Kcnc4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnc4
Entrez Gene ID	684516
Full Name	potassium voltage-gated channel subfamily C member 4
General protein information	Preferred Names potassium voltage-gated channel subfamily C member 4 Names potassium voltage-gated channel subfamily C member 4 potassium channel, voltage gated Shaw-related subfamily C, member 4 potassium voltage gated channel, Shaw-related subfamily, member 4 potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3) raw3 voltage-gated potassium channel subunit Kv3.4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122776.1	NP_001116248.1	potassium voltage-gated channel subfamily C member 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNC4	NP_001034663.1
Pan troglodytes (chimpanzee)	KCNC4	XP_513651.2
Canis lupus familiaris (dog)	KCNC4	XP_547235.3
Rattus norvegicus (Norway rat)	Kcnc4	NP_001116248.1
Danio rerio (zebrafish)	kcnc4	NP_001182125.1
Bos taurus (cattle)	KCNC4	NP_001179709.1
Mus musculus (house mouse)	Kcnc4	NP_666034.1
Gallus gallus (chicken)	KCNC4	XP_003642768.1
	KCNC4	XP_001099694.1
Xenopus tropicalis (tropical clawed frog)	kcnc4	XP_002933043.1

Gene Ontology
Bibliography

Related articles in PubMed

Kv3.4 channel function and dysfunction in nociceptors.
Ritter DM, Zemel BM, Lepore AC, Covarrubias M
Channels (Austin, Tex.)9(4)209-17(2015)

Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.
Huang CY, Chu D, Hwang WC, Tsaur ML
The Journal of comparative neurology520(16)3650-72(2012 Nov)

Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.
Boda E, Hoxha E, Pini A, Montarolo F, Tempia F
Journal of molecular neuroscience : MN46(3)606-15(2012 Mar)

KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel ?-subunit composition.
Kanda VA, Lewis A, Xu X, Abbott GW
Biophysical journal101(6)1364-75(2011 Sep)

KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels.
Kanda VA, Lewis A, Xu X, Abbott GW
Biophysical journal101(6)1354-63(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate ubiquitous expression of Kv3.4 potassium channel protein in nociceptors.
Title: Kv3.4 channel function and dysfunction in nociceptors.

the 15-lipoxygenase pathway via its metabolite, 15-hydroxyeicosatetraenoic acid , seems to play a role in the down-regulation of Kv3.4
Title: Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells.

Given the role of the Kv3 proteins in shaping neuronal excitability, these data highlight a role for homomeric Kv3.4 channels in spike timing and neurotransmitter release in low frequency firing neurons of the DVN.
Title: Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin.

Kv3.4 is expressed in nociceptive dorsal root ganglion neurons and is greatly reduced following neuropathic pain.
Title: Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity.

Up-regulation and increased activity of KV3.4 channels and their accessory sububnit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.
Title: Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.

The following Kcnc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01229	NM_001122776.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily C member 4 (Kcnc4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnc4 ( NM_001122776.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001116248.1 Rattus norvegicus potassium voltage-gated channel subfamily C member 4 (Kcnc4), mRNA.

Price & Availability↑

CloneID	ORa01229
Clone ID Related Accession (Same CDS sequence)	NM_001122776.1
Accession Version	NM_001122776.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily C member 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X62841.1. On Jan 24, 2009 this sequence version replaced XM_001070801.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: X62841.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATCAGCT CGGTGTGTGT CTCCTCCTAC CGCGGGCGCA AGTCGGGGAA CAAGCCTCCG 
TCCAAAACAT GTCTGAAGGA GGAGATGGCC AAGGGCGAGG CGTCGGAGAA GATCATCATC 
AACGTGGGCG GCACGCGACA TGAGACCTAC CGCAGCACCC TGCGCACCCT ACCGGGCACC 
CGCCTTGCCT GGCTGGCGGA TCCCGACGGC GGGGGTCGGC CAGAGTCGGA TGGCGGCGGT 
GCAGGCAGCA GCGGCAGCAG CGGCGGCGGC GGGGGCTGTG AGTTCTTCTT TGATCGGCAC 
CCGGGTGTTT TTGCCTATGT GCTCAACTAC TACCGCACGG GCAAGCTGCA TTGCCCCGCA 
GACGTCTGTG GGCCTCTCTT TGAGGAAGAG CTCACTTTCT GGGGTATCGA TGAGACAGAT 
GTGGAACCCT GCTGCTGGAT GACCTACCGG CAGCACCGCG ATGCTGAAGA GGCACTGGAC 
ATCTTCGAGA GCCCGGACGG GGGCGGGGGT GGCGCAGGGC CCGGCGACGA GGCTGGAGAC 
GATGAGCGGG AGTTGGCCTT GCAGCGCCTG GGCCCCCATG AAGGAGGCTC TGGCCCTGGT 
GCTGGGTCCG GGGGTTGCCG TGGCTGGCAG CCCCGAATGT GGGCGCTCTT CGAGGACCCG 
TACTCATCCC GGGCGGCCAG GGTGGTAGCC TTTGCCTCTC TCTTCTTCAT CTTGGTCTCC 
ATTACCACCT TCTGCCTGGA GACCCACGAG GCCTTCAACA TTGACCGAAA TGTGACGGAG 
ATCCACCGGG TAGGGAATAT CACCAGCGTG CGCTTCCGGC GGGAGGTAGA AACAGAACCC 
ATTCTTACCT ACATCGAGGG CGTGTGCGTG ATGTGGTTCA CTCTAGAGTT CCTGGTTCGC 
ATTGTGTGCT GCCCTGATAC GTTGGACTTT GTCAAGAACC TGCTCAACAT CATCGACTTT 
GTGGCCATCT TGCCCTTTTA CCTGGAGGTG GGATTGAGTG GCCTGTCATC CAAGGCAGCT 
CGAGATGTGC TGGGTTTCCT GCGTGTGGTG CGCTTTGTAC GCATCCTGCG GATCTTCAAG 
CTCACACGCC ACTTTGTGGG GCTGCGTGTG CTCGGCCACA CACTCCGGGC CAGCACCAAC 
GAGTTCCTGC TGCTTATCAT CTTCCTGGCC CTGGGTGTGC TCATCTTTGC CACCATGATC 
TATTATGCTG AGCGAATCGG GGCCAGGCCA TCTGACCCAC GGGGCAATGA CCACACCGAC 
TTCAAGAACA TCCCCATCGG TTTCTGGTGG GCTGTGGTCA CCATGACAAC GCTTGGCTAT 
GGGGACATGT ATCCTAAGAC ATGGTCAGGA ATGCTGGTGG GTGCGCTGTG TGCACTGGCT 
GGTGTGCTAA CCATTGCCAT GCCTGTGCCT GTCATCGTCA ATAACTTTGG TATGTACTAC 
TCCCTGGCTA TGGCCAAGCA GAAGCTTCCC AAGAAACGAA AGAAGCATGT ACCACGGCCA 
CCCCAGCTTG AGTCACCCAT TTACTGCAAG TCTGAGGAGA CTTCACCCCG GGACAGCACC 
TACAGTGACA CCAGCCCCCC TGCCCGGGAA GAGGGTATGG TCGAGAGGAA ACGAGCAGAC 
TCCAAGCAGA ATGGTGACGC TAATGCGGTG CTGTCCGATG AGGAGGGAGC TGGCCTCACC 
CAGCCCCTGG CCTCGGCCCC CACCCCTGAA GAGCGTCGAG CCCTGAGACG CTCAGGCACA 
CGGGACAGAA ACAAGAAGGC AGCTGCCTGC TTCCTGCTCA GTGCTGGGGA CTATGCCTGT 
GCTGATGGCA GTGTCCAGAA AGAAGGCAGT GTTGAGCCGA AAGCGTGCGT CCCAGTGTCT 
CACACCTGTG CTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116248.1
CDS	400..2277
Translation	MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIYCKSEETSPRDSTYSDTSPPAREEGMVERKRADSKQNGDANAVLSDEEGAGLTQPLASAPTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVQKEGSVEPKACVPVSHTCAL

Target ORF information:

RefSeq Version	NM_001122776.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily C member 4 (Kcnc4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122776.1

ORF Insert Sequence:

ATGATCAGCT CGGTGTGTGT CTCCTCCTAC CGCGGGCGCA AGTCGGGGAA CAAGCCTCCG 
TCCAAAACAT GTCTGAAGGA GGAGATGGCC AAGGGCGAGG CGTCGGAGAA GATCATCATC 
AACGTGGGCG GCACGCGACA TGAGACCTAC CGCAGCACCC TGCGCACCCT ACCGGGCACC 
CGCCTTGCCT GGCTGGCGGA TCCCGACGGC GGGGGTCGGC CAGAGTCGGA TGGCGGCGGT 
GCAGGCAGCA GCGGCAGCAG CGGCGGCGGC GGGGGCTGTG AGTTCTTCTT TGATCGGCAC 
CCGGGTGTTT TTGCCTATGT GCTCAACTAC TACCGCACGG GCAAGCTGCA TTGCCCCGCA 
GACGTCTGTG GGCCTCTCTT TGAGGAAGAG CTCACTTTCT GGGGTATCGA TGAGACAGAT 
GTGGAACCCT GCTGCTGGAT GACCTACCGG CAGCACCGCG ATGCTGAAGA GGCACTGGAC 
ATCTTCGAGA GCCCGGACGG GGGCGGGGGT GGCGCAGGGC CCGGCGACGA GGCTGGAGAC 
GATGAGCGGG AGTTGGCCTT GCAGCGCCTG GGCCCCCATG AAGGAGGCTC TGGCCCTGGT 
GCTGGGTCCG GGGGTTGCCG TGGCTGGCAG CCCCGAATGT GGGCGCTCTT CGAGGACCCG 
TACTCATCCC GGGCGGCCAG GGTGGTAGCC TTTGCCTCTC TCTTCTTCAT CTTGGTCTCC 
ATTACCACCT TCTGCCTGGA GACCCACGAG GCCTTCAACA TTGACCGAAA TGTGACGGAG 
ATCCACCGGG TAGGGAATAT CACCAGCGTG CGCTTCCGGC GGGAGGTAGA AACAGAACCC 
ATTCTTACCT ACATCGAGGG CGTGTGCGTG ATGTGGTTCA CTCTAGAGTT CCTGGTTCGC 
ATTGTGTGCT GCCCTGATAC GTTGGACTTT GTCAAGAACC TGCTCAACAT CATCGACTTT 
GTGGCCATCT TGCCCTTTTA CCTGGAGGTG GGATTGAGTG GCCTGTCATC CAAGGCAGCT 
CGAGATGTGC TGGGTTTCCT GCGTGTGGTG CGCTTTGTAC GCATCCTGCG GATCTTCAAG 
CTCACACGCC ACTTTGTGGG GCTGCGTGTG CTCGGCCACA CACTCCGGGC CAGCACCAAC 
GAGTTCCTGC TGCTTATCAT CTTCCTGGCC CTGGGTGTGC TCATCTTTGC CACCATGATC 
TATTATGCTG AGCGAATCGG GGCCAGGCCA TCTGACCCAC GGGGCAATGA CCACACCGAC 
TTCAAGAACA TCCCCATCGG TTTCTGGTGG GCTGTGGTCA CCATGACAAC GCTTGGCTAT 
GGGGACATGT ATCCTAAGAC ATGGTCAGGA ATGCTGGTGG GTGCGCTGTG TGCACTGGCT 
GGTGTGCTAA CCATTGCCAT GCCTGTGCCT GTCATCGTCA ATAACTTTGG TATGTACTAC 
TCCCTGGCTA TGGCCAAGCA GAAGCTTCCC AAGAAACGAA AGAAGCATGT ACCACGGCCA 
CCCCAGCTTG AGTCACCCAT TTACTGCAAG TCTGAGGAGA CTTCACCCCG GGACAGCACC 
TACAGTGACA CCAGCCCCCC TGCCCGGGAA GAGGGTATGG TCGAGAGGAA ACGAGCAGAC 
TCCAAGCAGA ATGGTGACGC TAATGCGGTG CTGTCCGATG AGGAGGGAGC TGGCCTCACC 
CAGCCCCTGG CCTCGGCCCC CACCCCTGAA GAGCGTCGAG CCCTGAGACG CTCAGGCACA 
CGGGACAGAA ACAAGAAGGC AGCTGCCTGC TTCCTGCTCA GTGCTGGGGA CTATGCCTGT 
GCTGATGGCA GTGTCCAGAA AGAAGGCAGT GTTGAGCCGA AAGCGTGCGT CCCAGTGTCT 
CACACCTGTG CTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Kv3.4 channel function and dysfunction in nociceptors.
Channels (Austin, Tex.)9(4)209-17(2015)
Ritter DM,Zemel BM,Lepore AC,Covarrubias M

Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.
The Journal of comparative neurology520(16)3650-72(2012 Nov)
Huang CY,Chu D,Hwang WC,Tsaur ML

Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.
Journal of molecular neuroscience : MN46(3)606-15(2012 Mar)
Boda E,Hoxha E,Pini A,Montarolo F,Tempia F

KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel ?-subunit composition.
Biophysical journal101(6)1364-75(2011 Sep)
Kanda VA,Lewis A,Xu X,Abbott GW

KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels.
Biophysical journal101(6)1354-63(2011 Sep)
Kanda VA,Lewis A,Xu X,Abbott GW

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Kcnc4 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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