Slc15a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc15a2
Entrez Gene ID	60577
Full Name	solute carrier family 15 member 2
General protein information	Preferred Names solute carrier family 15 member 2 Names solute carrier family 15 member 2 kidney H(+)/peptide cotransporter oligopeptide transporter, kidney isoform peptide transporter 2 solute carrier family 15 (H+/peptide transporter), member 2 solute carrier family 15 (oligopeptide transporter), member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q21
Summary	acts as a high affinity proton dependent peptide transporter; may transport peptides from cerebrospinal fluid to blood [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031672.2	NP_113860.2	solute carrier family 15 member 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SLC15A2	XP_422093.4
Xenopus tropicalis (tropical clawed frog)	slc15a2	XP_002943192.2
	SLC15A2	NP_001028125.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012154	XP_320378.4
Mus musculus (house mouse)	Slc15a2	NP_067276.2
Danio rerio (zebrafish)	slc15a2	NP_001034917.1
Canis lupus familiaris (dog)	SLC15A2	XP_545128.4
Caenorhabditis elegans (roundworm)	pept-3	NP_491767.3
Homo sapiens (human)	SLC15A2	NP_066568.3
Pan troglodytes (chimpanzee)	SLC15A2	XP_001165943.1
Rattus norvegicus (Norway rat)	Slc15a2	NP_113860.2
Oryza sativa (rice)	Os03g0235700	NP_001049488.1

Gene Ontology
Bibliography

Related articles in PubMed

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.
Gukasyan HJ, Uchiyama T, Kim KJ, Ehrhardt C, Wu SK, Borok Z, Crandall ED, Lee VHL
Pharmaceutical research34(12)2488-2497(2017 Dec)

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
Beale JH, Parker JL, Samsudin F, Barrett AL, Senan A, Bird LE, Scott D, Owens RJ, Sansom MS, Tucker SJ, Meredith D, Fowler PW, Newstead S
Structure (London, England : 1993)23(10)1889-99(2015 Oct)

Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
Hu Y, Xie Y, Keep RF, Smith DE
Journal of neurochemistry129(6)955-65(2014 Jun)

[Expression of PEPT2 mRNA in lung tissue of rats with pulmonary fibrosis].
Li L, Wang D, Zhang X, Song X, Ma X, Hu Z
Zhongguo fei ai za zhi = Chinese journal of lung cancer16(10)541-6(2013 Oct)

Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells.
Takano M, Horiuchi T, Sasaki Y, Kato Y, Nagai J, Yumoto R
Life sciences93(17)630-6(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.
Title: Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.

We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.

No significant changes of pulmonary PEPT2 mRNA expression levels in rats with pulmonary fibrosis compared to the controls.
Title: [Expression of PEPT2 mRNA in lung tissue of rats with pulmonary fibrosis].

PEPT2 is functionally expressed in alveolar type II epithelial cells, but the expression decreases along with transdifferentiation.
Title: Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells.

These findings represent the first evidence that peptide transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular cells.
Title: Functional expression of SLC15 peptide transporters in rat thyroid follicular cells.

The following Slc15a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc15a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12618	NM_031672.2 Latest version!	Rattus norvegicus solute carrier family 15 member 2 (Slc15a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc15a2 ( NM_031672.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113860.2 Rattus norvegicus solute carrier family 15 member 2 (Slc15a2), mRNA.

Price & Availability↑

CloneID	ORa12618
Clone ID Related Accession (Same CDS sequence)	NM_031672.2
Accession Version	NM_031672.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 15 member 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085327.1. On Sep 12, 2012 this sequence version replaced NM_031672.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085327.1, D63149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTTGAGG AGAGAGAGAG TAAGGAGCCA GCCATGAATC CTTTCCAGAA AAATGAGTCC 
AAGGAAACGC TTTTTTCACC TGTCTCTACT GAGGAGATGC TGCCTAGACC TCCGAGCCCT 
CCAAAGAAGT CACCTCCGAA AATCTTTGGC TCCAGCTACC CAGTCAGCAT TGCCTTCATC 
GTGGTGAATG AATTCTGCGA GCGATTTTCC TATTATGGCA TGAAAGCTGT GCTGACCTTG 
TACTTCCTGT ATTTCCTGCA CTGGAATGAA GACACGTCCA CCTCTGTCTA CCATGCCTTC 
AGCAGCCTCT GCTATTTCAC TCCCATCTTG GGTGCGGCCA TTGCTGACTC CTGGCTGGGA 
AAATTCAAGA CAATCATCTA TCTCTCCCTG GTGTATGTTC TTGGCCATGT ATTCAAGTCT 
TTGGGTGCCA TACCAATACT GGGAGGAAAA ATGCTACATA CAATCTTATC ATTGGTTGGT 
CTGAGTCTAA TTGCTCTGGG AACAGGAGGT ATCAAACCCT GTGTGGCAGC TTTCGGCGGA 
GACCAGTTTG AAGAGGAACA TGCAGAGGCA CGGACTAGAT ACTTCTCAGT CTTCTACCTC 
GCCATCAATG CGGGGAGCTT GATTTCCACG TTCATCACAC CCATGCTGAG AGGAGATGTG 
AAGTGTTTTG GCCAAGACTG CTATGCACTG GCTTTTGGAG TTCCAGGATT GCTCATGGTG 
CTGGCACTTG TTGTGTTTGC AATGGGAAGC AAGATGTACA GGAAACCACC TCCTGAAGGG 
AACATAGTGG CTCAAGTTAT CAAATGCATA TGGTTTGCTC TCTGCAACCG CTTCAGGAAC 
CGTTCTGGGG ACCTTCCGAA GCGACAACAC TGGCTAGACT GGGCAGCAGA AAAATATCCA 
AAGCATCTCA TCGCAGATGT GAAGGCCCTG ACCAGGGTAC TGTTTCTTTA TATCCCACTG 
CCCATGTTCT GGGCACTTTT GGACCAACAG GGCTCGCGGT GGACTCTGCA AGCTAACAAG 
ATGAATGGTG ACTTGGGTTT TTTTGTACTT CAGCCGGATC AGATGCAGGT GCTAAATCCC 
TTTCTGGTTC TTATCTTCAT CCCCTTGTTT GACCTTGTCA TTTACCGGCT GATCTCCAAG 
TGCAGAATTA ACTTCTCATC ACTCAGGAAA ATGGCAGTTG GTATGATCCT AGCGTGCTTG 
GCTTTTGCAG TTGCAGCACT TGTCGAGACA AAAATAAATG GAATGATCCA TCCCCAGCCA 
GCTTCCCAAG AGATATTTTT ACAAGTCTTG AATTTGGCAG ATGGTGATGT AAAGGTGACC 
GTGCTGGGCA GTAGAAATAA TTCTCTCTTG GTGGAGTCCG TCAGCTCTTT TCAGAACACA 
ACGCACTATT CAAAACTACA CCTGGAGGCA AAGAGCCAAG ATTTACATTT TCATCTGAAG 
TATAACAGCT TGTCTGTCCA CAATGACCAT TCTGTAGAGG AGAAGAACTG TTACCAGCTG 
CTCATTCACC AGGACGGGGA GAGTATCTCC AGCATGCTGG TCAAGGATAC AGGAATCAAA 
CCAGCCAATG GGATGGCAGC CATCAGGTTT ATTAACACTT TGCATAAAGA CTTGAACATC 
TCCTTGGATA CAGACGCTCC TCTCAGCGTG GGCAAAGACT ACGGAGTGTC TGCATACAGA 
ACTGTGCTAA GAGGAAAGTA TCCTGCAGTG CACTGTGAAA CTGAAGACAA AGTCTTTTCT 
CTCGATTTAG GTCAACTAGA CTTTGGTACA ACATATTTGT TCGTGATCAC TAATATCACC 
AGTCAGGGTC TTCAGGCCTG GAAGGCAGAG GACATTCCAG TCAATAAACT ATCCATTGCA 
TGGCAGCTAC CACAGTATGT CCTGGTTACA GCAGCAGAGG TCATGTTCTC AGTCACAGGA 
CTTGAATTTT CTTATTCTCA GGCACCATCT AGCATGAAAT CTGTGCTCCA GGCGGCCTGG 
TTGTTGACCG TTGCAGTTGG GAATATCATT GTGCTTGTCG TGGCTCAGTT CAGTGGCCTG 
GCACAGTGGG CCGAGTTCGT TTTGTTTTCC TGCCTCCTCC TGGTGGTCTG CCTGATCTTC 
TCCGTCATGG CCTACTACTA CGTTCCTCTA AAGTCAGAAG ATACCCGTGA GGCAACAGAT 
AAGCAGATTC CTGCCGTGCA GGGGAATATG ATTAACCTAG AAACCAAGAA TACAAGGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113860.2
CDS	140..2362
Translation	MLEERESKEPAMNPFQKNESKETLFSPVSTEEMLPRPPSPPKKSPPKIFGSSYPVSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVGLSLIALGTGGIKPCVAAFGGDQFEEEHAEARTRYFSVFYLAINAGSLISTFITPMLRGDVKCFGQDCYALAFGVPGLLMVLALVVFAMGSKMYRKPPPEGNIVAQVIKCIWFALCNRFRNRSGDLPKRQHWLDWAAEKYPKHLIADVKALTRVLFLYIPLPMFWALLDQQGSRWTLQANKMNGDLGFFVLQPDQMQVLNPFLVLIFIPLFDLVIYRLISKCRINFSSLRKMAVGMILACLAFAVAALVETKINGMIHPQPASQEIFLQVLNLADGDVKVTVLGSRNNSLLVESVSSFQNTTHYSKLHLEAKSQDLHFHLKYNSLSVHNDHSVEEKNCYQLLIHQDGESISSMLVKDTGIKPANGMAAIRFINTLHKDLNISLDTDAPLSVGKDYGVSAYRTVLRGKYPAVHCETEDKVFSLDLGQLDFGTTYLFVITNITSQGLQAWKAEDIPVNKLSIAWQLPQYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFSGLAQWAEFVLFSCLLLVVCLIFSVMAYYYVPLKSEDTREATDKQIPAVQGNMINLETKNTRL

Target ORF information:

RefSeq Version	NM_031672.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 15 member 2 (Slc15a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031672.2

ORF Insert Sequence:

ATGCTTGAGG AGAGAGAGAG TAAGGAGCCA GCCATGAATC CTTTCCAGAA AAATGAGTCC 
AAGGAAACGC TTTTTTCACC TGTCTCTACT GAGGAGATGC TGCCTAGACC TCCGAGCCCT 
CCAAAGAAGT CACCTCCGAA AATCTTTGGC TCCAGCTACC CAGTCAGCAT TGCCTTCATC 
GTGGTGAATG AATTCTGCGA GCGATTTTCC TATTATGGCA TGAAAGCTGT GCTGACCTTG 
TACTTCCTGT ATTTCCTGCA CTGGAATGAA GACACGTCCA CCTCTGTCTA CCATGCCTTC 
AGCAGCCTCT GCTATTTCAC TCCCATCTTG GGTGCGGCCA TTGCTGACTC CTGGCTGGGA 
AAATTCAAGA CAATCATCTA TCTCTCCCTG GTGTATGTTC TTGGCCATGT ATTCAAGTCT 
TTGGGTGCCA TACCAATACT GGGAGGAAAA ATGCTACATA CAATCTTATC ATTGGTTGGT 
CTGAGTCTAA TTGCTCTGGG AACAGGAGGT ATCAAACCCT GTGTGGCAGC TTTCGGCGGA 
GACCAGTTTG AAGAGGAACA TGCAGAGGCA CGGACTAGAT ACTTCTCAGT CTTCTACCTC 
GCCATCAATG CGGGGAGCTT GATTTCCACG TTCATCACAC CCATGCTGAG AGGAGATGTG 
AAGTGTTTTG GCCAAGACTG CTATGCACTG GCTTTTGGAG TTCCAGGATT GCTCATGGTG 
CTGGCACTTG TTGTGTTTGC AATGGGAAGC AAGATGTACA GGAAACCACC TCCTGAAGGG 
AACATAGTGG CTCAAGTTAT CAAATGCATA TGGTTTGCTC TCTGCAACCG CTTCAGGAAC 
CGTTCTGGGG ACCTTCCGAA GCGACAACAC TGGCTAGACT GGGCAGCAGA AAAATATCCA 
AAGCATCTCA TCGCAGATGT GAAGGCCCTG ACCAGGGTAC TGTTTCTTTA TATCCCACTG 
CCCATGTTCT GGGCACTTTT GGACCAACAG GGCTCGCGGT GGACTCTGCA AGCTAACAAG 
ATGAATGGTG ACTTGGGTTT TTTTGTACTT CAGCCGGATC AGATGCAGGT GCTAAATCCC 
TTTCTGGTTC TTATCTTCAT CCCCTTGTTT GACCTTGTCA TTTACCGGCT GATCTCCAAG 
TGCAGAATTA ACTTCTCATC ACTCAGGAAA ATGGCAGTTG GTATGATCCT AGCGTGCTTG 
GCTTTTGCAG TTGCAGCACT TGTCGAGACA AAAATAAATG GAATGATCCA TCCCCAGCCA 
GCTTCCCAAG AGATATTTTT ACAAGTCTTG AATTTGGCAG ATGGTGATGT AAAGGTGACC 
GTGCTGGGCA GTAGAAATAA TTCTCTCTTG GTGGAGTCCG TCAGCTCTTT TCAGAACACA 
ACGCACTATT CAAAACTACA CCTGGAGGCA AAGAGCCAAG ATTTACATTT TCATCTGAAG 
TATAACAGCT TGTCTGTCCA CAATGACCAT TCTGTAGAGG AGAAGAACTG TTACCAGCTG 
CTCATTCACC AGGACGGGGA GAGTATCTCC AGCATGCTGG TCAAGGATAC AGGAATCAAA 
CCAGCCAATG GGATGGCAGC CATCAGGTTT ATTAACACTT TGCATAAAGA CTTGAACATC 
TCCTTGGATA CAGACGCTCC TCTCAGCGTG GGCAAAGACT ACGGAGTGTC TGCATACAGA 
ACTGTGCTAA GAGGAAAGTA TCCTGCAGTG CACTGTGAAA CTGAAGACAA AGTCTTTTCT 
CTCGATTTAG GTCAACTAGA CTTTGGTACA ACATATTTGT TCGTGATCAC TAATATCACC 
AGTCAGGGTC TTCAGGCCTG GAAGGCAGAG GACATTCCAG TCAATAAACT ATCCATTGCA 
TGGCAGCTAC CACAGTATGT CCTGGTTACA GCAGCAGAGG TCATGTTCTC AGTCACAGGA 
CTTGAATTTT CTTATTCTCA GGCACCATCT AGCATGAAAT CTGTGCTCCA GGCGGCCTGG 
TTGTTGACCG TTGCAGTTGG GAATATCATT GTGCTTGTCG TGGCTCAGTT CAGTGGCCTG 
GCACAGTGGG CCGAGTTCGT TTTGTTTTCC TGCCTCCTCC TGGTGGTCTG CCTGATCTTC 
TCCGTCATGG CCTACTACTA CGTTCCTCTA AAGTCAGAAG ATACCCGTGA GGCAACAGAT 
AAGCAGATTC CTGCCGTGCA GGGGAATATG ATTAACCTAG AAACCAAGAA TACAAGGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.
Pharmaceutical research34(12)2488-2497(2017 Dec)
Gukasyan HJ,Uchiyama T,Kim KJ,Ehrhardt C,Wu SK,Borok Z,Crandall ED,Lee VHL

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
Structure (London, England : 1993)23(10)1889-99(2015 Oct)
Beale JH,Parker JL,Samsudin F,Barrett AL,Senan A,Bird LE,Scott D,Owens RJ,Sansom MS,Tucker SJ,Meredith D,Fowler PW,Newstead S

Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
Journal of neurochemistry129(6)955-65(2014 Jun)
Hu Y,Xie Y,Keep RF,Smith DE

[Expression of PEPT2 mRNA in lung tissue of rats with pulmonary fibrosis].
Zhongguo fei ai za zhi = Chinese journal of lung cancer16(10)541-6(2013 Oct)
Li L,Wang D,Zhang X,Song X,Ma X,Hu Z

Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells.
Life sciences93(17)630-6(2013 Oct)
Takano M,Horiuchi T,Sasaki Y,Kato Y,Nagai J,Yumoto R

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Slc15a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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