Tsn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tsn
Entrez Gene ID	60381
Full Name	translin
General protein information	Preferred Names translin Names translin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q11
Summary	interacts with the GS1 strand-specific DNA binding complex [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021762.1	NP_068530.1	translin
XM_008769496.2	XP_008767718.1	translin isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TSN	NP_004613.1
	TSN	XP_001085908.1
Bos taurus (cattle)	TSN	NP_001068890.1
Gallus gallus (chicken)	TSN	NP_990404.1
Neurospora crassa	NCU06664	XP_960911.1
Pan troglodytes (chimpanzee)	TSN	XP_515770.1
Mus musculus (house mouse)	Tsn	NP_035780.1
Arabidopsis thaliana (thale cress)	AT2G37020	NP_565857.2
Danio rerio (zebrafish)	tsn	NP_001020623.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005538	XP_315537.4
Magnaporthe oryzae (rice blast fungus)	MGG_05995	XP_003711841.1
Xenopus tropicalis (tropical clawed frog)	mllt4	NP_001007517.1
Canis lupus familiaris (dog)	TSN	XP_003639748.1
Rattus norvegicus (Norway rat)	Tsn	NP_068530.1
Schizosaccharomyces pombe (fission yeast)	tsn1	NP_594557.2
Oryza sativa (rice)	Os10g0443200	NP_001064703.1
Drosophila melanogaster (fruit fly)	trsn	NP_610591.1

Gene Ontology
Bibliography

Related articles in PubMed

Toward an understanding of the protein interaction network of the human liver.
Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X
Molecular systems biology7536(2011 Oct)

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.
Chiaruttini C, Vicario A, Li Z, Baj G, Braiuca P, Wu Y, Lee FS, Gardossi L, Baraban JM, Tongiorgi E
Proceedings of the National Academy of Sciences of the United States of America106(38)16481-6(2009 Sep)

CD8 chemokine receptors in chronic obstructive pulmonary disease.
Smyth LJ, Starkey C, Gordon FS, Vestbo J, Singh D
Clinical and experimental immunology154(1)56-63(2008 Oct)

Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis.
Cho YS, Iguchi N, Yang J, Handel MA, Hecht NB
Biology of reproduction73(4)840-7(2005 Oct)

Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA.
Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB
The Journal of biological chemistry276(16)13256-63(2001 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings implicate abnormal dendritic trafficking of BDNF mRNA in the pathophysiology of neuropsychiatric disorders linked to the translin G196A mutation.
Title: Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.

The following Tsn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tsn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05192	NM_021762.1 Latest version!	Rattus norvegicus translin (Tsn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa43513	XM_008769496.2 Latest version!	Rattus norvegicus translin (Tsn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tsn ( NM_021762.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068530.1 Rattus norvegicus translin (Tsn), mRNA.

Price & Availability↑

CloneID	ORa05192
Clone ID Related Accession (Same CDS sequence)	NM_021762.1
Accession Version	NM_021762.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	translin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF262356.1. ##Evidence-Data-START## Transcript exon combination :: AF262356.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTGCAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
TTACTCCAAG GGGTCCATCA GGGCACTGGG TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCTCGAGAAC ATTTTGGCAC GGTAAAAACA CATCTAACAT CCCTGAAGAC CAAGTTCCCT 
GCTGAACAGT ATTACAGGTT TCATGAGCAC TGGAGGTTTG TGCTTCAGCG CCTGGTCTTC 
CTGGCGGCCT TTGTAGTGTA TTTGGAAACA GAGACTCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATTGAACC GGATCGGGAA AAAGGGTTTC ATCTGGATGT GGAAGATTAT 
CTCTCAGGAG TTTTGATTCT TGCCAGTGAA CTGTCCAGGC TGTCTGTCAA CAGTGTCACT 
GCTGGAGATT ACTCCCGGCC CCTTCACATC TCTACTTTCA TCAATGAGTT GGATTCAGGT 
TTTCGCCTTC TCAATCTGAA AAACGACTCC CTGAGGAAAC GCTACGACGG CTTAAAGTAT 
GATGTGAAGA AAGTAGAGGA GGTGGTCTAT GACCTTTCCA TCCGAGGCTT CAATAAGGAG 
ACAGCAGCGG CTTGTGGTGA AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068530.1
CDS	107..793
Translation	MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK

Target ORF information:

RefSeq Version	NM_021762.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus translin (Tsn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021762.1

ORF Insert Sequence:

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTGCAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
TTACTCCAAG GGGTCCATCA GGGCACTGGG TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCTCGAGAAC ATTTTGGCAC GGTAAAAACA CATCTAACAT CCCTGAAGAC CAAGTTCCCT 
GCTGAACAGT ATTACAGGTT TCATGAGCAC TGGAGGTTTG TGCTTCAGCG CCTGGTCTTC 
CTGGCGGCCT TTGTAGTGTA TTTGGAAACA GAGACTCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATTGAACC GGATCGGGAA AAAGGGTTTC ATCTGGATGT GGAAGATTAT 
CTCTCAGGAG TTTTGATTCT TGCCAGTGAA CTGTCCAGGC TGTCTGTCAA CAGTGTCACT 
GCTGGAGATT ACTCCCGGCC CCTTCACATC TCTACTTTCA TCAATGAGTT GGATTCAGGT 
TTTCGCCTTC TCAATCTGAA AAACGACTCC CTGAGGAAAC GCTACGACGG CTTAAAGTAT 
GATGTGAAGA AAGTAGAGGA GGTGGTCTAT GACCTTTCCA TCCGAGGCTT CAATAAGGAG 
ACAGCAGCGG CTTGTGGTGA AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tsn ( XM_008769496.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008767718.1 Rattus norvegicus translin (Tsn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43513
Clone ID Related Accession (Same CDS sequence)	XM_008769496.2
Accession Version	XM_008769496.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	translin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769496.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTGCAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
TTACTCCAAG GGGTCCATCA GGGCACTGGG TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCTCGAGAAC ATTTTGGCAC GGTAAAAACA CATCTAACAT CCCTGAAGAC CAAGTTCCCT 
GCTGAACAGT ATTACAGGTT TCATGAGCAC TGGAGGTTTG TGCTTCAGCG CCTGGTCTTC 
CTGGCGGCCT TTGTAGTGTA TTTGGAAACA GAGACTCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATCCAGGC TGTCTGTCAA CAGTGTCACT GCTGGAGATT ACTCCCGGCC 
CCTTCACATC TCTACTTTCA TCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008767718.1
CDS	128..574
Translation	MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIQAVCQQCHCWRLLPAPSHLYFHQ

Target ORF information:

RefSeq Version	XM_008769496.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus translin (Tsn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008769496.2

ORF Insert Sequence:

ATGTCTGTGA GCGAGATCTT CGTGGAGCTG CAGGGCTTTT TGGCTGCCGA GCAGGACATC 
CGAGAGGAAA TACGAAAAGT TGTGCAGAGT TTAGAACAAA CTGCTCGAGA GATTTTGACC 
TTACTCCAAG GGGTCCATCA GGGCACTGGG TTTCAGGACA TTCCAAAGAG GTGCTTGAAA 
GCTCGAGAAC ATTTTGGCAC GGTAAAAACA CATCTAACAT CCCTGAAGAC CAAGTTCCCT 
GCTGAACAGT ATTACAGGTT TCATGAGCAC TGGAGGTTTG TGCTTCAGCG CCTGGTCTTC 
CTGGCGGCCT TTGTAGTGTA TTTGGAAACA GAGACTCTGG TGACCCGAGA GGCTGTTACA 
GAGATTCTTG GCATCCAGGC TGTCTGTCAA CAGTGTCACT GCTGGAGATT ACTCCCGGCC 
CCTTCACATC TCTACTTTCA TCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Toward an understanding of the protein interaction network of the human liver.
Molecular systems biology7536(2011 Oct)
Wang J,Huo K,Ma L,Tang L,Li D,Huang X,Yuan Y,Li C,Wang W,Guan W,Chen H,Jin C,Wei J,Zhang W,Yang Y,Liu Q,Zhou Y,Zhang C,Wu Z,Xu W,Zhang Y,Liu T,Yu D,Zhang Y,Chen L,Zhu D,Zhong X,Kang L,Gan X,Yu X,Ma Q,Yan J,Zhou L,Liu Z,Zhu Y,Zhou T,He F,Yang X

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.
Proceedings of the National Academy of Sciences of the United States of America106(38)16481-6(2009 Sep)
Chiaruttini C,Vicario A,Li Z,Baj G,Braiuca P,Wu Y,Lee FS,Gardossi L,Baraban JM,Tongiorgi E

CD8 chemokine receptors in chronic obstructive pulmonary disease.
Clinical and experimental immunology154(1)56-63(2008 Oct)
Smyth LJ,Starkey C,Gordon FS,Vestbo J,Singh D

Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis.
Biology of reproduction73(4)840-7(2005 Oct)
Cho YS,Iguchi N,Yang J,Handel MA,Hecht NB

Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA.
The Journal of biological chemistry276(16)13256-63(2001 Apr)
Chennathukuzhi VM,Kurihara Y,Bray JD,Hecht NB