Mapk12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mapk12
Entrez Gene ID	60352
Full Name	mitogen-activated protein kinase 12
Synonyms	Sapk3
General protein information	Preferred Names mitogen-activated protein kinase 12 Names mitogen-activated protein kinase 12 ERK-6 MAP kinase 12 MAP kinase p38 gamma MAPK 12 SAP kinase-3 extracellular signal-regulated kinase 6 mitogen-activated protein kinase p38 gamma stress-activated protein kinase 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	kinse activated by cellular stresses, bacterial endotoxin and inflammatory cytokines [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017595075.1	XP_017450564.1	mitogen-activated protein kinase 12 isoform X1
NM_021746.1	NP_068514.1	mitogen-activated protein kinase 12

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MAPK12	NP_001092423.1
Mus musculus (house mouse)	Mapk12	NP_038899.1
Gallus gallus (chicken)	MAPK12	XP_001233062.2
Homo sapiens (human)	MAPK12	NP_002960.2
	MAPK12	XP_001112462.1
Danio rerio (zebrafish)	mapk12b	NP_001038306.1
Xenopus tropicalis (tropical clawed frog)	mapk12	NP_001017080.1
Pan troglodytes (chimpanzee)	MAPK12	XP_001155820.3
Canis lupus familiaris (dog)	MAPK12	XP_848658.2
Rattus norvegicus (Norway rat)	Mapk12	NP_068514.1
Danio rerio (zebrafish)	mapk12a	NP_571482.1

Gene Ontology
Bibliography

Related articles in PubMed

Exenatide Regulates Substrate Preferences Through the p38? MAPK Pathway After Ischaemia/Reperfusion Injury in a Rat Heart.
Zheng A, Cao L, Qin S, Chen Y, Li Y, Zhang D
Heart, lung & circulation26(4)404-412(2017 Apr)

p38 MAP-kinases pathway regulation, function and role in human diseases.
Cuenda A, Rousseau S
Biochimica et biophysica acta1773(8)1358-75(2007 Aug)

Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain.
Yin J, Liu YH, Xu YF, Zhang YJ, Chen JG, Shu BH, Wang JZ
Journal of pineal research41(2)124-9(2006 Sep)

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
Eyers CE, McNeill H, Knebel A, Morrice N, Arthur SJ, Cuenda A, Cohen P
The Biochemical journal389(Pt 1)127-35(2005 Jul)

Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.
Court NW, Ingley E, Klinken SP, Bogoyevitch MA
Biochimica et biophysica acta1744(1)68-75(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrated that Exenatide improved cardiac function, increased translocation of GLUTs, and suppressed translocation of FAT/CD36 after myocardial I/R injury. This protective effect was mediated, at least in part, through modulation of the cardiac p38gamma MAPK.
Title: Exenatide Regulates Substrate Preferences Through the p38? MAPK Pathway After Ischaemia/Reperfusion Injury in a Rat Heart.

SAPK3 activity towards PDZ domain-containing substrates such as alpha1-Syntrophin is inhibited by outer membrane protein 25.
Title: Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.

SAPK3 phosphorylates mitochondrial protein Sab
Title: Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.

SAPK3/p38gamma binds preferentially to the 3d PDZ domain of SAP90 & phosphorylates Thr287 & Ser290 in vitro, & Ser290 in cells in response to cellular stresses. Phosphorylation of SAP90 depends on the binding of SAPK3/p38gamma to the PDZ domain of SAP90.
Title: Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.

distinct pattern of ERK6 expression in mature skeletal muscle cells and a specific role for ERK6 in muscle development or muscle function
Title: ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle.

The following Mapk12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mapk12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05149	NM_021746.1 Latest version!	Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa43507	XM_017595075.1 Latest version!	Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mapk12 ( NM_021746.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068514.1 Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12), mRNA.

Price & Availability↑

CloneID	ORa05149
Clone ID Related Accession (Same CDS sequence)	NM_021746.1
Accession Version	NM_021746.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase 12
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X96488.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X96488.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCTCCC CGCCACCCGC CCGCAAGGGC TTTTACCGCC AGGAGGTGAC CAAAACGGCC 
TGGGAGGTGC GCGCCGTGTA CCAGGACCTG CAGCCCGTTG GCTCTGGTGC CTATGGTGCA 
GTGTGCTCTG CAGTAGACAG CCGCACTGGC AACAAGGTGG CCATCAAGAA GTTGTACCGG 
CCCTTCCAGT CGGAGCTGTT TGCCAAGCGC GCCTACAGAG AGTTGCGCCT CCTCAAACAC 
ATGCGCCACG AGAACGTCAT TGGGCTGCTG GATGTGTTCA CTCCCGATGA GACTCTGGAT 
GACTTCACAG ACTTCTACCT GGTGATGCCA TTCATGGGCA CTGACCTGGG CAAGCTCATG 
AAGCACGAGA CTCTGAGTGA AGACAGAATC CAGTTTCTTG TGTATCAGAT GCTGAAGGGG 
CTGAAGTATA TCCACGCTGC CGGCGTCATC CACAGGGACT TGAAACCTGG AAACCTGGCT 
GTGAACGAGG ACTGTGAGCT GAAGATCCTA GATTTTGGCC TTGCCAGGCA GGCGGACAGT 
GAGATGACAG GATATGTGGT AACCCGGTGG TATCGGGCAC CAGAGGTCAT CTTGAATTGG 
ATGCGTTACA CACAGACAGT GGACATTTGG TCTGTTGGCT GCATCATGGC AGAGATGATT 
ACTGGAAAGA TCCTGTTCAA AGGCAATGAC CACCTGGACC AGCTGAAGGA GATCATGAAA 
GTCACAGGGA CACCCCCTCC TGAGTTTGTA CAGAAGCTAC AGAGTGCTGA GGCCAAGAAC 
TACATGGAAG GCCTCCCTGA GTTGGAAAAG AAGGATTTTG CTTCTGTCCT GACCAATGCA 
AGCCCTCAGG CCGTGAATCT CCTGGAAAAG ATGCTGGTGT TGGATGCGGA ACAGCGGGTG 
ACAGCAGCTG AGGCATTAGC CCACCCATAC TTTGAGTCCC TTCGGGACAC TGAGGATGAG 
CCCAAGGCCC AGAAATATGA TGACTCCTTT GATGACGTAG ACCGCACCCT TGAGGAATGG 
AAGCGTGTTA CGTATAAGGA AGTGCTCAGC TTCAAGCCTC CCAGGCAGCT AGGAGCCAGA 
GTTCCAAAGG AGACAGCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068514.1
CDS	181..1284
Translation	MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKVTGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLEKMLVLDAEQRVTAAEALAHPYFESLRDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL

Target ORF information:

RefSeq Version	NM_021746.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021746.1

ORF Insert Sequence:

ATGAGCTCCC CGCCACCCGC CCGCAAGGGC TTTTACCGCC AGGAGGTGAC CAAAACGGCC 
TGGGAGGTGC GCGCCGTGTA CCAGGACCTG CAGCCCGTTG GCTCTGGTGC CTATGGTGCA 
GTGTGCTCTG CAGTAGACAG CCGCACTGGC AACAAGGTGG CCATCAAGAA GTTGTACCGG 
CCCTTCCAGT CGGAGCTGTT TGCCAAGCGC GCCTACAGAG AGTTGCGCCT CCTCAAACAC 
ATGCGCCACG AGAACGTCAT TGGGCTGCTG GATGTGTTCA CTCCCGATGA GACTCTGGAT 
GACTTCACAG ACTTCTACCT GGTGATGCCA TTCATGGGCA CTGACCTGGG CAAGCTCATG 
AAGCACGAGA CTCTGAGTGA AGACAGAATC CAGTTTCTTG TGTATCAGAT GCTGAAGGGG 
CTGAAGTATA TCCACGCTGC CGGCGTCATC CACAGGGACT TGAAACCTGG AAACCTGGCT 
GTGAACGAGG ACTGTGAGCT GAAGATCCTA GATTTTGGCC TTGCCAGGCA GGCGGACAGT 
GAGATGACAG GATATGTGGT AACCCGGTGG TATCGGGCAC CAGAGGTCAT CTTGAATTGG 
ATGCGTTACA CACAGACAGT GGACATTTGG TCTGTTGGCT GCATCATGGC AGAGATGATT 
ACTGGAAAGA TCCTGTTCAA AGGCAATGAC CACCTGGACC AGCTGAAGGA GATCATGAAA 
GTCACAGGGA CACCCCCTCC TGAGTTTGTA CAGAAGCTAC AGAGTGCTGA GGCCAAGAAC 
TACATGGAAG GCCTCCCTGA GTTGGAAAAG AAGGATTTTG CTTCTGTCCT GACCAATGCA 
AGCCCTCAGG CCGTGAATCT CCTGGAAAAG ATGCTGGTGT TGGATGCGGA ACAGCGGGTG 
ACAGCAGCTG AGGCATTAGC CCACCCATAC TTTGAGTCCC TTCGGGACAC TGAGGATGAG 
CCCAAGGCCC AGAAATATGA TGACTCCTTT GATGACGTAG ACCGCACCCT TGAGGAATGG 
AAGCGTGTTA CGTATAAGGA AGTGCTCAGC TTCAAGCCTC CCAGGCAGCT AGGAGCCAGA 
GTTCCAAAGG AGACAGCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mapk12 ( XM_017595075.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450564.1 Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43507
Clone ID Related Accession (Same CDS sequence)	XM_017595075.1
Accession Version	XM_017595075.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCCACG AGAACGTCAT TGGGCTGCTG GATGTGTTCA CTCCCGATGA GACTCTGGAT 
GACTTCACAG ACTTCTACCT GGTGATGCCA TTCATGGGCA CTGACCTGGG CAAGCTCATG 
AAGCACGAGA CTCTGAGTGA AGACAGAATC CAGTTTCTTG TGTATCAGAT GCTGAAGGGG 
CTGAAGTATA TCCACGCTGC CGGCGTCATC CACAGGGACT TGAAACCTGG AAACCTGGCT 
GTGAACGAGG ACTGTGAGCT GAAGATCCTA GATTTTGGCC TTGCCAGGCA GGCGGACAGT 
GAGATGACAG GATATGTGGT AACCCGGTGG TATCGGGCAC CAGAGGTCAT CTTGAATTGG 
ATGCGTTACA CACAGACAGT GGACATTTGG TCTGTTGGCT GCATCATGGC AGAGATGATT 
ACTGGAAAGA TCCTGTTCAA AGGCAATGAC CACCTGGACC AGCTGAAGGA GATCATGAAA 
GTCACAGGGA CACCCCCTCC TGAGTTTGTA CAGAAGCTAC AGAGTGCTGA GGCCAAGAAC 
TACATGGAAG GCCTCCCTGA GTTGGAAAAG AAGGATTTTG CTTCTGTCCT GACCAATGCA 
AGCCCTCAGG CCGTGAATCT CCTGGAAAAG ATGCTGGTGT TGGATGCGGA ACAGCGGGTG 
ACAGCAGCTG AGGCATTAGC CCACCCATAC TTTGAGTCCC TTCGGGACAC TGAGGATGAG 
CCCAAGGCCC AGAAATATGA TGACTCCTTT GATGACGTAG ACCGCACCCT TGAGGAATGG 
AAGCGTGTTA CGTATAAGGA AGTGCTCAGC TTCAAGCCTC CCAGGCAGCT AGGAGCCAGA 
GTTCCAAAGG AGACAGCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450564.1
CDS	336..1199
Translation	MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKVTGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLEKMLVLDAEQRVTAAEALAHPYFESLRDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL

Target ORF information:

RefSeq Version	XM_017595075.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase 12 (Mapk12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595075.1

ORF Insert Sequence:

ATGCGCCACG AGAACGTCAT TGGGCTGCTG GATGTGTTCA CTCCCGATGA GACTCTGGAT 
GACTTCACAG ACTTCTACCT GGTGATGCCA TTCATGGGCA CTGACCTGGG CAAGCTCATG 
AAGCACGAGA CTCTGAGTGA AGACAGAATC CAGTTTCTTG TGTATCAGAT GCTGAAGGGG 
CTGAAGTATA TCCACGCTGC CGGCGTCATC CACAGGGACT TGAAACCTGG AAACCTGGCT 
GTGAACGAGG ACTGTGAGCT GAAGATCCTA GATTTTGGCC TTGCCAGGCA GGCGGACAGT 
GAGATGACAG GATATGTGGT AACCCGGTGG TATCGGGCAC CAGAGGTCAT CTTGAATTGG 
ATGCGTTACA CACAGACAGT GGACATTTGG TCTGTTGGCT GCATCATGGC AGAGATGATT 
ACTGGAAAGA TCCTGTTCAA AGGCAATGAC CACCTGGACC AGCTGAAGGA GATCATGAAA 
GTCACAGGGA CACCCCCTCC TGAGTTTGTA CAGAAGCTAC AGAGTGCTGA GGCCAAGAAC 
TACATGGAAG GCCTCCCTGA GTTGGAAAAG AAGGATTTTG CTTCTGTCCT GACCAATGCA 
AGCCCTCAGG CCGTGAATCT CCTGGAAAAG ATGCTGGTGT TGGATGCGGA ACAGCGGGTG 
ACAGCAGCTG AGGCATTAGC CCACCCATAC TTTGAGTCCC TTCGGGACAC TGAGGATGAG 
CCCAAGGCCC AGAAATATGA TGACTCCTTT GATGACGTAG ACCGCACCCT TGAGGAATGG 
AAGCGTGTTA CGTATAAGGA AGTGCTCAGC TTCAAGCCTC CCAGGCAGCT AGGAGCCAGA 
GTTCCAAAGG AGACAGCTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exenatide Regulates Substrate Preferences Through the p38? MAPK Pathway After Ischaemia/Reperfusion Injury in a Rat Heart.
Heart, lung & circulation26(4)404-412(2017 Apr)
Zheng A,Cao L,Qin S,Chen Y,Li Y,Zhang D

p38 MAP-kinases pathway regulation, function and role in human diseases.
Biochimica et biophysica acta1773(8)1358-75(2007 Aug)
Cuenda A,Rousseau S

Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain.
Journal of pineal research41(2)124-9(2006 Sep)
Yin J,Liu YH,Xu YF,Zhang YJ,Chen JG,Shu BH,Wang JZ

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
The Biochemical journal389(Pt 1)127-35(2005 Jul)
Eyers CE,McNeill H,Knebel A,Morrice N,Arthur SJ,Cuenda A,Cohen P

Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.
Biochimica et biophysica acta1744(1)68-75(2005 May)
Court NW,Ingley E,Klinken SP,Bogoyevitch MA

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Mapk12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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