Slc6a17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a17
Entrez Gene ID	613226
Full Name	solute carrier family 6 member 17
Synonyms	Ntt4
General protein information	Preferred Names solute carrier family 6 member 17 Names sodium-dependent neutral amino acid transporter SLC6A17 orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 sodium-dependent neurotransmitter transporter NTT4 solute carrier family 6 (neurotransmitter transporter), member 17 solute carrier family 6 (neutral amino acid transporter), member 17
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033079.1	NP_001028251.1	sodium-dependent neutral amino acid transporter SLC6A17

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC6A17	XP_513652.2
Rattus norvegicus (Norway rat)	Slc6a17	NP_001028251.1
Drosophila melanogaster (fruit fly)	CG43066	NP_611340.1
Mus musculus (house mouse)	Slc6a17	NP_758475.1
Gallus gallus (chicken)	SLC6A17	XP_417942.3
	SLC6A17	XP_001099500.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011279	XP_309367.2
Xenopus tropicalis (tropical clawed frog)	slc6a17	XP_002933031.1
Homo sapiens (human)	SLC6A17	NP_001010898.1
Bos taurus (cattle)	SLC6A17	NP_001160045.1
Canis lupus familiaris (dog)	SLC6A17	XP_547236.2
Danio rerio (zebrafish)	slc6a17	NP_001243653.1

Gene Ontology
Bibliography

Related articles in PubMed

Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems.
Iqbal Z, Willemsen MH, Papon MA, Musante L, Benevento M, Hu H, Venselaar H, Wissink-Lindhout WM, Vulto-van Silfhout AT, Vissers LE, de Brouwer AP, Marouillat S, Wienker TF, Ropers HH, Kahrizi K, Nadif Kasri N, Najmabadi H, Laumonnier F, Kleefstra T, van Bokhoven H
American journal of human genetics96(3)386-96(2015 Mar)

Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system.
H?gglund MG, Hellsten SV, Bagchi S, Ljungdahl A, Nilsson VC, Winnergren S, Stephansson O, Rumaks J, Svirskis S, Klusa V, Schi?th HB, Fredriksson R
BMC neuroscience1454(2013 May)

Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.
Zaia KA, Reimer RJ
The Journal of biological chemistry284(13)8439-48(2009 Mar)

Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, M?ller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC
The Journal of biological chemistry284(12)7606-22(2009 Mar)

The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine.
Parra LA, Baust T, El Mestikawy S, Quiroz M, Hoffman B, Haflett JM, Yao JK, Torres GE
Molecular pharmacology74(6)1521-32(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data of this results suggested that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses.
Title: Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system.

The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine.
Title: Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.

Expression of Slc6a17 increases ~9-fold at night in the rat pineal gland. Expression appears to be regulated by neural mechanisms involving norepinephrine and cyclic AMP signaling.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

The following Slc6a17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08500	NM_001033079.1 Latest version!	Rattus norvegicus solute carrier family 6 member 17 (Slc6a17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a17 ( NM_001033079.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001028251.1 Rattus norvegicus solute carrier family 6 member 17 (Slc6a17), mRNA.

Price & Availability↑

CloneID	ORa08500
Clone ID Related Accession (Same CDS sequence)	NM_001033079.1
Accession Version	NM_001033079.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	sodium-dependent neutral amino acid transporter SLC6A17
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L06434.2. ##Evidence-Data-START## Transcript exon combination :: L06434.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCGAAGA ACAGCAAGGT GACCCAGCGT GAACACAGCA ATGAGCATGT CACTGAGTCG 
GTGGCTGACC TGCTGGCCCT CGAGGAGCCT GTGGACTATA AGCAGAGTGT ACTGAACGTG 
GCTGGTGAGA CAGGTGGCAA GCAGAAGGTG GCGGAGGAGG AGCTGGACGC AGAGGACCGG 
CCAGCCTGGA ACAGCAAGCT GCAGTACATC CTGGCCCAGA TCGGCTTTTC TGTGGGCCTT 
GGCAACATCT GGAGGTTCCC CTACCTGTGC CAGAAAAATG GAGGAGGTGC CTACCTGGTG 
CCCTACCTGG TGCTGCTGAT CATTATTGGC ATCCCCCTCT TCTTTCTGGA GCTGGCTGTG 
GGCCAGAGGA TCCGCCGTGG CAGCATTGGG GTCTGGCACT ATGTGTGCCC CCGCCTGGGG 
GGCATTGGCT TTTCCAGCTG TATTGTCTGC CTCTTCGTTG GGCTGTACTA CAACGTGATC 
ATTGGATGGA GCGTCTTCTA CTTCTTCAAG TCTTTCCAGT ACCCACTGCC CTGGAGTGAA 
TGTCCTGTCA TCAGGAATGG GACTGTGGCA GTGGTGGAGC CTGAGTGCGA GAAGAGCTCA 
GCTACTACCT ACTTCTGGTA TCGAGAGGCC TTGGACATCT CCAACTCCAT CTCAGAGAGT 
GGGGGCCTCA ACTGGAAGAT GACAGTCTGC CTCCTTGTGG CCTGGAGCAT CGTGGGCATG 
GCTGTAGTCA AGGGCATCCA GTCCTCTGGA AAGGTAATGT ATTTCAGCTC CCTCTTCCCC 
TATGTGGTGT TGGCCTGCTT CCTGGTCCGG GGACTGCTGC TTCGAGGGGC AGTTGATGGC 
ATCCTGCACA TGTTCACTCC TAAGCTGGAC AAGATGCTGG ACCCCCAGGT GTGGCGGGAG 
GCAGCCACGC AGGTCTTCTT CGCCCTGGGG CTGGGCTTTG GAGGTGTCAT CGCCTTTTCC 
AGCTACAACA AACAGGACAA TAACTGCCAC TTCGATGCTG CCTTGGTGTC CTTCATCAAC 
TTCTTCACCT CCGTGTTGGC CACCCTCGTG GTGTTTGCAG TGCTGGGTTT CAAAGCTAAC 
ATCATGAATG AGAAGTGTGT GGTCGAGAAT GCTGAGAAAA TTCTAGGGTA CCTCAACTCC 
AATGTCTTGA GCCGGGACCT CATCCCACCC CACGTCAACT TCTCTCACCT GACCACCAAG 
GACTACTCAG AGATGTACAA TGTCATCATG ACTGTTAAGG AGAAGCAGTT CTCAGCCCTG 
GGCCTGGATC CTTGCCTCCT GGAGGATGAG CTGGACAAGT CTGTGCAGGG CACAGGCCTG 
GCCTTCATCG CCTTCACTGA GGCCATGACA CATTTCCCGG CCTCTCCGTT CTGGTCGGTC 
ATGTTCTTCC TGATGCTCAT CAACCTGGGC CTGGGCAGTA TGATTGGGAC CATGGCAGGA 
ATCACCACAC CTATCATCGA CACCTTCAAG GTGCCCAAGG AGATGTTCAC AGTGGGCTGC 
TGTGTCTTTG CATTCTTCGT GGGGCTATTG TTCGTCCAGC GCTCCGGAAA CTACTTTGTC 
ACCATGTTTG ATGACTATTC GGCCACCCTG CCACTCACCG TCATCGTCAT CCTTGAGAAC 
ATCGCTGTGG CCTGGATTTA CGGAACCAAG AAGTTTATGC AGGAGCTGAC AGAGATGCTG 
GGCTTCCGAC CGTACCGATT CTATTTCTAC ATGTGGAAGT TTGTGTCTCC ACTGTGCATG 
GCTGTCCTCA CCACAGCCAG CATCATCCAG CTGGGGGTGT CACCCCCAGG CTACAGTGCC 
TGGATTAAGG AGGAGGCCGC CGAGCGCTAC TTGTACTTCC CCAATTGGGC CATGGCACTG 
CTGATCACCC TCATTGCTGT GGCAACCCTG CCTATCCCTG TGGTGTTCAT CCTGAGGCAC 
TTCCACCTGC TCTCTGATGG TTCCAACACC CTCTCCGTGT CCTACAAGAA GGGCCGCATG 
ATGAAGGACA TCTCCAACCT GGAGGAGAAC GATGAGACAC GCTTCATCCT CAGCAAGGTG 
CCCAGTGAGG CACCCTCCCC CATGCCCACC CACCGCTCCT ATCTGGGGCC TGGCAGCACA 
TCACCCTTGG AGAGCAGCAG TCACCCCAAT GGACGATACG GGAGCGGCTA CCTCTTGGCC 
AGCACCCCTG AGTCAGAGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028251.1
CDS	475..2658
Translation	MPKNSKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGETGGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVVFILRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLESSSHPNGRYGSGYLLASTPESEL

Target ORF information:

RefSeq Version	NM_001033079.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 6 member 17 (Slc6a17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033079.1

ORF Insert Sequence:

ATGCCGAAGA ACAGCAAGGT GACCCAGCGT GAACACAGCA ATGAGCATGT CACTGAGTCG 
GTGGCTGACC TGCTGGCCCT CGAGGAGCCT GTGGACTATA AGCAGAGTGT ACTGAACGTG 
GCTGGTGAGA CAGGTGGCAA GCAGAAGGTG GCGGAGGAGG AGCTGGACGC AGAGGACCGG 
CCAGCCTGGA ACAGCAAGCT GCAGTACATC CTGGCCCAGA TCGGCTTTTC TGTGGGCCTT 
GGCAACATCT GGAGGTTCCC CTACCTGTGC CAGAAAAATG GAGGAGGTGC CTACCTGGTG 
CCCTACCTGG TGCTGCTGAT CATTATTGGC ATCCCCCTCT TCTTTCTGGA GCTGGCTGTG 
GGCCAGAGGA TCCGCCGTGG CAGCATTGGG GTCTGGCACT ATGTGTGCCC CCGCCTGGGG 
GGCATTGGCT TTTCCAGCTG TATTGTCTGC CTCTTCGTTG GGCTGTACTA CAACGTGATC 
ATTGGATGGA GCGTCTTCTA CTTCTTCAAG TCTTTCCAGT ACCCACTGCC CTGGAGTGAA 
TGTCCTGTCA TCAGGAATGG GACTGTGGCA GTGGTGGAGC CTGAGTGCGA GAAGAGCTCA 
GCTACTACCT ACTTCTGGTA TCGAGAGGCC TTGGACATCT CCAACTCCAT CTCAGAGAGT 
GGGGGCCTCA ACTGGAAGAT GACAGTCTGC CTCCTTGTGG CCTGGAGCAT CGTGGGCATG 
GCTGTAGTCA AGGGCATCCA GTCCTCTGGA AAGGTAATGT ATTTCAGCTC CCTCTTCCCC 
TATGTGGTGT TGGCCTGCTT CCTGGTCCGG GGACTGCTGC TTCGAGGGGC AGTTGATGGC 
ATCCTGCACA TGTTCACTCC TAAGCTGGAC AAGATGCTGG ACCCCCAGGT GTGGCGGGAG 
GCAGCCACGC AGGTCTTCTT CGCCCTGGGG CTGGGCTTTG GAGGTGTCAT CGCCTTTTCC 
AGCTACAACA AACAGGACAA TAACTGCCAC TTCGATGCTG CCTTGGTGTC CTTCATCAAC 
TTCTTCACCT CCGTGTTGGC CACCCTCGTG GTGTTTGCAG TGCTGGGTTT CAAAGCTAAC 
ATCATGAATG AGAAGTGTGT GGTCGAGAAT GCTGAGAAAA TTCTAGGGTA CCTCAACTCC 
AATGTCTTGA GCCGGGACCT CATCCCACCC CACGTCAACT TCTCTCACCT GACCACCAAG 
GACTACTCAG AGATGTACAA TGTCATCATG ACTGTTAAGG AGAAGCAGTT CTCAGCCCTG 
GGCCTGGATC CTTGCCTCCT GGAGGATGAG CTGGACAAGT CTGTGCAGGG CACAGGCCTG 
GCCTTCATCG CCTTCACTGA GGCCATGACA CATTTCCCGG CCTCTCCGTT CTGGTCGGTC 
ATGTTCTTCC TGATGCTCAT CAACCTGGGC CTGGGCAGTA TGATTGGGAC CATGGCAGGA 
ATCACCACAC CTATCATCGA CACCTTCAAG GTGCCCAAGG AGATGTTCAC AGTGGGCTGC 
TGTGTCTTTG CATTCTTCGT GGGGCTATTG TTCGTCCAGC GCTCCGGAAA CTACTTTGTC 
ACCATGTTTG ATGACTATTC GGCCACCCTG CCACTCACCG TCATCGTCAT CCTTGAGAAC 
ATCGCTGTGG CCTGGATTTA CGGAACCAAG AAGTTTATGC AGGAGCTGAC AGAGATGCTG 
GGCTTCCGAC CGTACCGATT CTATTTCTAC ATGTGGAAGT TTGTGTCTCC ACTGTGCATG 
GCTGTCCTCA CCACAGCCAG CATCATCCAG CTGGGGGTGT CACCCCCAGG CTACAGTGCC 
TGGATTAAGG AGGAGGCCGC CGAGCGCTAC TTGTACTTCC CCAATTGGGC CATGGCACTG 
CTGATCACCC TCATTGCTGT GGCAACCCTG CCTATCCCTG TGGTGTTCAT CCTGAGGCAC 
TTCCACCTGC TCTCTGATGG TTCCAACACC CTCTCCGTGT CCTACAAGAA GGGCCGCATG 
ATGAAGGACA TCTCCAACCT GGAGGAGAAC GATGAGACAC GCTTCATCCT CAGCAAGGTG 
CCCAGTGAGG CACCCTCCCC CATGCCCACC CACCGCTCCT ATCTGGGGCC TGGCAGCACA 
TCACCCTTGG AGAGCAGCAG TCACCCCAAT GGACGATACG GGAGCGGCTA CCTCTTGGCC 
AGCACCCCTG AGTCAGAGCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems.
American journal of human genetics96(3)386-96(2015 Mar)
Iqbal Z,Willemsen MH,Papon MA,Musante L,Benevento M,Hu H,Venselaar H,Wissink-Lindhout WM,Vulto-van Silfhout AT,Vissers LE,de Brouwer AP,Marouillat S,Wienker TF,Ropers HH,Kahrizi K,Nadif Kasri N,Najmabadi H,Laumonnier F,Kleefstra T,van Bokhoven H

Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system.
BMC neuroscience1454(2013 May)
H?gglund MG,Hellsten SV,Bagchi S,Ljungdahl A,Nilsson VC,Winnergren S,Stephansson O,Rumaks J,Svirskis S,Klusa V,Schi?th HB,Fredriksson R

Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.
The Journal of biological chemistry284(13)8439-48(2009 Mar)
Zaia KA,Reimer RJ

Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
The Journal of biological chemistry284(12)7606-22(2009 Mar)
Bailey MJ,Coon SL,Carter DA,Humphries A,Kim JS,Shi Q,Gaildrat P,Morin F,Ganguly S,Hogenesch JB,Weller JL,Rath MF,M?ller M,Baler R,Sugden D,Rangel ZG,Munson PJ,Klein DC

The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine.
Molecular pharmacology74(6)1521-32(2008 Dec)
Parra LA,Baust T,El Mestikawy S,Quiroz M,Hoffman B,Haflett JM,Yao JK,Torres GE

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Slc6a17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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