Wasl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Wasl
Entrez Gene ID	682507
Full Name	Wiskott-Aldrich syndrome-like
Synonyms	N-WASP,TRS4
General protein information	Preferred Names Wiskott-Aldrich syndrome-like Names neural Wiskott-Aldrich syndrome protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q22
Summary	involved in the regulation of the cortical actin cytoskeleton [RGD, Nov 2007].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001110365.1	NP_001103835.1	neural Wiskott-Aldrich syndrome protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Wasl	NP_082735.2
Rattus norvegicus (Norway rat)	Wasl	NP_001103835.1

Gene Ontology
Bibliography

Related articles in PubMed

Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.
Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J
Proceedings of the National Academy of Sciences of the United States of America112(47)E6436-45(2015 Nov)

The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
Jaudon F, Raynaud F, Wehrl? R, Bellanger JM, Doulazmi M, Vodjdani G, Gasman S, Fagni L, Dusart I, Debant A, Schmidt S
Molecular biology of the cell26(11)2112-27(2015 Jun)

Phase transitions of multivalent proteins can promote clustering of membrane receptors.
Banjade S, Rosen MK
eLife3(2014 Oct)

The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology.
Murk K, Blanco Suarez EM, Cockbill LM, Banks P, Hanley JG
Journal of cell science126(Pt 17)3873-83(2013 Sep)

The type?III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
Oh SY, Knelson EH, Blobe GC, Mythreye K
The Biochemical journal454(1)79-89(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nck was the most potent activator of N-WASP-driven actin assembly.
Title: Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.

biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck and N-WASP, is reported.
Title: Phase transitions of multivalent proteins can promote clustering of membrane receptors.

The Arp2/3 regulators PICK1, and N-WASP and WAVE2 function antagonistically to control the complexity of astrocyte branched morphology, and this mechanism underlies the morphological changes seen in astrocytes during their response to pathological insult.
Title: The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology.

N-WASP/IRSp53 interaction helps to regulate filopodial formation and cell adhesion in mammary epithelial cells.
Title: The type?III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.

tumor cells in vivo that have a decreased activity of N-WASP also have a reduced ability to form invadopodia, migrate, invade, intravasate and disseminate to lung compared with tumor cells with parental N-WASP levels
Title: N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors.

The following Wasl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wasl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13110	NM_001110365.1 Latest version!	Rattus norvegicus WASP like actin nucleation promoting factor (Wasl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Wasl ( NM_001110365.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103835.1 Rattus norvegicus WASP like actin nucleation promoting factor (Wasl), mRNA.

Price & Availability↑

CloneID	ORa13110
Clone ID Related Accession (Same CDS sequence)	NM_001110365.1
Accession Version	NM_001110365.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	neural Wiskott-Aldrich syndrome protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473959.1. On Nov 16, 2007 this sequence version replaced XM_001061794.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCTCGG GCCAGCAGCC CCCGCGGAGG GTCACCAACG TGGGCTCCCT GCTGCTCACC 
CCGCAAGAAA ACGAGTCTCT TTTCTCCTTC CTCGGCAAGA AATGTGTGAC TATGTCTTCA 
GCAGTGGTGC AGTTATATGC AGCTGATCGG AACTGTATGT GGTCAAAGAA GTGCAGTGGT 
GTTGCTTGTC TTGTTAAGGA CAATCCTCAG AGATCTTATT TTTTAAGAAT ATTTGACATT 
AAGGATGGGA AATTACTGTG GGAACAAGAG CTATACAATA ACTTTGTATA TAATAGTCCT 
AGAGGATATT TTCATACCTT TGCTGGAGAT ACTTGTCAAG TAGCTCTTAA TTTTGCCAAT 
GAAGAAGAAG CAAAAAAGTT CCGAAAAGCA GTTACAGACC TGTTGGGTCG ACGACAAAGG 
AAATCTGAAA AAAGACGAGA TGCTCCAAAT GGTCCCAATC TACCCATGGC TACAGTTGAC 
ATAAAAAATC CAGAAATCAC AACAAACAGG TTTTATGGTT CACAAGTCAA CAACATCTCC 
CACACCAAAG AAAAGAAGAA AGGAAAAGCT AAAAAGAAGA GATTAACCAA GGCAGATATT 
GGAACACCAA GTAATTTCCA GCACATTGGA CATGTTGGTT GGGATCCAAA TACAGGTTTT 
GATCTAAATA ATTTGGATCC AGAATTGAAG AATCTTTTTG ATATGTGTGG GATCTCTGAG 
GCCCAGCTTA AAGACAGAGA AACATCAAAA GTTATTTATG ACTTTATTGA AAAAACAGGA 
GGTGTAGAAG CTGTTAAAAA TGAACTCCGA AGGCAAGCAC CACCACCTCC TCCACCCTCA 
AGAGGAGGAC CTCCCCCTCC TCCTCCCCCT CCTCACAGCT CAGGCCCTCC TCCCCCTCCT 
GCCCGTGGAA GGGGGGCTCC TCCCCCGCCA CCATCAAGAG CTCCTACTGC TGCACCTCCA 
CCTCCACCTC CTTCTAGGCC TGGTGTTGTC GTTCCTCCAC CTCCTCCAAA CAGGATGTAC 
CCTCCTCCAC CACCAGCCCT GCCTTCCTCA GCACCTTCAG GCCCACCACC ACCTCCGCCT 
CTGTCTATGG CAGGGTCCAC AGCACCACCA CCTCCTCCAC CACCTCCCCC TCCACCAGGG 
CCACCACCTC CCCCTGGCCT GCCTTCTGAT GGTGACCATC AAGTTCCAGC TTCTTCAGGA 
AACAAAGCAG CTCTTTTGGA TCAAATTAGA GAGGGTGCTC AGCTAAAAAA AGTGGAGCAG 
AATAGTCGGC CCGTGTCCTG CTCAGGAAGG GATGCACTTC TAGACCAGAT ACGACAGGGC 
ATTCAGTTGA AATCCGTGTC TGATGGCCAA GAGTCCACAC CACCAACCCC CGCGCCCACT 
TCAGGAATTG TGGGTGCGCT GATGGAAGTG ATGCAGAAAA GGAGCAAAGC CATTCATTCC 
TCAGATGAAG ATGAAGATGA TGATGATGAA GAAGATTTTG AGGATGATGA TGAGTGGGAA 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103835.1
CDS	366..1871
Translation	MSSGQQPPRRVTNVGSLLLTPQENESLFSFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDAPNGPNLPMATVDIKNPEITTNRFYGSQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHSSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPGVVVPPPPPNRMYPPPPPALPSSAPSGPPPPPPLSMAGSTAPPPPPPPPPPPGPPPPPGLPSDGDHQVPASSGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVSDGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDDDDEEDFEDDDEWED

Target ORF information:

RefSeq Version	NM_001110365.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus WASP like actin nucleation promoting factor (Wasl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110365.1

ORF Insert Sequence:

ATGAGCTCGG GCCAGCAGCC CCCGCGGAGG GTCACCAACG TGGGCTCCCT GCTGCTCACC 
CCGCAAGAAA ACGAGTCTCT TTTCTCCTTC CTCGGCAAGA AATGTGTGAC TATGTCTTCA 
GCAGTGGTGC AGTTATATGC AGCTGATCGG AACTGTATGT GGTCAAAGAA GTGCAGTGGT 
GTTGCTTGTC TTGTTAAGGA CAATCCTCAG AGATCTTATT TTTTAAGAAT ATTTGACATT 
AAGGATGGGA AATTACTGTG GGAACAAGAG CTATACAATA ACTTTGTATA TAATAGTCCT 
AGAGGATATT TTCATACCTT TGCTGGAGAT ACTTGTCAAG TAGCTCTTAA TTTTGCCAAT 
GAAGAAGAAG CAAAAAAGTT CCGAAAAGCA GTTACAGACC TGTTGGGTCG ACGACAAAGG 
AAATCTGAAA AAAGACGAGA TGCTCCAAAT GGTCCCAATC TACCCATGGC TACAGTTGAC 
ATAAAAAATC CAGAAATCAC AACAAACAGG TTTTATGGTT CACAAGTCAA CAACATCTCC 
CACACCAAAG AAAAGAAGAA AGGAAAAGCT AAAAAGAAGA GATTAACCAA GGCAGATATT 
GGAACACCAA GTAATTTCCA GCACATTGGA CATGTTGGTT GGGATCCAAA TACAGGTTTT 
GATCTAAATA ATTTGGATCC AGAATTGAAG AATCTTTTTG ATATGTGTGG GATCTCTGAG 
GCCCAGCTTA AAGACAGAGA AACATCAAAA GTTATTTATG ACTTTATTGA AAAAACAGGA 
GGTGTAGAAG CTGTTAAAAA TGAACTCCGA AGGCAAGCAC CACCACCTCC TCCACCCTCA 
AGAGGAGGAC CTCCCCCTCC TCCTCCCCCT CCTCACAGCT CAGGCCCTCC TCCCCCTCCT 
GCCCGTGGAA GGGGGGCTCC TCCCCCGCCA CCATCAAGAG CTCCTACTGC TGCACCTCCA 
CCTCCACCTC CTTCTAGGCC TGGTGTTGTC GTTCCTCCAC CTCCTCCAAA CAGGATGTAC 
CCTCCTCCAC CACCAGCCCT GCCTTCCTCA GCACCTTCAG GCCCACCACC ACCTCCGCCT 
CTGTCTATGG CAGGGTCCAC AGCACCACCA CCTCCTCCAC CACCTCCCCC TCCACCAGGG 
CCACCACCTC CCCCTGGCCT GCCTTCTGAT GGTGACCATC AAGTTCCAGC TTCTTCAGGA 
AACAAAGCAG CTCTTTTGGA TCAAATTAGA GAGGGTGCTC AGCTAAAAAA AGTGGAGCAG 
AATAGTCGGC CCGTGTCCTG CTCAGGAAGG GATGCACTTC TAGACCAGAT ACGACAGGGC 
ATTCAGTTGA AATCCGTGTC TGATGGCCAA GAGTCCACAC CACCAACCCC CGCGCCCACT 
TCAGGAATTG TGGGTGCGCT GATGGAAGTG ATGCAGAAAA GGAGCAAAGC CATTCATTCC 
TCAGATGAAG ATGAAGATGA TGATGATGAA GAAGATTTTG AGGATGATGA TGAGTGGGAA 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.
Proceedings of the National Academy of Sciences of the United States of America112(47)E6436-45(2015 Nov)
Okrut J,Prakash S,Wu Q,Kelly MJ,Taunton J

The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
Molecular biology of the cell26(11)2112-27(2015 Jun)
Jaudon F,Raynaud F,Wehrl? R,Bellanger JM,Doulazmi M,Vodjdani G,Gasman S,Fagni L,Dusart I,Debant A,Schmidt S

Phase transitions of multivalent proteins can promote clustering of membrane receptors.
eLife3(2014 Oct)
Banjade S,Rosen MK

The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology.
Journal of cell science126(Pt 17)3873-83(2013 Sep)
Murk K,Blanco Suarez EM,Cockbill LM,Banks P,Hanley JG

The type?III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
The Biochemical journal454(1)79-89(2013 Aug)
Oh SY,Knelson EH,Blobe GC,Mythreye K

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Wasl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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