Cacna1s cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cacna1s
Entrez Gene ID	682930
Full Name	calcium voltage-gated channel subunit alpha1 S
Synonyms	Cchl1a3,RGD1565743
General protein information	Preferred Names calcium voltage-gated channel subunit alpha1 S Names voltage-dependent L-type calcium channel subunit alpha-1S ROB1 calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle calcium channel, voltage-dependent, L type, alpha 1S subunit voltage-gated calcium channel subunit alpha Cav1.1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	skeletal isoform and subunit of voltage dependent L-type Ca+2 channel; may mediate renal Ca+2 reabsorption; may play a role in bone metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053873.1	NP_446325.1	voltage-dependent L-type calcium channel subunit alpha-1S

Pathways from BioSystems

Homologies

	CACNA1S	XP_002802046.1
Rattus norvegicus (Norway rat)	Cacna1s	NP_446325.1
Homo sapiens (human)	CACNA1S	NP_000060.2
Pan troglodytes (chimpanzee)	CACNA1S	XP_525018.3
Canis lupus familiaris (dog)	CACNA1S	XP_848685.3
Bos taurus (cattle)	CACNA1S	XP_002694288.2
Mus musculus (house mouse)	Cacna1s	NP_001074492.1
Danio rerio (zebrafish)	cacna1sa	NP_001139622.1
Gallus gallus (chicken)	CACNA1S	XP_419259.3
Danio rerio (zebrafish)	cacna1sb	NP_999891.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased intracellular [Ca
Wang MM, Hao LY, Guo F, Zhong B, Zhong XM, Yuan J, Hao YF, Zhao S, Sun XF, Lei M, Jiao GY
Muscle & nerve56(6)1128-1136(2017 Dec)

Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
Tummala SR, Neinstein A, Fina ME, Dhingra A, Vardi N
Investigative ophthalmology & visual science55(3)1483-92(2014 Mar)

Reduced DHPR?1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.
Jiao GY, Hao LY, Gao CE, Chen L, Sun XF, Yang HL, Li Y, Dai YN
Muscle & nerve48(5)745-51(2013 Nov)

Voltage-gated calcium channels.
Catterall WA
Cold Spring Harbor perspectives in biology3(8)a003947(2011 Aug)

Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy.
Kraner SD, Wang Q, Novak KR, Cheng D, Cool DR, Peng J, Rich MM
American journal of physiology. Regulatory, integrative and comparative physiology300(6)R1384-91(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Septic diaphragm contractility and expression of Cacna1s and RyR1 are significantly decreased in a sepsis model compared with controls.
Title: Decreased intracellular [Ca

The expression levels of dihydropyridine alpha1s and RyR1 receptors (the isoforms of skeletal muscles) are significantly lower in septic rats than in control rats.
Title: Reduced DHPR?1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.

sequences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation
Title: Sequence differences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation.

The following Cacna1s gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cacna1s cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10917	NM_053873.1 Latest version!	Rattus norvegicus calcium voltage-gated channel subunit alpha1 S (Cacna1s), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cacna1s ( NM_053873.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446325.1 Rattus norvegicus calcium voltage-gated channel subunit alpha1 S (Cacna1s), mRNA.

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CloneID	ORa10917
Clone ID Related Accession (Same CDS sequence)	NM_053873.1
Accession Version	NM_053873.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5553bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	voltage-dependent L-type calcium channel subunit alpha-1S
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB374360.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB374360.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689600, SAMEA2689602 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCCGT CCTCACCCCA GGATGAGGGC CTGAGGAAGA AGCAGCCTAA GAAACCCGTC 
CCTGAGATTC TGCCGAGGCC ACCCCGGGCC TTGTTCTGCT TGACTCTCCA GAACCCCCTG 
AGGAAGGCCT GCATCAGCGT CGTGGAGTGG AAACCCTTCG AGACCATCAT CTTGCTCACC 
ATCTTCGCCA ACTGTGTGGC CCTGGCAGTG TACCTGCCCA TGCCAGAGGA TGACAACAAC 
ACTCTGAACC TTGGCCTGGA GAAACTGGAG TACTTCTTCC TCATCGTCTT CTCCATTGAG 
GCTGCTATGA AGATCATAGC CTATGGCTTC CTATTCCATC AGGATGCTTA CCTGCGCAGT 
GGCTGGAACG TGCTGGACTT CATCATTGTC TTTCTGGGTG TCTTCACCGC GATTCTGGAA 
CAAGTTAACA TCATTCAAAC CAACACGGCC CCCATGAGCA GCAAAGGAGC CGGCTTGGAT 
GTGAAGGCCC TGCGAGCTTT CCGCGTGCTC AGACCCCTGC GGCTGGTGTC AGGGGTGCCC 
AGCCTTCAGG TAGTCCTCAA CTCCATCTTC AAGGCCATGC TCCCCCTGTT CCACATCGCC 
CTGCTCGTCC TCTTCATGGT CATCATCTAT GCCATCATCG GGCTGGAGCT CTTCAAGGGC 
AAGATGCACA AGACGTGCTA CTTCATTGGG ACAGACATCG TGGCCACAGT AGAGAATGAG 
AAACCATCAC CCTGTGCTAG AACTGGCTCC GGGCGCCCCT GCACCATCAA CGGCAGCGAG 
TGCCGAGGAG GTTGGCCAGG ACCCAACCAT GGCATCACCC ACTTCGACAA CTTTGGCTTC 
TCTATGCTCA CTGTGTACCA GTGCATCTCC ATGGAGGGGT GGACCGATGT CCTGTACTGG 
GTCAATGATG CCATCGGGAA CGAGTGGCCC TGGATCTACT TTGTCACCCT CATTCTGCTG 
GGCTCCTTCT TCATCCTGAA CCTGGTGCTG GGTGTCCTGA GTGGAGAATT CACCAAGGAG 
CGAGAGAAGG CCAAGTCCAG AGGAACCTTC CAAAAGCTCC GGGAGAAGCA GCAGCTGGAG 
GAAGACCTTC GTGGTTACAT GAGTTGGATC ACACAGGGCG AGGTCATGGA CGTGGACGAC 
TTGAGAGAAG GCAAGCTGTC TTTGGATGAA GGGGGCTCGG ATACAGAGAG CTTATATGAA 
ATCGAGGGCT TGAACAAAAT CATCCAATTC ATTCGGCACT GGCGGCAGTG GAATCGCGTC 
TTCCGCTGGA AGTGCCATGA CCTAGTGAAA TCCAAGGTCT TCTATTGGCT GGTGATCCTG 
ATTGTGGCCC TCAACACCCT GTCCATTGCC TCAGAGCACC ACAACCAGCC ACTCTGGCTG 
ACGCATTTGC AAGATGTCGC CAACCGCGTG CTGCTGGCCC TCTTCACCAT CGAGATGCTC 
ATGAAGATGT ACGGGCTGGG CCTGCGCCAG TACTTCATGT CCATCTTCAA CCGCTTCGAC 
TGCTTCGTGG TGTGCAGCGG CATCCTGGAG ATCTTGCTGG TGGAGTCGGG AGCCATGACG 
CCCCTGGGCA TCTCTGTGCT CCGCTGCATC CGCCTCCTGA GGCTCTTCAA GATCACCAAG 
TACTGGACAT CGCTGAGCAA CCTGGTGGCC TCGCTGCTCA ACTCCATCCG CTCTATCGCT 
TCCCTCTTGC TGCTGCTCTT TCTTTTCATG ATCATCTTTG CCCTGCTAGG CATGCAGCTC 
TTTGGAGGCA GATACGACTT TGAAGACACG GAAGTACGAC GAAGCAACTT TGACAACTTC 
CCCCAGGCCC TCATCAGTGT CTTCCAGGTC CTGACGGGTG AAGACTGGAA CTCTGTGATG 
TACAATGGGA TCATGGCCTA CGGAGGCCCG TCCTACCCTG GCGTGCTCGT GTGCATTTAT 
TTCATCATCC TTTTTGTCTG TGGTAACTAC ATCCTTCTCA ATGTCTTCCT GGCTATCGCT 
GTGGACAACC TGGCAGAGGC TGAGAGCCTG ACATCTGCCC AGAAGGCCAA GGCTGAGGAG 
AGAAAGCGCA GGAAGATGTC TAGAGGGCTC CCAGACAAGT CAGAAGAGGA GAGATCCACA 
ATGACCAAGA AGCTGGAGCA GAAACCCAAG GGTGAAGGCA TCCCCACCAC TGCCAAGCTG 
AAAATCGATG AGTTTGAATC GAACGTCAAT GAGGTGAAAG ACCCCTACCC TTCAGCTGAC 
TTCCCAGGGG ACGACGAGGA AGATGAGCCT GAGATCCCAG CAAGCCCCCG ACCACGCCCT 
CTGGCTGAGC TGCAGCTGAA AGAGAAAGCG GTGCCCATCC CAGAGGCCAG CTCCTTCTTC 
ATCTTCAGCC CCACCAATAA GATCCGCGTC CTATGTCACC GCATTGTCAA CGCCACCTGG 
TTCACCAACT TTATCCTACT CTTCATCCTG CTCAGTAGTG CTGCTCTGGC CGCTGAGGAC 
CCCATCCGGG CCGACTCCAT GAGGAATCAG ATCCTTGAGT ATTTTGATTA TGTGTTCACT 
GCTGTTTTCA CTGTGGAGAT CGTCCTTAAG ATGACCACCT ATGGAGCCTT CCTGCACAAA 
GGCTCCTTCT GCCGCAACTA CTTCAACATC CTGGACCTGC TGGTAGTGGC TGTGTCTCTC 
ATCTCCATGG GCCTCGAGTC CAGCGCCATC TCCGTGGTGA AGATCTTGAG GGTCCTGAGG 
GTGTTGCGAC CACTCCGGGC CATAAACAGA GCCAAAGGGT TGAAGCACGT GGTGCAGTGC 
GTGTTTGTTG CTATCCGCAC CATCGGGAAC ATCGTGCTGG TCACCACGCT CCTGCAGTTC 
ATGTTTGCAT GCATCGGAGT CCAGCTTTTC AAGGGAAAAT TCTACAGCTG CAATGATTTA 
TCCAAGATGA CTGAAGAGGA GTGCAGGGGC TACTACTACA TATACAAGGA TGGAGACCCC 
ACGCAGATAG AGTTGCGACC CCGTCAGTGG ATACACAATG ACTTCCACTT TGACAATGTC 
CTGTCTGCTA TGATGTCACT CTTCACGGTC TCCACCTTTG AGGGTTGGCC TCAGCTACTG 
TACAAGGCCA TAGACTCCAA TGAGGAGGAC ACAGGCCCCG TCTACAACAA CCGAGTGGAG 
ATGGCCATCT TCTTCATCAT CTACATCATT CTCATCGCCT TCTTCATGAT GAACATCTTT 
GTGGGCTTCG TCATCGTCAC CTTCCAGGAG CAGGGGGAGA CTGAGTATAA GAACTGTGAG 
CTGGACAAGA ACCAGCGCCA ATGTGTGCAG TATGCCCTGA AGGCCCGCCC GCTGAGGTGT 
TACATCCCCA AAAACCCATA CCAGTATCAG GTGTGGTATG TCGTCACTTC CTCCTACTTT 
GAATACCTGA TGTTTGCTCT CATCATGCTC AACACTATCT GCCTAGGCAT GCAGCATTAC 
AACCAGTCGG AACAGATGAA CCACATATCG GACATCCTCA ATGTGGCTTT CACCATCATC 
TTCACCCTGG AGATGATCCT CAAGCTCATA GCTTTCAAGC CCAGGGGCTA TTTTGGAGAC 
CCCTGGAACG TGTTTGACTT TCTAATCGTC ATTGGCAGCA TCATTGACGT TATCCTGAGT 
GAGATCGATA CTTTGCTGGC CTCCAGCGGG GGACTATATT GCCTGGGTGG AGGCTGCGGG 
AACGTTGACC CAGATGAGAG CGCCCGCATC TCCAGTGCCT TCTTCCGCCT GTTCCGAGTC 
ATGCGACTGA TCAAGCTGCT GAGCCGGGCG GAGGGTGTGC GCACCCTGCT CTGGACGTTC 
ATCAAGTCCT TCCAGGCCCT GCCGTATGTG GCTTTGCTGA TCGTCATGCT CTTCTTCATC 
TACGCTGTCA TCGGCATGCA GATGTTCGGG AAGATCGCCA TGGTGGACGG GACGCAAATA 
AACCGGAACA ACAACTTCCA GACTTTCCCA CAAGCTGTGC TGCTGCTCTT CAGGTGTGCC 
ACAGGGGAAG CCTGGCAGGA GATCCTGCTG GCCTGCAGCT ACGGGAAACG CTGCGACCCG 
GAGTCTGACT ACGCACCGGG GGAGGAGTAC GCGTGTGGCA CCAACTTTGC CTACTACTAC 
TTCATCAGCT TCTACATGCT CTGCGCCTTC CTGATCATCA ACCTCTTTGT GGCTGTCATC 
ATGGACAACT TTGACTACCT CACAAGGGAC TGGTCCATTC TGGGCCCTCA CCACCTGGAT 
GAGTTCAAGG CCATCTGGGC TGAGTACGAC CCAGAGGCTA AGGGCAGGAT CAAGCACCTG 
GACGTGGTGA CCCTGCTGAG GAGGATCCAG CCCCCTCTGG GCTTTGGGAA GTTCTGCCCA 
CACAGGGTAG CATGTAAGAG GCTGGTGGGC ATGAACATGC CCCTGAATAG TGATGGCACA 
GTCACCTTCA ATGCCACACT CTTCGCCCTG GTACGCACAG CCCTCAAGAT CAAGACAGAA 
GGCAATTTTG AACAAGCCAA TGAGGAGCTG AGAGCCATCA TCAAAAAGAT CTGGAAGAGA 
ACCAGCATGA AGCTCCTGGA CCAAGTCATC CCTCCAATAG GAGATGACGA GGTGACAGTG 
GGGAAGTTCT ATGCCACATT CCTCATCCAG GAGCACTTTC GGAAGTTCAT GAAGCGCCAG 
GAGGAATATT ATGGGTATCG ACCCAAAAAG GACACAGTTC AGATACAGGC TGGATTGCGG 
ACCATAGAGG AAGAGGCAGC TCCTGAGATC CACCGAGCCA TCTCTGGAGA CCTGACGGCG 
GAGGAGGAGC TGGAGAGGGC CATGGTAGAG GCTGCCATGG AGGAGGGGAT ATTCCGGAGA 
ACTGGAGGCC TGTTTGGTCA AGTGGACAAC TTCCTGGAAA GGACCAACTC TCTGCCCCCT 
GTCATGGCTA ACCAAAGACC CCTCCAATTT GCCGAAATGG AGATGGAAGA GCTGGAGTCA 
CCAGTCTTTT TGGAGGACTT CCCTCAGAAC CCAGGCACCC ACCCTCTTGC TCGTGCCAAT 
ACCAACAACG CCAATGCCAA TGTTGCCTAT GGCAACAGCA GCCATAGAAA CAGCCCAGTG 
TTTTCCAGCA TCCGCTATGA AAGGGAGCTC CTGGAAGAGG CAGGCAGGCC TGTTACCAGA 
GAAGGACCCT TCAGTCAGCC CTGCAGCGTC TCTGGAGTTA ACAGCAGATC CCATGTGGAC 
AAACTGGAAA GACAGATGTC CCAAAGAAGA ATGCCCAAAG GCCAGGTGCC TCCTTCCCCA 
TGCCAGCTCT CCCAGGAAAA GCATCCTGTG CACGAAGAGG GGAAGGGCCC CAGGTCATGG 
TCTACGGAAA CATCTGACAG TGAGAGCTTT GAGGAGCGTG TTCCCAGGAA TTCGGCTCAC 
AAGTGCACAG CCCCAGCTAC CACCATGCTG ATCCAGGAGG CTCTGGTTCG AGGAGGACTA 
GACTCCTTAG CAGCAGATGC TAACTTCGTC ATGGCAACAG GCCAGGCCCT GGCAGATGCC 
TGCCAGATGG AACCAGAGGA AGTCGAGGTG GCAGCAACAG AGCTACTGAA GCGAGAATCC 
CCAAAGGGCG GGGCCATGCC CAGGGAGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446325.1
CDS	168..5720
Translation	MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVDDLREGKLSLDEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKSEEERSTMTKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPASPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKRCDPESDYAPGEEYACGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLRTIEEEAAPEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEMEMEELESPVFLEDFPQNPGTHPLARANTNNANANVAYGNSSHRNSPVFSSIRYERELLEEAGRPVTREGPFSQPCSVSGVNSRSHVDKLERQMSQRRMPKGQVPPSPCQLSQEKHPVHEEGKGPRSWSTETSDSESFEERVPRNSAHKCTAPATTMLIQEALVRGGLDSLAADANFVMATGQALADACQMEPEEVEVAATELLKRESPKGGAMPREP

Target ORF information:

RefSeq Version	NM_053873.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcium voltage-gated channel subunit alpha1 S (Cacna1s), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053873.1

ORF Insert Sequence:

ATGGAGCCGT CCTCACCCCA GGATGAGGGC CTGAGGAAGA AGCAGCCTAA GAAACCCGTC 
CCTGAGATTC TGCCGAGGCC ACCCCGGGCC TTGTTCTGCT TGACTCTCCA GAACCCCCTG 
AGGAAGGCCT GCATCAGCGT CGTGGAGTGG AAACCCTTCG AGACCATCAT CTTGCTCACC 
ATCTTCGCCA ACTGTGTGGC CCTGGCAGTG TACCTGCCCA TGCCAGAGGA TGACAACAAC 
ACTCTGAACC TTGGCCTGGA GAAACTGGAG TACTTCTTCC TCATCGTCTT CTCCATTGAG 
GCTGCTATGA AGATCATAGC CTATGGCTTC CTATTCCATC AGGATGCTTA CCTGCGCAGT 
GGCTGGAACG TGCTGGACTT CATCATTGTC TTTCTGGGTG TCTTCACCGC GATTCTGGAA 
CAAGTTAACA TCATTCAAAC CAACACGGCC CCCATGAGCA GCAAAGGAGC CGGCTTGGAT 
GTGAAGGCCC TGCGAGCTTT CCGCGTGCTC AGACCCCTGC GGCTGGTGTC AGGGGTGCCC 
AGCCTTCAGG TAGTCCTCAA CTCCATCTTC AAGGCCATGC TCCCCCTGTT CCACATCGCC 
CTGCTCGTCC TCTTCATGGT CATCATCTAT GCCATCATCG GGCTGGAGCT CTTCAAGGGC 
AAGATGCACA AGACGTGCTA CTTCATTGGG ACAGACATCG TGGCCACAGT AGAGAATGAG 
AAACCATCAC CCTGTGCTAG AACTGGCTCC GGGCGCCCCT GCACCATCAA CGGCAGCGAG 
TGCCGAGGAG GTTGGCCAGG ACCCAACCAT GGCATCACCC ACTTCGACAA CTTTGGCTTC 
TCTATGCTCA CTGTGTACCA GTGCATCTCC ATGGAGGGGT GGACCGATGT CCTGTACTGG 
GTCAATGATG CCATCGGGAA CGAGTGGCCC TGGATCTACT TTGTCACCCT CATTCTGCTG 
GGCTCCTTCT TCATCCTGAA CCTGGTGCTG GGTGTCCTGA GTGGAGAATT CACCAAGGAG 
CGAGAGAAGG CCAAGTCCAG AGGAACCTTC CAAAAGCTCC GGGAGAAGCA GCAGCTGGAG 
GAAGACCTTC GTGGTTACAT GAGTTGGATC ACACAGGGCG AGGTCATGGA CGTGGACGAC 
TTGAGAGAAG GCAAGCTGTC TTTGGATGAA GGGGGCTCGG ATACAGAGAG CTTATATGAA 
ATCGAGGGCT TGAACAAAAT CATCCAATTC ATTCGGCACT GGCGGCAGTG GAATCGCGTC 
TTCCGCTGGA AGTGCCATGA CCTAGTGAAA TCCAAGGTCT TCTATTGGCT GGTGATCCTG 
ATTGTGGCCC TCAACACCCT GTCCATTGCC TCAGAGCACC ACAACCAGCC ACTCTGGCTG 
ACGCATTTGC AAGATGTCGC CAACCGCGTG CTGCTGGCCC TCTTCACCAT CGAGATGCTC 
ATGAAGATGT ACGGGCTGGG CCTGCGCCAG TACTTCATGT CCATCTTCAA CCGCTTCGAC 
TGCTTCGTGG TGTGCAGCGG CATCCTGGAG ATCTTGCTGG TGGAGTCGGG AGCCATGACG 
CCCCTGGGCA TCTCTGTGCT CCGCTGCATC CGCCTCCTGA GGCTCTTCAA GATCACCAAG 
TACTGGACAT CGCTGAGCAA CCTGGTGGCC TCGCTGCTCA ACTCCATCCG CTCTATCGCT 
TCCCTCTTGC TGCTGCTCTT TCTTTTCATG ATCATCTTTG CCCTGCTAGG CATGCAGCTC 
TTTGGAGGCA GATACGACTT TGAAGACACG GAAGTACGAC GAAGCAACTT TGACAACTTC 
CCCCAGGCCC TCATCAGTGT CTTCCAGGTC CTGACGGGTG AAGACTGGAA CTCTGTGATG 
TACAATGGGA TCATGGCCTA CGGAGGCCCG TCCTACCCTG GCGTGCTCGT GTGCATTTAT 
TTCATCATCC TTTTTGTCTG TGGTAACTAC ATCCTTCTCA ATGTCTTCCT GGCTATCGCT 
GTGGACAACC TGGCAGAGGC TGAGAGCCTG ACATCTGCCC AGAAGGCCAA GGCTGAGGAG 
AGAAAGCGCA GGAAGATGTC TAGAGGGCTC CCAGACAAGT CAGAAGAGGA GAGATCCACA 
ATGACCAAGA AGCTGGAGCA GAAACCCAAG GGTGAAGGCA TCCCCACCAC TGCCAAGCTG 
AAAATCGATG AGTTTGAATC GAACGTCAAT GAGGTGAAAG ACCCCTACCC TTCAGCTGAC 
TTCCCAGGGG ACGACGAGGA AGATGAGCCT GAGATCCCAG CAAGCCCCCG ACCACGCCCT 
CTGGCTGAGC TGCAGCTGAA AGAGAAAGCG GTGCCCATCC CAGAGGCCAG CTCCTTCTTC 
ATCTTCAGCC CCACCAATAA GATCCGCGTC CTATGTCACC GCATTGTCAA CGCCACCTGG 
TTCACCAACT TTATCCTACT CTTCATCCTG CTCAGTAGTG CTGCTCTGGC CGCTGAGGAC 
CCCATCCGGG CCGACTCCAT GAGGAATCAG ATCCTTGAGT ATTTTGATTA TGTGTTCACT 
GCTGTTTTCA CTGTGGAGAT CGTCCTTAAG ATGACCACCT ATGGAGCCTT CCTGCACAAA 
GGCTCCTTCT GCCGCAACTA CTTCAACATC CTGGACCTGC TGGTAGTGGC TGTGTCTCTC 
ATCTCCATGG GCCTCGAGTC CAGCGCCATC TCCGTGGTGA AGATCTTGAG GGTCCTGAGG 
GTGTTGCGAC CACTCCGGGC CATAAACAGA GCCAAAGGGT TGAAGCACGT GGTGCAGTGC 
GTGTTTGTTG CTATCCGCAC CATCGGGAAC ATCGTGCTGG TCACCACGCT CCTGCAGTTC 
ATGTTTGCAT GCATCGGAGT CCAGCTTTTC AAGGGAAAAT TCTACAGCTG CAATGATTTA 
TCCAAGATGA CTGAAGAGGA GTGCAGGGGC TACTACTACA TATACAAGGA TGGAGACCCC 
ACGCAGATAG AGTTGCGACC CCGTCAGTGG ATACACAATG ACTTCCACTT TGACAATGTC 
CTGTCTGCTA TGATGTCACT CTTCACGGTC TCCACCTTTG AGGGTTGGCC TCAGCTACTG 
TACAAGGCCA TAGACTCCAA TGAGGAGGAC ACAGGCCCCG TCTACAACAA CCGAGTGGAG 
ATGGCCATCT TCTTCATCAT CTACATCATT CTCATCGCCT TCTTCATGAT GAACATCTTT 
GTGGGCTTCG TCATCGTCAC CTTCCAGGAG CAGGGGGAGA CTGAGTATAA GAACTGTGAG 
CTGGACAAGA ACCAGCGCCA ATGTGTGCAG TATGCCCTGA AGGCCCGCCC GCTGAGGTGT 
TACATCCCCA AAAACCCATA CCAGTATCAG GTGTGGTATG TCGTCACTTC CTCCTACTTT 
GAATACCTGA TGTTTGCTCT CATCATGCTC AACACTATCT GCCTAGGCAT GCAGCATTAC 
AACCAGTCGG AACAGATGAA CCACATATCG GACATCCTCA ATGTGGCTTT CACCATCATC 
TTCACCCTGG AGATGATCCT CAAGCTCATA GCTTTCAAGC CCAGGGGCTA TTTTGGAGAC 
CCCTGGAACG TGTTTGACTT TCTAATCGTC ATTGGCAGCA TCATTGACGT TATCCTGAGT 
GAGATCGATA CTTTGCTGGC CTCCAGCGGG GGACTATATT GCCTGGGTGG AGGCTGCGGG 
AACGTTGACC CAGATGAGAG CGCCCGCATC TCCAGTGCCT TCTTCCGCCT GTTCCGAGTC 
ATGCGACTGA TCAAGCTGCT GAGCCGGGCG GAGGGTGTGC GCACCCTGCT CTGGACGTTC 
ATCAAGTCCT TCCAGGCCCT GCCGTATGTG GCTTTGCTGA TCGTCATGCT CTTCTTCATC 
TACGCTGTCA TCGGCATGCA GATGTTCGGG AAGATCGCCA TGGTGGACGG GACGCAAATA 
AACCGGAACA ACAACTTCCA GACTTTCCCA CAAGCTGTGC TGCTGCTCTT CAGGTGTGCC 
ACAGGGGAAG CCTGGCAGGA GATCCTGCTG GCCTGCAGCT ACGGGAAACG CTGCGACCCG 
GAGTCTGACT ACGCACCGGG GGAGGAGTAC GCGTGTGGCA CCAACTTTGC CTACTACTAC 
TTCATCAGCT TCTACATGCT CTGCGCCTTC CTGATCATCA ACCTCTTTGT GGCTGTCATC 
ATGGACAACT TTGACTACCT CACAAGGGAC TGGTCCATTC TGGGCCCTCA CCACCTGGAT 
GAGTTCAAGG CCATCTGGGC TGAGTACGAC CCAGAGGCTA AGGGCAGGAT CAAGCACCTG 
GACGTGGTGA CCCTGCTGAG GAGGATCCAG CCCCCTCTGG GCTTTGGGAA GTTCTGCCCA 
CACAGGGTAG CATGTAAGAG GCTGGTGGGC ATGAACATGC CCCTGAATAG TGATGGCACA 
GTCACCTTCA ATGCCACACT CTTCGCCCTG GTACGCACAG CCCTCAAGAT CAAGACAGAA 
GGCAATTTTG AACAAGCCAA TGAGGAGCTG AGAGCCATCA TCAAAAAGAT CTGGAAGAGA 
ACCAGCATGA AGCTCCTGGA CCAAGTCATC CCTCCAATAG GAGATGACGA GGTGACAGTG 
GGGAAGTTCT ATGCCACATT CCTCATCCAG GAGCACTTTC GGAAGTTCAT GAAGCGCCAG 
GAGGAATATT ATGGGTATCG ACCCAAAAAG GACACAGTTC AGATACAGGC TGGATTGCGG 
ACCATAGAGG AAGAGGCAGC TCCTGAGATC CACCGAGCCA TCTCTGGAGA CCTGACGGCG 
GAGGAGGAGC TGGAGAGGGC CATGGTAGAG GCTGCCATGG AGGAGGGGAT ATTCCGGAGA 
ACTGGAGGCC TGTTTGGTCA AGTGGACAAC TTCCTGGAAA GGACCAACTC TCTGCCCCCT 
GTCATGGCTA ACCAAAGACC CCTCCAATTT GCCGAAATGG AGATGGAAGA GCTGGAGTCA 
CCAGTCTTTT TGGAGGACTT CCCTCAGAAC CCAGGCACCC ACCCTCTTGC TCGTGCCAAT 
ACCAACAACG CCAATGCCAA TGTTGCCTAT GGCAACAGCA GCCATAGAAA CAGCCCAGTG 
TTTTCCAGCA TCCGCTATGA AAGGGAGCTC CTGGAAGAGG CAGGCAGGCC TGTTACCAGA 
GAAGGACCCT TCAGTCAGCC CTGCAGCGTC TCTGGAGTTA ACAGCAGATC CCATGTGGAC 
AAACTGGAAA GACAGATGTC CCAAAGAAGA ATGCCCAAAG GCCAGGTGCC TCCTTCCCCA 
TGCCAGCTCT CCCAGGAAAA GCATCCTGTG CACGAAGAGG GGAAGGGCCC CAGGTCATGG 
TCTACGGAAA CATCTGACAG TGAGAGCTTT GAGGAGCGTG TTCCCAGGAA TTCGGCTCAC 
AAGTGCACAG CCCCAGCTAC CACCATGCTG ATCCAGGAGG CTCTGGTTCG AGGAGGACTA 
GACTCCTTAG CAGCAGATGC TAACTTCGTC ATGGCAACAG GCCAGGCCCT GGCAGATGCC 
TGCCAGATGG AACCAGAGGA AGTCGAGGTG GCAGCAACAG AGCTACTGAA GCGAGAATCC 
CCAAAGGGCG GGGCCATGCC CAGGGAGCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased intracellular [Ca
Muscle & nerve56(6)1128-1136(2017 Dec)
Wang MM,Hao LY,Guo F,Zhong B,Zhong XM,Yuan J,Hao YF,Zhao S,Sun XF,Lei M,Jiao GY

Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
Investigative ophthalmology & visual science55(3)1483-92(2014 Mar)
Tummala SR,Neinstein A,Fina ME,Dhingra A,Vardi N

Reduced DHPR?1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.
Muscle & nerve48(5)745-51(2013 Nov)
Jiao GY,Hao LY,Gao CE,Chen L,Sun XF,Yang HL,Li Y,Dai YN

Voltage-gated calcium channels.
Cold Spring Harbor perspectives in biology3(8)a003947(2011 Aug)
Catterall WA

Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy.
American journal of physiology. Regulatory, integrative and comparative physiology300(6)R1384-91(2011 Jun)
Kraner SD,Wang Q,Novak KR,Cheng D,Cool DR,Peng J,Rich MM

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Cacna1s cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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