Kcnk13 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk13
Entrez Gene ID	64120
Full Name	potassium two pore domain channel subfamily K member 13
Synonyms	THIK-1,prdx1
General protein information	Preferred Names potassium two pore domain channel subfamily K member 13 Names potassium channel subfamily K member 13 potassium channel, subfamily K, member 13 potassium channel, two pore domain subfamily K, member 13 tandem pore domain halothane-inhibited potassium channel 1 tandem pore domain potassium channel THIK-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	tandem pore domain halothane inhibited K(+) channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006240447.3	XP_006240509.1	potassium channel subfamily K member 13 isoform X1
XM_008776304.2	XP_008774526.1	potassium channel subfamily K member 13 isoform X2
NM_022293.1	NP_071629.1	potassium channel subfamily K member 13

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCNK13	XP_547951.2
Mus musculus (house mouse)	Kcnk13	NP_001157898.1
	KCNK13	XP_001089892.1
Rattus norvegicus (Norway rat)	Kcnk13	NP_071629.1
Gallus gallus (chicken)	KCNK13	XP_001235376.1
Danio rerio (zebrafish)	kcnk13b	NP_001020654.1
Xenopus tropicalis (tropical clawed frog)	kcnk13	XP_002933246.1
Danio rerio (zebrafish)	kcnk13a	NP_001103587.1
Homo sapiens (human)	KCNK13	NP_071337.2
Pan troglodytes (chimpanzee)	KCNK13	XP_001141129.1

Gene Ontology
Bibliography

Related articles in PubMed

Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K
Madry C, Kyrargyri V, Arancibia-C?rcamo IL, Jolivet R, Kohsaka S, Bryan RM, Attwell D
Neuron97(2)299-312.e6(2018 Jan)

Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons.
Haskins W, Benitez S, Mercado JM, Acosta CG
Molecular and cellular neurosciences8313-26(2017 Sep)

Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Theilig F, Goranova I, Hirsch JR, Wieske M, Unsal S, Bachmann S, Veh RW, Derst C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology21(1-3)63-74(2008)

Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway.
Hess A, Wijayanti N, Neusch?fer-Rube AP, Katz N, Kietzmann T, Immenschuh S
The Journal of biological chemistry278(46)45419-34(2003 Nov)

THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.
Rajan S, Wischmeyer E, Karschin C, Preisig-M?ller R, Grzeschik KH, Daut J, Karschin A, Derst C
The Journal of biological chemistry276(10)7302-11(2001 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.

The following Kcnk13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05644	NM_022293.1 Latest version!	Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa29543	XM_006240447.3 Latest version!	Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43558	XM_008776304.2 Latest version!	Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk13 ( NM_022293.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071629.1 Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), mRNA.

Price & Availability↑

CloneID	ORa05644
Clone ID Related Accession (Same CDS sequence)	NM_022293.1
Accession Version	NM_022293.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel subfamily K member 13
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF287301.1. On Apr 19, 2005 this sequence version replaced XM_234380.3. ##Evidence-Data-START## Transcript exon combination :: AF287301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGGCC GCGGTTGCAG CTGCAGCCCC GGCCACCTGA ACGAGGACAA CGCGCGCTTC 
CTGCTGCTCG CGGGGCTCAT CCTGCTTTAC CTGCTGGGCG GCGCCGCAGT CTTCTCCGCG 
CTGGAGCTAG CGCAGGAGCT GCAGGCCAAG CAGCGCTGGG AAGAGCGCCT GGCCAACTTC 
AGCAGGGGCC ACAACCTGAG CCGCGAAGAG CTGCGAGGCT TCCTCCGCCA CTACGAGGAA 
GCCACCAAGG CGGGCATCCG CATGGACAGC GTGCGCCCTC GCTGGGACTT CACGGGCGCC 
TTCTACTTCG TGGGCACAGT GGTAACTACC ATAGGGTTCG GGATGACGAC CCCAGCCACA 
ACGGGAGGGA AGGTTTTTCT GATCTTTTAT GGTCTCATTG GATGTGCGAG TACCATCCTC 
TTCTTCAACC TCTTTCTGGA GCGGCTGATC ACCGTCATCG CCTACGTCAT GAGAACCTGC 
CACCACCAGC AGCTGCGCAG ACGTGGGACG GTAGCCCGGG ACAACAGGAA GGCCCCTAGA 
AAGGGCGAGG CAGACAGCCT GGCTGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTGTGCTTGG CATCAGTAGC CATCTCCTGT GGAGCCTCGG CTCTGTACAC CACCATGGAA 
GGCTGGAGCT ACTTTGACTC CGTCTACTTC TGTTTTGTGG CTTCAAGCAC CATTGGCTTC 
GGGGACCTGG TGAGCAGCCA GAACGCTCAG TATGAGAACG AAGGGCTCTA CCGCTTTGTC 
AATTTCTTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCATGTTTAA CGTCATCTCC 
ATCCTGATCA AACAGACAGT GAACTGGATC CTGAGGAAAC TGGATAGCGG GTGCTTCCCA 
CAATGCCAAA GAGGACTCCT GCGGTCCAGG AGGAACGTGG TGATGCCGGG CAACATCCGG 
AACAGGTGCA ACATCTCCAT AGAGACGGAC GGGGTGATGG AAAGTGACAC TGATGGGCGA 
CGTCTCTCGG GGGAGATGAT CTCCATGAAG GACACCAACA AGGTCTCCCT GGCCATCCTG 
CAGAAGCAGT TGTCCGAGAT GGCCAATGGT GGACCCCACC AGACCAGCAC ATCCTCCCGG 
GATGATGAGT TCTCAGGGGG CGTGGGAGCC TTTGCAGTAA TGAATAACAG GTTGGCAGAG 
ACCAGTGGGG ACAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071629.1
CDS	97..1314
Translation	MAGRGCSCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGHNLSREELRGFLRHYEEATKAGIRMDSVRPRWDFTGAFYFVGTVVTTIGFGMTTPATTGGKVFLIFYGLIGCASTILFFNLFLERLITVIAYVMRTCHHQQLRRRGTVARDNRKAPRKGEADSLAGWKPSVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVASSTIGFGDLVSSQNAQYENEGLYRFVNFFFILMGVCCIYSMFNVISILIKQTVNWILRKLDSGCFPQCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTDGRRLSGEMISMKDTNKVSLAILQKQLSEMANGGPHQTSTSSRDDEFSGGVGAFAVMNNRLAETSGDR

Target ORF information:

RefSeq Version	NM_022293.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022293.1

ORF Insert Sequence:

ATGGCTGGCC GCGGTTGCAG CTGCAGCCCC GGCCACCTGA ACGAGGACAA CGCGCGCTTC 
CTGCTGCTCG CGGGGCTCAT CCTGCTTTAC CTGCTGGGCG GCGCCGCAGT CTTCTCCGCG 
CTGGAGCTAG CGCAGGAGCT GCAGGCCAAG CAGCGCTGGG AAGAGCGCCT GGCCAACTTC 
AGCAGGGGCC ACAACCTGAG CCGCGAAGAG CTGCGAGGCT TCCTCCGCCA CTACGAGGAA 
GCCACCAAGG CGGGCATCCG CATGGACAGC GTGCGCCCTC GCTGGGACTT CACGGGCGCC 
TTCTACTTCG TGGGCACAGT GGTAACTACC ATAGGGTTCG GGATGACGAC CCCAGCCACA 
ACGGGAGGGA AGGTTTTTCT GATCTTTTAT GGTCTCATTG GATGTGCGAG TACCATCCTC 
TTCTTCAACC TCTTTCTGGA GCGGCTGATC ACCGTCATCG CCTACGTCAT GAGAACCTGC 
CACCACCAGC AGCTGCGCAG ACGTGGGACG GTAGCCCGGG ACAACAGGAA GGCCCCTAGA 
AAGGGCGAGG CAGACAGCCT GGCTGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTGTGCTTGG CATCAGTAGC CATCTCCTGT GGAGCCTCGG CTCTGTACAC CACCATGGAA 
GGCTGGAGCT ACTTTGACTC CGTCTACTTC TGTTTTGTGG CTTCAAGCAC CATTGGCTTC 
GGGGACCTGG TGAGCAGCCA GAACGCTCAG TATGAGAACG AAGGGCTCTA CCGCTTTGTC 
AATTTCTTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCATGTTTAA CGTCATCTCC 
ATCCTGATCA AACAGACAGT GAACTGGATC CTGAGGAAAC TGGATAGCGG GTGCTTCCCA 
CAATGCCAAA GAGGACTCCT GCGGTCCAGG AGGAACGTGG TGATGCCGGG CAACATCCGG 
AACAGGTGCA ACATCTCCAT AGAGACGGAC GGGGTGATGG AAAGTGACAC TGATGGGCGA 
CGTCTCTCGG GGGAGATGAT CTCCATGAAG GACACCAACA AGGTCTCCCT GGCCATCCTG 
CAGAAGCAGT TGTCCGAGAT GGCCAATGGT GGACCCCACC AGACCAGCAC ATCCTCCCGG 
GATGATGAGT TCTCAGGGGG CGTGGGAGCC TTTGCAGTAA TGAATAACAG GTTGGCAGAG 
ACCAGTGGGG ACAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnk13 ( XM_006240447.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240509.1 Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29543
Clone ID Related Accession (Same CDS sequence)	XM_006240447.3
Accession Version	XM_006240447.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel subfamily K member 13 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240447.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGGCC GCGGTTGCAG CTGCAGCCCC GGCCACCTGA ACGAGGACAA CGCGCGCTTC 
CTGCTGCTCG CGGGGCTCAT CCTGCTTTAC CTGCTGGGCG GCGCCGCAGT CTTCTCCGCG 
CTGGAGCTAG CGCAGGAGCT GCAGGCCAAG CAGCGCTGGG AAGAGCGCCT GGCCAACTTC 
AGCAGGGGCC ACAACCTGAG CCGCGAAGAG CTGCGAGGCT TCCTCCGCCA CTACGAGGAA 
GCCACCAAGG CGGGCATCCG CATGGACAGC GTGCGCCCTC GCTGGGACTT CACGGGCGCC 
TTCTACTTCG TGGGCACAGT GGTAACTACC ATAGGGTTCG GGATGACGAC CCCAGCCACA 
ACGGGAGGGA AGGTTTTTCT GATCTTTTAT GGTCTCATTG GATGTGCGAG TACCATCCTC 
TTCTTCAACC TCTTTCTGGA GCGGCTGATC ACCGTCATCG CCTACGTCAT GAGAACCTGC 
CACCACCAGC AGCTGCGCAG ACGTGGGACG GTAGCCCGGG ACAACGGGAA GGCCCCTAGA 
AAGGGCGAGG CAGACAGCCT GGCTGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTGTGCTTGG CATCAGTAGC CATCTCCTGT GGAGCCTCGG CTCTGTACAC CACCATGGAA 
GGCTGGAGCT ACTTTGACTC CGTCTACTTC TGTTTTGTGG CTTTCAGCAC CATTGGCTTC 
GGGGACCTGG TGAGCAGCCA GAACGCTCAG TATGAGAACG AAGGGCTCTA CCGCTTTGTC 
AATTTCTTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCATGTTTAA CGTCATCTCC 
ATCCTGATCA AACAGACAGT GAACTGGATC CTGAGGAAAC TGGATAGCGG GTGCTTCCCA 
CAATGCCAAA GAGGACTCCT GCGGTCCAGG AGGAACGTGG TGATGCCGGG CAACATCCGG 
AACAGGTGCA ACATCTCCAT AGAGACGGAC GGGGTGATGG AAAGTGACAC TGATGGGCGA 
CGTCTCTCGG GGGAGATGAT CTCCATGAAG GACACCAACA AGGTCTCCCT GGCCATCCTG 
CAGAAGCAGT TGTCCGAGAT GGCCAATGGT GGACCCCACC AGACCAGCAC ATCCTCCCGG 
GATGATGAGT TCTCAGGGGG CGTGGGAGCC TTTGCAGTAA TGAATAACAG GTTGGCAGAG 
ACCAGTGGGG ACAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240509.1
CDS	3465..4682
Translation	MAGRGCSCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGHNLSREELRGFLRHYEEATKAGIRMDSVRPRWDFTGAFYFVGTVVTTIGFGMTTPATTGGKVFLIFYGLIGCASTILFFNLFLERLITVIAYVMRTCHHQQLRRRGTVARDNGKAPRKGEADSLAGWKPSVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVAFSTIGFGDLVSSQNAQYENEGLYRFVNFFFILMGVCCIYSMFNVISILIKQTVNWILRKLDSGCFPQCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTDGRRLSGEMISMKDTNKVSLAILQKQLSEMANGGPHQTSTSSRDDEFSGGVGAFAVMNNRLAETSGDR

Target ORF information:

RefSeq Version	XM_006240447.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240447.3

ORF Insert Sequence:

ATGGCTGGCC GCGGTTGCAG CTGCAGCCCC GGCCACCTGA ACGAGGACAA CGCGCGCTTC 
CTGCTGCTCG CGGGGCTCAT CCTGCTTTAC CTGCTGGGCG GCGCCGCAGT CTTCTCCGCG 
CTGGAGCTAG CGCAGGAGCT GCAGGCCAAG CAGCGCTGGG AAGAGCGCCT GGCCAACTTC 
AGCAGGGGCC ACAACCTGAG CCGCGAAGAG CTGCGAGGCT TCCTCCGCCA CTACGAGGAA 
GCCACCAAGG CGGGCATCCG CATGGACAGC GTGCGCCCTC GCTGGGACTT CACGGGCGCC 
TTCTACTTCG TGGGCACAGT GGTAACTACC ATAGGGTTCG GGATGACGAC CCCAGCCACA 
ACGGGAGGGA AGGTTTTTCT GATCTTTTAT GGTCTCATTG GATGTGCGAG TACCATCCTC 
TTCTTCAACC TCTTTCTGGA GCGGCTGATC ACCGTCATCG CCTACGTCAT GAGAACCTGC 
CACCACCAGC AGCTGCGCAG ACGTGGGACG GTAGCCCGGG ACAACGGGAA GGCCCCTAGA 
AAGGGCGAGG CAGACAGCCT GGCTGGCTGG AAGCCCTCCG TGTACTACGT CATGCTGATC 
CTGTGCTTGG CATCAGTAGC CATCTCCTGT GGAGCCTCGG CTCTGTACAC CACCATGGAA 
GGCTGGAGCT ACTTTGACTC CGTCTACTTC TGTTTTGTGG CTTTCAGCAC CATTGGCTTC 
GGGGACCTGG TGAGCAGCCA GAACGCTCAG TATGAGAACG AAGGGCTCTA CCGCTTTGTC 
AATTTCTTCT TCATCCTCAT GGGTGTCTGC TGCATCTACT CCATGTTTAA CGTCATCTCC 
ATCCTGATCA AACAGACAGT GAACTGGATC CTGAGGAAAC TGGATAGCGG GTGCTTCCCA 
CAATGCCAAA GAGGACTCCT GCGGTCCAGG AGGAACGTGG TGATGCCGGG CAACATCCGG 
AACAGGTGCA ACATCTCCAT AGAGACGGAC GGGGTGATGG AAAGTGACAC TGATGGGCGA 
CGTCTCTCGG GGGAGATGAT CTCCATGAAG GACACCAACA AGGTCTCCCT GGCCATCCTG 
CAGAAGCAGT TGTCCGAGAT GGCCAATGGT GGACCCCACC AGACCAGCAC ATCCTCCCGG 
GATGATGAGT TCTCAGGGGG CGTGGGAGCC TTTGCAGTAA TGAATAACAG GTTGGCAGAG 
ACCAGTGGGG ACAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnk13 ( XM_008776304.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008774526.1 Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa43558
Clone ID Related Accession (Same CDS sequence)	XM_008776304.2
Accession Version	XM_008776304.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel subfamily K member 13 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (AC_000074.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008776304.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCAT TCCTTCACGC GGATATATTC GATCCCCTGT GGCTAAACGG CTGGGGACCA 
GGTGTGTCTG AAGGGCACGC AGCGCCCTCT TCTGGCCCCA GAGGGCCAGA ACATGCAGAC 
CATCGAGGCT CTCGACCTCT TAAACAACCA CTCCAGGGAT CGGCACAACC GGGTGGAAGC 
ATCGCTGCTC CCTTCCGAGC TCCCGGCGAT CGCGGGCGGA GACCTGCGCA GGAGACTGGC 
CCTGAGGCCA AGAGGCGGAC ACCGGGTGGA GTCGCCACGG TTGGCAGCAG CAGGGCTCCA 
CCTGTTGCAG TGTTTGAGCA CTCCACAGAG AAGGCAGCTC CGGGCACCGA CTTCTGCTCC 
CAGCCCCACT GGGCAGGGCA AGACCATTTG AGAAGGGGAG CCCGGGACCA TCCTGAACCT 
GTCGCACAGA GCAGCGGTCC GCCCTCATGC TGCTGCGGAG CCCGTGTGCC CAGTGGAGAT 
CCGAGCCGGC TGATCTGCCC TTCGCACTGT CCCTGCATCC GTGCGTCTGT CCCAGACCGG 
TCCCAGCCTC TGAGCCTTGG TTGTTCTGGT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008774526.1
CDS	2297..2869
Translation	MNPFLHADIFDPLWLNGWGPGVSEGHAAPSSGPRGPEHADHRGSRPLKQPLQGSAQPGGSIAAPFRAPGDRGRRPAQETGPEAKRRTPGGVATVGSSRAPPVAVFEHSTEKAAPGTDFCSQPHWAGQDHLRRGARDHPEPVAQSSGPPSCCCGARVPSGDPSRLICPSHCPCIRASVPDRSQPLSLGCSG

Target ORF information:

RefSeq Version	XM_008776304.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium two pore domain channel subfamily K member 13 (Kcnk13), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008776304.2

ORF Insert Sequence:

ATGAATCCAT TCCTTCACGC GGATATATTC GATCCCCTGT GGCTAAACGG CTGGGGACCA 
GGTGTGTCTG AAGGGCACGC AGCGCCCTCT TCTGGCCCCA GAGGGCCAGA ACATGCAGAC 
CATCGAGGCT CTCGACCTCT TAAACAACCA CTCCAGGGAT CGGCACAACC GGGTGGAAGC 
ATCGCTGCTC CCTTCCGAGC TCCCGGCGAT CGCGGGCGGA GACCTGCGCA GGAGACTGGC 
CCTGAGGCCA AGAGGCGGAC ACCGGGTGGA GTCGCCACGG TTGGCAGCAG CAGGGCTCCA 
CCTGTTGCAG TGTTTGAGCA CTCCACAGAG AAGGCAGCTC CGGGCACCGA CTTCTGCTCC 
CAGCCCCACT GGGCAGGGCA AGACCATTTG AGAAGGGGAG CCCGGGACCA TCCTGAACCT 
GTCGCACAGA GCAGCGGTCC GCCCTCATGC TGCTGCGGAG CCCGTGTGCC CAGTGGAGAT 
CCGAGCCGGC TGATCTGCCC TTCGCACTGT CCCTGCATCC GTGCGTCTGT CCCAGACCGG 
TCCCAGCCTC TGAGCCTTGG TTGTTCTGGT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K
Neuron97(2)299-312.e6(2018 Jan)
Madry C,Kyrargyri V,Arancibia-C?rcamo IL,Jolivet R,Kohsaka S,Bryan RM,Attwell D

Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons.
Molecular and cellular neurosciences8313-26(2017 Sep)
Haskins W,Benitez S,Mercado JM,Acosta CG

Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology21(1-3)63-74(2008)
Theilig F,Goranova I,Hirsch JR,Wieske M,Unsal S,Bachmann S,Veh RW,Derst C

Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway.
The Journal of biological chemistry278(46)45419-34(2003 Nov)
Hess A,Wijayanti N,Neusch?fer-Rube AP,Katz N,Kietzmann T,Immenschuh S

THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.
The Journal of biological chemistry276(10)7302-11(2001 Mar)
Rajan S,Wischmeyer E,Karschin C,Preisig-M?ller R,Grzeschik KH,Daut J,Karschin A,Derst C

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Kcnk13 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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