Tdo2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tdo2
Entrez Gene ID	64206
Full Name	tryptophan 2,3-dioxygenase
Synonyms	TO,Tdo
General protein information	Preferred Names tryptophan 2,3-dioxygenase Names tryptophan 2,3-dioxygenase TRPO tryptamin 2,3-dioxygenase tryptophan 2,3-dioxygenase A tryptophan oxygenase tryptophan pyrrolase tryptophan-23-dioxygenase tryptophanase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	rate-limiting enzyme in the catabolism of tryptophan [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022403.2	NP_071798.1	tryptophan 2,3-dioxygenase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TDO2	XP_001140187.1
Rattus norvegicus (Norway rat)	Tdo2	NP_071798.1
Bos taurus (cattle)	TDO2	NP_001039778.1
Mus musculus (house mouse)	Tdo2	NP_064295.2
Danio rerio (zebrafish)	tdo2b	NP_956150.1
Danio rerio (zebrafish)	tdo2a	NP_001096086.1
Caenorhabditis elegans (roundworm)	C28H8.11	NP_498284.1
Xenopus tropicalis (tropical clawed frog)	tdo2	NP_001015733.1
Gallus gallus (chicken)	TDO2	XP_420377.3
Drosophila melanogaster (fruit fly)	v	NP_511113.1
Canis lupus familiaris (dog)	TDO2	XP_532700.2
Anopheles gambiae (African malaria mosquito)	T23O_ANOGA	XP_312204.2
Homo sapiens (human)	TDO2	NP_005642.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.
Ferreira P, Shin I, Sosova I, Dornevil K, Jain S, Dewey D, Liu F, Liu A
Molecular genetics and metabolism120(4)317-324(2017 Apr)

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat.
Nagy-Gr?cz G, Laborc KF, Veres G, Bajtai A, Boh?r Z, Z?dori D, Fejes-Szab? A, Spekker E, V?csei L, P?rdutz ?
Frontiers in neurology8278(2017)

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Lewis-Ballester A, Forouhar F, Kim SM, Lew S, Wang Y, Karkashon S, Seetharaman J, Batabyal D, Chiang BY, Hussain M, Correia MA, Yeh SR, Tong L
Scientific reports635169(2016 Oct)

TDO as a therapeutic target in brain diseases.
Yu CP, Pan ZZ, Luo DY
Metabolic brain disease31(4)737-47(2016 Aug)

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
Woodling NS, Colas D, Wang Q, Minhas P, Panchal M, Liang X, Mhatre SD, Brown H, Ko N, Zagol-Ikapitte I, van der Hart M, Khroyan TV, Chuluun B, Priyam PG, Milne GL, Rassoulpour A, Boutaud O, Manning-Bo? AB, Heller HC, Andreasson KI
Brain : a journal of neurology139(Pt 7)2063-81(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that stress-induced corticosterone and consequent activation of hepatic TDO, tryptophan metabolism and production of kynurenine provoke a depression-related behavioural phenotype
Title: Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour.

these data show that the nucleosome array in the regulatory region of the actively transcribed tdo gene in vivo is disturbed.
Title: [Nucleosome remodeling on the regulatory region of the rat tryptophan dioxygenase (tdo) gene during transcription in vivo].

tryptophan oxygenase gene might rely on the binding of the enhancer (the -8.5kb S/MAR-GRE) and the promoter to the inner nuclear matrix.
Title: Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene.

The cerebrocortical TDO2 genes were increased in aged rats. Certain age dependent transcriptional changes might influence the mechanism of Alzheimer dis and other neurodegenerative disorders.
Title: [The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain].

Data support the involvement of insulin in modulation of glucocorticoid receptor signaling pathway which mediates, in part, the activity of tryptophan oxygenase.
Title: Comparative analysis of tryptophan oxygenase activity and glucocorticoid receptor under the influence of insulin.

The following Tdo2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tdo2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05762	NM_022403.2 Latest version!	Rattus norvegicus tryptophan 2,3-dioxygenase (Tdo2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tdo2 ( NM_022403.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071798.1 Rattus norvegicus tryptophan 2,3-dioxygenase (Tdo2), mRNA.

Price & Availability↑

CloneID	ORa05762
Clone ID Related Accession (Same CDS sequence)	NM_022403.2
Accession Version	NM_022403.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	tryptophan 2,3-dioxygenase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M55167.1. On Feb 21, 2013 this sequence version replaced NM_022403.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M55167.1, BC089802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355, SAMN01906358 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGGGT GCCCATTTTC AGGAAACAGT GTAGGATATA CTTTGAAAAA CTTATCTATG 
GAAGACAATG AAGAAGACGG AGCTCAAACT GGTGTAAACA GAGCCAGCAA AGGAGGACTT 
ATCTATGGGG ACTACTTGCA GTTGGAGAAG ATTTTGAATG CACAAGAACT TCAAAGTGAA 
ATCAAAGGGA ATAAAATCCA CGACGAGCAC CTCTTTATTA TAACTCACCA AGCTTATGAA 
CTTTGGTTTA AACAAATTCT CTGGGAACTT GATTCTGTTC GTGAGATTTT TCAAAATGGC 
CATGTCAGGG ATGAGAGGAA CATGCTCAAG GTGATGACTC GGATGCACCG TGTGGTGGTC 
ATCTTCAAGC TCCTGGTACA GCAGTTCTCG GTTCTGGAAA CAATGACTGC CTTGGACTTC 
AATGACTTCA GAGAGTACCT GTCTCCAGCA TCAGGCTTCC AGAGTCTTCA GTTCCGGCTG 
CTAGAAAATA AGATAGGTGT TCTTCAGAGC TTGAGAGTCC CTTACAACAG GAAACACTAT 
CGTGATAACT TTGAAGGAGA CTACAATGAG CTGCTGCTGA AATCGGAGCA GGAGCAGACG 
CTATTGCAGC TGGTGGAGGC ATGGCTGGAA CGCACACCTG GCTTAGAGCC ACATGGATTC 
AATTTCTGGG GAAAGTTTGA AAAAAATATC TTGAAGGGTC TGGAAGAGGA GTTCCTAAAG 
ATTCAGGCGA AAAAGGACTC TGAAGAAAAA GAGGAACAGA TGGCAGAGTT CCGGAAGCAG 
AAAGAGGTGC TGCTCTGCTT GTTCGATGAG AAGCGTCATG ACTACCTTCT GAGTAAAGGT 
GAACGACGAC TGTCATACCG TGCACTCCAG GGAGCACTGA TGATATATTT TTACAGGGAG 
GAGCCTCGAT TCCAGGTCCC TTTCCAGTTG CTGACCTCAC TTATGGACAT TGACACACTC 
ATGACCAAAT GGAGATATAA TCATGTGTGC ATGGTGCACA GGATGCTAGG CAGCAAGGCT 
GGCACTGGGG GATCCTCAGG CTATTATTAT CTGCGCTCAA CTGTGAGCGA CAGGTACAAG 
GTGTTCGTGG ATTTATTTAA CCTCTCATCG TACCTGGTTC CCCGACACTG GATACCAAAG 
ATGAATCCGA TCATTCACAA GTTCCTTTAC ACAGCTGAGT ACAGCGACAG CTCCTACTTC 
AGCAGCGATG AATCAGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071798.1
CDS	40..1260
Translation	MSGCPFSGNSVGYTLKNLSMEDNEEDGAQTGVNRASKGGLIYGDYLQLEKILNAQELQSEIKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVMTRMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFEGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPHGFNFWGKFEKNILKGLEEEFLKIQAKKDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGSKAGTGGSSGYYYLRSTVSDRYKVFVDLFNLSSYLVPRHWIPKMNPIIHKFLYTAEYSDSSYFSSDESD

Target ORF information:

RefSeq Version	NM_022403.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tryptophan 2,3-dioxygenase (Tdo2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022403.2

ORF Insert Sequence:

ATGAGTGGGT GCCCATTTTC AGGAAACAGT GTAGGATATA CTTTGAAAAA CTTATCTATG 
GAAGACAATG AAGAAGACGG AGCTCAAACT GGTGTAAACA GAGCCAGCAA AGGAGGACTT 
ATCTATGGGG ACTACTTGCA GTTGGAGAAG ATTTTGAATG CACAAGAACT TCAAAGTGAA 
ATCAAAGGGA ATAAAATCCA CGACGAGCAC CTCTTTATTA TAACTCACCA AGCTTATGAA 
CTTTGGTTTA AACAAATTCT CTGGGAACTT GATTCTGTTC GTGAGATTTT TCAAAATGGC 
CATGTCAGGG ATGAGAGGAA CATGCTCAAG GTGATGACTC GGATGCACCG TGTGGTGGTC 
ATCTTCAAGC TCCTGGTACA GCAGTTCTCG GTTCTGGAAA CAATGACTGC CTTGGACTTC 
AATGACTTCA GAGAGTACCT GTCTCCAGCA TCAGGCTTCC AGAGTCTTCA GTTCCGGCTG 
CTAGAAAATA AGATAGGTGT TCTTCAGAGC TTGAGAGTCC CTTACAACAG GAAACACTAT 
CGTGATAACT TTGAAGGAGA CTACAATGAG CTGCTGCTGA AATCGGAGCA GGAGCAGACG 
CTATTGCAGC TGGTGGAGGC ATGGCTGGAA CGCACACCTG GCTTAGAGCC ACATGGATTC 
AATTTCTGGG GAAAGTTTGA AAAAAATATC TTGAAGGGTC TGGAAGAGGA GTTCCTAAAG 
ATTCAGGCGA AAAAGGACTC TGAAGAAAAA GAGGAACAGA TGGCAGAGTT CCGGAAGCAG 
AAAGAGGTGC TGCTCTGCTT GTTCGATGAG AAGCGTCATG ACTACCTTCT GAGTAAAGGT 
GAACGACGAC TGTCATACCG TGCACTCCAG GGAGCACTGA TGATATATTT TTACAGGGAG 
GAGCCTCGAT TCCAGGTCCC TTTCCAGTTG CTGACCTCAC TTATGGACAT TGACACACTC 
ATGACCAAAT GGAGATATAA TCATGTGTGC ATGGTGCACA GGATGCTAGG CAGCAAGGCT 
GGCACTGGGG GATCCTCAGG CTATTATTAT CTGCGCTCAA CTGTGAGCGA CAGGTACAAG 
GTGTTCGTGG ATTTATTTAA CCTCTCATCG TACCTGGTTC CCCGACACTG GATACCAAAG 
ATGAATCCGA TCATTCACAA GTTCCTTTAC ACAGCTGAGT ACAGCGACAG CTCCTACTTC 
AGCAGCGATG AATCAGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.
Molecular genetics and metabolism120(4)317-324(2017 Apr)
Ferreira P,Shin I,Sosova I,Dornevil K,Jain S,Dewey D,Liu F,Liu A

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat.
Frontiers in neurology8278(2017)
Nagy-Gr?cz G,Laborc KF,Veres G,Bajtai A,Boh?r Z,Z?dori D,Fejes-Szab? A,Spekker E,V?csei L,P?rdutz ?

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Scientific reports635169(2016 Oct)
Lewis-Ballester A,Forouhar F,Kim SM,Lew S,Wang Y,Karkashon S,Seetharaman J,Batabyal D,Chiang BY,Hussain M,Correia MA,Yeh SR,Tong L

TDO as a therapeutic target in brain diseases.
Metabolic brain disease31(4)737-47(2016 Aug)
Yu CP,Pan ZZ,Luo DY

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
Brain : a journal of neurology139(Pt 7)2063-81(2016 Jul)
Woodling NS,Colas D,Wang Q,Minhas P,Panchal M,Liang X,Mhatre SD,Brown H,Ko N,Zagol-Ikapitte I,van der Hart M,Khroyan TV,Chuluun B,Priyam PG,Milne GL,Rassoulpour A,Boutaud O,Manning-Bo? AB,Heller HC,Andreasson KI

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Tdo2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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