Shank3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Shank3
Entrez Gene ID	59312
Full Name	SH3 and multiple ankyrin repeat domains 3
Synonyms	Prosap2
General protein information	Preferred Names SH3 and multiple ankyrin repeat domains 3 Names SH3 and multiple ankyrin repeat domains protein 3 SH3/ankyrin domain gene 3 SPANK-2 Shank postsynaptic density protein 3a proline-rich synapse-associated protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	may be involved in the structural and functional organization of the post synaptic density [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021676.1	NP_067708.1	SH3 and multiple ankyrin repeat domains protein 3
NM_021676.2	NP_067708.2	SH3 and multiple ankyrin repeat domains protein 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Shank3	NP_067398.2
Rattus norvegicus (Norway rat)	Shank3	NP_067708.1
	LOC100430318	XP_002798472.1
Danio rerio (zebrafish)	shank3b	XP_005164655.1
Xenopus tropicalis (tropical clawed frog)	shank3	XP_002941881.2
Homo sapiens (human)	SHANK3	NP_277052.1
Pan troglodytes (chimpanzee)	SHANK3	XP_003317380.2
Canis lupus familiaris (dog)	SHANK3	XP_005626259.1
Bos taurus (cattle)	SHANK3	XP_002688036.2

Gene Ontology
Bibliography

Related articles in PubMed

Shank Proteins Differentially Regulate Synaptic Transmission.
Shi R, Redman P, Ghose D, Liu Y, Ren X, Ding LJ, Liu M, Jones KJ, Xu W
eNeuro4(6)(2017 Nov-Dec)

Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution.
Ponna SK, Myllykoski M, Boeckers TM, Kursula P
Biochemical and biophysical research communications490(3)806-812(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The SH3 domain from Shank3 was studied at sub-atomic resolution. The Shank family has lost the canonical peptide-binding site of the SH3 domain. The Shank SH3 domain may have lost or altered canonical SH3 domain functions.
Title: Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution.

SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane.
Title: SHANK proteins limit integrin activation by directly interacting with Rap1 and?R-Ras.

The data of this study support the concept that Shank3 is a crucial regulator of zinc-dependent signaling at excitatory synapses.
Title: Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.

In primary hippocampal cultures, Shank3 was always expressed. In stage 2 neurons, it was in soma, neuritis, and growth cones. In stage 3, it was also in the tau-positive neurites. shRNA-mediated Shank 3 knockdown upregulates GluN1 in axon terminals.
Title: Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals.

NMDA-induced accumulation of Shank3 at the PSD was transient.
Title: Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses.

The following Shank3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Shank3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa63316	NM_021676.2 Latest version!	Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
ORa05025	NM_021676.1 Latest version!	Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$951.30 $1359.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Shank3 ( NM_021676.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067708.2 Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3), mRNA.

Price & Availability↑

CloneID	ORa63316
Clone ID Related Accession (Same CDS sequence)	NM_021676.2
Accession Version	NM_021676.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5421bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Rattus norvegicus(Norway rat)
Product	SH3 and multiple ankyrin repeat domains protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ133120.1. On Jun 21, 2019 this sequence version replaced NM_021676.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ133120.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCAGCTAA ACCGTGCCGC CGTCGCCGCC GCCGCTGCGC CTGCGGAGCC CCCGGAGCCG 
CTGTCCCCCG CGCTGGCCCC GGCCCCGGCC CCCCCCGGCC CCCTCCCGCG TAGCGCGGTC 
GGCGGGACTC TGGCGGGGGG TCAGGGGGGG CCAGGGCGCC GCGCGGAGTC CCCGTGCGCT 
CCTCTCTCCG CCGGGAACAG TCAGGGCCCC GGCGCTAGCA CCGGGATGGA CGGCCCCGGG 
GCCAGCGCCG TGGTCGTGCG CGTCGGCATC CCGGACCTGC AACAAACGAA GTGCCTGCGT 
CTGGATCCAA CCGCGCCCGT GTGGGCCGCC AAGCAGCGTG TGCTCTGCGC CCTCAACCAC 
AGCCTTCAGG ACGCGCTCAA CTACGGGCTA TTCCAGCCTC CCTCCCGGGG TCGCGCCGGC 
AAGTTCCTGG ATGAAGAGCG GCTCTTACAG GACTACCCGC CTAACCTGGA CACGCCCCTG 
CCCTATCTGG AGTTTCGATA CAAGCGGAGA GTTTATGCCC AGAACCTCAT AGATGACAAG 
CAGTTTGCAA AGCTGCACAC AAAGGCAAAC CTGAAGAAGT TCATGGACTA TGTCCAGCTA 
CACAGCACAG ACAAGGTGGC CCGCCTGCTG GACAAGGGGC TGGACCCCAA TTTCCATGAC 
CCTGACTCAG GAGAGTGCCC TCTGAGCCTT GCAGCACAGT TGGACAACGC CACTGACCTC 
CTGAAGGTTC TTCGCAATGG CGGTGCTCAT CTGGACTTCC GAACCCGAGA TGGGCTAACC 
GCTGTCCACT GCGCCACCCG ACAGCGGAAT GCGGGAGCAT TGACGACCCT GCTGGACCTG 
GGGGCTTCAC CTGACTACAA GGACAGCCGC GGCCTGACGC CCCTGTACCA TAGTGCCCTA 
GGGGGCGGGG ATGCCCTCTG CTGTGAGCTG CTTCTCCATG ATCACGCACA GTTGGGGACC 
ACTGACGAGA ATGGCTGGCA GGAGATCCAT CAGGCCTGTC GCTTTGGGCA TGTACAGCAC 
TTGGAGCACC TGCTGTTCTA TGGGGCCAAC ATGGGTGCCC AGAACGCCTC GGGAAACACA 
GCCTTGCACA TCTGTGCCCT CTATAACCAG GAGAGCTGTG CCCGCGTCCT GCTTTTCCGT 
GGTGCCAACA AGGACGTCCG CAATTACAAC AGCCAGACAG CCTTCCAGGT GGCCATTATT 
GCAGGGAACT TTGAGCTTGC CGAGGTAATC AAGACCCACA AAGACTCGGA TGTCGTACCA 
TTCAGGGAAA CCCCCAGCTA TGCAAAGCGA CGACGTCTGG CTGGCCCAAG TGGCTTGGCA 
TCCCCTCGGC CCTTACAGCG CTCAGCCAGT GATATCAACC TGAAGGGTGA CCAGCCCGCA 
GCTTCTCCCG GGCCCACTCT CCGAAGCCTC CCTCACCAAC TGCTGCTCCA GAGGCTTCAG 
GAGGAGAAAG ACCGGGACAG GGATGGTGAG CAGGAGAACG ACATCAGCGG TCCCTCAGCA 
GGCAGGGGCG GCCACAGCAA GATCAGCCCC AGCGGGCCCG GCGGATCCGG CCCCGCGCCC 
GGCCCCGGCC CGGCGTCTCC CGCGCCCCCC GCGCCGCCGC CCCGGGGCCC GAAGCGGAAA 
CTTTACAGTG CCGTCCCCGG CCGCAAGTTC ATCGCTGTGA AGGCGCACAG CCCGCAGGGC 
GAGGGCGAGA TCCCGCTGCA CCGCGGCGAG GCCGTGAAGG TGCTCAGCAT TGGGGAGGGC 
GGTTTCTGGG AGGGAACCGT GAAGGGCCGT ACAGGCTGGT TCCCAGCTGA CTGTGTGGAG 
GAAGTGCAGA TGCGACAGTA TGACACACGG CATGAAACTC GAGAGGACCG GACGAAGCGT 
CTTTTCCGCC ACTACACTGT GGGTTCCTAT GACAGCCTCA CTTCACACAG TGATTATGTC 
ATTGATGATA AGGTGGCTAT CCTGCAAAAA CGGGACCATG AGGGTTTTGG CTTTGTTCTC 
CGGGGAGCCA AAGCAGAGAC CCCCATTGAG GAGTTTACAC CCACACCTGC CTTCCCTGCG 
CTCCAGTACC TTGAGTCTGT AGATGTGGAA GGTGTGGCCT GGAAGGCTGG GCTTCGCACT 
GGGGACTTCC TCATTGAGGT AAACGGAGTG AACGTCGTGA AGGTTGGACA CAAGCAAGTG 
GTGGGTCTCA TCCGTCAGGG TGGCAACCGT CTGGTCATGA AGGTTGTGTC TGTTACCAGG 
AAGCCAGAGG AGGATAGTGC TCGGCGCAGA GCCCCACCAC CTCCCAAGAG GGCCCCCAGC 
ACCACGCTGA CCCTGCGGTC CAAGTCCATG ACGGCTGAGC TCGAGGAACT CGCTTCCATT 
CGGAGAAGGA AAGGGGAGAA GTTGGATGAG ATCCTGGCGG TTGCTGCGGA ACCAACGCTG 
AGGCCAGACA TTGCAGACGC TGATTCCAGG GCAGCCACTG TCAAGCAGCG GCCCACCAGC 
CGGAGGATTA CCCCTGCCGA GATCAGCTCA TTGTTTGAGC GACAGGGCCT CCCGGGCCCA 
GAGAAGCTGC CGGGCTCTCT GCGGAAGGGG ATTCCACGGA CCAAATCTGT AGGGGAGGAT 
GAGAAGCTGG CATCCCTACT GGAAGGGCGT TTCCCACGCA GCACATCAAT GCAAGACACA 
GTGCGTGAAG GCCGAGGCAT TCCGCCCCCA CCGCAGACCG CCCCGCCACC CCCACCCGCG 
CCCTACTACT TCGACTCCGG GCCACCCCCC ACCTTCTCAC CACCGCCACC ACCACCGGGC 
CGGGCCTATG ACACTGTGCG CTCCAGCTTC AAGCCAGGCC TGGAGGCTCG TCTGGGTGCA 
GGGGCAGCTG GCCTGTATGA TTCTGGCACA CCTCTGGGCC CGCTGCCCTA CCCTGAGCGC 
CAGAAGCGTG CACGCTCCAT GATCATATTG CAGGACTCTG CGCCAGAAGT GGGCGATGTA 
CCCCGGCCTG CGCCTGCAGC CACACCGCCT GAGCGCCCCA AGCGCCGGCC TCGGCCGTCA 
GGCCCTGATA GTCCCTATGC CAACCTGGGC GCCTTCAGTG CCAGCCTCTT TGCTCCGTCG 
AAACCGCAGC GCCGCAAGAG TCCGCTGGTG AAGCAGCTTC AGGTGGAGGA CGCTCAGGAG 
CGCGCGGCGT TGGCCGTGGG TAGCCCGGGA CCAGTGGGTG GAAGCTTTGC ACGAGAACCC 
TCCCCAACGC ACCGCGGGCC CCGACCGGGC GGCCTTGACT ACAGCTCTGG AGAAGGCCTG 
GGGCTCACCT TTGGCGGCCC TAGCCCTGGC CCAGTCAAGG AGCGGCGCCT GGAGGAGCGA 
CGCCGTTCCA CTGTGTTCCT GTCTGTGGGT GCCATCGAGG GCAGCCCTCC CAGCGCGGAT 
CTGCCATCCC TACAGCCCTC CCGCTCCATT GATGAGCGCC TCCTGGGGAC AGGCGCCACC 
ACTGGCCGCG ATTTGCTGCT CCCCTCCCCT GTCTCTGCTC TGAAGCCATT GGTCGGTGGT 
CCCAGCCTTG GGCCCTCAGG CTCCACCTTC ATCCATCCTC TTACTGGCAA ACCCTTGGAT 
CCTAGCTCAC CCCTAGCTCT TGCTCTGGCT GCCCGAGAGC GGGCTCTGGC CTCGCAAACA 
CCTTCCCGGT CCCCCACACC CGTGCACAGT CCTGATGCTG ACCGCCCTGG ACCCCTCTTT 
GTGGATGTGC AAACCCGAGA CTCCGAGAGA GGACCCTTGG CCTCCCCAGC CTTCTCCCCT 
CGGAGTCCAG CCTGGATTCC AGTGCCTGCT CGCAGAGAGG CAGAGAAGCC CACTCGGGAA 
GAGCGGAAGT CACCAGAGGA CAAGAAATCC ATGATCCTCA GCGTCTTGGA CACGTCCTTG 
CAACGGCCAG CTGGTCTCAT TGTTGTGCAT GCCACCAGCA ATGGACAGGA GCCCAACAGG 
CTGGGGGCTG AAGAGGAGCG CCCGGGTACT CCGGAGCTGG CCCCAACCCC CATGCAGGCA 
GCAGCTGTGG CAGAGCCCAT GCCAAGCCCA CGAGCCCAGC CCCCTGGCAG CATCCCAGCA 
GATCCCGGGC CAGGCCAAGG CAGCTCAGAG GAGGAGCCAG AGCTGGTATT CGCTGTGAAC 
CTGCCACCTG CTCAGCTGTC CTCCAGCGAT GAGGAGACCA GAGAGGAGCT GGCCCGCATT 
GGGCTAGTGC CACCCCCTGA AGAGTTTGCC AATGGGATCC TGCTGGCCAC CCCACCCCCA 
GGACCGGGCC CCCTGCCCAC CACGGTACCC AGCCCGGCCT CAGGGAAGCC CAGCAGCGAG 
CTGCCCCCTG CCCCTGAGTC TGCAGCTGAC TCTGGAGTAG AGGAGGCCGA CACTCGAAGC 
TCCAGTGACC CCCACCTGGA GACCACAAGC ACCATTTCCA CAGTGTCCAG CATGTCCACC 
CTGAGCTCGG AGAGTGGAGA ACTCACTGAC ACCCACACCT CCTTTGCCGA TGGACACACT 
TTTCTACTCG AGAAGCCACC AGTGCCTCCC AAGCCCAAAC TCAAGTCCCC GCTGGGGAAG 
GGGCCGGTGA CCTTCAGGGA CCCGCTGCTG AAGCAATCCT CGGACAGTGA GCTCATGGCC 
CAGCAGCACC ATGCCACCTC TACTGGGTTG ACTTCTGCTG CGGGGCCTGC CCGCCCTCGC 
TACCTCTTCC AGAGAAGGTC CAAGCTGTGG GGGGACCCCG TGGAGAGTCG GGGGCTCCCT 
GGGCCTGAGG ATGACAAACC AACTGTGATC AGTGAGCTCA GCTCCCGTCT GCAGCAGCTG 
AATAAAGACA CTCGCTCCTT GGGGGAGGAA CCAGTTGGTG GCCTGGGCAG CCTGCTGGAC 
CCTGCTAAGA AGTCGCCCAT TGCAGCAGCT CGGCTCTTCA GCAGCCTCGG TGAGCTGAGC 
ACCATCTCAG CGCAGCGCAG CCCCGGGGGC CCGGGCGGAG GGGCCTCCTA CTCGGTGCGG 
CCCAGCGGCC GGTACCCCGT GGCGAGACGA GCCCCGAGCC CAGTGAAACC CGCATCGCTG 
GAGCGGGTGG AGGGGCTGGG GGCGGGCGTG GGAGGCGCGG GGCGGCCCTT CGGCCTCACG 
CCTCCCACCA TCCTCAAGTC GTCCAGCCTC TCCATCCCGC ACGAACCCAA GGAAGTGCGC 
TTCGTGGTGC GAAGTGTGAG TGCGCGCAGC CGCTCCCCCT CACCATCTCC GCTGCCCTCG 
CCTTCTCCTG GCTCTGGCCC CAGTGCCGGC CCGCGTCGGC CATTTCAACA GAAGCCCCTG 
CAGCTTTGGA GCAAGTTCGA TGTGGGCGAC TGGCTGGAGA GCATCCACTT AGGCGAGCAC 
CGAGACCGCT TCGAGGACCA TGAGATCGAA GGCGCACACC TGCCTGCGCT CACCAAGGAA 
GACTTCGTGG AGCTGGGAGT CACACGCGTT GGCCACCGCA TGAACATCGA GCGTGCGCTC 
AGGCAGCTGG ATGGCAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067708.2
CDS	10..5430
Translation	MQLNRAAVAAAAAPAEPPEPLSPALAPAPAPPGPLPRSAVGGTLAGGQGGPGRRAESPCAPLSAGNSQGPGASTGMDGPGASAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGDQPAASPGPTLRSLPHQLLLQRLQEEKDRDRDGEQENDISGPSAGRGGHSKISPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWKAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKPEEDSARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAVAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDSGPPPTFSPPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYDSGTPLGPLPYPERQKRARSMIILQDSAPEVGDVPRPAPAATPPERPKRRPRPSGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPVGGSFAREPSPTHRGPRPGGLDYSSGEGLGLTFGGPSPGPVKERRLEERRRSTVFLSVGAIEGSPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRDSERGPLASPAFSPRSPAWIPVPARREAEKPTREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPNRLGAEEERPGTPELAPTPMQAAAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGILLATPPPGPGPLPTTVPSPASGKPSSELPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHATSTGLTSAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSTISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGVGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPSPGSGPSAGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKEDFVELGVTRVGHRMNIERALRQLDGS

Target ORF information:

RefSeq Version	NM_021676.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021676.2

ORF Insert Sequence:

ATGCAGCTAA ACCGTGCCGC CGTCGCCGCC GCCGCTGCGC CTGCGGAGCC CCCGGAGCCG 
CTGTCCCCCG CGCTGGCCCC GGCCCCGGCC CCCCCCGGCC CCCTCCCGCG TAGCGCGGTC 
GGCGGGACTC TGGCGGGGGG TCAGGGGGGG CCAGGGCGCC GCGCGGAGTC CCCGTGCGCT 
CCTCTCTCCG CCGGGAACAG TCAGGGCCCC GGCGCTAGCA CCGGGATGGA CGGCCCCGGG 
GCCAGCGCCG TGGTCGTGCG CGTCGGCATC CCGGACCTGC AACAAACGAA GTGCCTGCGT 
CTGGATCCAA CCGCGCCCGT GTGGGCCGCC AAGCAGCGTG TGCTCTGCGC CCTCAACCAC 
AGCCTTCAGG ACGCGCTCAA CTACGGGCTA TTCCAGCCTC CCTCCCGGGG TCGCGCCGGC 
AAGTTCCTGG ATGAAGAGCG GCTCTTACAG GACTACCCGC CTAACCTGGA CACGCCCCTG 
CCCTATCTGG AGTTTCGATA CAAGCGGAGA GTTTATGCCC AGAACCTCAT AGATGACAAG 
CAGTTTGCAA AGCTGCACAC AAAGGCAAAC CTGAAGAAGT TCATGGACTA TGTCCAGCTA 
CACAGCACAG ACAAGGTGGC CCGCCTGCTG GACAAGGGGC TGGACCCCAA TTTCCATGAC 
CCTGACTCAG GAGAGTGCCC TCTGAGCCTT GCAGCACAGT TGGACAACGC CACTGACCTC 
CTGAAGGTTC TTCGCAATGG CGGTGCTCAT CTGGACTTCC GAACCCGAGA TGGGCTAACC 
GCTGTCCACT GCGCCACCCG ACAGCGGAAT GCGGGAGCAT TGACGACCCT GCTGGACCTG 
GGGGCTTCAC CTGACTACAA GGACAGCCGC GGCCTGACGC CCCTGTACCA TAGTGCCCTA 
GGGGGCGGGG ATGCCCTCTG CTGTGAGCTG CTTCTCCATG ATCACGCACA GTTGGGGACC 
ACTGACGAGA ATGGCTGGCA GGAGATCCAT CAGGCCTGTC GCTTTGGGCA TGTACAGCAC 
TTGGAGCACC TGCTGTTCTA TGGGGCCAAC ATGGGTGCCC AGAACGCCTC GGGAAACACA 
GCCTTGCACA TCTGTGCCCT CTATAACCAG GAGAGCTGTG CCCGCGTCCT GCTTTTCCGT 
GGTGCCAACA AGGACGTCCG CAATTACAAC AGCCAGACAG CCTTCCAGGT GGCCATTATT 
GCAGGGAACT TTGAGCTTGC CGAGGTAATC AAGACCCACA AAGACTCGGA TGTCGTACCA 
TTCAGGGAAA CCCCCAGCTA TGCAAAGCGA CGACGTCTGG CTGGCCCAAG TGGCTTGGCA 
TCCCCTCGGC CCTTACAGCG CTCAGCCAGT GATATCAACC TGAAGGGTGA CCAGCCCGCA 
GCTTCTCCCG GGCCCACTCT CCGAAGCCTC CCTCACCAAC TGCTGCTCCA GAGGCTTCAG 
GAGGAGAAAG ACCGGGACAG GGATGGTGAG CAGGAGAACG ACATCAGCGG TCCCTCAGCA 
GGCAGGGGCG GCCACAGCAA GATCAGCCCC AGCGGGCCCG GCGGATCCGG CCCCGCGCCC 
GGCCCCGGCC CGGCGTCTCC CGCGCCCCCC GCGCCGCCGC CCCGGGGCCC GAAGCGGAAA 
CTTTACAGTG CCGTCCCCGG CCGCAAGTTC ATCGCTGTGA AGGCGCACAG CCCGCAGGGC 
GAGGGCGAGA TCCCGCTGCA CCGCGGCGAG GCCGTGAAGG TGCTCAGCAT TGGGGAGGGC 
GGTTTCTGGG AGGGAACCGT GAAGGGCCGT ACAGGCTGGT TCCCAGCTGA CTGTGTGGAG 
GAAGTGCAGA TGCGACAGTA TGACACACGG CATGAAACTC GAGAGGACCG GACGAAGCGT 
CTTTTCCGCC ACTACACTGT GGGTTCCTAT GACAGCCTCA CTTCACACAG TGATTATGTC 
ATTGATGATA AGGTGGCTAT CCTGCAAAAA CGGGACCATG AGGGTTTTGG CTTTGTTCTC 
CGGGGAGCCA AAGCAGAGAC CCCCATTGAG GAGTTTACAC CCACACCTGC CTTCCCTGCG 
CTCCAGTACC TTGAGTCTGT AGATGTGGAA GGTGTGGCCT GGAAGGCTGG GCTTCGCACT 
GGGGACTTCC TCATTGAGGT AAACGGAGTG AACGTCGTGA AGGTTGGACA CAAGCAAGTG 
GTGGGTCTCA TCCGTCAGGG TGGCAACCGT CTGGTCATGA AGGTTGTGTC TGTTACCAGG 
AAGCCAGAGG AGGATAGTGC TCGGCGCAGA GCCCCACCAC CTCCCAAGAG GGCCCCCAGC 
ACCACGCTGA CCCTGCGGTC CAAGTCCATG ACGGCTGAGC TCGAGGAACT CGCTTCCATT 
CGGAGAAGGA AAGGGGAGAA GTTGGATGAG ATCCTGGCGG TTGCTGCGGA ACCAACGCTG 
AGGCCAGACA TTGCAGACGC TGATTCCAGG GCAGCCACTG TCAAGCAGCG GCCCACCAGC 
CGGAGGATTA CCCCTGCCGA GATCAGCTCA TTGTTTGAGC GACAGGGCCT CCCGGGCCCA 
GAGAAGCTGC CGGGCTCTCT GCGGAAGGGG ATTCCACGGA CCAAATCTGT AGGGGAGGAT 
GAGAAGCTGG CATCCCTACT GGAAGGGCGT TTCCCACGCA GCACATCAAT GCAAGACACA 
GTGCGTGAAG GCCGAGGCAT TCCGCCCCCA CCGCAGACCG CCCCGCCACC CCCACCCGCG 
CCCTACTACT TCGACTCCGG GCCACCCCCC ACCTTCTCAC CACCGCCACC ACCACCGGGC 
CGGGCCTATG ACACTGTGCG CTCCAGCTTC AAGCCAGGCC TGGAGGCTCG TCTGGGTGCA 
GGGGCAGCTG GCCTGTATGA TTCTGGCACA CCTCTGGGCC CGCTGCCCTA CCCTGAGCGC 
CAGAAGCGTG CACGCTCCAT GATCATATTG CAGGACTCTG CGCCAGAAGT GGGCGATGTA 
CCCCGGCCTG CGCCTGCAGC CACACCGCCT GAGCGCCCCA AGCGCCGGCC TCGGCCGTCA 
GGCCCTGATA GTCCCTATGC CAACCTGGGC GCCTTCAGTG CCAGCCTCTT TGCTCCGTCG 
AAACCGCAGC GCCGCAAGAG TCCGCTGGTG AAGCAGCTTC AGGTGGAGGA CGCTCAGGAG 
CGCGCGGCGT TGGCCGTGGG TAGCCCGGGA CCAGTGGGTG GAAGCTTTGC ACGAGAACCC 
TCCCCAACGC ACCGCGGGCC CCGACCGGGC GGCCTTGACT ACAGCTCTGG AGAAGGCCTG 
GGGCTCACCT TTGGCGGCCC TAGCCCTGGC CCAGTCAAGG AGCGGCGCCT GGAGGAGCGA 
CGCCGTTCCA CTGTGTTCCT GTCTGTGGGT GCCATCGAGG GCAGCCCTCC CAGCGCGGAT 
CTGCCATCCC TACAGCCCTC CCGCTCCATT GATGAGCGCC TCCTGGGGAC AGGCGCCACC 
ACTGGCCGCG ATTTGCTGCT CCCCTCCCCT GTCTCTGCTC TGAAGCCATT GGTCGGTGGT 
CCCAGCCTTG GGCCCTCAGG CTCCACCTTC ATCCATCCTC TTACTGGCAA ACCCTTGGAT 
CCTAGCTCAC CCCTAGCTCT TGCTCTGGCT GCCCGAGAGC GGGCTCTGGC CTCGCAAACA 
CCTTCCCGGT CCCCCACACC CGTGCACAGT CCTGATGCTG ACCGCCCTGG ACCCCTCTTT 
GTGGATGTGC AAACCCGAGA CTCCGAGAGA GGACCCTTGG CCTCCCCAGC CTTCTCCCCT 
CGGAGTCCAG CCTGGATTCC AGTGCCTGCT CGCAGAGAGG CAGAGAAGCC CACTCGGGAA 
GAGCGGAAGT CACCAGAGGA CAAGAAATCC ATGATCCTCA GCGTCTTGGA CACGTCCTTG 
CAACGGCCAG CTGGTCTCAT TGTTGTGCAT GCCACCAGCA ATGGACAGGA GCCCAACAGG 
CTGGGGGCTG AAGAGGAGCG CCCGGGTACT CCGGAGCTGG CCCCAACCCC CATGCAGGCA 
GCAGCTGTGG CAGAGCCCAT GCCAAGCCCA CGAGCCCAGC CCCCTGGCAG CATCCCAGCA 
GATCCCGGGC CAGGCCAAGG CAGCTCAGAG GAGGAGCCAG AGCTGGTATT CGCTGTGAAC 
CTGCCACCTG CTCAGCTGTC CTCCAGCGAT GAGGAGACCA GAGAGGAGCT GGCCCGCATT 
GGGCTAGTGC CACCCCCTGA AGAGTTTGCC AATGGGATCC TGCTGGCCAC CCCACCCCCA 
GGACCGGGCC CCCTGCCCAC CACGGTACCC AGCCCGGCCT CAGGGAAGCC CAGCAGCGAG 
CTGCCCCCTG CCCCTGAGTC TGCAGCTGAC TCTGGAGTAG AGGAGGCCGA CACTCGAAGC 
TCCAGTGACC CCCACCTGGA GACCACAAGC ACCATTTCCA CAGTGTCCAG CATGTCCACC 
CTGAGCTCGG AGAGTGGAGA ACTCACTGAC ACCCACACCT CCTTTGCCGA TGGACACACT 
TTTCTACTCG AGAAGCCACC AGTGCCTCCC AAGCCCAAAC TCAAGTCCCC GCTGGGGAAG 
GGGCCGGTGA CCTTCAGGGA CCCGCTGCTG AAGCAATCCT CGGACAGTGA GCTCATGGCC 
CAGCAGCACC ATGCCACCTC TACTGGGTTG ACTTCTGCTG CGGGGCCTGC CCGCCCTCGC 
TACCTCTTCC AGAGAAGGTC CAAGCTGTGG GGGGACCCCG TGGAGAGTCG GGGGCTCCCT 
GGGCCTGAGG ATGACAAACC AACTGTGATC AGTGAGCTCA GCTCCCGTCT GCAGCAGCTG 
AATAAAGACA CTCGCTCCTT GGGGGAGGAA CCAGTTGGTG GCCTGGGCAG CCTGCTGGAC 
CCTGCTAAGA AGTCGCCCAT TGCAGCAGCT CGGCTCTTCA GCAGCCTCGG TGAGCTGAGC 
ACCATCTCAG CGCAGCGCAG CCCCGGGGGC CCGGGCGGAG GGGCCTCCTA CTCGGTGCGG 
CCCAGCGGCC GGTACCCCGT GGCGAGACGA GCCCCGAGCC CAGTGAAACC CGCATCGCTG 
GAGCGGGTGG AGGGGCTGGG GGCGGGCGTG GGAGGCGCGG GGCGGCCCTT CGGCCTCACG 
CCTCCCACCA TCCTCAAGTC GTCCAGCCTC TCCATCCCGC ACGAACCCAA GGAAGTGCGC 
TTCGTGGTGC GAAGTGTGAG TGCGCGCAGC CGCTCCCCCT CACCATCTCC GCTGCCCTCG 
CCTTCTCCTG GCTCTGGCCC CAGTGCCGGC CCGCGTCGGC CATTTCAACA GAAGCCCCTG 
CAGCTTTGGA GCAAGTTCGA TGTGGGCGAC TGGCTGGAGA GCATCCACTT AGGCGAGCAC 
CGAGACCGCT TCGAGGACCA TGAGATCGAA GGCGCACACC TGCCTGCGCT CACCAAGGAA 
GACTTCGTGG AGCTGGGAGT CACACGCGTT GGCCACCGCA TGAACATCGA GCGTGCGCTC 
AGGCAGCTGG ATGGCAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Shank3 ( NM_021676.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067708.1 Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3), mRNA.

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CloneID	ORa05025
Clone ID Related Accession (Same CDS sequence)	NM_021676.1
Accession Version	NM_021676.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5223bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	SH3 and multiple ankyrin repeat domains protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF133301.1. On or before Jan 12, 2005 this sequence version replaced XM_346810.1, NM_021675.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133301.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGACGGCC CCGGGGCCAG CGCCGTGGTC GTGCGCGTCG GCATCCCGGA CCTGCAACAA 
ACGAAGTGCC TGCGTCTGGA TCCAACCGCG CCCGTGTGGG CCGCCAAGCA GCGTGTGCTC 
TGCGCCCTCA ACCACAGCCT TCAGGACGCG CTCAACTACG GGCTATTCCA GCCTCCCTCC 
CGGGGTCGCG CCGGCAAGTT CCTGGATGAA GAGCGGCTCT TACAGGACTA CCCGCCTAAC 
CTGGACACGC CCCTGCCCTA TCTGGAGTTT CGATACAAGC GGAGAGTTTA TGCCCAGAAC 
CTCATAGATG ACAAGCAGTT TGCAAAGCTG CACACAAAGG CAAACCTGAA GAAGTTCATG 
GACTATGTCC AGCTACACAG CACAGACAAG GTGGCCCGCC TGCTGGACAA GGGGCTGGAC 
CCCAATTTCC ATGACCCTGA CTCAGGAGAG TGCCCTCTGA GCCTTGCAGC ACAGTTGGAC 
AACGCCACTG ACCTCCTGAA GGTTCTTCGC AATGGCGGTG CTCATCTGGA CTTCCGAACC 
CGAGATGGGC TAACCGCTGT CCACTGCGCC ACCCGACAGC GGAATGCGGG AGCATTGACG 
ACCCTGCTGG ACCTGGGGGC TTCACCTGAC TACAAGGACA GCCGCGGCCT GACGCCCCTG 
TACCATAGTG CCCTAGGGGG CGGGGATGCC CTCTGCTGTG AGCTGCTTCT CCATGATCAC 
GCACAGTTGG GGACCACTGA CGAGAATGGC TGGCAGGAGA TCCATCAGGC CTGTCGCTTT 
GGGCATGTAC AGCACTTGGA GCACCTGCTG TTCTATGGGG CCAACATGGG TGCCCAGAAC 
GCCTCGGGAA ACACAGCCTT GCACATCTGT GCCCTCTATA ACCAGGAGAG CTGTGCCCGC 
GTCCTGCTTT TCCGTGGTGC CAACAAGGAC GTCCGCAATT ACAACAGCCA GACAGCCTTC 
CAGGTGGCCA TTATTGCAGG GAACTTTGAG CTTGCCGAGG TAATCAAGAC CCACAAAGAC 
TCGGATGTCG TACCATTCAG GGAAACCCCC AGCTATGCAA AGCGACGACG TCTGGCTGGC 
CCGAGTGGCT TGGCATCCCC TCGGCCCTTA CAGCGCTCAG CCAGTGATAT CAACCTGAAG 
GGTGACCAGC CCGCAGCTTC TCCCGGGCCC ACTCTCCGAA GCCTCCCTCA CCAACTGCTG 
CTCCAGAGGC TTCAGGAGGA GAAAGACCGG GACAGGGATG GTGAGCAGGA GAACGACATC 
AGCGGTCCCT CAGCAGGCAG GGGCGGCCAC AGCAAGATCA GCCCCAGCGG GCCCGGCGGA 
TCCGGCCCCG CGCCCGGCCC CGGCCCGGCG TCTCCCGCGC CCCCCGCGCC GCCGCCCCGG 
GGCCCGAAGC GGAAACTTTA CAGTGCCGTC CCCGGCCGCA AGTTCATCGC TGTGAAGGCG 
CACAGCCCGC AGGGCGAGGG CGAGATCCCG CTGCACCGCG GCGAGGCCGT GAAGGTGCTC 
AGCATTGGGG AGGGCGGTTT CTGGGAGGGA ACCGTGAAGG GCCGTACAGG CTGGTTCCCA 
GCTGACTGTG TGGAGGAAGT GCAGATGCGA CAGTATGACA CACGGCATGA AACTCGAGAG 
GACCGGACGA AGCGTCTTTT CCGCCACTAC ACTGTGGGTT CCTATGACAG CCTCACTTCA 
CACAGTGATT ATGTCATTGA TGATAAGGTG GCTATCCTGC AAAAACGGGA CCATGAGGGT 
TTTGGCTTTG TTCTCCGGGG AGCCAAAGCA GAGACCCCCA TTGAGGAGTT TACACCCACA 
CCTGCCTTCC CTGCGCTCCA GTACCTTGAG TCTGTAGATG TGGAAGGTGT GGCCTGGAAG 
GCTGGGCTTC GCACTGGGGA CTTCCTCATT GAGGTAAACG GAGTGAACGT CGTGAAGGTT 
GGACACAAGC AAGTGGTGGG TCTCATCCGT CAGGGTGGCA ACCGTCTGGT CATGAAGGTT 
GTGTCTGTTA CCAGGAAGCC AGAGGAGGAT AGTGCTCGGC GCAGAGCCCC ACCACCTCCC 
AAGAGGGCCC CCAGCACCAC GCTGACCCTG CGGTCCAAGT CCATGACGGC TGAGCTCGAG 
GAACTCGCTT CCATTCGGAG AAGGAAAGGG GAGAAGTTGG ATGAGATCCT GGCGGTTGCT 
GCGGAACCAA CGCTGAGGCC AGACATTGCA GACGCTGATT CCAGGGCAGC CACTGTCAAG 
CAGCGGCCCA CCAGCCGGAG GATTACCCCT GCCGAGATCA GCTCATTGTT TGAGCGACAG 
GGCCTCCCGG GCCCAGAGAA GCTGCCGGGC TCTCTGCGGA AGGGGATTCC ACGGACCAAA 
TCTGTAGGGG AGGATGAGAA GCTGGCATCC CTACTGGAAG GGCGTTTCCC ACGCAGCACA 
TCAATGCAAG ACACAGTGCG TGAAGGCCGA GGCATTCCGC CCCCACCGCA GACCGCCCCG 
CCACCCCCAC CCGCGCCCTA CTACTTCGAC TCCGGGCCAC CCCCCACCTT CTCACCACCG 
CCACCACCAC CGGGCCGGGC CTATGACACT GTGCGCTCCA GCTTCAAGCC AGGCCTGGAG 
GCTCGTCTGG GTGCAGGGGC AGCTGGCCTG TATGATTCTG GCACACCTCT GGGCCCGCTG 
CCCTACCCTG AGCGCCAGAA GCGTGCACGC TCCATGATCA TATTGCAGGA CTCTGCGCCA 
GAAGTGGGCG ATGTACCCCG GCCTGCGCCT GCAGCCACAC CGCCTGAGCG CCCCAAGCGC 
CGGCCTCGGC CGTCAGGCCC TGATAGTCCC TATGCCAACC TGGGCGCCTT CAGTGCCAGC 
CTCTTTGCTC CGTCGAAACC GCAGCGCCGC AAGAGTCCGC TGGTGAAGCA GCTTCAGGTG 
GAGGACGCTC AGGAGCGCGC GGCGTTGGCC GTGGGTAGCC CGGGACCAGT GGGTGGAAGC 
TTTGCACGAG AACCCTCCCC AACGCACCGC GGGCCCCGAC CGGGCGGCCT TGACTACAGC 
TCTGGAGAAG GCCTGGGGCT CACCTTTGGC GGCCCTAGCC CTGGCCCAGT CAAGGAGCGG 
CGCCTGGAGG AGCGACGCCG TTCCACTGTG TTCCTGTCTG TGGGTGCCAT CGAGGGCAAC 
CCTCCCAGCG CGGATCTGCC ATCCCTACAA CCCTCCCGCT CCATTGATGA GCGCCTCCTG 
GGGACAGGCG CCACCACTGG CCGAGATTTG CTGCTCCCCT CCCCTGTCTC TGCTCTGAAG 
CCATTGGTCG GTGGTCCCAA CCTTGGGCCC TCAAGCTCCA CCTTCATCCA TCCTCTTACT 
GGCAAACCCT TGGATCCTAG CTCACCCCTA GCTCTTGCTC TGGCTGCCCG AGAGCGGGCT 
CTGGCCTCGC AAACACCTTC CCGGTCCCCC ACACCCGTGC ACAGTCCTGA TGCTGACCGC 
CCTGGACCCC TCTTTGTGGA TGTGCAAACC CGAGACTCCG AGAGAGGACC CTTGGCCTCC 
CCAGCCTTCT CCCCTCGGAG TCCAGCCTGG ATTCCAGTGC CTGCTCGCAG AGAGGCAGAG 
AAGCCCACTC GGGAAGAGCG GAAGTCACCA GAGGACAAGA AATCCATGAT CCTCAGCGTC 
TTGGACACGT CCTTGCAACG GCCAGCTGGC CTCATTGTTG TGCATGCCAC CAGCAATGGA 
CAGGAGCCCA ACAGGCTGGG GGCTGAAGAG GAGCGCCCGG GTACTCCGGA GCTGGCCCCA 
ACCCCCATGC AGGCAGCAGC TGTGGCAGAG CCCATGCCAA GCCCACGAGC CCAACCCCCT 
GGCAACATCC CAGCAGATCC CGGGCCAAGC CAAGGCAACT CAGAGGAGGA GCCAAAGCTG 
GTATTCGCTG TGAACCTGCC ACCTGCTCAA CTGTCCTCCA ACGATGAGGA GACCAGAGAG 
GAGCTGGCCC GCATTGGGCT AGTGCCACCC CCTGAAGAGT TTGCCAATGG GATCCTGCTG 
GCCACCCCAC CCCCAGGACC GGGCCCCTTG CCCACCACGG TACCCAGCCC GGCCTCAGGG 
AAGCCCAGCA GCGAGCTGCC CCCTGCCCCG GAGTCTGCAG CTGACTCTGG AGTAGAGGAG 
GCCGACACTC GAAGCTCCAG TGACCCCCAC CTGGAGACCA CAAGCACCAT TTCCACAGTG 
TCCAGCATGT CCACCCTGAG CTCGGAGAGT GGAGAACTCA CTGACACCCA CACCTCCTTT 
GCCGATGGAC ACACTTTTCT ACTCGAGAAG CCACCAGTGC CTCCCAAGCC CAAACTCAAG 
TCCCCGCTGG GGAAGGGGCC GGTGACCTTC AGGGGCCCGC TGCTGAAGCA ATCCTCGGAC 
AGTGAGCTCA TGGCCCAGCA GCACCATGCC ACCTCTACTG GGTTGACTTC TGCTGCTGGG 
CCTGCCCGCC CTCGCTACCT CTTCCAGAGA AGGTCCAAGC TGTGGGGGGA CCCCGTGGAG 
AGTCGGGGGC TCCCTGGGCC TGAGGATGAC AAACCAACTG TGATCAGTGA GCTCAGCTCC 
CGTCTGCAGC AGCTGAATAA AGACACTCGC TCCTTGGGGG AGGAACCAGT TGGTGGCCTG 
GGTAGCCTGC TGGACCCTGC TAAGAAGTCG CCCATTGCAG CAGCTCGCTG CGCGGTGGTC 
CCGAGTGCCG GCTGGCTCTT CAGCAGCCTC GGTGAGCTGA GCACCATCTC AGCGCAGCGC 
AGCCCCGGGG GCCCGGGCGG AGGGGCCTCC TACTCGGTGC GGCCCAGCGG CCGGTACCCC 
GTGGCGAGAC GAGCCCCGAG CCCAGTGAAA CCCGCATCGC TGGAGCGGGT GGAGGGGCTG 
GGGGCGGGCG TGGGAGGCGC GGGGCGGCCC TTCGGCCTCA CGCCTCCCAC CATCCTCAAG 
TCGTCCAGCC TCTCCATCCC GCACGAACCC AAGGAAGTGC GCTTCGTGGT GCGAAGTGCG 
AGTGCGCGCA GCCGCTCCCC CTCACCATCT CCGCTGCCCT CGCCTTCTCC TGGCTCTGGC 
CCCAGTGCCG GCCCGCGTCG GCCATTTCAA CAGAAGCCCC TGCAGCTTTG GAGCAAGTTC 
GATGTGGGCG ACTGGCTGGA GAGCATCCAC TTAGGCGAGC ACCGAGACCG CTTCGAGGAC 
CATGAGATCG AAGGCGCACA CCTGCCTGCG CTCACCAAGG AAGACTTCGT GGAGCTGGGA 
GTCACACGCG TTGGCCACCG CATGAACATC GAGCGTGCGC TCAGGCAGCT GGATGGCAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067708.1
CDS	234..5456
Translation	MDGPGASAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGDQPAASPGPTLRSLPHQLLLQRLQEEKDRDRDGEQENDISGPSAGRGGHSKISPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWKAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKPEEDSARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAVAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDSGPPPTFSPPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYDSGTPLGPLPYPERQKRARSMIILQDSAPEVGDVPRPAPAATPPERPKRRPRPSGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPVGGSFAREPSPTHRGPRPGGLDYSSGEGLGLTFGGPSPGPVKERRLEERRRSTVFLSVGAIEGNPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPNLGPSSSTFIHPLTGKPLDPSSPLALALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRDSERGPLASPAFSPRSPAWIPVPARREAEKPTREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPNRLGAEEERPGTPELAPTPMQAAAVAEPMPSPRAQPPGNIPADPGPSQGNSEEEPKLVFAVNLPPAQLSSNDEETREELARIGLVPPPEEFANGILLATPPPGPGPLPTTVPSPASGKPSSELPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRGPLLKQSSDSELMAQQHHATSTGLTSAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARCAVVPSAGWLFSSLGELSTISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGVGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSASARSRSPSPSPLPSPSPGSGPSAGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKEDFVELGVTRVGHRMNIERALRQLDGS

Target ORF information:

RefSeq Version	NM_021676.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH3 and multiple ankyrin repeat domains 3 (Shank3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021676.1

ORF Insert Sequence:

ATGGACGGCC CCGGGGCCAG CGCCGTGGTC GTGCGCGTCG GCATCCCGGA CCTGCAACAA 
ACGAAGTGCC TGCGTCTGGA TCCAACCGCG CCCGTGTGGG CCGCCAAGCA GCGTGTGCTC 
TGCGCCCTCA ACCACAGCCT TCAGGACGCG CTCAACTACG GGCTATTCCA GCCTCCCTCC 
CGGGGTCGCG CCGGCAAGTT CCTGGATGAA GAGCGGCTCT TACAGGACTA CCCGCCTAAC 
CTGGACACGC CCCTGCCCTA TCTGGAGTTT CGATACAAGC GGAGAGTTTA TGCCCAGAAC 
CTCATAGATG ACAAGCAGTT TGCAAAGCTG CACACAAAGG CAAACCTGAA GAAGTTCATG 
GACTATGTCC AGCTACACAG CACAGACAAG GTGGCCCGCC TGCTGGACAA GGGGCTGGAC 
CCCAATTTCC ATGACCCTGA CTCAGGAGAG TGCCCTCTGA GCCTTGCAGC ACAGTTGGAC 
AACGCCACTG ACCTCCTGAA GGTTCTTCGC AATGGCGGTG CTCATCTGGA CTTCCGAACC 
CGAGATGGGC TAACCGCTGT CCACTGCGCC ACCCGACAGC GGAATGCGGG AGCATTGACG 
ACCCTGCTGG ACCTGGGGGC TTCACCTGAC TACAAGGACA GCCGCGGCCT GACGCCCCTG 
TACCATAGTG CCCTAGGGGG CGGGGATGCC CTCTGCTGTG AGCTGCTTCT CCATGATCAC 
GCACAGTTGG GGACCACTGA CGAGAATGGC TGGCAGGAGA TCCATCAGGC CTGTCGCTTT 
GGGCATGTAC AGCACTTGGA GCACCTGCTG TTCTATGGGG CCAACATGGG TGCCCAGAAC 
GCCTCGGGAA ACACAGCCTT GCACATCTGT GCCCTCTATA ACCAGGAGAG CTGTGCCCGC 
GTCCTGCTTT TCCGTGGTGC CAACAAGGAC GTCCGCAATT ACAACAGCCA GACAGCCTTC 
CAGGTGGCCA TTATTGCAGG GAACTTTGAG CTTGCCGAGG TAATCAAGAC CCACAAAGAC 
TCGGATGTCG TACCATTCAG GGAAACCCCC AGCTATGCAA AGCGACGACG TCTGGCTGGC 
CCGAGTGGCT TGGCATCCCC TCGGCCCTTA CAGCGCTCAG CCAGTGATAT CAACCTGAAG 
GGTGACCAGC CCGCAGCTTC TCCCGGGCCC ACTCTCCGAA GCCTCCCTCA CCAACTGCTG 
CTCCAGAGGC TTCAGGAGGA GAAAGACCGG GACAGGGATG GTGAGCAGGA GAACGACATC 
AGCGGTCCCT CAGCAGGCAG GGGCGGCCAC AGCAAGATCA GCCCCAGCGG GCCCGGCGGA 
TCCGGCCCCG CGCCCGGCCC CGGCCCGGCG TCTCCCGCGC CCCCCGCGCC GCCGCCCCGG 
GGCCCGAAGC GGAAACTTTA CAGTGCCGTC CCCGGCCGCA AGTTCATCGC TGTGAAGGCG 
CACAGCCCGC AGGGCGAGGG CGAGATCCCG CTGCACCGCG GCGAGGCCGT GAAGGTGCTC 
AGCATTGGGG AGGGCGGTTT CTGGGAGGGA ACCGTGAAGG GCCGTACAGG CTGGTTCCCA 
GCTGACTGTG TGGAGGAAGT GCAGATGCGA CAGTATGACA CACGGCATGA AACTCGAGAG 
GACCGGACGA AGCGTCTTTT CCGCCACTAC ACTGTGGGTT CCTATGACAG CCTCACTTCA 
CACAGTGATT ATGTCATTGA TGATAAGGTG GCTATCCTGC AAAAACGGGA CCATGAGGGT 
TTTGGCTTTG TTCTCCGGGG AGCCAAAGCA GAGACCCCCA TTGAGGAGTT TACACCCACA 
CCTGCCTTCC CTGCGCTCCA GTACCTTGAG TCTGTAGATG TGGAAGGTGT GGCCTGGAAG 
GCTGGGCTTC GCACTGGGGA CTTCCTCATT GAGGTAAACG GAGTGAACGT CGTGAAGGTT 
GGACACAAGC AAGTGGTGGG TCTCATCCGT CAGGGTGGCA ACCGTCTGGT CATGAAGGTT 
GTGTCTGTTA CCAGGAAGCC AGAGGAGGAT AGTGCTCGGC GCAGAGCCCC ACCACCTCCC 
AAGAGGGCCC CCAGCACCAC GCTGACCCTG CGGTCCAAGT CCATGACGGC TGAGCTCGAG 
GAACTCGCTT CCATTCGGAG AAGGAAAGGG GAGAAGTTGG ATGAGATCCT GGCGGTTGCT 
GCGGAACCAA CGCTGAGGCC AGACATTGCA GACGCTGATT CCAGGGCAGC CACTGTCAAG 
CAGCGGCCCA CCAGCCGGAG GATTACCCCT GCCGAGATCA GCTCATTGTT TGAGCGACAG 
GGCCTCCCGG GCCCAGAGAA GCTGCCGGGC TCTCTGCGGA AGGGGATTCC ACGGACCAAA 
TCTGTAGGGG AGGATGAGAA GCTGGCATCC CTACTGGAAG GGCGTTTCCC ACGCAGCACA 
TCAATGCAAG ACACAGTGCG TGAAGGCCGA GGCATTCCGC CCCCACCGCA GACCGCCCCG 
CCACCCCCAC CCGCGCCCTA CTACTTCGAC TCCGGGCCAC CCCCCACCTT CTCACCACCG 
CCACCACCAC CGGGCCGGGC CTATGACACT GTGCGCTCCA GCTTCAAGCC AGGCCTGGAG 
GCTCGTCTGG GTGCAGGGGC AGCTGGCCTG TATGATTCTG GCACACCTCT GGGCCCGCTG 
CCCTACCCTG AGCGCCAGAA GCGTGCACGC TCCATGATCA TATTGCAGGA CTCTGCGCCA 
GAAGTGGGCG ATGTACCCCG GCCTGCGCCT GCAGCCACAC CGCCTGAGCG CCCCAAGCGC 
CGGCCTCGGC CGTCAGGCCC TGATAGTCCC TATGCCAACC TGGGCGCCTT CAGTGCCAGC 
CTCTTTGCTC CGTCGAAACC GCAGCGCCGC AAGAGTCCGC TGGTGAAGCA GCTTCAGGTG 
GAGGACGCTC AGGAGCGCGC GGCGTTGGCC GTGGGTAGCC CGGGACCAGT GGGTGGAAGC 
TTTGCACGAG AACCCTCCCC AACGCACCGC GGGCCCCGAC CGGGCGGCCT TGACTACAGC 
TCTGGAGAAG GCCTGGGGCT CACCTTTGGC GGCCCTAGCC CTGGCCCAGT CAAGGAGCGG 
CGCCTGGAGG AGCGACGCCG TTCCACTGTG TTCCTGTCTG TGGGTGCCAT CGAGGGCAAC 
CCTCCCAGCG CGGATCTGCC ATCCCTACAA CCCTCCCGCT CCATTGATGA GCGCCTCCTG 
GGGACAGGCG CCACCACTGG CCGAGATTTG CTGCTCCCCT CCCCTGTCTC TGCTCTGAAG 
CCATTGGTCG GTGGTCCCAA CCTTGGGCCC TCAAGCTCCA CCTTCATCCA TCCTCTTACT 
GGCAAACCCT TGGATCCTAG CTCACCCCTA GCTCTTGCTC TGGCTGCCCG AGAGCGGGCT 
CTGGCCTCGC AAACACCTTC CCGGTCCCCC ACACCCGTGC ACAGTCCTGA TGCTGACCGC 
CCTGGACCCC TCTTTGTGGA TGTGCAAACC CGAGACTCCG AGAGAGGACC CTTGGCCTCC 
CCAGCCTTCT CCCCTCGGAG TCCAGCCTGG ATTCCAGTGC CTGCTCGCAG AGAGGCAGAG 
AAGCCCACTC GGGAAGAGCG GAAGTCACCA GAGGACAAGA AATCCATGAT CCTCAGCGTC 
TTGGACACGT CCTTGCAACG GCCAGCTGGC CTCATTGTTG TGCATGCCAC CAGCAATGGA 
CAGGAGCCCA ACAGGCTGGG GGCTGAAGAG GAGCGCCCGG GTACTCCGGA GCTGGCCCCA 
ACCCCCATGC AGGCAGCAGC TGTGGCAGAG CCCATGCCAA GCCCACGAGC CCAACCCCCT 
GGCAACATCC CAGCAGATCC CGGGCCAAGC CAAGGCAACT CAGAGGAGGA GCCAAAGCTG 
GTATTCGCTG TGAACCTGCC ACCTGCTCAA CTGTCCTCCA ACGATGAGGA GACCAGAGAG 
GAGCTGGCCC GCATTGGGCT AGTGCCACCC CCTGAAGAGT TTGCCAATGG GATCCTGCTG 
GCCACCCCAC CCCCAGGACC GGGCCCCTTG CCCACCACGG TACCCAGCCC GGCCTCAGGG 
AAGCCCAGCA GCGAGCTGCC CCCTGCCCCG GAGTCTGCAG CTGACTCTGG AGTAGAGGAG 
GCCGACACTC GAAGCTCCAG TGACCCCCAC CTGGAGACCA CAAGCACCAT TTCCACAGTG 
TCCAGCATGT CCACCCTGAG CTCGGAGAGT GGAGAACTCA CTGACACCCA CACCTCCTTT 
GCCGATGGAC ACACTTTTCT ACTCGAGAAG CCACCAGTGC CTCCCAAGCC CAAACTCAAG 
TCCCCGCTGG GGAAGGGGCC GGTGACCTTC AGGGGCCCGC TGCTGAAGCA ATCCTCGGAC 
AGTGAGCTCA TGGCCCAGCA GCACCATGCC ACCTCTACTG GGTTGACTTC TGCTGCTGGG 
CCTGCCCGCC CTCGCTACCT CTTCCAGAGA AGGTCCAAGC TGTGGGGGGA CCCCGTGGAG 
AGTCGGGGGC TCCCTGGGCC TGAGGATGAC AAACCAACTG TGATCAGTGA GCTCAGCTCC 
CGTCTGCAGC AGCTGAATAA AGACACTCGC TCCTTGGGGG AGGAACCAGT TGGTGGCCTG 
GGTAGCCTGC TGGACCCTGC TAAGAAGTCG CCCATTGCAG CAGCTCGCTG CGCGGTGGTC 
CCGAGTGCCG GCTGGCTCTT CAGCAGCCTC GGTGAGCTGA GCACCATCTC AGCGCAGCGC 
AGCCCCGGGG GCCCGGGCGG AGGGGCCTCC TACTCGGTGC GGCCCAGCGG CCGGTACCCC 
GTGGCGAGAC GAGCCCCGAG CCCAGTGAAA CCCGCATCGC TGGAGCGGGT GGAGGGGCTG 
GGGGCGGGCG TGGGAGGCGC GGGGCGGCCC TTCGGCCTCA CGCCTCCCAC CATCCTCAAG 
TCGTCCAGCC TCTCCATCCC GCACGAACCC AAGGAAGTGC GCTTCGTGGT GCGAAGTGCG 
AGTGCGCGCA GCCGCTCCCC CTCACCATCT CCGCTGCCCT CGCCTTCTCC TGGCTCTGGC 
CCCAGTGCCG GCCCGCGTCG GCCATTTCAA CAGAAGCCCC TGCAGCTTTG GAGCAAGTTC 
GATGTGGGCG ACTGGCTGGA GAGCATCCAC TTAGGCGAGC ACCGAGACCG CTTCGAGGAC 
CATGAGATCG AAGGCGCACA CCTGCCTGCG CTCACCAAGG AAGACTTCGT GGAGCTGGGA 
GTCACACGCG TTGGCCACCG CATGAACATC GAGCGTGCGC TCAGGCAGCT GGATGGCAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Shank Proteins Differentially Regulate Synaptic Transmission.
eNeuro4(6)(2017 Nov-Dec)
Shi R,Redman P,Ghose D,Liu Y,Ren X,Ding LJ,Liu M,Jones KJ,Xu W

Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution.
Biochemical and biophysical research communications490(3)806-812(2017 08)
Ponna SK,Myllykoski M,Boeckers TM,Kursula P

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Shank3 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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