Neurog3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Neurog3
Entrez Gene ID	60329
Full Name	neurogenin 3
Synonyms	Ngn3,Relax
General protein information	Preferred Names neurogenin 3 Names neurogenin-3 transcriptional regulator, Relax
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q11
Summary	a basic helix-loop-helix transcriptional regulator that is involved in neural fate determination [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021700.1	NP_067732.1	neurogenin-3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Neurog3	NP_033849.3
Bos taurus (cattle)	NEUROG3	XP_005226543.1
Pan troglodytes (chimpanzee)	NEUROG3	XP_003312656.2
	NEUROG3	XP_001109816.1
Canis lupus familiaris (dog)	NEUROG3	XP_546140.1
Homo sapiens (human)	NEUROG3	NP_066279.2
Rattus norvegicus (Norway rat)	Neurog3	NP_067732.1
Xenopus tropicalis (tropical clawed frog)	neurog3	XP_002935814.2

Gene Ontology
Bibliography

Related articles in PubMed

Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
Marzioni M, Agostinelli L, Candelaresi C, Saccomanno S, De Minicis S, Maroni L, Mingarelli E, Rychlicki C, Trozzi L, Banales JM, Benedetti A, Baroni GS
Hepatology (Baltimore, Md.)60(4)1324-35(2014 Oct)

Short-reactivation of neurogenin-3 and mesenchymal microenvironment is require for ?-cells differentiation during fetal pancreas development and islet regeneration.
Yang K, Wang Y, Du Z, Zhang X
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie55(2)305-11(2014)

Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic ?-cells.
Liang XD, Guo YY, Sun M, Ding Y, Wang N, Yuan L, De W
World journal of gastroenterology17(23)2812-20(2011 Jun)

Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons.
Simon-Areces J, Dopazo A, Dettenhofer M, Rodriguez-Tebar A, Garcia-Segura LM, Arevalo MA
PloS one6(7)e21825(2011)

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets.
Piper Hanley K, Hearn T, Berry A, Carvell MJ, Patch AM, Williams LJ, Sugden SA, Wilson DI, Ellard S, Hanley NA
The Journal of endocrinology207(2)151-61(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
Title: Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.

The expression of transcription factor Ngn3 and pancreatic mesenchymal microenvironment are important and necessary to promote pancreatic progenitors differentiated to islet cells regardless of pancreatic development or islets regeneration.
Title: Short-reactivation of neurogenin-3 and mesenchymal microenvironment is require for ?-cells differentiation during fetal pancreas development and islet regeneration.

Data show that Ngn3 and Pax4, a transcription factor that lies downstream of Ngn3 and plays an important role in beta-cell differentiation, were expressed in the alpha-cells of STZ-treated rats.
Title: Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic ?-cells.

OVOL1, a downstream target of NGN3, may play an important role in regulating the balance between proliferation and differentiation of pancreatic cells
Title: OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.

Ngn3 expressed together with Nkx6.1 or MafA induces AR42J-B13 cells to differentiate into insulin-producing cells, supporting the use of these cells as a model system for studying beta-cell differentiation in vitro.
Title: Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells.

The following Neurog3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Neurog3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41932	NM_021700.1 Latest version!	Rattus norvegicus neurogenin 3 (Neurog3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Neurog3 ( NM_021700.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067732.1 Rattus norvegicus neurogenin 3 (Neurog3), mRNA.

Price & Availability↑

CloneID	ORa41932
Clone ID Related Accession (Same CDS sequence)	NM_021700.1
Accession Version	NM_021700.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	neurogenin-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y10619.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y10619.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCGCCTC ATCCCTTGGA TGCGCCCACC ATCCAAGTGT CCCAAGAGAC CCAGCAACCC 
TTTCCCGGAG CCTCGGACCA CGAAGTGCTC AGTTCCAATT CCACCCCACC TAGCCCCACT 
CTCGTACCGA GGGACTGCTC CGAAGCAGAA GCAGGTGACT GCCGAGGGAC ATCGAGGAAG 
CTCCGTGCGC GGCGCGGAGG GCGCAACAGG CCCAAGAGCG AGTTGGCACT GAGCAAGCAG 
CGACGAAGCC GGCGCAAGAA GGCCAACGAC CGGGAGCGCA ACCGCATGCA CAACCTTAAC 
TCCGCGCTGG ATGCGCTGCG CGGTGTCCTG CCCACCTTCC CGGATGACGC CAAACTTACA 
AAGATCGAGA CCCTGCGCTT CGCCCACAAC TACATTTGGG CACTGACTCA GACGCTGCGC 
ATAGCGGACC ACAGCTTCTA CGGCCCCGAG CCCCCTGTGC CCTGTGGGGA GCTGGGAAGC 
CCGGGAGGGG GCTCCAGCGG CGACTGGGGC TCTATCTACT CCCCAGTTTC CCAAGCTGGT 
AGCCTGAGCC CCACAGCCTC ATTGGAGGAG TTCCCTGGCC TGCAGGTGCC CAGCTCCCCA 
TCCTGTCTGC TCCCGGGCAC CCTGGTGTTC TCAGACTTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067732.1
CDS	459..1103
Translation	MAPHPLDAPTIQVSQETQQPFPGASDHEVLSSNSTPPSPTLVPRDCSEAEAGDCRGTSRKLRARRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGSPGGGSSGDWGSIYSPVSQAGSLSPTASLEEFPGLQVPSSPSCLLPGTLVFSDFL

Target ORF information:

RefSeq Version	NM_021700.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurogenin 3 (Neurog3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021700.1

ORF Insert Sequence:

ATGGCGCCTC ATCCCTTGGA TGCGCCCACC ATCCAAGTGT CCCAAGAGAC CCAGCAACCC 
TTTCCCGGAG CCTCGGACCA CGAAGTGCTC AGTTCCAATT CCACCCCACC TAGCCCCACT 
CTCGTACCGA GGGACTGCTC CGAAGCAGAA GCAGGTGACT GCCGAGGGAC ATCGAGGAAG 
CTCCGTGCGC GGCGCGGAGG GCGCAACAGG CCCAAGAGCG AGTTGGCACT GAGCAAGCAG 
CGACGAAGCC GGCGCAAGAA GGCCAACGAC CGGGAGCGCA ACCGCATGCA CAACCTTAAC 
TCCGCGCTGG ATGCGCTGCG CGGTGTCCTG CCCACCTTCC CGGATGACGC CAAACTTACA 
AAGATCGAGA CCCTGCGCTT CGCCCACAAC TACATTTGGG CACTGACTCA GACGCTGCGC 
ATAGCGGACC ACAGCTTCTA CGGCCCCGAG CCCCCTGTGC CCTGTGGGGA GCTGGGAAGC 
CCGGGAGGGG GCTCCAGCGG CGACTGGGGC TCTATCTACT CCCCAGTTTC CCAAGCTGGT 
AGCCTGAGCC CCACAGCCTC ATTGGAGGAG TTCCCTGGCC TGCAGGTGCC CAGCTCCCCA 
TCCTGTCTGC TCCCGGGCAC CCTGGTGTTC TCAGACTTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
Hepatology (Baltimore, Md.)60(4)1324-35(2014 Oct)
Marzioni M,Agostinelli L,Candelaresi C,Saccomanno S,De Minicis S,Maroni L,Mingarelli E,Rychlicki C,Trozzi L,Banales JM,Benedetti A,Baroni GS

Short-reactivation of neurogenin-3 and mesenchymal microenvironment is require for ?-cells differentiation during fetal pancreas development and islet regeneration.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie55(2)305-11(2014)
Yang K,Wang Y,Du Z,Zhang X

Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic ?-cells.
World journal of gastroenterology17(23)2812-20(2011 Jun)
Liang XD,Guo YY,Sun M,Ding Y,Wang N,Yuan L,De W

Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons.
PloS one6(7)e21825(2011)
Simon-Areces J,Dopazo A,Dettenhofer M,Rodriguez-Tebar A,Garcia-Segura LM,Arevalo MA

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets.
The Journal of endocrinology207(2)151-61(2010 Nov)
Piper Hanley K,Hearn T,Berry A,Carvell MJ,Patch AM,Williams LJ,Sugden SA,Wilson DI,Ellard S,Hanley NA

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Neurog3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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