Cdc42 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdc42
Entrez Gene ID	64465
Full Name	cell division cycle 42
General protein information	Preferred Names cell division cycle 42 Names cell division control protein 42 homolog cell division cycle 42 (GTP binding protein) cell division cycle 42 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	small GTPase; involved in formation of cellular asymmetry [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008764287.2	XP_008762509.1	cell division control protein 42 homolog isoform X2
XM_008764286.2	XP_008762508.1	cell division control protein 42 homolog isoform X1
NM_171994.4	NP_741991.3	cell division control protein 42 homolog precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cdc42	NP_741991.3
Danio rerio (zebrafish)	cdc42	NP_956926.1
Pan troglodytes (chimpanzee)	CDC42	XP_003949365.1
	CDC42	XP_001100552.1
Mus musculus (house mouse)	Cdc42	NP_033991.1

Gene Ontology
Bibliography

Related articles in PubMed

Membrane shape-mediated wave propagation of cortical protein dynamics.
Wu Z, Su M, Tong C, Wu M, Liu J
Nature communications9(1)136(2018 01)

Effect of Cdc42 on myocardial ischemia-reperfusion of rats.
Xu X, Kong L, Song X, Hao Z, Yuan F
Cellular and molecular biology (Noisy-le-Grand, France)63(7)31-34(2017 Aug)

Regulation of microtubule-associated motors drives intermediate filament network polarization.
Leduc C, Etienne-Manneville S
The Journal of cell biology216(6)1689-1703(2017 Jun)

Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines.
Mi Z, Si T, Kapadia K, Li Q, Muma NA
Neuropharmacology11793-105(2017 May)

High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
Yang D, Zhang Y, Cheng Y, Hong L, Wang C, Wei Z, Cai Q, Yan R
Digestive diseases and sciences62(4)958-967(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Polarity signaling via CDC42/atypical protein kinase C can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.
Title: Regulation of microtubule-associated motors drives intermediate filament network polarization.

studies demonstrate that TGase-catalyzed transamidation and activation of rac1 and cdc42 results from stimulation of multiple types of receptors and this novel signaling pathway can regulate dendritic spine morphology and plasticity.
Title: Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines.

These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
Title: HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation.

Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.

These findings reveal the activation of Cdc42 in embryonic spinal commissural axon growth cones and support the conclusion that src family kinase activation downstream of deleted in colorectal cancer is required for Cdc42 activation by netrin-1.
Title: FLIM FRET Visualization of Cdc42 Activation by Netrin-1 in Embryonic Spinal Commissural Neuron Growth Cones.

The following Cdc42 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdc42 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13738	NM_171994.4 Latest version!	Rattus norvegicus cell division cycle 42 (Cdc42), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa13738	XM_008764286.2 Latest version!	Rattus norvegicus cell division cycle 42 (Cdc42), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa28829	XM_008764287.2 Latest version!	Rattus norvegicus cell division cycle 42 (Cdc42), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdc42 ( NM_171994.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_741991.3 Rattus norvegicus cell division cycle 42 (Cdc42), mRNA.

Price & Availability↑

CloneID	ORa13738
Clone ID Related Accession (Same CDS sequence)	XM_008764286.2 , NM_171994.4
Accession Version	NM_171994.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Rattus norvegicus(Norway rat)
Product	cell division control protein 42 homolog precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC060535.1. On Apr 14, 2007 this sequence version replaced NM_171994.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060535.1, FQ225045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGCAGACAA TTAAGTGTGT TGTTGTTGGT GATGGTGCTG TTGGTAAAAC ATGTCTCCTG 
ATATCCTACA CAACAAACAA ATTCCCGTCG GAGTATGTAC CAACTGTTTT TGACAACTAT 
GCAGTCACAG TTATGATTGG TGGAGAGCCA TACACTCTTG GACTTTTTGA TACTGCAGGG 
CAAGAGGATT ATGACAGACT ACGACCGTTA AGTTATCCAC AGACAGATGT TTTTCTAGTA 
TGTTTCTCAG TGGTCTCTCC ATCCTCATTT GAAAATGTGA AAGAAAAGTG GGTGCCTGAG 
ATAACTCACC ACTGTCCAAA GACTCCTTTC TTGCTTGTCG GGACCCAAAT TGATCTCAGA 
GATGACCCTT CTACTATTGA GAAACTTGCC AAGAACAAAC AGAAGCCTAT TACTCCAGAG 
ACTGCTGAAA AGCTGGCGCG GGATCTGAAG GCTGTCAAGT ATGTGGAGTG TTCCGCCCTC 
ACACAGAAAG GCCTAAAGAA TGTGTTTGAT GAAGCAATAT TGGCTGCCTT GGAGCCTCCA 
GAACCGAAGA AGAGCCGCAG GTGTGTGCTG CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_741991.3
CDS	74..649
Translation	MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL

Target ORF information:

RefSeq Version	NM_171994.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cell division cycle 42 (Cdc42), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_171994.4

ORF Insert Sequence:

ATGCAGACAA TTAAGTGTGT TGTTGTTGGT GATGGTGCTG TTGGTAAAAC ATGTCTCCTG 
ATATCCTACA CAACAAACAA ATTCCCGTCG GAGTATGTAC CAACTGTTTT TGACAACTAT 
GCAGTCACAG TTATGATTGG TGGAGAGCCA TACACTCTTG GACTTTTTGA TACTGCAGGG 
CAAGAGGATT ATGACAGACT ACGACCGTTA AGTTATCCAC AGACAGATGT TTTTCTAGTA 
TGTTTCTCAG TGGTCTCTCC ATCCTCATTT GAAAATGTGA AAGAAAAGTG GGTGCCTGAG 
ATAACTCACC ACTGTCCAAA GACTCCTTTC TTGCTTGTCG GGACCCAAAT TGATCTCAGA 
GATGACCCTT CTACTATTGA GAAACTTGCC AAGAACAAAC AGAAGCCTAT TACTCCAGAG 
ACTGCTGAAA AGCTGGCGCG GGATCTGAAG GCTGTCAAGT ATGTGGAGTG TTCCGCCCTC 
ACACAGAAAG GCCTAAAGAA TGTGTTTGAT GAAGCAATAT TGGCTGCCTT GGAGCCTCCA 
GAACCGAAGA AGAGCCGCAG GTGTGTGCTG CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdc42 ( XM_008764286.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762508.1 Rattus norvegicus cell division cycle 42 (Cdc42), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13738
Clone ID Related Accession (Same CDS sequence)	XM_008764286.2 , NM_171994.4
Accession Version	XM_008764286.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cell division control protein 42 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764286.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGACAA TTAAGTGTGT TGTTGTTGGT GATGGTGCTG TTGGTAAAAC ATGTCTCCTG 
ATATCCTACA CAACAAACAA ATTCCCGTCG GAGTATGTAC CAACTGTTTT TGACAACTAT 
GCAGTCACAG TTATGATTGG TGGAGAGCCA TACACTCTTG GACTTTTTGA TACTGCAGGG 
CAAGAGGATT ATGACAGACT ACGACCGTTA AGTTATCCAC AGACAGATGT TTTTCTAGTA 
TGTTTCTCAG TGGTCTCTCC ATCCTCATTT GAAAATGTGA AAGAAAAGTG GGTGCCTGAG 
ATAACTCACC ACTGTCCAAA GACTCCTTTC TTGCTTGTCG GGACCCAAAT TGATCTCAGA 
GATGACCCTT CTACTATTGA GAAACTTGCC AAGAACAAAC AGAAGCCTAT TACTCCAGAG 
ACTGCTGAAA AGCTGGCGCG GGATCTGAAG GCTGTCAAGT ATGTGGAGTG TTCCGCCCTC 
ACACAGAAAG GCCTAAAGAA TGTGTTTGAT GAAGCAATAT TGGCTGCCTT GGAGCCTCCA 
GAACCGAAGA AGAGCCGCAG GTGTGTGCTG CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762508.1
CDS	571..1146
Translation	MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL

Target ORF information:

RefSeq Version	XM_008764286.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cell division cycle 42 (Cdc42), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764286.2

ORF Insert Sequence:

ATGCAGACAA TTAAGTGTGT TGTTGTTGGT GATGGTGCTG TTGGTAAAAC ATGTCTCCTG 
ATATCCTACA CAACAAACAA ATTCCCGTCG GAGTATGTAC CAACTGTTTT TGACAACTAT 
GCAGTCACAG TTATGATTGG TGGAGAGCCA TACACTCTTG GACTTTTTGA TACTGCAGGG 
CAAGAGGATT ATGACAGACT ACGACCGTTA AGTTATCCAC AGACAGATGT TTTTCTAGTA 
TGTTTCTCAG TGGTCTCTCC ATCCTCATTT GAAAATGTGA AAGAAAAGTG GGTGCCTGAG 
ATAACTCACC ACTGTCCAAA GACTCCTTTC TTGCTTGTCG GGACCCAAAT TGATCTCAGA 
GATGACCCTT CTACTATTGA GAAACTTGCC AAGAACAAAC AGAAGCCTAT TACTCCAGAG 
ACTGCTGAAA AGCTGGCGCG GGATCTGAAG GCTGTCAAGT ATGTGGAGTG TTCCGCCCTC 
ACACAGAAAG GCCTAAAGAA TGTGTTTGAT GAAGCAATAT TGGCTGCCTT GGAGCCTCCA 
GAACCGAAGA AGAGCCGCAG GTGTGTGCTG CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdc42 ( XM_008764287.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762509.1 Rattus norvegicus cell division cycle 42 (Cdc42), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa28829
Clone ID Related Accession (Same CDS sequence)	XM_008764287.2
Accession Version	XM_008764287.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cell division control protein 42 homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764287.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGACAA TTAAGTGTGT TGTTGTTGGT GATGGTGCTG TTGGTAAAAC ATGTCTCCTG 
ATATCCTACA CAACAAACAA ATTCCCGTCG GAGTATGTAC CAACTGTTTT TGACAACTAT 
GCAGTCACAG TTATGATTGG TGGAGAGCCA TACACTCTTG GACTTTTTGA TACTGCAGGG 
CAAGAGGATT ATGACAGACT ACGACCGTTA AGTTATCCAC AGACAGATGT TTTTCTAGTA 
TGTTTCTCAG TGGTCTCTCC ATCCTCATTT GAAAATGTGA AAGAAAAGTG GGTGCCTGAG 
ATAACTCACC ACTGTCCAAA GACTCCTTTC TTGCTTGTCG GGACCCAAAT TGATCTCAGA 
GATGACCCTT CTACTATTGA GAAACTTGCC AAGAACAAAC AGAAGCCTAT TACTCCAGAG 
ACTGCTGAAA AGCTGGCGCG GGATCTGAAG GCTGTCAAGT ATGTGGAGTG TTCCGCCCTC 
ACACAGAGAG GTCTGAAGAA TGTGTTTGAT GAGGCTATCC TAGCTGCCCT CGAGCCTCCG 
GAAACTCAAC CCAAAAGGAA GTGCTGTATA TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762509.1
CDS	155..730
Translation	MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF

Target ORF information:

RefSeq Version	XM_008764287.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cell division cycle 42 (Cdc42), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764287.2

ORF Insert Sequence:

ATGCAGACAA TTAAGTGTGT TGTTGTTGGT GATGGTGCTG TTGGTAAAAC ATGTCTCCTG 
ATATCCTACA CAACAAACAA ATTCCCGTCG GAGTATGTAC CAACTGTTTT TGACAACTAT 
GCAGTCACAG TTATGATTGG TGGAGAGCCA TACACTCTTG GACTTTTTGA TACTGCAGGG 
CAAGAGGATT ATGACAGACT ACGACCGTTA AGTTATCCAC AGACAGATGT TTTTCTAGTA 
TGTTTCTCAG TGGTCTCTCC ATCCTCATTT GAAAATGTGA AAGAAAAGTG GGTGCCTGAG 
ATAACTCACC ACTGTCCAAA GACTCCTTTC TTGCTTGTCG GGACCCAAAT TGATCTCAGA 
GATGACCCTT CTACTATTGA GAAACTTGCC AAGAACAAAC AGAAGCCTAT TACTCCAGAG 
ACTGCTGAAA AGCTGGCGCG GGATCTGAAG GCTGTCAAGT ATGTGGAGTG TTCCGCCCTC 
ACACAGAGAG GTCTGAAGAA TGTGTTTGAT GAGGCTATCC TAGCTGCCCT CGAGCCTCCG 
GAAACTCAAC CCAAAAGGAA GTGCTGTATA TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Membrane shape-mediated wave propagation of cortical protein dynamics.
Nature communications9(1)136(2018 01)
Wu Z,Su M,Tong C,Wu M,Liu J

Effect of Cdc42 on myocardial ischemia-reperfusion of rats.
Cellular and molecular biology (Noisy-le-Grand, France)63(7)31-34(2017 Aug)
Xu X,Kong L,Song X,Hao Z,Yuan F

Regulation of microtubule-associated motors drives intermediate filament network polarization.
The Journal of cell biology216(6)1689-1703(2017 Jun)
Leduc C,Etienne-Manneville S

Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines.
Neuropharmacology11793-105(2017 May)
Mi Z,Si T,Kapadia K,Li Q,Muma NA

High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
Digestive diseases and sciences62(4)958-967(2017 04)
Yang D,Zhang Y,Cheng Y,Hong L,Wang C,Wei Z,Cai Q,Yan R

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Cdc42 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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