Slc2a5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc2a5
Entrez Gene ID	65197
Full Name	solute carrier family 2 member 5
General protein information	Preferred Names solute carrier family 2 member 5 Names solute carrier family 2, facilitated glucose transporter member 5 GLUT-5 fructose transporter glucose transporter type 5, small intestine solute carrier family 2 (facilitated glucose transporter), member 5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	membrane carrier protein that functions primarily as a fructose transporte; also transports glucose to a lesser extent [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031741.1	NP_113929.1	solute carrier family 2, facilitated glucose transporter member 5

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC2A5	NP_003030.1
Canis lupus familiaris (dog)	SLC2A5	XP_005620546.1
Rattus norvegicus (Norway rat)	Slc2a5	NP_113929.1
	SLC2A5	XP_001118341.2
Bos taurus (cattle)	SLC2A5	NP_001094512.1
Mus musculus (house mouse)	Slc2a5	NP_062715.2
Xenopus tropicalis (tropical clawed frog)	slc2a5	NP_001008187.1
Gallus gallus (chicken)	SLC2A5	XP_417596.4
Pan troglodytes (chimpanzee)	SLC2A5	NP_001233520.1

Gene Ontology
Bibliography

Related articles in PubMed

Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.
Ebert K, Ludwig M, Geillinger KE, Schoberth GC, Essenwanger J, Stolz J, Daniel H, Witt H
The Journal of membrane biology250(2)171-182(2017 Apr)

Structure and mechanism of the mammalian fructose transporter GLUT5.
Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D
Nature526(7573)397-401(2015 Oct)

Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption.
Patel C, Douard V, Yu S, Gao N, Ferraris RP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(9)4046-58(2015 Sep)

Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine.
Suzuki T, Douard V, Mochizuki K, Goda T, Ferraris RP
The Biochemical journal435(1)43-53(2011 Apr)

Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.
Sakar Y, Nazaret C, Lett?ron P, Ait Omar A, Avenati M, Viollet B, Ducroc R, Bado A
PloS one4(11)e7935(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively
Title: Structure and mechanism of the mammalian fructose transporter GLUT5.

investigation of influence of dietary carbohydrates on expression of Glut5 in small intestine: Glut5 mRNA increased with fructose perfusion and age, a pattern that matched that of Pol II binding and histone H3 acetylation at Glut5 promoter
Title: Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine.

regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
Title: Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.

The expression and metabolism of GLUT5 during the postnatal developmental process are reported.
Title: Developmental reprogramming of rat GLUT5 requires glucocorticoid receptor translocation to the nucleus.

The essential role of chloride and fructose absorbing Slc2a5 is reported.
Title: Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.

The following Slc2a5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc2a5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08631	NM_031741.1 Latest version!	Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$293.30 $419.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc2a5 ( NM_031741.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113929.1 Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA.

Price & Availability↑

CloneID	ORa08631
Clone ID Related Accession (Same CDS sequence)	NM_031741.1
Accession Version	NM_031741.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 2, facilitated glucose transporter member 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D13871.1. On Jun 25, 2006 this sequence version replaced XM_001075869.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D13871.1, L05195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAAG AGGATCAAGA GAAGACAGGG AAGCTGACCC TGGTCCTTGC CCTGGCAACT 
TTCCTAGCTG CCTTTGGCTC CTCCTTCCAG TATGGGTACA ACGTGGCTGC TGTCAACTCG 
CCCTCAGAGT TCATGCAGCA GTTCTACAAT GACACCTACT ACGACAGAAA CAAGGAGAAC 
ATTGAGTCCT TCACCCTGAC GCTGCTGTGG TCCCTGACTG TCTCCATGTT CCCCTTTGGA 
GGTTTTATAG GATCTCTCAT GGTTGGATTC TTGGTGAATA ACTTGGGCAG AAAAGGGGCC 
TTACTGTTCA ACAACATATT CTCCATCCTG CCGGCCATCT TGATGGGGTG CAGCAAAATT 
GCCAAATCCT TTGAGATAAT AATTGCTTCC AGACTTCTGG TTGGAATATG TGCAGGTATA 
TCTTCCAACG TGGTCCCCAT GTACTTAGGG GAGCTAGCCC CCAAAAACCT GCGAGGGGCT 
CTTGGAGTGG TTCCTCAGCT CTTCATCACT GTGGGCATCC TTGTGGCCCA GCTGTTTGGC 
CTTCGGAGTG TCTTGGCAAG CGAGGAAGGC TGGCCAATCC TCCTGGGTCT GACTGGAGTC 
CCTGCCGGCC TGCAGCTCCT CTTGCTGCCC TTCTTTCCTG AGAGCCCCCG CTACCTGCTG 
ATTCAGAAGA AAAATGAATC AGCTGCTGAG AAAGCCCTTC AGACCCTTCG AGGTTGGAAA 
GATGTGGACA TGGAGATGGA GGAAATCCGG AAGGAGGATG AGGCTGAGAA GGCGGCAGGC 
TTCATCTCTG TGTGGAAGCT GTTCCGCATG CAGTCCCTCC GCTGGCAACT CATCTCCACG 
ATCGTCCTCA TGACCGGCCA GCAGCTGTCA GGAGTGAACG CGATTTACTA CTACGCTGAC 
CAGATCTACC TCAGCGCAGG GGTGAAAAGC AACGACGTCC AATATGTGAC GGCTGGGACT 
GGGGCCGTCA ACGTGTTCAT GACCATGGTC ACGGTTTTTG TGGTAGAGCT TTGGGGACGT 
CGGAATCTTC TCCTCATCGG CTTCTCCACC TGCCTCACAG CTTGCATAGT GCTGACGGTC 
GCACTGGCAC TGCAGAACAC CATCTCCTGG ATGCCCTATG TCAGCATCGT CTGTGTCATT 
GTCTACGTCA TAGGACACGC CGTGGGGCCC AGTCCCATCC CTGCCCTGTT CATCACCGAG 
ATCTTCCTGC AATCCTCTCG ACCATCCGCC TACATGATCG GAGGCAGCGT CCACTGGCTC 
TCTAACTTCA TCGTGGGCCT CATCTTCCCG TTCATTCAAG TGGGCCTTGG TCCTTACAGC 
TTCATCATCT TTGCGATTAT ATGTCTCCTC ACCTCCATCT ACATCTTCAT GGTCGTCCCA 
GAGACCAAGG GCAGGACGTT TGTCGAGATC AACCAGATTT TTGCCAAGAA GAACAAGGTA 
TCGGACGTAT ATCCGGAGAA GGAGGAAAAG GAGCTTAATG ACCTCCCACC TGCTACCCGG 
GAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113929.1
CDS	43..1551
Translation	MEKEDQEKTGKLTLVLALATFLAAFGSSFQYGYNVAAVNSPSEFMQQFYNDTYYDRNKENIESFTLTLLWSLTVSMFPFGGFIGSLMVGFLVNNLGRKGALLFNNIFSILPAILMGCSKIAKSFEIIIASRLLVGICAGISSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQLFGLRSVLASEEGWPILLGLTGVPAGLQLLLLPFFPESPRYLLIQKKNESAAEKALQTLRGWKDVDMEMEEIRKEDEAEKAAGFISVWKLFRMQSLRWQLISTIVLMTGQQLSGVNAIYYYADQIYLSAGVKSNDVQYVTAGTGAVNVFMTMVTVFVVELWGRRNLLLIGFSTCLTACIVLTVALALQNTISWMPYVSIVCVIVYVIGHAVGPSPIPALFITEIFLQSSRPSAYMIGGSVHWLSNFIVGLIFPFIQVGLGPYSFIIFAIICLLTSIYIFMVVPETKGRTFVEINQIFAKKNKVSDVYPEKEEKELNDLPPATREQ

Target ORF information:

RefSeq Version	NM_031741.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031741.1

ORF Insert Sequence:

ATGGAGAAAG AGGATCAAGA GAAGACAGGG AAGCTGACCC TGGTCCTTGC CCTGGCAACT 
TTCCTAGCTG CCTTTGGCTC CTCCTTCCAG TATGGGTACA ACGTGGCTGC TGTCAACTCG 
CCCTCAGAGT TCATGCAGCA GTTCTACAAT GACACCTACT ACGACAGAAA CAAGGAGAAC 
ATTGAGTCCT TCACCCTGAC GCTGCTGTGG TCCCTGACTG TCTCCATGTT CCCCTTTGGA 
GGTTTTATAG GATCTCTCAT GGTTGGATTC TTGGTGAATA ACTTGGGCAG AAAAGGGGCC 
TTACTGTTCA ACAACATATT CTCCATCCTG CCGGCCATCT TGATGGGGTG CAGCAAAATT 
GCCAAATCCT TTGAGATAAT AATTGCTTCC AGACTTCTGG TTGGAATATG TGCAGGTATA 
TCTTCCAACG TGGTCCCCAT GTACTTAGGG GAGCTAGCCC CCAAAAACCT GCGAGGGGCT 
CTTGGAGTGG TTCCTCAGCT CTTCATCACT GTGGGCATCC TTGTGGCCCA GCTGTTTGGC 
CTTCGGAGTG TCTTGGCAAG CGAGGAAGGC TGGCCAATCC TCCTGGGTCT GACTGGAGTC 
CCTGCCGGCC TGCAGCTCCT CTTGCTGCCC TTCTTTCCTG AGAGCCCCCG CTACCTGCTG 
ATTCAGAAGA AAAATGAATC AGCTGCTGAG AAAGCCCTTC AGACCCTTCG AGGTTGGAAA 
GATGTGGACA TGGAGATGGA GGAAATCCGG AAGGAGGATG AGGCTGAGAA GGCGGCAGGC 
TTCATCTCTG TGTGGAAGCT GTTCCGCATG CAGTCCCTCC GCTGGCAACT CATCTCCACG 
ATCGTCCTCA TGACCGGCCA GCAGCTGTCA GGAGTGAACG CGATTTACTA CTACGCTGAC 
CAGATCTACC TCAGCGCAGG GGTGAAAAGC AACGACGTCC AATATGTGAC GGCTGGGACT 
GGGGCCGTCA ACGTGTTCAT GACCATGGTC ACGGTTTTTG TGGTAGAGCT TTGGGGACGT 
CGGAATCTTC TCCTCATCGG CTTCTCCACC TGCCTCACAG CTTGCATAGT GCTGACGGTC 
GCACTGGCAC TGCAGAACAC CATCTCCTGG ATGCCCTATG TCAGCATCGT CTGTGTCATT 
GTCTACGTCA TAGGACACGC CGTGGGGCCC AGTCCCATCC CTGCCCTGTT CATCACCGAG 
ATCTTCCTGC AATCCTCTCG ACCATCCGCC TACATGATCG GAGGCAGCGT CCACTGGCTC 
TCTAACTTCA TCGTGGGCCT CATCTTCCCG TTCATTCAAG TGGGCCTTGG TCCTTACAGC 
TTCATCATCT TTGCGATTAT ATGTCTCCTC ACCTCCATCT ACATCTTCAT GGTCGTCCCA 
GAGACCAAGG GCAGGACGTT TGTCGAGATC AACCAGATTT TTGCCAAGAA GAACAAGGTA 
TCGGACGTAT ATCCGGAGAA GGAGGAAAAG GAGCTTAATG ACCTCCCACC TGCTACCCGG 
GAGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.
The Journal of membrane biology250(2)171-182(2017 Apr)
Ebert K,Ludwig M,Geillinger KE,Schoberth GC,Essenwanger J,Stolz J,Daniel H,Witt H

Structure and mechanism of the mammalian fructose transporter GLUT5.
Nature526(7573)397-401(2015 Oct)
Nomura N,Verdon G,Kang HJ,Shimamura T,Nomura Y,Sonoda Y,Hussien SA,Qureshi AA,Coincon M,Sato Y,Abe H,Nakada-Nakura Y,Hino T,Arakawa T,Kusano-Arai O,Iwanari H,Murata T,Kobayashi T,Hamakubo T,Kasahara M,Iwata S,Drew D

Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(9)4046-58(2015 Sep)
Patel C,Douard V,Yu S,Gao N,Ferraris RP

Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine.
The Biochemical journal435(1)43-53(2011 Apr)
Suzuki T,Douard V,Mochizuki K,Goda T,Ferraris RP

Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.
PloS one4(11)e7935(2009 Nov)
Sakar Y,Nazaret C,Lett?ron P,Ait Omar A,Avenati M,Viollet B,Ducroc R,Bado A

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Slc2a5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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