Ccnd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccnd2
Entrez Gene ID	64033
Full Name	cyclin D2
General protein information	Preferred Names cyclin D2 Names G1/S-specific cyclin-D2 vin-1 proto-oncogene
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	plays a role in the G1 to S phase transition; involved in regulation of cell proliferation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022267.1	NP_071603.1	G1/S-specific cyclin-D2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	ccnd2	XP_002940348.2
Canis lupus familiaris (dog)	CCND2	XP_854586.1
Mus musculus (house mouse)	Ccnd2	NP_033959.1
Pan troglodytes (chimpanzee)	CCND2	XP_001156857.1
Drosophila melanogaster (fruit fly)	CycD	NP_727913.2
Bos taurus (cattle)	CCND2	NP_001069840.1
Rattus norvegicus (Norway rat)	Ccnd2	NP_071603.1
Danio rerio (zebrafish)	ccnd2a	NP_001082914.1
Homo sapiens (human)	CCND2	NP_001750.1
Gallus gallus (chicken)	CCND2	NP_989544.1

Gene Ontology
Bibliography

Related articles in PubMed

High glucose concentration induces endothelial cell proliferation by regulating cyclin-D2-related miR-98.
Li XX, Liu YM, Li YJ, Xie N, Yan YF, Chi YL, Zhou L, Xie SY, Wang PY
Journal of cellular and molecular medicine20(6)1159-69(2016 06)

CDK4 is an essential insulin effector in adipocytes.
Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escot? X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Hur? S, Abella A, Tinahones FJ, Vendrell J, Dubus P, Bosch F, Kahn CR, Fajas L
The Journal of clinical investigation126(1)335-48(2016 Jan)

Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription.
Murray TV, Smyrnias I, Schnelle M, Mistry RK, Zhang M, Beretta M, Martin D, Anilkumar N, de Silva SM, Shah AM, Brewer AC
Journal of molecular and cellular cardiology7954-68(2015 Feb)

Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer.
Gong J, Li J, Wang Y, Liu C, Jia H, Jiang C, Wang Y, Luo M, Zhao H, Dong L, Song W, Wang F, Wang W, Zhang J, Yu J
Carcinogenesis35(2)497-506(2014 Feb)

Impaired long-term memory retention: common denominator for acutely or genetically reduced hippocampal neurogenesis in adult mice.
Ben Abdallah NM, Filipkowski RK, Pruschy M, Jaholkowski P, Winkler J, Kaczmarek L, Lipp HP
Behavioural brain research252275-86(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study demonstrated that high glucose concentration induces cyclin D2 up-regulation and miR-98 down-regulation in the rat aortic endothelial cells.
Title: High glucose concentration induces endothelial cell proliferation by regulating cyclin-D2-related miR-98.

Activation of the ERK1/2 signalling pathway, increased phosphorylation of c-myc and significantly increased expression of cyclin D2 protein, are demonstrated.
Title: Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription.

FSH acutely regulated CCND2 expression through both PKA and PI3K signaling pathways during granulosa cell proliferation and also accelerated its ubiquitination-proteasomal degradation.
Title: Regulation of cyclin D2 expression and degradation by follicle-stimulating hormone during rat granulosa cell proliferation in vitro.

Data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity.
Title: Atrial natriuretic peptide promotes pancreatic islet beta-cell growth and Akt/Foxo1a/cyclin D2 signaling.

Distinct mechanisms keep cyclin D1 and cyclin D2 from activating cell cycle in terminally differentiated cardiomyocytes.
Title: Differential regulation of cyclin D1 and D2 in protecting against cardiomyocyte proliferation.

The following Ccnd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccnd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05586	NM_022267.1 Latest version!	Rattus norvegicus cyclin D2 (Ccnd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccnd2 ( NM_022267.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071603.1 Rattus norvegicus cyclin D2 (Ccnd2), mRNA.

Price & Availability↑

CloneID	ORa05586
Clone ID Related Accession (Same CDS sequence)	NM_022267.1
Accession Version	NM_022267.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	G1/S-specific cyclin-D2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L09752.1. On Jan 20, 2005 this sequence version replaced XM_216276.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L09752.1, FQ233117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTGC TGTGCTGTGA GGTGGACCCG GTCCGCAGGG CCGTGCCGGA CCGCAACCTG 
CTGGAAGACC GCGTCCTGCA GAACCTGTTG ACTATCGAGG AGCGCTACCT CCCGCAATGT 
TCCTATTTCA AGTGCGTGCA GAAGGACATC CAGCCGTACA TGCGCAGGAT GGTGGCTACC 
TGGATGCTAG AGGTCTGTGA GGAACAGAAG TGTGAAGAAG AGGTCTTTCC TCTGGCCATG 
AATTACCTGG ACCGTTTCTT GGCTGGAGTC CCGACTCCTA AGACCCATCT TCAGCTCCTG 
GGCGCTGTGT GCATGTTCCT AGCTTCCAAG CTGAAAGAGA CCATCCCGCT GACTGCGGAA 
AAGCTGTGTA TTTACACCGA CAACTCTGTG AAGCCCCAGG AGCTGCTGGA GTGGGAACTG 
GTAGTGTTGG GTAAGCTGAA GTGGAACCTG GCCGCAGTCA CCCCTCACGA CTTCATTGAG 
CACATCCTTC GCAAGCTGCC CCAGCAAAAG GAGAAGCTGT CCCTGATCCG CAAGCATGCG 
CAGACCTTCA TCGCTCTGTG TGCTACCGAC TTCAAGTTTG CCATGTACCC GCCATCGATG 
ATCGCAACTG GAAGCGTGGG AGCAGCCATC TGCGGGCTTC AGCAGGACGA GGAAGTGAAT 
GCACTCACGT GCGATGCCCT GACGGAGCTG CTGACCAAGA TCACCCACAC CGATGTGGAT 
TGTCTCAAAG CCTGCCAGGA GCAAATCGAG GCTGTGCTGC TTAACAGCCT TCAGCAGTTC 
CGTCAAGAGC AGCACAACGG CTCCAAGTCT GTGGAAGATC CGGACCAAGC CACCACCCCT 
ACAGACGTGC GGGATGTTGA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071603.1
CDS	1..867
Translation	MELLCCEVDPVRRAVPDRNLLEDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQKEKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVNALTCDALTELLTKITHTDVDCLKACQEQIEAVLLNSLQQFRQEQHNGSKSVEDPDQATTPTDVRDVDL

Target ORF information:

RefSeq Version	NM_022267.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin D2 (Ccnd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022267.1

ORF Insert Sequence:

ATGGAGCTGC TGTGCTGTGA GGTGGACCCG GTCCGCAGGG CCGTGCCGGA CCGCAACCTG 
CTGGAAGACC GCGTCCTGCA GAACCTGTTG ACTATCGAGG AGCGCTACCT CCCGCAATGT 
TCCTATTTCA AGTGCGTGCA GAAGGACATC CAGCCGTACA TGCGCAGGAT GGTGGCTACC 
TGGATGCTAG AGGTCTGTGA GGAACAGAAG TGTGAAGAAG AGGTCTTTCC TCTGGCCATG 
AATTACCTGG ACCGTTTCTT GGCTGGAGTC CCGACTCCTA AGACCCATCT TCAGCTCCTG 
GGCGCTGTGT GCATGTTCCT AGCTTCCAAG CTGAAAGAGA CCATCCCGCT GACTGCGGAA 
AAGCTGTGTA TTTACACCGA CAACTCTGTG AAGCCCCAGG AGCTGCTGGA GTGGGAACTG 
GTAGTGTTGG GTAAGCTGAA GTGGAACCTG GCCGCAGTCA CCCCTCACGA CTTCATTGAG 
CACATCCTTC GCAAGCTGCC CCAGCAAAAG GAGAAGCTGT CCCTGATCCG CAAGCATGCG 
CAGACCTTCA TCGCTCTGTG TGCTACCGAC TTCAAGTTTG CCATGTACCC GCCATCGATG 
ATCGCAACTG GAAGCGTGGG AGCAGCCATC TGCGGGCTTC AGCAGGACGA GGAAGTGAAT 
GCACTCACGT GCGATGCCCT GACGGAGCTG CTGACCAAGA TCACCCACAC CGATGTGGAT 
TGTCTCAAAG CCTGCCAGGA GCAAATCGAG GCTGTGCTGC TTAACAGCCT TCAGCAGTTC 
CGTCAAGAGC AGCACAACGG CTCCAAGTCT GTGGAAGATC CGGACCAAGC CACCACCCCT 
ACAGACGTGC GGGATGTTGA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High glucose concentration induces endothelial cell proliferation by regulating cyclin-D2-related miR-98.
Journal of cellular and molecular medicine20(6)1159-69(2016 06)
Li XX,Liu YM,Li YJ,Xie N,Yan YF,Chi YL,Zhou L,Xie SY,Wang PY

CDK4 is an essential insulin effector in adipocytes.
The Journal of clinical investigation126(1)335-48(2016 Jan)
Lagarrigue S,Lopez-Mejia IC,Denechaud PD,Escot? X,Castillo-Armengol J,Jimenez V,Chavey C,Giralt A,Lai Q,Zhang L,Martinez-Carreres L,Delacuisine B,Annicotte JS,Blanchet E,Hur? S,Abella A,Tinahones FJ,Vendrell J,Dubus P,Bosch F,Kahn CR,Fajas L

Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription.
Journal of molecular and cellular cardiology7954-68(2015 Feb)
Murray TV,Smyrnias I,Schnelle M,Mistry RK,Zhang M,Beretta M,Martin D,Anilkumar N,de Silva SM,Shah AM,Brewer AC

Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer.
Carcinogenesis35(2)497-506(2014 Feb)
Gong J,Li J,Wang Y,Liu C,Jia H,Jiang C,Wang Y,Luo M,Zhao H,Dong L,Song W,Wang F,Wang W,Zhang J,Yu J

Impaired long-term memory retention: common denominator for acutely or genetically reduced hippocampal neurogenesis in adult mice.
Behavioural brain research252275-86(2013 Sep)
Ben Abdallah NM,Filipkowski RK,Pruschy M,Jaholkowski P,Winkler J,Kaczmarek L,Lipp HP

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Ccnd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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