Hcn4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hcn4
Entrez Gene ID	59266
Full Name	hyperpolarization activated cyclic nucleotide-gated potassium channel 4
General protein information	Preferred Names hyperpolarization activated cyclic nucleotide-gated potassium channel 4 Names potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	may act as a neuronal pacemaker channel; may play a role in neurotransmitter release [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021658.1	NP_067690.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Pathways from BioSystems

Homologies

	HCN4	XP_002804905.1
Mus musculus (house mouse)	Hcn4	NP_001074661.1
Danio rerio (zebrafish)	hcn4	XP_686078.4
Xenopus tropicalis (tropical clawed frog)	hcn4	XP_004916024.1
Pan troglodytes (chimpanzee)	HCN4	XP_003952750.1
Bos taurus (cattle)	HCN4	XP_002690539.1
Gallus gallus (chicken)	HCN4	XP_425050.3
Homo sapiens (human)	HCN4	NP_005468.1
Danio rerio (zebrafish)	hcn4l	XP_684730.5
Rattus norvegicus (Norway rat)	Hcn4	NP_067690.1

Gene Ontology
Bibliography

Related articles in PubMed

Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics.
Negrini D, Marcozzi C, Solari E, Bossi E, Cinquetti R, Reguzzoni M, Moriondo A
American journal of physiology. Heart and circulatory physiology311(4)H892-H903(2016 Oct)

Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
Z??iga R, Gonz?lez D, Valenzuela C, Brown N, Z??iga L
Biochemical and biophysical research communications478(3)1429-35(2016 09)

Dynamic Expression of Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 4 Involved in Microwave Induced Pacemaker Cell Injuries.
Liu YQ, Zhao L, Gao YB, Dong J, Wang H, Yao BW, Zhou HM, Wang SM, Peng RY
Biomedical and environmental sciences : BES28(11)823-8(2015 Nov)

Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial Infarction.
Yu HD, Xia S, Zha CQ, Deng SB, Du JL, She Q
Journal of cardiovascular pharmacology65(6)587-92(2015 Jun)

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A
Nature chemical biology10(6)457-62(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that HCN channels might play an important role in affecting contraction frequency of lymphatic muscle cells.
Title: Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics.

the expression and relative abundances of HCN channels in cerebellum and primary cultures of cerebellar granule neurons, is described.
Title: Expression and cellular localization of HCN channels in rat cerebellar granule neurons.

involved in microwave-induced heart pacemaker cell injuries
Title: Dynamic Expression of Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 4 Involved in Microwave Induced Pacemaker Cell Injuries.

Spironolactone increased miRNA-1 expression in myocardium after myocardial infarction. Upregulation of miRNA-1 expression contributed to the posttranscriptional repression of HCN2/4 expression.
Title: Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial Infarction.

The results of this study indicated that HCN4 subunits are expressed in several populations of spinal and hippocampal interneurons.
Title: HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.

The following Hcn4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hcn4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04969	NM_021658.1 Latest version!	Rattus norvegicus hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hcn4 ( NM_021658.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067690.1 Rattus norvegicus hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4), mRNA.

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CloneID	ORa04969
Clone ID Related Accession (Same CDS sequence)	NM_021658.1
Accession Version	NM_021658.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-31
Organism	Rattus norvegicus(Norway rat)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF247453.1. Sequence Note: This sequence has been modified as follows: removed 22 bp suspected to be vector contamination from the 3' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF247453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTTCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GATGGTGAGG AAGAGGGGGC CGGGGGCCTC 
CAGGACCCAA GCCGAAGGAG CATTCGGCTG CGGCCGCTGC CCTCGCCCTC GCCCTCGGTG 
GCCGCCGGCT GCTCCGAGTC CCGGGGTGCG GCCCTCGGGG CGGCAGACAG CGAGGGGCCG 
GGCCGCAGCG CCGGCAAGTC CAGCACCAAC GGTGACTGCA GGCGCTTCCG CGGGAGTCTG 
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGT GGTGGAGCAG GGGGCGGCAG CAGTCTCGGG 
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG CTGAGGGCGA TGCGTCCCCC 
GGCGAGGACA GGACGCCCCC GGGCCTGGCG ACCGAGCCCG AGCGCCCGGG CGCCGCGGCA 
CAACCCGCAG CCTCGCCGCC GCCCCAACAG CCGCCGCAGC CGGCCTCCGC CTCCTGCGAG 
CAGCCCTCGG CGGACACAGC TATCAAAGTG GAAGGAGGCG CGGCCGCCAG CGACCAGATC 
CTCCCTGAGG CCGAGGTGCG CCTGGGCCAG AGCGGCTTCA TGCAGCGCCA GTTCGGTGCC 
ATGCTGCAAC CTGGGGTCAA CAAATTCTCG CTAAGGATGT TCGGCAGCCA GAAAGCAGTG 
GAGCGTGAGC AGGAGAGGGT TAAGTCAGCT GGGTTTTGGA TTATCCACCC CTACAGCGAC 
TTCAGATTTT ACTGGGACCT GACGATGCTG TTGCTGATGG TGGGGAATCT GATCATCATC 
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACCC CCTGGATCGT CTTCAACGTG 
GTGTCAGACA CATTCTTCCT CATTGACTTG GTCCTCAACT TCCGCACGGG GATCGTGGTG 
GAGGACAACA CAGAAATCAT CCTTGACCCA CAGCGGATCA AGATGAAGTA CCTGAAAAGC 
TGGTTTGTGG TGGACTTCAT CTCCTCCATC CCCGTGGACT ACATCTTCCT TATAGTGGAG 
ACTCGCATTG ACTCGGAGGT CTACAAAACC GCCAGGGCTC TGCGCATTGT CCGCTTCACG 
AAGATCCTCA GCCTCCTGCG CCTCCTGCGG CTTTCCCGCC TCATTCGGTA CATTCACCAG 
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGTG CCGTGGTACG CATCGTGAAC 
CTCATTGGCA TGATGCTTCT GCTTTGCCAC TGGGATGGCT GCCTGCAGTT CCTGGTGCCC 
ATGCTGCAGG ACTTCCCCCA TGACTGCTGG GTGTCCATCA ACGGCATGGT GAATAACTCC 
TGGGGGAAGC AGTACTCCTA TGCCCTCTTC AAGGCCATGA GCCACATGCT GTGTATTGGG 
TACGGACGGC AGGCACCCGT AGGCATGTCT GACGTCTGGC TCACCATGCT CAGCATGATC 
GTGGGCGCCA CCTGCTATGC CATGTTCATC GGGCACGCCA CTGCCCTCAT CCAGTCGCTG 
GACTCCTCCC GGCGCCAGTA CCAGGAGAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTC 
CACAAGCTCC CGCCTGACAC CAGGCAGCGC ATCCACGACT ACTACGAACA CCGCTACCAG 
GGCAAGATGT TTGACGAGGA AAGCATCCTG GGTGAGCTGA GTGAGCCGCT TCGAGAGGAG 
ATCATCAACT TTAACTGCCG GAAGCTGGTG GCATCCATGC CACTGTTCGC CAATGCAGAC 
CCCAACTTTG TGACGTCTAT GCTGACCAAG TTGCGTTTTG AGGTCTTTCA GCCTGGGGAC 
TACATCATCC GTGAAGGCAC CATCGGCAAG AAGATGTACT TTATCCAGCA CGGCGTGGTC 
AGTGTGCTCA CTAAGGGCAA CAAGGAGACC AAGCTGGCTG ATGGCTCCTA TTTTGGAGAG 
ATCTGCTTGC TGACCCGAGG CCGTCGCACA GCGAGCGTGA GGGCGGATAC TTACTGCCGC 
CTCTACTCAC TGAGCGTGGA CAACTTCAAC GAGGTGCTGG AGGAGTATCC CATGATGCGC 
AGGGCTTTCG AGACGGTTGC GCTGGACCGT CTGGACCGCA TAGGCAAGAA GAACTCCATC 
CTCCTCCACA AGGTGCAGCA CGACCTCAAC TCAGGCGTCT TCAACTACCA AGAGAACGAG 
ATCATCCAGC AGATCGTGCG GCATGACCGT GAGATGGCCC ACTGTGCTCA CCGCGTCCAG 
GCTGCTGCCT CAGCCACCCC AACCCCAACG CCTGTCATAT GGACCCCACT GATCCAGGCA 
CCACTGCAGG CTGCTGCTGC TACTACTTCG GTGGCCATAG CCCTCACACA CCACCCCCGC 
CTGCCAGCCG CTATCTTCCG GCCCCCTCCC GGACCTGGGC TGGGTAACCT GGGGGCTGGA 
CAGACACCGA GGCACCCAAG GAGGTTGCAG TCCTTGATCC CTTCAGCGCT AGGCTCTGCT 
TCACCAGCCA GCAGCCCCTC ACAGGTGGAC ACACCGTCTT CATCTTCCTT CCACATCCAA 
CAGCTGGCTG GATTCTCTGC ACCTCCTGGA TTGAGTCCTC TCTTGCCCTC CTCTAGCTCT 
TCCCCACCTC CAGGAGCCTG CAGTTCTCCC CCAGCCCCCA CTCCATCCAC CTCCACTGCT 
GCCACCACCA CCGGGTTCGG CCACTTTCAT AAGGCGCTAG GTGGCTCCCT GTCTTCCTCT 
GATTCCCCGC TGCTCACCCC ACTGCAACCG GGCGCTCGCT CTCCACAGGC TGCCCAGCCG 
CCACCCCCAC TGCCTGGGGC CCGAGGAGGC CTGGGACTCC TGGAGCACTT CTTGCCGCCC 
CCACCTTCGT CCCGGTCACC ATCATCTAGC CCTGGGCAGC TGGGCCAGCC TCCTGGAGAG 
TTGTCCCCAG GTCTGGCAGC TGGTCCACCA AGTACACCAG AGACACCCCC GCGGCCCGAA 
CGGCCATCCT TTATGGCAGG GGCCTCTGGG GGGGCTTCTC CTGTAGCCTT TACCCCCCGA 
GGAGGCCTCA GCCCTCCGGG CCACAGCCCA GGACCCCCAA GAACTTTCCC GAGTGCCCCA 
CCCCGGGCCT CTGGCTCCCA TGGTTCCCTG CTCCTGCCAC CTGCATCCAG CCCTCCGCCT 
CCCCAGGTCC CACAGCGCAG GGGCACACCA CCCCTCACCC CCGGCCGCCT CACACAGGAC 
CTGAAGCTCA TCTCAGCCTC TCAGCCAGCC CTCCCCCAGG ATGGGGCACA GACTCTACGC 
AGGGCCTCTC CTCACTCCTC AGGGGAGTCG ATGGCTGCCT TCTCACTCTA CCCCAGAGCT 
GGGGGTGGCA GTGGGAGCAG TGGGGGCCTT GGGCCTCCTG GAAGGCCATA TGGTGCCATC 
CCAGGCCAGC ATGTCACTTT GCCTCGGAAG ACATCCTCAG GTTCTTTGCC ACCCCCACTT 
TCTTTGTTTG GGGCAAGAGC CGCCTCTTCT GGAGGGCCCC CTCTGACTGC TGCACCCCAG 
AGGGAACCTG GCGCTAGGTC CGAGCCAGTA CGCTCCAAAC TGCCGTCTAA TTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067690.1
CDS	228..3824
Translation	MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGLQDPSRRSIRLRPLPSPSPSVAAGCSESRGAALGAADSEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPPGLATEPERPGAAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACSSPPAPTPSTSTAATTTGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSPGLAAGPPSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFSLYPRAGGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLTAAPQREPGARSEPVRSKLPSNL

Target ORF information:

RefSeq Version	NM_021658.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021658.1

ORF Insert Sequence:

ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTTCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GATGGTGAGG AAGAGGGGGC CGGGGGCCTC 
CAGGACCCAA GCCGAAGGAG CATTCGGCTG CGGCCGCTGC CCTCGCCCTC GCCCTCGGTG 
GCCGCCGGCT GCTCCGAGTC CCGGGGTGCG GCCCTCGGGG CGGCAGACAG CGAGGGGCCG 
GGCCGCAGCG CCGGCAAGTC CAGCACCAAC GGTGACTGCA GGCGCTTCCG CGGGAGTCTG 
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGT GGTGGAGCAG GGGGCGGCAG CAGTCTCGGG 
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG CTGAGGGCGA TGCGTCCCCC 
GGCGAGGACA GGACGCCCCC GGGCCTGGCG ACCGAGCCCG AGCGCCCGGG CGCCGCGGCA 
CAACCCGCAG CCTCGCCGCC GCCCCAACAG CCGCCGCAGC CGGCCTCCGC CTCCTGCGAG 
CAGCCCTCGG CGGACACAGC TATCAAAGTG GAAGGAGGCG CGGCCGCCAG CGACCAGATC 
CTCCCTGAGG CCGAGGTGCG CCTGGGCCAG AGCGGCTTCA TGCAGCGCCA GTTCGGTGCC 
ATGCTGCAAC CTGGGGTCAA CAAATTCTCG CTAAGGATGT TCGGCAGCCA GAAAGCAGTG 
GAGCGTGAGC AGGAGAGGGT TAAGTCAGCT GGGTTTTGGA TTATCCACCC CTACAGCGAC 
TTCAGATTTT ACTGGGACCT GACGATGCTG TTGCTGATGG TGGGGAATCT GATCATCATC 
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACCC CCTGGATCGT CTTCAACGTG 
GTGTCAGACA CATTCTTCCT CATTGACTTG GTCCTCAACT TCCGCACGGG GATCGTGGTG 
GAGGACAACA CAGAAATCAT CCTTGACCCA CAGCGGATCA AGATGAAGTA CCTGAAAAGC 
TGGTTTGTGG TGGACTTCAT CTCCTCCATC CCCGTGGACT ACATCTTCCT TATAGTGGAG 
ACTCGCATTG ACTCGGAGGT CTACAAAACC GCCAGGGCTC TGCGCATTGT CCGCTTCACG 
AAGATCCTCA GCCTCCTGCG CCTCCTGCGG CTTTCCCGCC TCATTCGGTA CATTCACCAG 
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGTG CCGTGGTACG CATCGTGAAC 
CTCATTGGCA TGATGCTTCT GCTTTGCCAC TGGGATGGCT GCCTGCAGTT CCTGGTGCCC 
ATGCTGCAGG ACTTCCCCCA TGACTGCTGG GTGTCCATCA ACGGCATGGT GAATAACTCC 
TGGGGGAAGC AGTACTCCTA TGCCCTCTTC AAGGCCATGA GCCACATGCT GTGTATTGGG 
TACGGACGGC AGGCACCCGT AGGCATGTCT GACGTCTGGC TCACCATGCT CAGCATGATC 
GTGGGCGCCA CCTGCTATGC CATGTTCATC GGGCACGCCA CTGCCCTCAT CCAGTCGCTG 
GACTCCTCCC GGCGCCAGTA CCAGGAGAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTC 
CACAAGCTCC CGCCTGACAC CAGGCAGCGC ATCCACGACT ACTACGAACA CCGCTACCAG 
GGCAAGATGT TTGACGAGGA AAGCATCCTG GGTGAGCTGA GTGAGCCGCT TCGAGAGGAG 
ATCATCAACT TTAACTGCCG GAAGCTGGTG GCATCCATGC CACTGTTCGC CAATGCAGAC 
CCCAACTTTG TGACGTCTAT GCTGACCAAG TTGCGTTTTG AGGTCTTTCA GCCTGGGGAC 
TACATCATCC GTGAAGGCAC CATCGGCAAG AAGATGTACT TTATCCAGCA CGGCGTGGTC 
AGTGTGCTCA CTAAGGGCAA CAAGGAGACC AAGCTGGCTG ATGGCTCCTA TTTTGGAGAG 
ATCTGCTTGC TGACCCGAGG CCGTCGCACA GCGAGCGTGA GGGCGGATAC TTACTGCCGC 
CTCTACTCAC TGAGCGTGGA CAACTTCAAC GAGGTGCTGG AGGAGTATCC CATGATGCGC 
AGGGCTTTCG AGACGGTTGC GCTGGACCGT CTGGACCGCA TAGGCAAGAA GAACTCCATC 
CTCCTCCACA AGGTGCAGCA CGACCTCAAC TCAGGCGTCT TCAACTACCA AGAGAACGAG 
ATCATCCAGC AGATCGTGCG GCATGACCGT GAGATGGCCC ACTGTGCTCA CCGCGTCCAG 
GCTGCTGCCT CAGCCACCCC AACCCCAACG CCTGTCATAT GGACCCCACT GATCCAGGCA 
CCACTGCAGG CTGCTGCTGC TACTACTTCG GTGGCCATAG CCCTCACACA CCACCCCCGC 
CTGCCAGCCG CTATCTTCCG GCCCCCTCCC GGACCTGGGC TGGGTAACCT GGGGGCTGGA 
CAGACACCGA GGCACCCAAG GAGGTTGCAG TCCTTGATCC CTTCAGCGCT AGGCTCTGCT 
TCACCAGCCA GCAGCCCCTC ACAGGTGGAC ACACCGTCTT CATCTTCCTT CCACATCCAA 
CAGCTGGCTG GATTCTCTGC ACCTCCTGGA TTGAGTCCTC TCTTGCCCTC CTCTAGCTCT 
TCCCCACCTC CAGGAGCCTG CAGTTCTCCC CCAGCCCCCA CTCCATCCAC CTCCACTGCT 
GCCACCACCA CCGGGTTCGG CCACTTTCAT AAGGCGCTAG GTGGCTCCCT GTCTTCCTCT 
GATTCCCCGC TGCTCACCCC ACTGCAACCG GGCGCTCGCT CTCCACAGGC TGCCCAGCCG 
CCACCCCCAC TGCCTGGGGC CCGAGGAGGC CTGGGACTCC TGGAGCACTT CTTGCCGCCC 
CCACCTTCGT CCCGGTCACC ATCATCTAGC CCTGGGCAGC TGGGCCAGCC TCCTGGAGAG 
TTGTCCCCAG GTCTGGCAGC TGGTCCACCA AGTACACCAG AGACACCCCC GCGGCCCGAA 
CGGCCATCCT TTATGGCAGG GGCCTCTGGG GGGGCTTCTC CTGTAGCCTT TACCCCCCGA 
GGAGGCCTCA GCCCTCCGGG CCACAGCCCA GGACCCCCAA GAACTTTCCC GAGTGCCCCA 
CCCCGGGCCT CTGGCTCCCA TGGTTCCCTG CTCCTGCCAC CTGCATCCAG CCCTCCGCCT 
CCCCAGGTCC CACAGCGCAG GGGCACACCA CCCCTCACCC CCGGCCGCCT CACACAGGAC 
CTGAAGCTCA TCTCAGCCTC TCAGCCAGCC CTCCCCCAGG ATGGGGCACA GACTCTACGC 
AGGGCCTCTC CTCACTCCTC AGGGGAGTCG ATGGCTGCCT TCTCACTCTA CCCCAGAGCT 
GGGGGTGGCA GTGGGAGCAG TGGGGGCCTT GGGCCTCCTG GAAGGCCATA TGGTGCCATC 
CCAGGCCAGC ATGTCACTTT GCCTCGGAAG ACATCCTCAG GTTCTTTGCC ACCCCCACTT 
TCTTTGTTTG GGGCAAGAGC CGCCTCTTCT GGAGGGCCCC CTCTGACTGC TGCACCCCAG 
AGGGAACCTG GCGCTAGGTC CGAGCCAGTA CGCTCCAAAC TGCCGTCTAA TTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics.
American journal of physiology. Heart and circulatory physiology311(4)H892-H903(2016 Oct)
Negrini D,Marcozzi C,Solari E,Bossi E,Cinquetti R,Reguzzoni M,Moriondo A

Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
Biochemical and biophysical research communications478(3)1429-35(2016 09)
Z??iga R,Gonz?lez D,Valenzuela C,Brown N,Z??iga L

Dynamic Expression of Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 4 Involved in Microwave Induced Pacemaker Cell Injuries.
Biomedical and environmental sciences : BES28(11)823-8(2015 Nov)
Liu YQ,Zhao L,Gao YB,Dong J,Wang H,Yao BW,Zhou HM,Wang SM,Peng RY

Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial Infarction.
Journal of cardiovascular pharmacology65(6)587-92(2015 Jun)
Yu HD,Xia S,Zha CQ,Deng SB,Du JL,She Q

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nature chemical biology10(6)457-62(2014 Jun)
Lolicato M,Bucchi A,Arrigoni C,Zucca S,Nardini M,Schroeder I,Simmons K,Aquila M,DiFrancesco D,Bolognesi M,Schwede F,Kashin D,Fishwick CW,Johnson AP,Thiel G,Moroni A

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Hcn4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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