Fxyd7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fxyd7
Entrez Gene ID	63848
Full Name	FXYD domain-containing ion transport regulator 7
General protein information	Preferred Names FXYD domain-containing ion transport regulator 7 Names FXYD domain-containing ion transport regulator 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	This reference sequence was derived from multiple ESTs and validated by similar mouse cDNA and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022008.1	NP_071291.1	FXYD domain-containing ion transport regulator 7
XM_006228843.3	XP_006228905.1	FXYD domain-containing ion transport regulator 7 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	FXYD7	NP_071289.1
	LOC718457	XP_001111156.2
Bos taurus (cattle)	FXYD7	NP_001032716.1
Rattus norvegicus (Norway rat)	Fxyd7	NP_071291.1
Mus musculus (house mouse)	Fxyd7	NP_071290.1

Gene Ontology
Bibliography

Related articles in PubMed

FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.
B?guin P, Crambert G, Monnet-Tschudi F, Uldry M, Horisberger JD, Garty H, Geering K
The EMBO journal21(13)3264-73(2002 Jul)

The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.
Sweadner KJ, Rael E
Genomics68(1)41-56(2000 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expressed only in brain, rat FXYD7 is a type I membrane protein with N-terminal, post-translational Thr modifications, important for stability. FXYD7 is a tissue- and isoform-specific Na,K-ATPase regulator. It may play a role in neuronal excitability.
Title: FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.

The following Fxyd7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fxyd7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05354	NM_022008.1 Latest version!	Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa22619	XM_006228843.3 Latest version!	Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fxyd7 ( NM_022008.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071291.1 Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), mRNA.

Price & Availability↑

CloneID	ORa05354
Clone ID Related Accession (Same CDS sequence)	NM_022008.1
Accession Version	NM_022008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	FXYD domain-containing ion transport regulator 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from AW914994.1. ##Evidence-Data-START## Transcript exon combination :: CB616439.1, CB614424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN04563759 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCC CAACCCAGAG CCCCACAAAC GTTCCTGAAG AAACAGATCC TTTTTTCTAT 
GACTATGCCA CCGTGCAGAC TGTGGGGATG ACCCTGGCCA CTATCATGTT CGTGCTGGGC 
ATCATCATCA TCATCAGCAA GAAGGTTAAG TGCAGGAAGG CGGACTCCAG GTCTGAGAGC 
CCAACATGCA AATCCTGTAA GTCGGAACTG CCCTCCTCAG CCCCTGGAGG TGGCGGTGTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071291.1
CDS	88..330
Translation	MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIIIISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV

Target ORF information:

RefSeq Version	NM_022008.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022008.1

ORF Insert Sequence:

ATGGCCACCC CAACCCAGAG CCCCACAAAC GTTCCTGAAG AAACAGATCC TTTTTTCTAT 
GACTATGCCA CCGTGCAGAC TGTGGGGATG ACCCTGGCCA CTATCATGTT CGTGCTGGGC 
ATCATCATCA TCATCAGCAA GAAGGTTAAG TGCAGGAAGG CGGACTCCAG GTCTGAGAGC 
CCAACATGCA AATCCTGTAA GTCGGAACTG CCCTCCTCAG CCCCTGGAGG TGGCGGTGTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fxyd7 ( XM_006228843.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006228905.1 Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22619
Clone ID Related Accession (Same CDS sequence)	XM_006228843.3
Accession Version	XM_006228843.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 234bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	FXYD domain-containing ion transport regulator 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228843.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCACCC CAACCCAGAG CCCCACAAAC GTTCCTGAAG AAACAGATCC TTTTTTCTAT 
GACTATGCCA CCGTGCAGAC TGTGGGGATG ACCCTGGCCA CTATCATGTT CGTGCTGGGC 
ATCATCATCA TCATCAGCAA GAAGGTTAAG TGCAGGAAGG CGGACTCCAG CCCAACATGC 
AAATCCTGTA AGTCGGAACT GCCCTCCTCA GCCCCTGGAG GTGGCGGTGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006228905.1
CDS	169..402
Translation	MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIIIISKKVKCRKADSSPTCKSCKSELPSSAPGGGGV

Target ORF information:

RefSeq Version	XM_006228843.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228843.3

ORF Insert Sequence:

ATGGCCACCC CAACCCAGAG CCCCACAAAC GTTCCTGAAG AAACAGATCC TTTTTTCTAT 
GACTATGCCA CCGTGCAGAC TGTGGGGATG ACCCTGGCCA CTATCATGTT CGTGCTGGGC 
ATCATCATCA TCATCAGCAA GAAGGTTAAG TGCAGGAAGG CGGACTCCAG CCCAACATGC 
AAATCCTGTA AGTCGGAACT GCCCTCCTCA GCCCCTGGAG GTGGCGGTGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes.
The EMBO journal21(13)3264-73(2002 Jul)
B?guin P,Crambert G,Monnet-Tschudi F,Uldry M,Horisberger JD,Garty H,Geering K

The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.
Genomics68(1)41-56(2000 Aug)
Sweadner KJ,Rael E

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Fxyd7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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