Cnn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnn1
Entrez Gene ID	65204
Full Name	calponin 1
General protein information	Preferred Names calponin 1 Names calponin-1 basic calponin calponin 1, basic, smooth muscle calponin 1, smooth muscle calponin H1, smooth muscle
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13
Summary	binds actin stress fibers; involved in actin bundling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031747.1	NP_113935.1	calponin-1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cnn1	NP_113935.1
Homo sapiens (human)	CNN1	NP_001290.2
Canis lupus familiaris (dog)	CNN1	XP_542053.1
Bos taurus (cattle)	CNN1	NP_001039844.1
Mus musculus (house mouse)	Cnn1	NP_034052.3
Pan troglodytes (chimpanzee)	CNN1	XP_001168396.2
Danio rerio (zebrafish)	LOC572250	XP_701038.5
Xenopus tropicalis (tropical clawed frog)	cnn2	NP_001015796.1
Drosophila melanogaster (fruit fly)	CG5023	NP_650867.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000749	XP_311284.5

Gene Ontology
Bibliography

Related articles in PubMed

Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling.
Parente JM, Pereira CA, Oliveira-Paula GH, Tanus-Santos JE, Tostes RC, Castro MM
Basic & clinical pharmacology & toxicology121(4)246-256(2017 Oct)

Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
Xu H, Wu F, Zhang H, Yang C, Li K, Wang H, Yang H, Liu Y, Ding B, Tan Y, Yuan M, Li Y, Dai Z
Biochimie138184-193(2017 Jul)

Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.
Belo VA, Parente JM, Tanus-Santos JE, Castro MM
Biochemical pharmacology11850-58(2016 Oct)

XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling.
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y, Xu Q
Arteriosclerosis, thrombosis, and vascular biology35(10)2134-44(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity.
Title: Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.

Data suggest that proteolysis of calponin-1 by Mmp2 (matrix metallopeptidase 2) contributes to the down-regulation of calponin-1 in cytoplasm of endothelium and smooth muscle of aorta/arteries in early (1-week) hypertension; however, at 2-weeks, calponin-1 is up-regulated.
Title: Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.

Calponin 1 is present in the cervix of virgin, 11 day, and 20 day pregnant rats.
Title: The persistence of active smooth muscle in the female rat cervix through pregnancy.

Data indicte that desmin and h1-calponin are expressed in mesenchymal stem cells (MSC).
Title: Differentiated markers in undifferentiated cells: expression of smooth muscle contractile proteins in multipotent bone marrow mesenchymal stem cells.

Calponin-1 is a target of MMP-2, which contributes to endotoxemia-induced vascular hypocontractility.
Title: Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats.

The following Cnn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08643	NM_031747.1 Latest version!	Rattus norvegicus calponin 1 (Cnn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnn1 ( NM_031747.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113935.1 Rattus norvegicus calponin 1 (Cnn1), mRNA.

Price & Availability↑

CloneID	ORa08643
Clone ID Related Accession (Same CDS sequence)	NM_031747.1
Accession Version	NM_031747.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Rattus norvegicus(Norway rat)
Product	calponin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D14437.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D14437.1, BC061809.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGTCTTCCG CACACTTTAA CCGAGGTCCT GCCTACGGCC TGTCTGCTGA GGTAAAGAAC 
AAGCTGGCCC AGAAATACGA CCACCAGCGT GAGCAGGAGC TGAGAGAGTG GATCGAAGGG 
GTGACAGGCC GCCGCATCGG GAGCAACTTC ATGGATGGCC TCAAGGACGG GATCATTCTT 
TGCGAATTTA TCAACAAGCT CCAGCCGGGA TCTGTGAAGA AGGTCAATGA GTCAACCCAG 
AACTGGCACC AGCTGGAGAA CATAGGAAAT TTCATCAAAG CCATTACCGA GTATGGGGTG 
AAACCCCACG ACATTTTTGA GGCCAATGAC CTGTTTGAAA ACACCAATCA TACACAAGTT 
CAGTCTACTC TCTTGGCTCT GGCCAGCATG GCAAAGACAA AAGGAAACAA AGTCAATGTG 
GGGGTCAAAT ATGCAGAGAA ACAAGAGCGG AGATTTGAGC CTGAGAAGCT GAGAGAAGGC 
AGGAACATCA TTGGCCTACA GATGGGCACC AATAAGTTTG CCAGTCAGCA GGGCATGACA 
GCCTATGGTA CCCGGCGTCA CCTCTATGAT CCCAAACTGG GTACAGATCA ACCCCTGGAT 
CAGGCAACTA TCAGTCTACA GATGGGTACC AACAAGGGCG CCAGCCAGGC TGGCATGACT 
GCACCGGGCA CCAAGCGGCA GATCTTTGAG CCAGGTCTGG GCATGGAACA CTGTGACACG 
CTCAACGTCA GCTTGCAGAT GGGCAGCAAC AAGGGGGCCT CACAGAGGGG CATGACGGTG 
TATGGGCTGC CCCGCCAGGT GTATGATCCC AAGTACTGCC TGACCCCGGA ATATCCAGAG 
CTGGACGAGC CCACCCACAA TCACCACCCA CACAACTACT ATAACTCTGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113935.1
CDS	67..960
Translation	MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGSNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITEYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELDEPTHNHHPHNYYNSA

Target ORF information:

RefSeq Version	NM_031747.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calponin 1 (Cnn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031747.1

ORF Insert Sequence:

ATGTCTTCCG CACACTTTAA CCGAGGTCCT GCCTACGGCC TGTCTGCTGA GGTAAAGAAC 
AAGCTGGCCC AGAAATACGA CCACCAGCGT GAGCAGGAGC TGAGAGAGTG GATCGAAGGG 
GTGACAGGCC GCCGCATCGG GAGCAACTTC ATGGATGGCC TCAAGGACGG GATCATTCTT 
TGCGAATTTA TCAACAAGCT CCAGCCGGGA TCTGTGAAGA AGGTCAATGA GTCAACCCAG 
AACTGGCACC AGCTGGAGAA CATAGGAAAT TTCATCAAAG CCATTACCGA GTATGGGGTG 
AAACCCCACG ACATTTTTGA GGCCAATGAC CTGTTTGAAA ACACCAATCA TACACAAGTT 
CAGTCTACTC TCTTGGCTCT GGCCAGCATG GCAAAGACAA AAGGAAACAA AGTCAATGTG 
GGGGTCAAAT ATGCAGAGAA ACAAGAGCGG AGATTTGAGC CTGAGAAGCT GAGAGAAGGC 
AGGAACATCA TTGGCCTACA GATGGGCACC AATAAGTTTG CCAGTCAGCA GGGCATGACA 
GCCTATGGTA CCCGGCGTCA CCTCTATGAT CCCAAACTGG GTACAGATCA ACCCCTGGAT 
CAGGCAACTA TCAGTCTACA GATGGGTACC AACAAGGGCG CCAGCCAGGC TGGCATGACT 
GCACCGGGCA CCAAGCGGCA GATCTTTGAG CCAGGTCTGG GCATGGAACA CTGTGACACG 
CTCAACGTCA GCTTGCAGAT GGGCAGCAAC AAGGGGGCCT CACAGAGGGG CATGACGGTG 
TATGGGCTGC CCCGCCAGGT GTATGATCCC AAGTACTGCC TGACCCCGGA ATATCCAGAG 
CTGGACGAGC CCACCCACAA TCACCACCCA CACAACTACT ATAACTCTGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling.
Basic & clinical pharmacology & toxicology121(4)246-256(2017 Oct)
Parente JM,Pereira CA,Oliveira-Paula GH,Tanus-Santos JE,Tostes RC,Castro MM

Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
Biochimie138184-193(2017 Jul)
Xu H,Wu F,Zhang H,Yang C,Li K,Wang H,Yang H,Liu Y,Ding B,Tan Y,Yuan M,Li Y,Dai Z

Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.
Biochemical pharmacology11850-58(2016 Oct)
Belo VA,Parente JM,Tanus-Santos JE,Castro MM

XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling.
Arteriosclerosis, thrombosis, and vascular biology35(10)2134-44(2015 Oct)
Zeng L,Li Y,Yang J,Wang G,Margariti A,Xiao Q,Zampetaki A,Yin X,Mayr M,Mori K,Wang W,Hu Y,Xu Q

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Cnn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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