Il1rn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il1rn
Entrez Gene ID	60582
Full Name	interleukin 1 receptor antagonist
Synonyms	IL-1ra
General protein information	Preferred Names interleukin 1 receptor antagonist Names interleukin-1 receptor antagonist protein IL-1RN IL1 inhibitor IRAP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p13
Summary	binds to IL-1 receptor, blocking the binding of IL-1 alpha and -beta [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022194.2	NP_071530.1	interleukin-1 receptor antagonist protein precursor
XM_006233636.3	XP_006233698.1	interleukin-1 receptor antagonist protein isoform X1
XM_006233637.3	XP_006233699.1	interleukin-1 receptor antagonist protein isoform X2
XM_006233638.3	XP_006233700.1	interleukin-1 receptor antagonist protein isoform X2

Pathways from BioSystems

Homologies

	IL1RN	XP_001091833.1
Canis lupus familiaris (dog)	IL1RN	NP_001003096.1
Mus musculus (house mouse)	Il1rn	NP_001034790.1
Homo sapiens (human)	IL1RN	NP_776214.1
Pan troglodytes (chimpanzee)	IL1RN	XP_003949932.1
Bos taurus (cattle)	IL1RN	NP_776782.1
Rattus norvegicus (Norway rat)	Il1rn	NP_071530.1
Gallus gallus (chicken)	IL1B	NP_989855.1

Gene Ontology
Bibliography

Related articles in PubMed

Tobacco smoking associated with the increases of the bronchoalveolar levels of interleukin-5 and interleukin-1 receptor antagonist in acute eosinophilic pneumonia.
Teng Y, Gao Y
European review for medical and pharmacological sciences18(6)887-93(2014)

Brain interleukin-1? and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats.
Yamato M, Tamura Y, Eguchi A, Kume S, Miyashige Y, Nakano M, Watanabe Y, Kataoka Y
PloS one9(3)e90950(2014)

Therapeutic effect of exogenous bone marrow?derived mesenchymal stem cell transplantation on silicosis via paracrine mechanisms in rats.
Zhao MM, Cui JZ, Cui Y, Li R, Tian YX, Song SX, Zhang J, Gao JL
Molecular medicine reports8(3)741-6(2013 Sep)

Interleukin-1? and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis.
Prins M, Eriksson C, Wierinckx A, Bol JG, Binnekade R, Tilders FJ, Van Dam AM
PloS one8(12)e83835(2013)

Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease.
Vijmasi T, Chen FY, Chen YT, Gallup M, McNamara N
Molecular vision191957-65(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state
Title: Brain interleukin-1? and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats.

Gene expression of the natural IL-1 receptor antagonist IL-1ra and IL-18 (but not TNFalpha) is increased in the ipsilateral hippocampus during long-term potentiation.
Title: A cytokine network involving brain-borne IL-1?, IL-1ra, IL-18, IL-6, and TNF? operates during long-term potentiation and learning.

Interleukin-1beta and interleukin-1 receptor antagonist appear in grey matter additionally to white matter during experimental multiple sclerosis
Title: Interleukin-1? and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis.

the IL-1ra gene could be transferred and expressed in corneal tissue efficiently. This may be a novel technique for gene transfection to the cornea in situ.
Title: An experimental study on in situ transfection of the interleukin-1 receptor antagonist (IL-1ra) gene into the rat cornea.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.
Title: Energy-sensing factors coactivator peroxisome proliferator-activated receptor ? coactivator 1-? (PGC-1?) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

The following Il1rn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il1rn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13381	NM_022194.2 Latest version!	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa25474	XM_006233636.3 Latest version!	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa25475	XM_006233638.3 Latest version!	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa25475	XM_006233637.3 Latest version!	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il1rn ( NM_022194.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071530.1 Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), mRNA.

Price & Availability↑

CloneID	ORa13381
Clone ID Related Accession (Same CDS sequence)	NM_022194.2
Accession Version	NM_022194.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-1 receptor antagonist protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CK364274.1 and BC070930.1. On or before Jun 25, 2006 this sequence version replaced XM_001071294.1, XM_001071330.1, NM_022194.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070930.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAATCT GCAGGGGACC TTACAGTCAC CTAATCTCTC TCCTTCTCAT CCTTCTGTTT 
CGTTCAGAGT CAGCTGGCCA CCCTGCTGGG AAAAGACCCT GCAAGATGCA AGCCTTCAGA 
ATCTGGGATA CTAACCAGAA GACCTTCTAC CTGAGGAACA ACCAGCTCAT TGCTGGGTAC 
TTACAAGGAC CAAATACCAA ACTAGAAGAA AAGATAGACA TGGTGCCTAT TGACTTTCGG 
AATGTGTTCT TGGGCATCCA CGGGGGCAAG CTGTGCCTGT CTTGTGTCAA GTCTGGAGAT 
GACACCAAGC TCCAGCTGGA GGAGGTTAAC ATCACTGATC TGAACAAGAA CAAAGAAGAA 
GACAAGCGCT TTACCTTCAT CCGCTCCGAG ACAGGCCCTA CCACCAGCTT CGAATCACTT 
GCCTGTCCAG GATGGTTCCT CTGCACAACA CTAGAGGCTG ATCATCCCGT GAGCCTCACC 
AACACACCAA AAGAGCCCTG TACAGTCACA AAGTTCTACT TCCAGGAAGA CCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071530.1
CDS	5..541
Translation	MEICRGPYSHLISLLLILLFRSESAGHPAGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDTKLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLTNTPKEPCTVTKFYFQEDQ

Target ORF information:

RefSeq Version	NM_022194.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022194.2

ORF Insert Sequence:

ATGGAAATCT GCAGGGGACC TTACAGTCAC CTAATCTCTC TCCTTCTCAT CCTTCTGTTT 
CGTTCAGAGT CAGCTGGCCA CCCTGCTGGG AAAAGACCCT GCAAGATGCA AGCCTTCAGA 
ATCTGGGATA CTAACCAGAA GACCTTCTAC CTGAGGAACA ACCAGCTCAT TGCTGGGTAC 
TTACAAGGAC CAAATACCAA ACTAGAAGAA AAGATAGACA TGGTGCCTAT TGACTTTCGG 
AATGTGTTCT TGGGCATCCA CGGGGGCAAG CTGTGCCTGT CTTGTGTCAA GTCTGGAGAT 
GACACCAAGC TCCAGCTGGA GGAGGTTAAC ATCACTGATC TGAACAAGAA CAAAGAAGAA 
GACAAGCGCT TTACCTTCAT CCGCTCCGAG ACAGGCCCTA CCACCAGCTT CGAATCACTT 
GCCTGTCCAG GATGGTTCCT CTGCACAACA CTAGAGGCTG ATCATCCCGT GAGCCTCACC 
AACACACCAA AAGAGCCCTG TACAGTCACA AAGTTCTACT TCCAGGAAGA CCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il1rn ( XM_006233636.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233698.1 Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25474
Clone ID Related Accession (Same CDS sequence)	XM_006233636.3
Accession Version	XM_006233636.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-1 receptor antagonist protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233636.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTCAG AGTCAGCTGG CCACCCTGCT GGGAAAAGAC CCTGCAAGAT GCAAGCCTTC 
AGAATCTGGG ATACTAACCA GAAGACCTTC TACCTGAGGA ACAACCAGCT CATTGCTGGG 
TACTTACAAG GACCAAATAC CAAACTAGAA GAAAAGATAG ACATGGTGCC TATTGACTTT 
CGGAATGTGT TCTTGGGCAT CCACGGGGGC AAGCTGTGCC TGTCTTGTGT CAAGTCTGGA 
GATGACACCA AGCTCCAGCT GGAGGAGGTT AACATCACTG ATCTGAACAA GAACAAAGAA 
GAAGACAAGC GCTTTACCTT CATCCGCTCC GAGACAGGCC CTACCACCAG CTTCGAATCA 
CTTGCCTGTC CAGGATGGTT CCTCTGCACA ACACTAGAGG CTGATCATCC CGTGAGCCTC 
ACCAACACAC CAAAAGAGCC CTGTACAGTC ACAAAGTTCT ACTTCCAGGA AGACCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233698.1
CDS	3063..3542
Translation	MASESAGHPAGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDTKLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLTNTPKEPCTVTKFYFQEDQ

Target ORF information:

RefSeq Version	XM_006233636.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233636.3

ORF Insert Sequence:

ATGGCTTCAG AGTCAGCTGG CCACCCTGCT GGGAAAAGAC CCTGCAAGAT GCAAGCCTTC 
AGAATCTGGG ATACTAACCA GAAGACCTTC TACCTGAGGA ACAACCAGCT CATTGCTGGG 
TACTTACAAG GACCAAATAC CAAACTAGAA GAAAAGATAG ACATGGTGCC TATTGACTTT 
CGGAATGTGT TCTTGGGCAT CCACGGGGGC AAGCTGTGCC TGTCTTGTGT CAAGTCTGGA 
GATGACACCA AGCTCCAGCT GGAGGAGGTT AACATCACTG ATCTGAACAA GAACAAAGAA 
GAAGACAAGC GCTTTACCTT CATCCGCTCC GAGACAGGCC CTACCACCAG CTTCGAATCA 
CTTGCCTGTC CAGGATGGTT CCTCTGCACA ACACTAGAGG CTGATCATCC CGTGAGCCTC 
ACCAACACAC CAAAAGAGCC CTGTACAGTC ACAAAGTTCT ACTTCCAGGA AGACCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il1rn ( XM_006233637.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233699.1 Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa25475
Clone ID Related Accession (Same CDS sequence)	XM_006233637.3 , XM_006233638.3
Accession Version	XM_006233637.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-1 receptor antagonist protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233637.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAAGCCT TCAGAATCTG GGATACTAAC CAGAAGACCT TCTACCTGAG GAACAACCAG 
CTCATTGCTG GGTACTTACA AGGACCAAAT ACCAAACTAG AAGAAAAGAT AGACATGGTG 
CCTATTGACT TTCGGAATGT GTTCTTGGGC ATCCACGGGG GCAAGCTGTG CCTGTCTTGT 
GTCAAGTCTG GAGATGACAC CAAGCTCCAG CTGGAGGAGG TTAACATCAC TGATCTGAAC 
AAGAACAAAG AAGAAGACAA GCGCTTTACC TTCATCCGCT CCGAGACAGG CCCTACCACC 
AGCTTCGAAT CACTTGCCTG TCCAGGATGG TTCCTCTGCA CAACACTAGA GGCTGATCAT 
CCCGTGAGCC TCACCAACAC ACCAAAAGAG CCCTGTACAG TCACAAAGTT CTACTTCCAG 
GAAGACCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233699.1
CDS	145..576
Translation	MQAFRIWDTNQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDTKLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLTNTPKEPCTVTKFYFQEDQ

Target ORF information:

RefSeq Version	XM_006233637.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233637.3

ORF Insert Sequence:

ATGCAAGCCT TCAGAATCTG GGATACTAAC CAGAAGACCT TCTACCTGAG GAACAACCAG 
CTCATTGCTG GGTACTTACA AGGACCAAAT ACCAAACTAG AAGAAAAGAT AGACATGGTG 
CCTATTGACT TTCGGAATGT GTTCTTGGGC ATCCACGGGG GCAAGCTGTG CCTGTCTTGT 
GTCAAGTCTG GAGATGACAC CAAGCTCCAG CTGGAGGAGG TTAACATCAC TGATCTGAAC 
AAGAACAAAG AAGAAGACAA GCGCTTTACC TTCATCCGCT CCGAGACAGG CCCTACCACC 
AGCTTCGAAT CACTTGCCTG TCCAGGATGG TTCCTCTGCA CAACACTAGA GGCTGATCAT 
CCCGTGAGCC TCACCAACAC ACCAAAAGAG CCCTGTACAG TCACAAAGTT CTACTTCCAG 
GAAGACCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il1rn ( XM_006233638.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233700.1 Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa25475
Clone ID Related Accession (Same CDS sequence)	XM_006233637.3 , XM_006233638.3
Accession Version	XM_006233638.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-1 receptor antagonist protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233638.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAAGCCT TCAGAATCTG GGATACTAAC CAGAAGACCT TCTACCTGAG GAACAACCAG 
CTCATTGCTG GGTACTTACA AGGACCAAAT ACCAAACTAG AAGAAAAGAT AGACATGGTG 
CCTATTGACT TTCGGAATGT GTTCTTGGGC ATCCACGGGG GCAAGCTGTG CCTGTCTTGT 
GTCAAGTCTG GAGATGACAC CAAGCTCCAG CTGGAGGAGG TTAACATCAC TGATCTGAAC 
AAGAACAAAG AAGAAGACAA GCGCTTTACC TTCATCCGCT CCGAGACAGG CCCTACCACC 
AGCTTCGAAT CACTTGCCTG TCCAGGATGG TTCCTCTGCA CAACACTAGA GGCTGATCAT 
CCCGTGAGCC TCACCAACAC ACCAAAAGAG CCCTGTACAG TCACAAAGTT CTACTTCCAG 
GAAGACCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233700.1
CDS	125..556
Translation	MQAFRIWDTNQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDTKLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLTNTPKEPCTVTKFYFQEDQ

Target ORF information:

RefSeq Version	XM_006233638.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233638.3

ORF Insert Sequence:

ATGCAAGCCT TCAGAATCTG GGATACTAAC CAGAAGACCT TCTACCTGAG GAACAACCAG 
CTCATTGCTG GGTACTTACA AGGACCAAAT ACCAAACTAG AAGAAAAGAT AGACATGGTG 
CCTATTGACT TTCGGAATGT GTTCTTGGGC ATCCACGGGG GCAAGCTGTG CCTGTCTTGT 
GTCAAGTCTG GAGATGACAC CAAGCTCCAG CTGGAGGAGG TTAACATCAC TGATCTGAAC 
AAGAACAAAG AAGAAGACAA GCGCTTTACC TTCATCCGCT CCGAGACAGG CCCTACCACC 
AGCTTCGAAT CACTTGCCTG TCCAGGATGG TTCCTCTGCA CAACACTAGA GGCTGATCAT 
CCCGTGAGCC TCACCAACAC ACCAAAAGAG CCCTGTACAG TCACAAAGTT CTACTTCCAG 
GAAGACCAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tobacco smoking associated with the increases of the bronchoalveolar levels of interleukin-5 and interleukin-1 receptor antagonist in acute eosinophilic pneumonia.
European review for medical and pharmacological sciences18(6)887-93(2014)
Teng Y,Gao Y

Brain interleukin-1? and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats.
PloS one9(3)e90950(2014)
Yamato M,Tamura Y,Eguchi A,Kume S,Miyashige Y,Nakano M,Watanabe Y,Kataoka Y

Therapeutic effect of exogenous bone marrow?derived mesenchymal stem cell transplantation on silicosis via paracrine mechanisms in rats.
Molecular medicine reports8(3)741-6(2013 Sep)
Zhao MM,Cui JZ,Cui Y,Li R,Tian YX,Song SX,Zhang J,Gao JL

Interleukin-1? and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis.
PloS one8(12)e83835(2013)
Prins M,Eriksson C,Wierinckx A,Bol JG,Binnekade R,Tilders FJ,Van Dam AM

Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease.
Molecular vision191957-65(2013)
Vijmasi T,Chen FY,Chen YT,Gallup M,McNamara N

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Il1rn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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