Cldn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cldn1
Entrez Gene ID	65129
Full Name	claudin 1
General protein information	Preferred Names claudin 1 Names claudin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q22
Summary	may be involved in maintaining Schwann cell structure during myelination [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031699.2	NP_113887.2	claudin-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CLDN1	XP_850248.1
Bos taurus (cattle)	CLDN1	NP_001001854.1
Homo sapiens (human)	CLDN1	NP_066924.1
Gallus gallus (chicken)	CLDN1	NP_001013629.1
Pan troglodytes (chimpanzee)	CLDN1	XP_516949.2
	CLDN1	XP_001093143.1
Xenopus tropicalis (tropical clawed frog)	cldn1	NP_001015704.1
Mus musculus (house mouse)	Cldn1	NP_057883.1
Rattus norvegicus (Norway rat)	Cldn1	NP_113887.2
Danio rerio (zebrafish)	cldn1	NP_571845.1

Gene Ontology
Bibliography

Related articles in PubMed

Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing.
Volksdorf T, Heilmann J, Eming SA, Schawjinski K, Zorn-Kruppa M, Ueck C, Vidal-Y-Sy S, Windhorst S, J?cker M, Moll I, Brandner JM
The American journal of pathology187(6)1301-1312(2017 Jun)

The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress.
Wang J, Chen J, Tang Z, Li Y, Hu L, Pan J
Biological trace element research174(1)132-141(2016 Nov)

Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells.
Bulldan A, Dietze R, Shihan M, Scheiner-Bobis G
Cellular signalling28(8)1075-85(2016 08)

Platelet endothelial cell adhesion molecule-1 (PECAM1) plays a critical role in the maintenance of human vascular endothelial barrier function.
Ren Q, Ren L, Ren C, Liu X, Dong C, Zhang X
Cell biochemistry and function33(8)560-5(2015 Dec)

Single-Nucleotide Polymorphisms of Tight Junction Component Claudin-1 Associated with Leukoaraiosis.
Yadav BK, Shin BS
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association24(7)1662-70(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified four claudin isoforms (1, 3, 5, and 12) and showed that their expression levels were regulated as a group by copper
Title: The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress.

in Sertoli cells, testosterone acts through the receptor ZIP9 to trigger the non-classical signaling cascade, resulting in increased claudin expression and tight junction formation.
Title: Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells.

Cardiotonic steroids may influence the formation of the blood-testis barrier via regulation of Cldn1 and Cldn11 expression.
Title: Cardiotonic steroid ouabain stimulates expression of blood-testis barrier proteins claudin-1 and -11 and formation of tight junctions in Sertoli cells.

siRNA knockdown of Rab3Gap1 prevented plasma membrane Claudin-1 expression and the formation of a barrier competent epithelium
Title: Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition.

claudin-1 is the major sealing component in the perineurium, and could be modulated to facilitate drug delivery or, potentially, reseal the barrier under pathological conditions.
Title: Transient opening of the perineurial barrier for analgesic drug delivery.

The following Cldn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cldn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08511	NM_031699.2 Latest version!	Rattus norvegicus claudin 1 (Cldn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cldn1 ( NM_031699.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113887.2 Rattus norvegicus claudin 1 (Cldn1), mRNA.

Price & Availability↑

CloneID	ORa08511
Clone ID Related Accession (Same CDS sequence)	NM_031699.2
Accession Version	NM_031699.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	claudin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061992.1. On Mar 27, 2005 this sequence version replaced NM_031699.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061992.1, FQ220868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAACG CGGGGTTGCA GCTTCTGGGT TTCATCCTGG CTTCGCTGGG ATGGATCGGC 
TCTATCGTCA GCACTGCCCT GCCCCAATGG AAGATTTACT CCTATGCTGG GGACAACATC 
GTGACTGCTC AGGCCATCTA CGAGGGACTG TGGATGTCCT GCGTTTCGCA AAGCACCGGG 
CAGATACAGT GCAAAGTCTT CGACTCCTTG CTGAATCTGA ATAGTACTTT GCAGGCAACC 
AGAGCCTTGA TGGTAATTGG CATCCTGCTG GGGCTGATCG CAATCTTTGT GTCCACCATT 
GGCATGAAGT GCATGAGGTG CTTAGAAGAT GATGAAGTGC AAAAGATGTG GATGGCTGTC 
ATCGGGGGCA TAATATTTGT AATTTCAGGT CTGGCGACAT TAGTGGCCAC AGCATGGTAT 
GGAAATAGAA TTGTTCAAGA ATTCTATGAC CCCATGACCC CTATCAATGC CAGGTATGAA 
TTTGGCCAGG CTCTCTTTAC TGGCTGGGCT GCTGCCTCCC TCTGCCTCCT GGGAGGTGCC 
CTACTTTCCT GCTCCTGTCC CCGGAAAACA ACCTCTTACC CAACACCACG GCCTTATCCC 
AAGCCAACAC CTTCTACTGG GAAAGACTAC GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113887.2
CDS	180..815
Translation	MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPINARYEFGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSTGKDYV

Target ORF information:

RefSeq Version	NM_031699.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus claudin 1 (Cldn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031699.2

ORF Insert Sequence:

ATGGCCAACG CGGGGTTGCA GCTTCTGGGT TTCATCCTGG CTTCGCTGGG ATGGATCGGC 
TCTATCGTCA GCACTGCCCT GCCCCAATGG AAGATTTACT CCTATGCTGG GGACAACATC 
GTGACTGCTC AGGCCATCTA CGAGGGACTG TGGATGTCCT GCGTTTCGCA AAGCACCGGG 
CAGATACAGT GCAAAGTCTT CGACTCCTTG CTGAATCTGA ATAGTACTTT GCAGGCAACC 
AGAGCCTTGA TGGTAATTGG CATCCTGCTG GGGCTGATCG CAATCTTTGT GTCCACCATT 
GGCATGAAGT GCATGAGGTG CTTAGAAGAT GATGAAGTGC AAAAGATGTG GATGGCTGTC 
ATCGGGGGCA TAATATTTGT AATTTCAGGT CTGGCGACAT TAGTGGCCAC AGCATGGTAT 
GGAAATAGAA TTGTTCAAGA ATTCTATGAC CCCATGACCC CTATCAATGC CAGGTATGAA 
TTTGGCCAGG CTCTCTTTAC TGGCTGGGCT GCTGCCTCCC TCTGCCTCCT GGGAGGTGCC 
CTACTTTCCT GCTCCTGTCC CCGGAAAACA ACCTCTTACC CAACACCACG GCCTTATCCC 
AAGCCAACAC CTTCTACTGG GAAAGACTAC GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing.
The American journal of pathology187(6)1301-1312(2017 Jun)
Volksdorf T,Heilmann J,Eming SA,Schawjinski K,Zorn-Kruppa M,Ueck C,Vidal-Y-Sy S,Windhorst S,J?cker M,Moll I,Brandner JM

The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress.
Biological trace element research174(1)132-141(2016 Nov)
Wang J,Chen J,Tang Z,Li Y,Hu L,Pan J

Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells.
Cellular signalling28(8)1075-85(2016 08)
Bulldan A,Dietze R,Shihan M,Scheiner-Bobis G

Platelet endothelial cell adhesion molecule-1 (PECAM1) plays a critical role in the maintenance of human vascular endothelial barrier function.
Cell biochemistry and function33(8)560-5(2015 Dec)
Ren Q,Ren L,Ren C,Liu X,Dong C,Zhang X

Single-Nucleotide Polymorphisms of Tight Junction Component Claudin-1 Associated with Leukoaraiosis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association24(7)1662-70(2015 Jul)
Yadav BK,Shin BS

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Cldn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報