The international journal of biochemistry & cell biology40(11)2544-52(2008)
Heng AE,Ventadour S,Jarzaguet M,Pouch-P?lissier MN,Guezennec CY,Bigard X,Attaix D,Taillandier D

Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology293(6)H3396-403(2007 Dec)
Nakano N,Hori H,Abe M,Shibata H,Arimura T,Sasaoka T,Sawabe M,Chida K,Arai T,Nakahara K,Kubo T,Sugimoto K,Katsuya T,Ogihara T,Doi Y,Izumi T,Kimura A

Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.
Journal of the American College of Cardiology44(11)2192-201(2004 Dec)
Hayashi T,Arimura T,Itoh-Satoh M,Ueda K,Hohda S,Inagaki N,Takahashi M,Hori H,Yasunami M,Nishi H,Koga Y,Nakamura H,Matsuzaki M,Choi BY,Bae SW,You CW,Han KH,Park JE,Kn?ll R,Hoshijima M,Chien KR,Kimura A

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.
Cell111(7)943-55(2002 Dec)
Kn?ll R,Hoshijima M,Hoffman HM,Person V,Lorenzen-Schmidt I,Bang ML,Hayashi T,Shiga N,Yasukawa H,Schaper W,McKenna W,Yokoyama M,Schork NJ,Omens JH,McCulloch AD,Kimura A,Gregorio CC,Poller W,Schaper J,Schultheiss HP,Chien KR

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Tcap cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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