Gpr88 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr88
Entrez Gene ID	64443
Full Name	G-protein coupled receptor 88
General protein information	Preferred Names G-protein coupled receptor 88 Names probable G-protein coupled receptor 88 striatum-specific G-protein coupled receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q41
Summary	orphan G-protein coupled receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006233221.3	XP_006233283.1	probable G-protein coupled receptor 88 isoform X1
XM_006233220.3	XP_006233282.1	probable G-protein coupled receptor 88 isoform X1
NM_031696.1	NP_113884.1	probable G-protein coupled receptor 88
XM_006233222.3	XP_006233284.1	probable G-protein coupled receptor 88 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GPR88	XP_001135440.1
	LOC716520	XP_001107294.2
Homo sapiens (human)	GPR88	NP_071332.2
Gallus gallus (chicken)	GPR88	XP_004936972.1
Danio rerio (zebrafish)	gpr88	XP_001342529.1
Bos taurus (cattle)	GPR88	NP_001192341.1
Mus musculus (house mouse)	Gpr88	NP_071872.1
Rattus norvegicus (Norway rat)	Gpr88	NP_113884.1
Canis lupus familiaris (dog)	GPR88	XP_005622173.1
Xenopus tropicalis (tropical clawed frog)	gpr88	XP_002934189.1

Gene Ontology
Bibliography

Related articles in PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
Calder?n-Zamora L, Ruiz-Hernandez A, Romero-Nava R, Le?n-Sicairos N, Canizalez-Rom?n A, Hong E, Huang F, Villafa?a S
Clinical and experimental hypertension (New York, N.Y. : 1993)39(6)513-519(2017)

Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.
Massart R, Mignon V, Stanic J, Munoz-Tello P, Becker JA, Kieffer BL, Darmon M, Sokoloff P, Diaz J
The Journal of comparative neurology524(14)2776-802(2016 Oct)

Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.
Meirsman AC, Le Merrer J, Pellissier LP, Diaz J, Clesse D, Kieffer BL, Becker JA
Biological psychiatry79(11)917-27(2016 Jun)

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
Ingallinesi M, Le Bouil L, Biguet NF, Thi AD, Mannoury la Cour C, Millan MJ, Ravassard P, Mallet J, Meloni R
Molecular psychiatry20(8)951-8(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the developing cortex, GPR88 shifts on the day of birth to the nuclei of neurons in layers V to II.
Title: Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.

Results suggest a role for Gpr88 in the regulation of cognitive and motor functions, and support its relevance to the pathophysiology and treatment of schizophrenia and other disorders involving dysfunction of the accumbens-striatal complex
Title: Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.

GPR88 is confined to striatal medium spiny neurons and indicate that L-DOPA-mediated behavioural effects in hemiparkinsonian rats may involve normalization of striatal GPR88 levels
Title: Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents.

The following Gpr88 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr88 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08502	NM_031696.1 Latest version!	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
ORa25212	XM_006233222.3 Latest version!	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
ORa25212	XM_006233221.3 Latest version!	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
ORa25212	XM_006233220.3 Latest version!	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr88 ( NM_031696.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113884.1 Rattus norvegicus G-protein coupled receptor 88 (Gpr88), mRNA.

Price & Availability↑

CloneID	ORa08502
Clone ID Related Accession (Same CDS sequence)	NM_031696.1
Accession Version	NM_031696.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	probable G-protein coupled receptor 88
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB042407.1. ##Evidence-Data-START## Transcript exon combination :: AB042407.1, DV216004.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCATCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTACAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113884.1
CDS	449..1603
Translation	MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPAGSAEPPGDWDSGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTAGMLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGAGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW

Target ORF information:

RefSeq Version	NM_031696.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031696.1

ORF Insert Sequence:

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCATCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTACAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpr88 ( XM_006233221.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233283.1 Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa25212
Clone ID Related Accession (Same CDS sequence)	XM_006233221.3 , XM_006233220.3 , XM_006233222.3
Accession Version	XM_006233221.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	probable G-protein coupled receptor 88 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233221.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCACCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTATAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233283.1
CDS	1310..2464
Translation	MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPAGSAEPPGDWDSGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTAGMLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGAGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW

Target ORF information:

RefSeq Version	XM_006233221.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233221.3

ORF Insert Sequence:

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCACCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTATAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpr88 ( XM_006233220.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233282.1 Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25212
Clone ID Related Accession (Same CDS sequence)	XM_006233221.3 , XM_006233220.3 , XM_006233222.3
Accession Version	XM_006233220.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	probable G-protein coupled receptor 88 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233220.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCACCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTATAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233282.1
CDS	1365..2519
Translation	MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPAGSAEPPGDWDSGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTAGMLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGAGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW

Target ORF information:

RefSeq Version	XM_006233220.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233220.3

ORF Insert Sequence:

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCACCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTATAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpr88 ( XM_006233222.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233284.1 Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X3, mRNA.

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CloneID	ORa25212
Clone ID Related Accession (Same CDS sequence)	XM_006233221.3 , XM_006233220.3 , XM_006233222.3
Accession Version	XM_006233222.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	probable G-protein coupled receptor 88 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233222.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCACCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTATAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233284.1
CDS	1307..2461
Translation	MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPAGSAEPPGDWDSGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTAGMLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGAGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW

Target ORF information:

RefSeq Version	XM_006233222.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233222.3

ORF Insert Sequence:

ATGACCAACT CCTCCTCCAC TTCGACCTCC ACCACCACCG GAGGATCCCT GCTGCTGCTC 
TGCGAGGAAG AAGAATCGTG GGCGGGCCGG CGGATCCCGG TGTCTCTCCT GTACTCGGGG 
CTGGCCATCG GGGGCACGCT GGCCAACGGT ATGGTCATCT ATCTTGTGTC GTCCTTCCGA 
AAGCTGCAGA CCACCAGCAA CGCCTTCATT GTGAATGGCT GCGCCGCGGA TCTCAGCGTC 
TGCGCCCTCT GGATGCCACA GGAGGCGGTA CTGGGGCTCC TGCCCGCCGG CTCCGCGGAG 
CCCCCGGGGG ACTGGGACAG TGGCGGAGGC AGCTACAGAC TGCTCCGGGG CGGGTTGTTG 
GGCCTCGGGC TCACTGTGTC CCTTCTGTCC CATTGCCTCG TGGCTCTGAA CCGCTACTTG 
CTCATCACCA GGGCGCCTGC CACCTACCAG GTGCTGTACC AGCGGCGCCA CACGGCGGGC 
ATGCTGGCAC TGTCCTGGGC GCTCGCCTTG GGTCTGGTGT TGTTGCTCCC GCCTTGGGCT 
CCCAAGCCGG GAGCGGAGCC CCCGCAAGTC CACTACCCCG CGCTCCTGGC GGCGGGAGCG 
TTGCTGGCAC AGACGGCGCT GCTGCTGCAC TGCTACCTGG GCATCGTGCG CCGCGTGCGC 
GTCAGCGTCA AGCGGGTCAG CGTGCTCAAC TTCCACCTGC TGCACCAGCT ACCGGGCTGC 
GCCGCCGCCG CCGCCGCCTT CCCCGCCGCC CCGCACGCTC CGGGTGCCGG AGGCGCCGCT 
CATCCCGCGC AGCCTCAACC CCTGCCGGCC GCCCTGCAGC CTCGTCGGGC GCAGCGGCGT 
CTCAGCGGTT TGTCTGTGCT GCTGCTCTGC TGCGTCTTCC TGCTGGCCAC GCAGCCGCTG 
GTGTGGGTGA GCCTGGCCAG CGGCTTCTCC CTCCCGGTGC CCTGGGGCGT GCAGGCGGCC 
AGCTGGCTCC TGTGCTGCGC CCTGTCGGCG CTCAACCCGC TGCTCTATAC TTGGAGGAAC 
GAGGAGTTCC GCAGATCAGT GCGTTCAGTT CTGCCCGGCG TCGGGGACGC AGCTGCGGCC 
GCTGCAGCCG CCACCGCGGT GCCAGCCATG TCCCAGGCGC AACTGGGTAC CCGGGCGGCT 
GGCCAGCATT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
Clinical and experimental hypertension (New York, N.Y. : 1993)39(6)513-519(2017)
Calder?n-Zamora L,Ruiz-Hernandez A,Romero-Nava R,Le?n-Sicairos N,Canizalez-Rom?n A,Hong E,Huang F,Villafa?a S

Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.
The Journal of comparative neurology524(14)2776-802(2016 Oct)
Massart R,Mignon V,Stanic J,Munoz-Tello P,Becker JA,Kieffer BL,Darmon M,Sokoloff P,Diaz J

Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.
Biological psychiatry79(11)917-27(2016 Jun)
Meirsman AC,Le Merrer J,Pellissier LP,Diaz J,Clesse D,Kieffer BL,Becker JA

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
Molecular psychiatry20(8)951-8(2015 Aug)
Ingallinesi M,Le Bouil L,Biguet NF,Thi AD,Mannoury la Cour C,Millan MJ,Ravassard P,Mallet J,Meloni R

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Gpr88 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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