Casp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp2
Entrez Gene ID	64314
Full Name	caspase 2
General protein information	Preferred Names caspase 2 Names caspase-2 CASP-2 ICH-1 protease protease ICH-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24
Summary	may play a role in proteolysis and programmed cell death [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017592877.1	XP_017448366.1	caspase-2 isoform X2
XM_017592876.1	XP_017448365.1	caspase-2 isoform X1
NM_022522.2	NP_071967.2	caspase-2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CASP2	NP_001182080.1
Gallus gallus (chicken)	CASP2	NP_001161173.1
Bos taurus (cattle)	CASP2	NP_001137576.1
Rattus norvegicus (Norway rat)	Casp2	NP_071967.2
Danio rerio (zebrafish)	casp2	NP_001036160.1
Homo sapiens (human)	CASP2	NP_116764.2
Pan troglodytes (chimpanzee)	CASP2	XP_519448.2
Mus musculus (house mouse)	Casp2	NP_031636.1
Xenopus tropicalis (tropical clawed frog)	LOC100486813	XP_002941266.2

Gene Ontology
Bibliography

Related articles in PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Jean YY, Ribe EM, Pero ME, Moskalenko M, Iqbal Z, Marks LJ, Greene LA, Troy CM
The Biochemical journal455(1)15-25(2013 Oct)

Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal.
Vigneswara V, Berry M, Logan A, Ahmed Z
PloS one8(2)e57861(2013)

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.
Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, D?tsch V, Rajalingam K
The EMBO journal31(11)2615-28(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Title: Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.

SiRNA-mediated downregulation of CASP2 protected 50% of DRGN from apoptosis after serum withdrawal.
Title: Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal.

ras-induced down-regulation of caspase-2 represents a novel mechanism by which oncogenic Ras protects malignant intestinal epithelial cells from anoikis
Title: Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.

Retinal ganglion cell apoptosis induced by optic nerve injury involves activation of caspase-2, and synthetic siRNAs designed to inhibit expression of caspase-2 represent potential neuroprotective agents for intervention in diseases involving RGC loss
Title: Ocular neuroprotection by siRNA targeting caspase-2.

Blockade of caspase 2 activation prevents heat-induced germ cell apoptosis in rats by suppressing the MAPK14- and NO-mediated intrinsic pathway signaling.
Title: Role of caspase 2 in apoptotic signaling in primate and murine germ cells.

The following Casp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05830	NM_022522.2 Latest version!	Rattus norvegicus caspase 2 (Casp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa61001	XM_017592876.1 Latest version!	Rattus norvegicus caspase 2 (Casp2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa61002	XM_017592877.1 Latest version!	Rattus norvegicus caspase 2 (Casp2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp2 ( NM_022522.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071967.2 Rattus norvegicus caspase 2 (Casp2), mRNA.

Price & Availability↑

CloneID	ORa05830
Clone ID Related Accession (Same CDS sequence)	NM_022522.2
Accession Version	NM_022522.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	caspase-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U77933.1. On Apr 4, 2002 this sequence version replaced NM_022522.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U77933.1, AF136231.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGT CGAGCGGGAG GTCTCAGTCT TCCCTGCACA GGAAGGGGCT GATGGCGGCT 
GACAGGAGGA GCAGGATTTT GGCAGTGTGT GGAATGCATC CTGACCATCA GGAAACTCTG 
AAAAAGAATC GAGTGGTGCT GGCCAAACAG CTGCTGCTGA GCGAACTGTT AGAACATCTC 
CTAGAAAAGG ACATTATCAC TTTGGAAATG AGGGAGCTAA TCCAGGCCAA AGGGGGCAGT 
TTCAGCCAGA ATGTGGAACT CCTCAACCTG CTGCCAAAGA GAGGACCCCA GGCTTTTGAT 
GCCTTCTGTG AAGCCCTGCG GGAGACCAGG CAGGGTCACT TGGAAGACTT ACTGCTCACA 
ACCCTCTCTG ATATCCAGCA CATACTCCCA CCGTTGAGCT GTGACTATGA CTCAAGTCTC 
CCCTTCTCGG TGTGTGAGTC CTGCCCTCCT CACAAGCAGT CCCGCCTATC CACAGATACT 
ATGGAACACT CCTTAGATAA TGGTGATGGT CCTCCCTGTC TTCAGGTGAA GCCATGCACT 
CCTGAGTTTT ACCAGGCACA CTACCAGCTG GCCTATAGGT TGCAGTCTCA GCCTCGTGGC 
TTGGCACTGG TGATGAGTAA TGTGCACTTC ACTGGAGAGA AAGACCTGGA ATTTCGCTCC 
GGAGGGGATG TGGACCACAC TACTCTAGTC ACCCTCTTCA AGCTTTTGGG CTACAATGTC 
CATGTGCTGT ATGACCAGAC TGCACAGGAA ATGCAAGAGA AACTTCAGAA TTTTGCACAG 
TTACCTGCAC ACCGGGTCAC AGACTCCTGC ATAGTAGCAC TCCTCTCACA TGGTGTGGAA 
GGTGGCATCT ACGGGGTGGA TGGCAAACTG CTTCAGCTCC AAGAGGTTTT TCGACTTTTT 
GACAATGCTA ACTGTCCAAG TCTACAGAAC AAACCAAAAA TGTTCTTCAT CCAAGCATGT 
CGTGGAGATG AGACAGATAG AGGGGTTGAC CAGCAAGATG GAAAGAACCA TGCACAATCC 
CCTGGATGTG AGGAGAGTGA TGCTGGCAAG GAGGAATTAA TGAAGATGAG ACTTCCTACT 
CGCTCAGACA TGATATGTGG CTATGCTTGC CTTAAAGGCA ATGCTGCCAT GCGGAATACC 
AAACGGGGTT CCTGGTACAT TGAGGCCCTC ACTCAGGTGT TCTCTGAGAG AGCTTGTGAC 
ATGCACGTGG CCGACATGCT TGTTAAGGTG AATGCCCTTA TCAAGGAGCG TGAAGGCTAT 
GCCCCTGGTA CAGAATTCCA CCGATGCAAG GAGATGTCTG AGTACTGTAG TACTCTGTGC 
CAGCAGCTCT ACCTGTTCCC AGGCTACCCA CCCACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071967.2
CDS	7..1365
Translation	MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT

Target ORF information:

RefSeq Version	NM_022522.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus caspase 2 (Casp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022522.2

ORF Insert Sequence:

ATGGCGGCGT CGAGCGGGAG GTCTCAGTCT TCCCTGCACA GGAAGGGGCT GATGGCGGCT 
GACAGGAGGA GCAGGATTTT GGCAGTGTGT GGAATGCATC CTGACCATCA GGAAACTCTG 
AAAAAGAATC GAGTGGTGCT GGCCAAACAG CTGCTGCTGA GCGAACTGTT AGAACATCTC 
CTAGAAAAGG ACATTATCAC TTTGGAAATG AGGGAGCTAA TCCAGGCCAA AGGGGGCAGT 
TTCAGCCAGA ATGTGGAACT CCTCAACCTG CTGCCAAAGA GAGGACCCCA GGCTTTTGAT 
GCCTTCTGTG AAGCCCTGCG GGAGACCAGG CAGGGTCACT TGGAAGACTT ACTGCTCACA 
ACCCTCTCTG ATATCCAGCA CATACTCCCA CCGTTGAGCT GTGACTATGA CTCAAGTCTC 
CCCTTCTCGG TGTGTGAGTC CTGCCCTCCT CACAAGCAGT CCCGCCTATC CACAGATACT 
ATGGAACACT CCTTAGATAA TGGTGATGGT CCTCCCTGTC TTCAGGTGAA GCCATGCACT 
CCTGAGTTTT ACCAGGCACA CTACCAGCTG GCCTATAGGT TGCAGTCTCA GCCTCGTGGC 
TTGGCACTGG TGATGAGTAA TGTGCACTTC ACTGGAGAGA AAGACCTGGA ATTTCGCTCC 
GGAGGGGATG TGGACCACAC TACTCTAGTC ACCCTCTTCA AGCTTTTGGG CTACAATGTC 
CATGTGCTGT ATGACCAGAC TGCACAGGAA ATGCAAGAGA AACTTCAGAA TTTTGCACAG 
TTACCTGCAC ACCGGGTCAC AGACTCCTGC ATAGTAGCAC TCCTCTCACA TGGTGTGGAA 
GGTGGCATCT ACGGGGTGGA TGGCAAACTG CTTCAGCTCC AAGAGGTTTT TCGACTTTTT 
GACAATGCTA ACTGTCCAAG TCTACAGAAC AAACCAAAAA TGTTCTTCAT CCAAGCATGT 
CGTGGAGATG AGACAGATAG AGGGGTTGAC CAGCAAGATG GAAAGAACCA TGCACAATCC 
CCTGGATGTG AGGAGAGTGA TGCTGGCAAG GAGGAATTAA TGAAGATGAG ACTTCCTACT 
CGCTCAGACA TGATATGTGG CTATGCTTGC CTTAAAGGCA ATGCTGCCAT GCGGAATACC 
AAACGGGGTT CCTGGTACAT TGAGGCCCTC ACTCAGGTGT TCTCTGAGAG AGCTTGTGAC 
ATGCACGTGG CCGACATGCT TGTTAAGGTG AATGCCCTTA TCAAGGAGCG TGAAGGCTAT 
GCCCCTGGTA CAGAATTCCA CCGATGCAAG GAGATGTCTG AGTACTGTAG TACTCTGTGC 
CAGCAGCTCT ACCTGTTCCC AGGCTACCCA CCCACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp2 ( XM_017592876.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448365.1 Rattus norvegicus caspase 2 (Casp2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa61001
Clone ID Related Accession (Same CDS sequence)	XM_017592876.1
Accession Version	XM_017592876.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	caspase-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGT CGAGCGGGAG GTCTCAGTCT TCCCTGCACA GGAAGGGGCT GATGGCGGCT 
GACAGGAGGA GCAGGATTTT GGCAGTGTGT GGAATGCATC CTGACCATCA GGAAACTCTG 
AAAAAGAATC GAGTGGTGCT GGCCAAACAG CTGCTGCTGA GCGAACTGTT AGAACATCTC 
CTAGAAAAGG ACATTATCAC TTTGGAAATG AGGGAGCTAA TCCAGGCCAA AGGGGGCAGT 
TTCAGCCAGA ATGTGGAACT CCTCAACCTG CTGCCAAAGA GAGGACCCCA GGCTTTTGAT 
GCCTTCTGTG AAGCCCTGCG GGAGACCAGG CAGGGTCACT TGGAAGACTT ACTGCTCACA 
ACCCTCTCTG ATATCCAGCA CATACTCCCA CCGTTGAGCT GTGACTATGA CTCAAGTCTC 
CCCTTCTCGG TGTGTGAGTC CTGCCCTCCT CACAAGCAGT CCCGCCTATC CACAGATACT 
ATGGAACACT CCTTAGATAA TGGTGATGGT CCTCCCTGTC TTCAGGTGAA GCCATGCACT 
CCTGAGTTTT ACCAGGCACA CTACCAGCTG GGTAACGACA TTGCCTGTCA TCAAGAAGCT 
CCTGGTCTAA TTGGCCTCCT CCTTCTAGGC CTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448365.1
CDS	81..716
Translation	MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLGNDIACHQEAPGLIGLLLLGL

Target ORF information:

RefSeq Version	XM_017592876.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus caspase 2 (Casp2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592876.1

ORF Insert Sequence:

ATGGCGGCGT CGAGCGGGAG GTCTCAGTCT TCCCTGCACA GGAAGGGGCT GATGGCGGCT 
GACAGGAGGA GCAGGATTTT GGCAGTGTGT GGAATGCATC CTGACCATCA GGAAACTCTG 
AAAAAGAATC GAGTGGTGCT GGCCAAACAG CTGCTGCTGA GCGAACTGTT AGAACATCTC 
CTAGAAAAGG ACATTATCAC TTTGGAAATG AGGGAGCTAA TCCAGGCCAA AGGGGGCAGT 
TTCAGCCAGA ATGTGGAACT CCTCAACCTG CTGCCAAAGA GAGGACCCCA GGCTTTTGAT 
GCCTTCTGTG AAGCCCTGCG GGAGACCAGG CAGGGTCACT TGGAAGACTT ACTGCTCACA 
ACCCTCTCTG ATATCCAGCA CATACTCCCA CCGTTGAGCT GTGACTATGA CTCAAGTCTC 
CCCTTCTCGG TGTGTGAGTC CTGCCCTCCT CACAAGCAGT CCCGCCTATC CACAGATACT 
ATGGAACACT CCTTAGATAA TGGTGATGGT CCTCCCTGTC TTCAGGTGAA GCCATGCACT 
CCTGAGTTTT ACCAGGCACA CTACCAGCTG GGTAACGACA TTGCCTGTCA TCAAGAAGCT 
CCTGGTCTAA TTGGCCTCCT CCTTCTAGGC CTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp2 ( XM_017592877.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448366.1 Rattus norvegicus caspase 2 (Casp2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa61002
Clone ID Related Accession (Same CDS sequence)	XM_017592877.1
Accession Version	XM_017592877.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	caspase-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGT CGAGCGGGAG GTCTCAGTCT TCCCTGCACA GGAAGGGGCT GATGGCGGCT 
GACAGGAGGA GCAGGATTTT GGCAGTGTGT GGAATGCATC CTGACCATCA GGAAACTCTG 
AAAAAGAATC GAGTGGTGCT GGCCAAACAG CTGCTGCTGA GCGAACTGTT AGAACATCTC 
CTAGAAAAGG ACATTATCAC TTTGGAAATG AGGGAGCTAA TCCAGGCCAA AGGGGGCAGT 
TTCAGCCAGA ATGTGGAACT CCTCAACCTG CTGCCAAAGA GAGGACCCCA GGCTTTTGAT 
GCCTTCTGTG AAGCCCTGCG GGAGACCAGG CAGGGTCACT TGGAAGACTT ACTGCTCACA 
ACCCTCTCTG ATATCCAGCA CATACTCCCA CCGTTGAGCT GTGACTATGA CTCAAGTCTC 
CCCTTCTCGG TGTGTGAGTC CTGCCCTCCT CACAAGCAGT CCCGCCTATC CACAGATGAG 
AAATACAATT TACTGTGTAT GTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448366.1
CDS	80..586
Translation	MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDEKYNLLCMF

Target ORF information:

RefSeq Version	XM_017592877.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus caspase 2 (Casp2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592877.1

ORF Insert Sequence:

ATGGCGGCGT CGAGCGGGAG GTCTCAGTCT TCCCTGCACA GGAAGGGGCT GATGGCGGCT 
GACAGGAGGA GCAGGATTTT GGCAGTGTGT GGAATGCATC CTGACCATCA GGAAACTCTG 
AAAAAGAATC GAGTGGTGCT GGCCAAACAG CTGCTGCTGA GCGAACTGTT AGAACATCTC 
CTAGAAAAGG ACATTATCAC TTTGGAAATG AGGGAGCTAA TCCAGGCCAA AGGGGGCAGT 
TTCAGCCAGA ATGTGGAACT CCTCAACCTG CTGCCAAAGA GAGGACCCCA GGCTTTTGAT 
GCCTTCTGTG AAGCCCTGCG GGAGACCAGG CAGGGTCACT TGGAAGACTT ACTGCTCACA 
ACCCTCTCTG ATATCCAGCA CATACTCCCA CCGTTGAGCT GTGACTATGA CTCAAGTCTC 
CCCTTCTCGG TGTGTGAGTC CTGCCCTCCT CACAAGCAGT CCCGCCTATC CACAGATGAG 
AAATACAATT TACTGTGTAT GTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
The Biochemical journal455(1)15-25(2013 Oct)
Jean YY,Ribe EM,Pero ME,Moskalenko M,Iqbal Z,Marks LJ,Greene LA,Troy CM

Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal.
PloS one8(2)e57861(2013)
Vigneswara V,Berry M,Logan A,Ahmed Z

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.
The EMBO journal31(11)2615-28(2012 May)
Imre G,Heering J,Takeda AN,Husmann M,Thiede B,zu Heringdorf DM,Green DR,van der Goot FG,Sinha B,D?tsch V,Rajalingam K

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Casp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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