Smn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Smn1
Entrez Gene ID	64301
Full Name	survival of motor neuron 1, telomeric
Synonyms	Smn
General protein information	Preferred Names survival of motor neuron 1, telomeric Names survival motor neuron protein survival motor neuron 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q12
Summary	human homolog is deleted in spinal muscular atrophy, which is characterized by degeneration of spinal cord and brainstem motoneurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022509.1	NP_071954.1	survival motor neuron protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SMN1	NP_783632.1
Rattus norvegicus (Norway rat)	Smn1	NP_071954.1
Gallus gallus (chicken)	SMN	NP_989530.1
Homo sapiens (human)	SMN2	NP_075014.1
Pan troglodytes (chimpanzee)	SMN1	XP_001156259.1
Mus musculus (house mouse)	Smn1	NP_035550.1
Homo sapiens (human)	SMN1	NP_075012.1
	SMN1	XP_001096348.2
Canis lupus familiaris (dog)	SMN	NP_001003226.1
Danio rerio (zebrafish)	smn1	NP_571266.1
Xenopus tropicalis (tropical clawed frog)	smn2	NP_001093710.1

Gene Ontology
Bibliography

Related articles in PubMed

Chronic uranium contamination alters spinal motor neuron integrity via modulation of SMN1 expression and microglia recruitment.
Saint-Marc B, Elie C, Manens L, Tack K, Benderitter M, Gueguen Y, Ibanez C
Toxicology letters25437-44(2016 Jul)

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.
Zhao DY, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JF
Nature529(7584)48-53(2016 Jan)

SMN regulates axonal local translation via miR-183/mTOR pathway.
Kye MJ, Niederst ED, Wertz MH, Gon?alves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M
Human molecular genetics23(23)6318-31(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report decreased number of motor neurons and a decrease of SMN1 protein expression in spinal cords of rats exposed to uranyl nitrate.
Title: Chronic uranium contamination alters spinal motor neuron integrity via modulation of SMN1 expression and microglia recruitment.

Reduced SMN protein level alters miRNA expression and distribution in neurons.
Title: SMN regulates axonal local translation via miR-183/mTOR pathway.

RNAi-mediated degradation of endogenous Elk-1 resulted in elimination of the mcl-1 message
Title: ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target.

Involvement of SMN in formation of stress granules may play an important role in cell survival.
Title: SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress.

Smn knockdown in PC12 cells alters the expression pattern of profilin II, resulting in an increase in the neuronal-specific profilin IIa isoform.
Title: Smn depletion alters profilin II expression and leads to upregulation of the RhoA/ROCK pathway and defects in neuronal integrity.

The following Smn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Smn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05799	NM_022509.1 Latest version!	Rattus norvegicus survival of motor neuron 1, telomeric (Smn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Smn1 ( NM_022509.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071954.1 Rattus norvegicus survival of motor neuron 1, telomeric (Smn1), mRNA.

Price & Availability↑

CloneID	ORa05799
Clone ID Related Accession (Same CDS sequence)	NM_022509.1
Accession Version	NM_022509.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	survival motor neuron protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U75369.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U75369.1, FQ212707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGATGG GCAGCGGCGG CGGCGCGGGC TCTGAGCAGG AAGACACCGT GCTGTTCCGG 
CGTGGCACCG GCCAGAGTGA TGATTCTGAC ATTTGGGATG ATACAGCATT GATAAAAGCT 
TACGATAAAG CCGTGGCCTC CTTTAAGCAT GCTCTAAAGA ACGGTGACAT GTGTGAAACT 
TCAGATAAGC CAAAAGGCAC AGCTAGAAGA AAACCTGCTA AGAAGAATAA AAACCAAAAG 
AAGAATGCCA CAGCTCCATT GAAACAGTGG AAAGCTGGTG ACAAATGCTC TGCCGTTTGG 
TCGGAAGATG GCTGCGTTTA CCCAGCTACC ATCACGTCAG TTGACCTTAA GAGAGAAACC 
TGTGTCGTGG TTTATACTGG ATATGGAAAC AAAGAGGAGC AAAACCTATC TGATCTGCTT 
TCCCCGACCT GTGAAGTAGC TAACAATACA GAACAGAACA CTCAGGAGAA TGAAAGCCAA 
GTTTCCACAG ACGACAGTGA ACACTCCTCC AGATCGCTCA GAAGTAAAGC ACACAGCAAG 
TCCAAAGCTG CTCCATGGAC CTCGTTTCTC CCTCCACCTC CCCCGGTGCC CGGGGCGGGA 
TTAGGACCAG GAAAGCCAGG TCTAAGGTTC AGTGGGCCAC CGCCGCCGCC ACCTCCCCCT 
CCCCCGTTCT TGCCGTGTTG GATGCCTCCG TTCCCTTCAG GACCACCAAT AATTCCTCCA 
CCCCCTCCCA TATCTCCCGA CTGTCTGGAT GACACGGATG CTCTGGGCAG TATGCTAATC 
TCTTGGTACA TGAGTGGTTA CCACACTGGT TACTATATGG GTTTCAGACA AAATAAAAAG 
GAGGGAAAGA AGTGCTCACA TACAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071954.1
CDS	39..908
Translation	MAMGSGGGAGSEQEDTVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDMCETSDKPKGTARRKPAKKNKNQKKNATAPLKQWKAGDKCSAVWSEDGCVYPATITSVDLKRETCVVVYTGYGNKEEQNLSDLLSPTCEVANNTEQNTQENESQVSTDDSEHSSRSLRSKAHSKSKAAPWTSFLPPPPPVPGAGLGPGKPGLRFSGPPPPPPPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALGSMLISWYMSGYHTGYYMGFRQNKKEGKKCSHTN

Target ORF information:

RefSeq Version	NM_022509.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus survival of motor neuron 1, telomeric (Smn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022509.1

ORF Insert Sequence:

ATGGCGATGG GCAGCGGCGG CGGCGCGGGC TCTGAGCAGG AAGACACCGT GCTGTTCCGG 
CGTGGCACCG GCCAGAGTGA TGATTCTGAC ATTTGGGATG ATACAGCATT GATAAAAGCT 
TACGATAAAG CCGTGGCCTC CTTTAAGCAT GCTCTAAAGA ACGGTGACAT GTGTGAAACT 
TCAGATAAGC CAAAAGGCAC AGCTAGAAGA AAACCTGCTA AGAAGAATAA AAACCAAAAG 
AAGAATGCCA CAGCTCCATT GAAACAGTGG AAAGCTGGTG ACAAATGCTC TGCCGTTTGG 
TCGGAAGATG GCTGCGTTTA CCCAGCTACC ATCACGTCAG TTGACCTTAA GAGAGAAACC 
TGTGTCGTGG TTTATACTGG ATATGGAAAC AAAGAGGAGC AAAACCTATC TGATCTGCTT 
TCCCCGACCT GTGAAGTAGC TAACAATACA GAACAGAACA CTCAGGAGAA TGAAAGCCAA 
GTTTCCACAG ACGACAGTGA ACACTCCTCC AGATCGCTCA GAAGTAAAGC ACACAGCAAG 
TCCAAAGCTG CTCCATGGAC CTCGTTTCTC CCTCCACCTC CCCCGGTGCC CGGGGCGGGA 
TTAGGACCAG GAAAGCCAGG TCTAAGGTTC AGTGGGCCAC CGCCGCCGCC ACCTCCCCCT 
CCCCCGTTCT TGCCGTGTTG GATGCCTCCG TTCCCTTCAG GACCACCAAT AATTCCTCCA 
CCCCCTCCCA TATCTCCCGA CTGTCTGGAT GACACGGATG CTCTGGGCAG TATGCTAATC 
TCTTGGTACA TGAGTGGTTA CCACACTGGT TACTATATGG GTTTCAGACA AAATAAAAAG 
GAGGGAAAGA AGTGCTCACA TACAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chronic uranium contamination alters spinal motor neuron integrity via modulation of SMN1 expression and microglia recruitment.
Toxicology letters25437-44(2016 Jul)
Saint-Marc B,Elie C,Manens L,Tack K,Benderitter M,Gueguen Y,Ibanez C

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.
Nature529(7584)48-53(2016 Jan)
Zhao DY,Gish G,Braunschweig U,Li Y,Ni Z,Schmitges FW,Zhong G,Liu K,Li W,Moffat J,Vedadi M,Min J,Pawson TJ,Blencowe BJ,Greenblatt JF

SMN regulates axonal local translation via miR-183/mTOR pathway.
Human molecular genetics23(23)6318-31(2014 Dec)
Kye MJ,Niederst ED,Wertz MH,Gon?alves Ido C,Akten B,Dover KZ,Peters M,Riessland M,Neveu P,Wirth B,Kosik KS,Sardi SP,Monani UR,Passini MA,Sahin M

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Smn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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