The following Iqsec2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Iqsec2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa42277 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001277386.1 | |
| Accession Version | NM_001277386.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2850bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-23 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | IQ motif and SEC7 domain-containing protein 2 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01109522.1 and AAHX01109523.1. Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMN04563758 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## | |
1 | ATGGAACCCC CCTGGAAGAG CAGCAGGTCC ACAGCGTCTC ATACTCTACA CCAGTATTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001264315.1 |
| CDS | 1..2850 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001277386.1 |
1 | ATGGAACCCC CCTGGAAGAG CAGCAGGTCC ACAGCGTCTC ATACTCTACA CCAGTATTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa41828 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001277425.1 | |
| Accession Version | NM_001277425.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4467bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-23 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | IQ motif and SEC7 domain-containing protein 2 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01109521.1, AAHX01109522.1 and AAHX01109523.1. On or before Apr 17, 2013 this sequence version replaced XM_003754753.1, XM_002727537.2, XM_002727538.2, XM_002730218.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## | |
1 | ATGGAGGCGG GGTCCGGTCC TCCGGGTGGC CCGGGATCTG AGAGCCCCAA CCGGGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001264354.1 |
| CDS | 151..4617 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001277425.1 |
1 | ATGGAGGCGG GGTCCGGTCC TCCGGGTGGC CCGGGATCTG AGAGCCCCAA CCGGGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. |
Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression. |
Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked Intellectual Disability in the MRX78 Family. |
IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina. |
IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses. |
