Mlst8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mlst8
Entrez Gene ID	64226
Full Name	MTOR associated protein, LST8 homolog
Synonyms	Gbl
General protein information	Preferred Names MTOR associated protein, LST8 homolog Names target of rapamycin complex subunit LST8 G beta-like protein TORC subunit LST8 mammalian lethal with SEC13 protein 8 protein GbetaL
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	cytosolic protein similar to an insulin receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597522.1	XP_017453011.1	target of rapamycin complex subunit LST8 isoform X1
NM_022404.2	NP_071799.2	target of rapamycin complex subunit LST8

Pathways from BioSystems

Homologies

Homo sapiens (human)	MLST8	NP_001186102.1
Mus musculus (house mouse)	Mlst8	NP_001239392.1
Xenopus tropicalis (tropical clawed frog)	mlst8	NP_001011443.1
Drosophila melanogaster (fruit fly)	Lst8	NP_572572.1
Saccharomyces cerevisiae (baker's yeast)	LST8	NP_014392.3
Kluyveromyces lactis	KLLA0D04840g	XP_453275.1
Eremothecium gossypii	AGOS_AAL009C	NP_982533.1
Pan troglodytes (chimpanzee)	MLST8	XP_510741.3
	MLST8	XP_001084050.1
Bos taurus (cattle)	MLST8	NP_001030488.1
Gallus gallus (chicken)	MLST8	XP_004945304.1
Magnaporthe oryzae (rice blast fungus)	MGG_07284	XP_003715510.1
Canis lupus familiaris (dog)	MLST8	XP_853618.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001036	XP_560261.3
Rattus norvegicus (Norway rat)	Mlst8	NP_071799.2
Danio rerio (zebrafish)	mlst8	NP_956171.1
Schizosaccharomyces pombe (fission yeast)	pop3	NP_595682.1
Neurospora crassa	NCU04281	XP_961071.2
Arabidopsis thaliana (thale cress)	AT3G18140	NP_188442.1
Oryza sativa (rice)	Os03g0681700	NP_001050907.1

Gene Ontology
Bibliography

Related articles in PubMed

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.
Kamano Y, Saeki M, Egusa H, Kakihara Y, Houry WA, Yatani H, Kamisaki Y
FEBS letters587(20)3303-8(2013 Oct)

mTOR signaling in growth control and disease.
Laplante M, Sabatini DM
Cell149(2)274-93(2012 Apr)

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.
Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, Kitamura M
Cell death and differentiation19(2)310-20(2012 Feb)

Molecular mechanisms of mTOR-mediated translational control.
Ma XM, Blenis J
Nature reviews. Molecular cell biology10(5)307-18(2009 May)

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Jacinto E, Loewith R, Schmidt A, Lin S, R?egg MA, Hall A, Hall MN
Nature cell biology6(11)1122-8(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results disclosed that, under endoplasmic reticulum stress conditions, mTORC1 causes apoptosis through suppression of Akt and consequent induction of the IRE1-JNK pathway.
Title: mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.

The following Mlst8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mlst8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05764	NM_022404.2 Latest version!	Rattus norvegicus MTOR associated protein, LST8 homolog (Mlst8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa05764	XM_017597522.1 Latest version!	Rattus norvegicus MTOR associated protein, LST8 homolog (Mlst8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mlst8 ( NM_022404.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071799.2 Rattus norvegicus MTOR associated protein, LST8 homolog (Mlst8), mRNA.

Price & Availability↑

CloneID	ORa05764
Clone ID Related Accession (Same CDS sequence)	XM_017597522.1 , NM_022404.2
Accession Version	NM_022404.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	target of rapamycin complex subunit LST8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC103090.7 and BC097319.1. On Oct 12, 2007 this sequence version replaced NM_022404.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. ##Evidence-Data-START## Transcript exon combination :: BC097319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00632252 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATACCA CCCCAGGCAC AGTGGGCAGT GACCCTGTCA TCTTAGCAAC TGCAGGCTAT 
GACCACACAG TGCGCTTTTG GCAGGCTCAC AGTGGAATCT GCACTCGAAC AGTGCAGCAT 
CAGGACTCTC AGGTGAATGC ATTGGAGATC ACTCCAGACC GGAGCATGAT TGCTGCTGCA 
GGTTACCAAC ATATCCGCAT GTATGATCTC AACTCCAATA ACCCCAACCC CATCATCAGT 
TATGACGGAG TCAGTAAGAA CATCGCATCA GTGGGTTTTC ATGAGGATGG CCGCTGGATG 
TATACAGGTG GAGAGGACTG CACGGCTCGC ATCTGGGACC TCAGGTCCCG GAACCTGCAG 
TGTCAGCGTA TCTTCCAGGT GAATGCACCC ATTAATTGCG TGTGTCTACA TCCCAACCAG 
GCAGAACTCA TCGTGGGTGA CCAGAGCGGT GCTATCCACA TCTGGGACCT GAAGACAGAC 
CACAATGAGC AGCTGATCCC TGAGCCTGAG TTTTCCATCA CATCTGCCCA CATTGACCCC 
GATGCCAGCT ACATGGCGGC AGTCAATAGT GCCGGAAACT GCTTTGTCTG GAACCTGACG 
GGGGGCATTG GTGACGAGGT GACTCAGCTC ATCCCCAAGA CCAAGATCCC AGCCCACACG 
CGCTACGCCC TGCAGTGCCG CTTCAGCCCC GACTCCACGT TACTTGCGAC CTGTTCGGCT 
GACCAGACGT GTAAAATCTG GAGGACATCC AACTTCTCCC TGATGACAGA ACTCAGCATC 
AAGAGTAGTA ACCCCGGAGA GTCATCCCGT GGCTGGATGT GGGGCTGCGC CTTCTCAGGG 
GATTCCCAGT ATATCGTCAC AGCTTCTTCA GACAACCTGG CCCGGCTCTG GTGTGTAGAG 
ACTGGAGAGA TCAAGAGAGA GTATGGTGGC CATCAGAAAG CTGTCGTCTG CTTGGCCTTC 
AACGACAGCG TGCTGGGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071799.2
CDS	362..1342
Translation	MNTTPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSSNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG

Target ORF information:

RefSeq Version	NM_022404.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MTOR associated protein, LST8 homolog (Mlst8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022404.2

ORF Insert Sequence:

ATGAATACCA CCCCAGGCAC AGTGGGCAGT GACCCTGTCA TCTTAGCAAC TGCAGGCTAT 
GACCACACAG TGCGCTTTTG GCAGGCTCAC AGTGGAATCT GCACTCGAAC AGTGCAGCAT 
CAGGACTCTC AGGTGAATGC ATTGGAGATC ACTCCAGACC GGAGCATGAT TGCTGCTGCA 
GGTTACCAAC ATATCCGCAT GTATGATCTC AACTCCAATA ACCCCAACCC CATCATCAGT 
TATGACGGAG TCAGTAAGAA CATCGCATCA GTGGGTTTTC ATGAGGATGG CCGCTGGATG 
TATACAGGTG GAGAGGACTG CACGGCTCGC ATCTGGGACC TCAGGTCCCG GAACCTGCAG 
TGTCAGCGTA TCTTCCAGGT GAATGCACCC ATTAATTGCG TGTGTCTACA TCCCAACCAG 
GCAGAACTCA TCGTGGGTGA CCAGAGCGGT GCTATCCACA TCTGGGACCT GAAGACAGAC 
CACAATGAGC AGCTGATCCC TGAGCCTGAG TTTTCCATCA CATCTGCCCA CATTGACCCC 
GATGCCAGCT ACATGGCGGC AGTCAATAGT GCCGGAAACT GCTTTGTCTG GAACCTGACG 
GGGGGCATTG GTGACGAGGT GACTCAGCTC ATCCCCAAGA CCAAGATCCC AGCCCACACG 
CGCTACGCCC TGCAGTGCCG CTTCAGCCCC GACTCCACGT TACTTGCGAC CTGTTCGGCT 
GACCAGACGT GTAAAATCTG GAGGACATCC AACTTCTCCC TGATGACAGA ACTCAGCATC 
AAGAGTAGTA ACCCCGGAGA GTCATCCCGT GGCTGGATGT GGGGCTGCGC CTTCTCAGGG 
GATTCCCAGT ATATCGTCAC AGCTTCTTCA GACAACCTGG CCCGGCTCTG GTGTGTAGAG 
ACTGGAGAGA TCAAGAGAGA GTATGGTGGC CATCAGAAAG CTGTCGTCTG CTTGGCCTTC 
AACGACAGCG TGCTGGGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mlst8 ( XM_017597522.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453011.1 Rattus norvegicus MTOR associated protein, LST8 homolog (Mlst8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa05764
Clone ID Related Accession (Same CDS sequence)	XM_017597522.1 , NM_022404.2
Accession Version	XM_017597522.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	target of rapamycin complex subunit LST8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATACCA CCCCAGGCAC AGTGGGCAGT GACCCTGTCA TCTTAGCAAC TGCAGGCTAT 
GACCACACAG TGCGCTTTTG GCAGGCTCAC AGTGGAATCT GCACTCGAAC AGTGCAGCAT 
CAGGACTCTC AGGTGAATGC ATTGGAGATC ACTCCAGACC GGAGCATGAT TGCTGCTGCA 
GGTTACCAAC ATATCCGCAT GTATGATCTC AACTCCAATA ACCCCAACCC CATCATCAGT 
TATGACGGAG TCAGTAAGAA CATCGCATCA GTGGGTTTTC ATGAGGATGG CCGCTGGATG 
TATACAGGTG GAGAGGACTG CACGGCTCGC ATCTGGGACC TCAGGTCCCG GAACCTGCAG 
TGTCAGCGTA TCTTCCAGGT GAATGCACCC ATTAATTGCG TGTGTCTACA TCCCAACCAG 
GCAGAACTCA TCGTGGGTGA CCAGAGCGGT GCTATCCACA TCTGGGACCT GAAGACAGAC 
CACAATGAGC AGCTGATCCC TGAGCCTGAG TTTTCCATCA CATCTGCCCA CATTGACCCC 
GATGCCAGCT ACATGGCGGC AGTCAATAGT GCCGGAAACT GCTTTGTCTG GAACCTGACG 
GGGGGCATTG GTGACGAGGT GACTCAGCTC ATCCCCAAGA CCAAGATCCC AGCCCACACG 
CGCTACGCCC TGCAGTGCCG CTTCAGCCCC GACTCCACGT TACTTGCGAC CTGTTCGGCT 
GACCAGACGT GTAAAATCTG GAGGACATCC AACTTCTCCC TGATGACAGA ACTCAGCATC 
AAGAGTAGTA ACCCCGGAGA GTCATCCCGT GGCTGGATGT GGGGCTGCGC CTTCTCAGGG 
GATTCCCAGT ATATCGTCAC AGCTTCTTCA GACAACCTGG CCCGGCTCTG GTGTGTAGAG 
ACTGGAGAGA TCAAGAGAGA GTATGGTGGC CATCAGAAAG CTGTCGTCTG CTTGGCCTTC 
AACGACAGCG TGCTGGGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453011.1
CDS	528..1508
Translation	MNTTPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSSNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG

Target ORF information:

RefSeq Version	XM_017597522.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MTOR associated protein, LST8 homolog (Mlst8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597522.1

ORF Insert Sequence:

ATGAATACCA CCCCAGGCAC AGTGGGCAGT GACCCTGTCA TCTTAGCAAC TGCAGGCTAT 
GACCACACAG TGCGCTTTTG GCAGGCTCAC AGTGGAATCT GCACTCGAAC AGTGCAGCAT 
CAGGACTCTC AGGTGAATGC ATTGGAGATC ACTCCAGACC GGAGCATGAT TGCTGCTGCA 
GGTTACCAAC ATATCCGCAT GTATGATCTC AACTCCAATA ACCCCAACCC CATCATCAGT 
TATGACGGAG TCAGTAAGAA CATCGCATCA GTGGGTTTTC ATGAGGATGG CCGCTGGATG 
TATACAGGTG GAGAGGACTG CACGGCTCGC ATCTGGGACC TCAGGTCCCG GAACCTGCAG 
TGTCAGCGTA TCTTCCAGGT GAATGCACCC ATTAATTGCG TGTGTCTACA TCCCAACCAG 
GCAGAACTCA TCGTGGGTGA CCAGAGCGGT GCTATCCACA TCTGGGACCT GAAGACAGAC 
CACAATGAGC AGCTGATCCC TGAGCCTGAG TTTTCCATCA CATCTGCCCA CATTGACCCC 
GATGCCAGCT ACATGGCGGC AGTCAATAGT GCCGGAAACT GCTTTGTCTG GAACCTGACG 
GGGGGCATTG GTGACGAGGT GACTCAGCTC ATCCCCAAGA CCAAGATCCC AGCCCACACG 
CGCTACGCCC TGCAGTGCCG CTTCAGCCCC GACTCCACGT TACTTGCGAC CTGTTCGGCT 
GACCAGACGT GTAAAATCTG GAGGACATCC AACTTCTCCC TGATGACAGA ACTCAGCATC 
AAGAGTAGTA ACCCCGGAGA GTCATCCCGT GGCTGGATGT GGGGCTGCGC CTTCTCAGGG 
GATTCCCAGT ATATCGTCAC AGCTTCTTCA GACAACCTGG CCCGGCTCTG GTGTGTAGAG 
ACTGGAGAGA TCAAGAGAGA GTATGGTGGC CATCAGAAAG CTGTCGTCTG CTTGGCCTTC 
AACGACAGCG TGCTGGGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.
FEBS letters587(20)3303-8(2013 Oct)
Kamano Y,Saeki M,Egusa H,Kakihara Y,Houry WA,Yatani H,Kamisaki Y

mTOR signaling in growth control and disease.
Cell149(2)274-93(2012 Apr)
Laplante M,Sabatini DM

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.
Cell death and differentiation19(2)310-20(2012 Feb)
Kato H,Nakajima S,Saito Y,Takahashi S,Katoh R,Kitamura M

Molecular mechanisms of mTOR-mediated translational control.
Nature reviews. Molecular cell biology10(5)307-18(2009 May)
Ma XM,Blenis J

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Nature cell biology6(11)1122-8(2004 Nov)
Jacinto E,Loewith R,Schmidt A,Lin S,R?egg MA,Hall A,Hall MN

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Mlst8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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