Calu cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Calu
Entrez Gene ID	64366
Full Name	calumenin
Synonyms	Cbp50,Rcn
General protein information	Preferred Names calumenin Names calumenin CBP-50 crocalbin reticulocalbin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q22
Summary	binds calcium; localized to the endoplasmic reticulum lumen [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022535.2	NP_071980.2	calumenin isoform a precursor
NM_001033898.1	NP_001029070.1	calumenin isoform b precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CALU	NP_001233521.1
Danio rerio (zebrafish)	calua	NP_001002151.1
Homo sapiens (human)	CALU	NP_001186600.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010392	XP_311555.3
Bos taurus (cattle)	CALU	NP_001029837.1
Drosophila melanogaster (fruit fly)	scf	NP_477392.1
Mus musculus (house mouse)	Calu	NP_908942.1
Rattus norvegicus (Norway rat)	Calu	NP_001029070.1
	CALU	XP_001091525.2
Canis lupus familiaris (dog)	CALU	XP_858778.1
Caenorhabditis elegans (roundworm)	calu-1	NP_001024806.1
Xenopus tropicalis (tropical clawed frog)	calu	NP_998840.1

Gene Ontology
Bibliography

Related articles in PubMed

Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes.
Wang Y, Xuan L, Cui X, Wang Y, Chen S, Wei C, Zhao M
PloS one12(4)e0173469(2017)

Calumenin has a role in the alleviation of ER stress in neonatal rat cardiomyocytes.
Lee JH, Kwon EJ, Kim DH
Biochemical and biophysical research communications439(3)327-32(2013 Sep)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature.
Galamb O, Gy?rffy B, Sipos F, Spis?k S, N?meth AM, Miheller P, Tulassay Z, Dinya E, Moln?r B
Disease markers25(1)1-16(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study suggests another cardioprotective effect of the antiarrhythmic agent ibutilide whereby pretreatment leads to the attenuation of endoplasmic reticulum stress induced apoptosis by regulating calumenin expression. This study provides further evidence for the role of calumenin in the cardiomyocyte endoplasmic reticulum stress response.
Title: Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes.

Calumenin was upregulated by endoplasmic reticulum stress in neonatal rat ventricular cardiomyocytes.
Title: Calumenin has a role in the alleviation of ER stress in neonatal rat cardiomyocytes.

Data suggest that calumenin interacts with SERCA2 in the cardiac sarcoplasmic reticulum and may play an important role in the regulation of Ca2+ uptake during excitation-contraction coupling.
Title: Calumenin interacts with SERCA2 in rat cardiac sarcoplasmic reticulum.

The following Calu gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Calu cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05870	NM_022535.2 Latest version!	Rattus norvegicus calumenin (Calu), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa08717	NM_001033898.1 Latest version!	Rattus norvegicus calumenin (Calu), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Calu ( NM_022535.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071980.2 Rattus norvegicus calumenin (Calu), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa05870
Clone ID Related Accession (Same CDS sequence)	NM_022535.2
Accession Version	NM_022535.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Rattus norvegicus(Norway rat)
Product	calumenin isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK476875.1 and BC101908.1. On Oct 12, 2007 this sequence version replaced NM_022535.1. Transcript Variant: This variant (1) encodes isoform a. Both isoforms are of the same length but differ in their internal aa sequence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EX489359.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTGC GTCAGTTTCT TATGTGCCTG TCCCTGTGCA CGGCCTTTGC TTTGAGCAAG 
CCTACAGAAA AGAAGGACCG AGTACACCAT GAACCTCAGC TCAGCGACAA AGTTCACAAC 
GATGCTCAGA ATTTTGACTA TGACCATGAT GCCTTCTTGG GAGCAGAAGA GGCAAAGAGT 
TTTGATCAGC TGACACCAGA AGAGAGCAAG GAAAGGCTTG GAAAGATTGT AAATAAAATA 
GATGGCGACA AGGATGGGTT TGTCACTGTG GATGAACTCA AAGGCTGGAT TAAGTTTGCA 
CAAAAGCGCT GGATTCACGA GGATGTAGAG CGGCAGTGGA AGGGGCACGA CCTCAATGAG 
GATGGCCTCG TTTCCTGGGA GGAGTATAAA AATGCCACCT ACAGCTACGT TTTAGATGAT 
CCAGACCCTG ATGATGGATT TAATTATAAA CAGATGATGG TTAGAGATGA GCGGAGGTTC 
AAAATGGCAG ACAAAGATGG AGACCTAATT GCCACAAAGG AGGAGTTTAC CGCTTTTCTG 
CACCCTGAGG AATATGACTA CATGAAAGAC ATAGTCGTGC AGGAAACCAT GGAGGATATA 
GACAAGAATG CTGATGGTTT TATTGATCTA GAAGAGTATA TTGGTGACAT GTACAGTCAT 
GATGGGAATG CTGATGAACC AGAGTGGGTG AAGACAGAGC GGGAGCAGTT CGTTGAGTTT 
CGAGATAAGA ACCGGGATGG AAAGATGGAC AAGGAAGAGA CCAAAGACTG GATCCTCCCT 
TCAGACTATG ACCATGCAGA GGCCGAAGCC AGGCATCTCG TCTATGAGTC CGACCAAGAC 
AAGGATGGCA AGCTCACCAA GGAGGAGATT GTCGACAAGT ATGATTTATT TGTGGGCAGC 
CAGGCCACAG ATTTCGGGGA GGCCTTAGTA CGACACGATG AGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071980.2
CDS	45..992
Translation	MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQNFDYDHDAFLGAEEAKSFDQLTPEESKERLGKIVNKIDGDKDGFVTVDELKGWIKFAQKRWIHEDVERQWKGHDLNEDGLVSWEEYKNATYSYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQDKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF

Target ORF information:

RefSeq Version	NM_022535.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calumenin (Calu), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022535.2

ORF Insert Sequence:

ATGGACCTGC GTCAGTTTCT TATGTGCCTG TCCCTGTGCA CGGCCTTTGC TTTGAGCAAG 
CCTACAGAAA AGAAGGACCG AGTACACCAT GAACCTCAGC TCAGCGACAA AGTTCACAAC 
GATGCTCAGA ATTTTGACTA TGACCATGAT GCCTTCTTGG GAGCAGAAGA GGCAAAGAGT 
TTTGATCAGC TGACACCAGA AGAGAGCAAG GAAAGGCTTG GAAAGATTGT AAATAAAATA 
GATGGCGACA AGGATGGGTT TGTCACTGTG GATGAACTCA AAGGCTGGAT TAAGTTTGCA 
CAAAAGCGCT GGATTCACGA GGATGTAGAG CGGCAGTGGA AGGGGCACGA CCTCAATGAG 
GATGGCCTCG TTTCCTGGGA GGAGTATAAA AATGCCACCT ACAGCTACGT TTTAGATGAT 
CCAGACCCTG ATGATGGATT TAATTATAAA CAGATGATGG TTAGAGATGA GCGGAGGTTC 
AAAATGGCAG ACAAAGATGG AGACCTAATT GCCACAAAGG AGGAGTTTAC CGCTTTTCTG 
CACCCTGAGG AATATGACTA CATGAAAGAC ATAGTCGTGC AGGAAACCAT GGAGGATATA 
GACAAGAATG CTGATGGTTT TATTGATCTA GAAGAGTATA TTGGTGACAT GTACAGTCAT 
GATGGGAATG CTGATGAACC AGAGTGGGTG AAGACAGAGC GGGAGCAGTT CGTTGAGTTT 
CGAGATAAGA ACCGGGATGG AAAGATGGAC AAGGAAGAGA CCAAAGACTG GATCCTCCCT 
TCAGACTATG ACCATGCAGA GGCCGAAGCC AGGCATCTCG TCTATGAGTC CGACCAAGAC 
AAGGATGGCA AGCTCACCAA GGAGGAGATT GTCGACAAGT ATGATTTATT TGTGGGCAGC 
CAGGCCACAG ATTTCGGGGA GGCCTTAGTA CGACACGATG AGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Calu ( NM_001033898.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029070.1 Rattus norvegicus calumenin (Calu), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa08717
Clone ID Related Accession (Same CDS sequence)	NM_001033898.1
Accession Version	NM_001033898.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Rattus norvegicus(Norway rat)
Product	calumenin isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC101908.1. On Sep 30, 2005 this sequence version replaced XM_346694.2. Transcript Variant: This variant (2) lacks one alternate in-frame exon and contains another alternate in-frame exon compare to variant 1. The resulting isoform (b) is of the same size as isoform a, but it differs in its internal aa sequence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101908.1, AJ001929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTGC GTCAGTTTCT TATGTGCCTG TCCCTGTGCA CGGCCTTTGC TTTGAGCAAG 
CCTACAGAAA AGAAGGACCG AGTACACCAT GAACCTCAGC TCAGCGACAA AGTTCACAAC 
GATGCTCAGA ATTTTGACTA TGACCATGAT GCCTTCTTGG GAGCAGAAGA GGCAAAGAGT 
TTTGATCAGC TGACACCAGA AGAGAGCAAG GAAAGGCTTG GAATGATTGT AGATAAAATA 
GACACCGATA AAGATGGGTT TGTGACGAAG GGGGAGCTGA AGTCCTGGAT TAAGCACGCC 
CAGAAGAAAT ACATATATGA CAATGTTGAA AACCAGTGGC AGGAGTTTGA TATGAATCAA 
GACGGCTTAA TCTCCTGGGA TGAGTACAGA AACGTGACTT ATGGCACTTA CCTGGATGAT 
CCAGACCCTG ATGATGGATT TAATTATAAA CAGATGATGG TTAGAGATGA GCGGAGGTTC 
AAAATGGCAG ACAAAGATGG AGACCTAATT GCCACAAAGG AGGAGTTTAC CGCTTTTCTG 
CACCCTGAGG AATATGACTA CATGAAAGAC ATAGTCGTGC AGGAAACCAT GGAGGATATA 
GACAAGAATG CTGATGGTTT TATTGATCTA GAAGAGTATA TTGGTGACAT GTACAGTCAT 
GATGGGAATG CTGATGAACC AGAGTGGGTG AAGACAGAGC GGGAGCAGTT CGTTGAGTTT 
CGAGATAAGA ACCGGGATGG AAAGATGGAC AAGGAAGAGA CCAAAGACTG GATCCTCCCT 
TCAGACTATG ACCATGCAGA GGCCGAAGCC AGGCATCTCG TCTATGAGTC CGACCAAGAC 
AAGGATGGCA AGCTCACCAA GGAGGAGATT GTCGACAAGT ATGATTTATT TGTGGGCAGC 
CAGGCCACAG ATTTCGGGGA GGCCTTAGTA CGACACGATG AGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029070.1
CDS	45..992
Translation	MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQNFDYDHDAFLGAEEAKSFDQLTPEESKERLGMIVDKIDTDKDGFVTKGELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQDKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF

Target ORF information:

RefSeq Version	NM_001033898.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calumenin (Calu), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033898.1

ORF Insert Sequence:

ATGGACCTGC GTCAGTTTCT TATGTGCCTG TCCCTGTGCA CGGCCTTTGC TTTGAGCAAG 
CCTACAGAAA AGAAGGACCG AGTACACCAT GAACCTCAGC TCAGCGACAA AGTTCACAAC 
GATGCTCAGA ATTTTGACTA TGACCATGAT GCCTTCTTGG GAGCAGAAGA GGCAAAGAGT 
TTTGATCAGC TGACACCAGA AGAGAGCAAG GAAAGGCTTG GAATGATTGT AGATAAAATA 
GACACCGATA AAGATGGGTT TGTGACGAAG GGGGAGCTGA AGTCCTGGAT TAAGCACGCC 
CAGAAGAAAT ACATATATGA CAATGTTGAA AACCAGTGGC AGGAGTTTGA TATGAATCAA 
GACGGCTTAA TCTCCTGGGA TGAGTACAGA AACGTGACTT ATGGCACTTA CCTGGATGAT 
CCAGACCCTG ATGATGGATT TAATTATAAA CAGATGATGG TTAGAGATGA GCGGAGGTTC 
AAAATGGCAG ACAAAGATGG AGACCTAATT GCCACAAAGG AGGAGTTTAC CGCTTTTCTG 
CACCCTGAGG AATATGACTA CATGAAAGAC ATAGTCGTGC AGGAAACCAT GGAGGATATA 
GACAAGAATG CTGATGGTTT TATTGATCTA GAAGAGTATA TTGGTGACAT GTACAGTCAT 
GATGGGAATG CTGATGAACC AGAGTGGGTG AAGACAGAGC GGGAGCAGTT CGTTGAGTTT 
CGAGATAAGA ACCGGGATGG AAAGATGGAC AAGGAAGAGA CCAAAGACTG GATCCTCCCT 
TCAGACTATG ACCATGCAGA GGCCGAAGCC AGGCATCTCG TCTATGAGTC CGACCAAGAC 
AAGGATGGCA AGCTCACCAA GGAGGAGATT GTCGACAAGT ATGATTTATT TGTGGGCAGC 
CAGGCCACAG ATTTCGGGGA GGCCTTAGTA CGACACGATG AGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes.
PloS one12(4)e0173469(2017)
Wang Y,Xuan L,Cui X,Wang Y,Chen S,Wei C,Zhao M

Calumenin has a role in the alleviation of ER stress in neonatal rat cardiomyocytes.
Biochemical and biophysical research communications439(3)327-32(2013 Sep)
Lee JH,Kwon EJ,Kim DH

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature.
Disease markers25(1)1-16(2008)
Galamb O,Gy?rffy B,Sipos F,Spis?k S,N?meth AM,Miheller P,Tulassay Z,Dinya E,Moln?r B

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Calu cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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